Houston vs Duke Prediction, Picks & Odds | 05 Apr 2025

Houston and Duke to Play Out High-Scoring Game

Houston Cougars (34-4, 19-1 Big 12) lock horns with Duke Blue Devils (35-3, 19-1 ACC) in this NCAA Tournament Final Four matchup at Alamodome in San Antonio, Texas.

Over 136.5 points are expected to be scored when Houston and Duke meet, with this prediction available at odds of -110 and this looks like a value bet.

Duke Came Out on Top in Previous H2H

Houston Cougars won 69-50 against Tennessee Volunteers in their previous game.

Duke Blue Devils won 85-65 against Alabama Crimson Tide in their last game.

Head-to-Head Statistics

Duke won the last matchup between the pair. Enjoying a 54-51 triumph when facing Houston.

NCAAB Regular Season	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	0-0	0	0	0	0-0	0-0	-
Houston	0-0	0	0	0	0-0	0-0	-

View Full Standings

Houston vs Duke Prediction & Picks

There’s juice available when it comes to backing Over 136.5 points in this college game and that’s the betting angle we’re pursuing. Our pick is priced up at -110 which looks worth taking.

The expert college basketball handicappers at Sportsgambler.com are aware of injuries that could affect the outcome along with the form guide. We also leave no stone unturned when it comes to analyzing the latest stats.

Key Houston vs Duke stats:

• The 136.5 line has been covered in 9 of the last 10 Duke games.
• The 136.5 line has been covered in 17 of the last 20 Duke games.
• The 136.5 line has been covered in the last 4 Duke games.

Over 136.5 Probability

According to the sportsbooks, there’s a 52.4% likelihood of our pick landing a return. Based on our analysts research, we calculate the actual probability to be closer to 60%. This college basketball bet can therefore be backed with confidence.

If you’re wanting bigger odds when wagering on the Totals, then the good news is that you can be in control of the line. Get more juice by betting Over a certain number.

Best Bet

Over 136.5 Points @ -110 Bet Now

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Player Prop Picks

Top Pick: LJ Cryer Over 16.5 Points +118

LJ Cryer (Houston) can be wagered to score Over 16.5 points at +118. We are going to choose a Player Points prop bet which will hopefully see him cover the line.

Latest LJ Cryer Player Prop Odds

Points

Over 15.5

-108

Under 15.5

-120

Assists

Over 2.5

+118

Under 2.5

-154

Rebounds

Over 2.5

+120

Under 2.5

-156

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Milos Uzan Under 3.5 Assists -102

Milos Uzan (Houston) can be backed to finish with Under 3.5 assists at -102. He might fall short when it comes to covering the Player Assists line and we’re confident when it comes to this prop bet.

Latest Milos Uzan Player Prop Odds

Points

Over 12.5

-100

Under 12.5

-130

Assists

Over 3.5

-123

Under 3.5

-105

Rebounds

Over 2.5

-167

Under 2.5

+128

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Correct Score Prediction

Houston 67 - 76 Duke

For those wanting a big return from a small stake, consider the correct score lines. For example, Duke can be backed to win 76-67 at huge betting odds.

Houston vs Duke Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Duke Moneyline Odds Suggest Victory

Duke are -250 favorites and that means a 71% chance of winning this college game according to the Moneyline betting odds with the sportsbooks. If you’re looking for an alternative angle, Houston are trading at +198.

4.5 is where the spread lies, with total points being 137.5 right now. Basketball fans regularly enjoy the opportunity to bet on the Totals. If you want to back Over 137.5, it’s -105.

If you’re keen on Duke reaching 20 points before their opponents, the favorites are -175 to oblige. Conversely, Houston can be backed at +125 to make this total first.

Whether you are wagering pre-game or in-game, you can feast on plenty of game lines and team props. The selections are practically endless and it’s great to have so many options.

Moneyline

Houston

+198

Duke

-250

Point Spread

Houston +4.5

-110

Duke -4.5

-110

Total Points

Under 137.5

-115

Over 137.5

-105

Cooper Flagg Favorite to Score the Most Baskets

The favorite to score most points is Cooper Flagg. You can get -115 that he scores Over 19.5 points or -112 that he goes Under.

Cooper Flagg (Duke)

Over 19.5

-115

Under 19.5

-112

LJ Cryer (Houston)

Over 15.5

-108

Under 15.5

-120

Kon Knueppel (Duke)

Over 14.5

-114

Under 14.5

-114

Emanuel Sharp (Houston)

Over 13.5

+115

Under 13.5

-149

Tyrese Proctor (Duke)

Over 12.5

-110

Under 12.5

-118

Milos Uzan (Houston)

Over 12.5

-100

Under 12.5

-130

J'Wan Roberts (Houston)

Over 10.5

-123

Under 10.5

-105

Khaman Maluach (Duke)

Over 8.5

-125

Under 8.5

-103

Sion James (Duke)

Over 7.5

-100

Under 7.5

-130

Cooper Flagg (Duke)

Over 5.5

+110

Under 5.5

-143

Milos Uzan (Houston)

Over 3.5

-123

Under 3.5

-105

LJ Cryer (Houston)

Over 2.5

+118

Under 2.5

-154

Kon Knueppel (Duke)

Over 2.5

-167

Under 2.5

+128

Tyrese Proctor (Duke)

Over 2.5

+144

Under 2.5

-189

Sion James (Duke)

Over 2.5

+110

Under 2.5

-143

J'Wan Roberts (Houston)

Over 1.5

-156

Under 1.5

+120

Emanuel Sharp (Houston)

Over 0.5

-141

Under 0.5

+105

Khaman Maluach (Duke)

Over 0.5

+115

Under 0.5

-154

Cooper Flagg (Duke)

Over 7.5

-135

Under 7.5

+104

Khaman Maluach (Duke)

Over 7.5

+115

Under 7.5

-149

J'Wan Roberts (Houston)

Over 6.5

+110

Under 6.5

-143

Kon Knueppel (Duke)

Over 4.5

+126

Under 4.5

-164

Sion James (Duke)

Over 3.5

-156

Under 3.5

+120

LJ Cryer (Houston)

Over 2.5

+120

Under 2.5

-156

Emanuel Sharp (Houston)

Over 2.5

-156

Under 2.5

+120

Tyrese Proctor (Duke)

Over 2.5

-105

Under 2.5

-123

Milos Uzan (Houston)

Over 2.5

-167

Under 2.5

+128

Micro Betting

There are some exciting college basketball micro betting lines that are created and they are available in-game. Among them are Next Field Goal, where you select if the shot will be a two or three-pointer. The long-ball option pays better, and in today’s game, you can never discount the three-pointer.

Last 5 & H2H

Latest regular season and playoff games stats.

Houston Stats

Duke Stats

Moneyline

• 10 wins and 0 defeats in the last 10 games

Moneyline

• 10 wins and 0 defeats in the last 10 games

Point Spread

• +5.5 Betting Line: Have covered the spread in the last 10 games

Point Spread

• -5.5 Betting Line: Have covered the spread in 9 of the last 10 games

Total Points

• Game Totals: An average of 131.20 pts in the previous 10 games
• Over 136.5: Covered in 3 of the previous 10 games
• Team Totals: Have scored an average of 71.60 pts and allowed 59.60 pts in the last 10 games

Total Points

• Game Totals: An average of 153.70 pts in the previous 10 games
• Over 136.5: Covered in 9 of the previous 10 games
• Team Totals: Have scored an average of 86.70 pts and allowed 67.00 pts in the last 10 games

NCAAB Regular Season Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Boston College	0-0	0	0	0	0-0	0-0	-
Notre Dame	0-0	0	0	0	0-0	0-0	-
Virginia Tech	0-0	0	0	0	0-0	0-0	-
Virginia	0-0	0	0	0	0-0	0-0	-
Syracuse	0-0	0	0	0	0-0	0-0	-
Stanford	0-0	0	0	0	0-0	0-0	-
SMU	0-0	0	0	0	0-0	0-0	-
Pittsburgh	0-0	0	0	0	0-0	0-0	-
North Carolina	0-0	0	0	0	0-0	0-0	-
California	0-0	0	0	0	0-0	0-0	-
NC State	0-0	0	0	0	0-0	0-0	-
Miami	0-0	0	0	0	0-0	0-0	-
Louisville	0-0	0	0	0	0-0	0-0	-
Florida State	0-0	0	0	0	0-0	0-0	-
Duke	0-0	0	0	0	0-0	0-0	-
Clemson	0-0	0	0	0	0-0	0-0	-
Wake Forest	0-0	0	0	0	0-0	0-0	-

Big 12	Overall	PF	PA	N. Pts	Home	Away	Strk
Arizona State	0-0	0	0	0	0-0	0-0	-
Arizona	0-0	0	0	0	0-0	0-0	-
BYU	0-0	0	0	0	0-0	0-0	-
Cincinnati	0-0	0	0	0	0-0	0-0	-
Colorado	0-0	0	0	0	0-0	0-0	-
Houston	0-0	0	0	0	0-0	0-0	-
Iowa State	0-0	0	0	0	0-0	0-0	-
Kansas	0-0	0	0	0	0-0	0-0	-
Kansas State	0-0	0	0	0	0-0	0-0	-
Oklahoma State	0-0	0	0	0	0-0	0-0	-
TCU	0-0	0	0	0	0-0	0-0	-
UCF	0-0	0	0	0	0-0	0-0	-
Utah	0-0	0	0	0	0-0	0-0	-
West Virginia	0-0	0	0	0	0-0	0-0	-

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak