Santa Clara vs Xavier Prediction, Picks & Odds | 10 Nov 2025

College Basketball Betting Preview: Santa Clara vs Xavier

The Santa Clara Broncos go up against the Xavier Musketeers, with tip-off scheduled for 20:30 on Monday, November 10. Our betting preview features expert NCAAB predictions, betting tips, the latest odds and H2H stats.

Santa Clara to Cover the Line?

We’re confident that the underdogs can either win or suffer a narrow defeat. That makes Santa Clara at +2.5 the best wager when they clash with Xavier and -115 are available.

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Each Team Bidding to Secure Another Win

Santa Clara Broncos previous game saw them claim a 79-67 home win over McNeese State Cowboys.

Xavier Musketeers last game saw them claim a 74-69 home win over Le Moyne Dolphins.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Xavier	2-0	140	131	9	2-0	0-0	2W
Santa Clara	2-0	162	120	42	2-0	0-0	2W

View Full Standings

Santa Clara vs Xavier Prediction & Picks

We dive into the best Santa Clara vs Xavier betting angles, including a key match prediction, our correct score forecast and a value-focused bet builder. Read on for the full breakdown.

Game Prediction

Our pick is that Santa Clara will cover the line and prove to be competitive. It’s currently set at +2.5 for this college matchup and that makes lots of appeal, with odds of -115 available.

Sportsgambler.com brings strong college hoops expertise, built on knowing the team news as soon as it’s confirmed. Recent form plays a big part in our basketball picks and we always back it up with the most relevant stats.

Key Santa Clara vs Xavier stats:

• The +2.5 line has been covered by Santa Clara in 4 of their last 5 games.
• The +2.5 line has been covered by Santa Clara in 7 of their last 10 games.
• The +2.5 line has been covered by Santa Clara in 2 consecutive games.

Santa Clara +2.5 Probability

The best sportsbooks are estimating that there is a 53.5% chance of this pick winning. Our cappers think there’s a stronger chance of success and calculate the probability to be closer to 60%. This is why we regard this as a value wager.

Bettors can choose between buying or selling points depending on their attitude to risk. When you move the line in either direction, the odds change accordingly.

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Best Bet

Santa Clara +2.5 @ -115 Bet Now

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Correct Score Prediction

Santa Clara 76 - 74 Xavier

There might not be too much between these teams, with our correct score pick being a 76-74 win for Santa Clara. There are huge odds available when it comes to this selection.

Santa Clara vs Xavier Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Books Make Xavier Likelier Winners

Xavier are -147 favorites and that means a 60% chance of winning this college game according to the Moneyline betting odds with the sportsbooks. For those wanting to back Santa Clara, you will find +122 about the underdogs.

The spread is currently 2.5, with the total points line at 157.5. The Totals offers basketball fans an alternative way of getting involved. If you fancy Under 157.5, then the odds are -110.

If you’re planning to place a bet on a college basketball matchup, head to the top betting apps and explore the wide range of team props and game lines. Look for the lines that offer the most value.

Moneyline

Santa Clara

+122

Xavier

-147

Point Spread

Santa Clara +2.5

-115

Xavier -2.5

-105

Total Points

Under 157.5

-110

Over 157.5

-110

Player Props & Micro Betting

We’re fond of player props as an alternative to betting on the game result. The gambling sites will have Points, Assists, Three-Pointers, Rebounds and Steals among the choices and you can take a particular view.

It’s good to consider all wagering options when it comes to college basketball and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether the next shot will be a Two or a Three-pointer.

Last 5 & H2H

Latest regular season and playoff games stats.

Santa Clara Stats

Xavier Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 8 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

• Game Totals: An average of 156.70 pts in the previous 10 games
• Game Totals on the Road: An average of 159.30 pts in the previous 10 games on the road
• Over 157.5: Covered in 5 of the previous 10 games
• Over 157.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 84.50 pts and allowed 72.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 84.20 pts and allowed 75.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 150.70 pts in the previous 10 games
• Game Totals at Home: An average of 145.00 pts in the previous 10 home games
• Over 157.5: Covered in 4 of the previous 10 games
• Over 157.5 at Home: Covered in 1 of the previous 10 home games
• Team Totals: Have scored an average of 78.50 pts and allowed 72.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 76.60 pts and allowed 68.40 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	2-0	189	102	87	2-0	0-0	2W
Marquette	3-0	280	212	68	2-0	1-0	3W
Butler	2-0	200	138	62	2-0	0-0	2W
DePaul	2-0	164	126	38	2-0	0-0	2W
Seton Hall	2-0	145	111	34	2-0	0-0	2W
Georgetown	2-0	157	130	27	1-0	1-0	2W
Creighton	1-0	92	76	16	1-0	0-0	1W
Xavier	2-0	140	131	9	2-0	0-0	2W
St. John's	1-1	204	177	27	1-1	0-0	1L
Villanova	1-1	160	145	15	1-0	0-1	1W
Providence	1-1	190	186	4	1-0	0-1	1L

West Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Loyola Marymount	3-0	301	188	113	3-0	0-0	3W
Gonzaga	2-0	181	111	70	2-0	0-0	2W
Portland	3-0	270	220	50	3-0	0-0	3W
Saint Mary's	2-0	171	124	47	2-0	0-0	2W
Santa Clara	2-0	162	120	42	2-0	0-0	2W
Oregon State	2-0	143	138	5	2-0	0-0	2W
San Francisco	1-1	168	129	39	1-0	0-1	1L
Pacific	1-1	160	134	26	1-0	0-1	1L
San Diego	1-1	156	130	26	1-1	0-0	1L
Seattle	1-1	155	146	9	1-1	0-0	1L
Pepperdine	1-1	151	154	-3	1-0	0-1	1L
Washington State	0-2	150	168	-18	0-1	0-1	2L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak