Villanova vs USC Prediction, Picks & Odds | 03 Apr 2025

Back USC to Frustrate Villanova

Villanova Wildcats (20-14, 12-10 Big East) play USC Trojans (17-17, 8-14 Big Ten) in this College Basketball Crown second round matchup at MGM Grand Garden Arena in Las Vegas.

Our prediction is that USC will be able to cover the spread against Villanova, with +5.5 looking favorable for our bet. Take the -115 that is currently available.

Both Teams Won Last Time Out

Villanova Wildcats won 85-64 against Colorado Buffaloes in their previous game.

USC Trojans secured a 89-60 win in their last game over Tulane Green Wave.

NCAAB Regular Season	Overall	PF	PA	N. Pts	Home	Away	Strk
USC	0-0	0	0	0	0-0	0-0	-
Villanova	0-0	0	0	0	0-0	0-0	-

View Full Standings

Villanova vs USC Prediction & Picks

We’re expecting a spirited performance from USC which leads us to backing the underdogs against the spread for this college contest. They should be able to cover the +5.5 line where -115 can be found.

The latest team news and current form are always useful information when it comes to providing college basketball predictions. It’s also important to pay attention to the available stats so that we can make the best picks.

Key Villanova vs USC stats:

• The +5.5 line has been covered by USC in 4 of their last 5 games.
• The +5.5 line has been covered by USC in 6 of their last 10 games.
• The +5.5 line has been covered by USC in 3 consecutive games.
• The -5.5 line hasn’t been covered by Villanova in 13 of their last 20 games.
• The -5.5 line hasn’t been covered by Villanova in 6 of their last 10 games.

USC +5.5 Probability

According to the latest odds, our pick has a 53.5% chance of winning. However, our cappers in-depth research has found that the actual probability is closer to 60%. This college basketball wager can therefore be backed with confidence.

If you want to secure a bigger possible payout on your bet, there’s the option to move the line. Take a look at the various prices and see which line you think will be covered.

Best Bet

USC +5.5 @ -115 Bet Now

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Correct Score Prediction

Villanova 74 - 71 USC

We’ll throw a dart when it comes to Villanova claiming a 74-71 victory. This correct score pick is available at huge odds and could be an entertaining bet to place.

Villanova vs USC Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Books Think Villanova Likeliest to Win

Sportsbooks’ favorites Villanova are regarded as likeliest victors for this college game and the -208 about them triumphing means a 68% chance based on their current Moneyline betting odds. The market suggests that USC are least likely to win at +172.

The spread is currently 4.5, with the total points line at 150.5. Basketball fans regularly enjoy the opportunity to bet on the Totals. There’s the chance to back Under 150.5 at -110.

There are stacks of game lines and team props s when it comes to wagering on college basketball and we recommend visiting the top betting sites to find the bet that matches your view on the contest.

Moneyline

Villanova

-208

USC

+172

Point Spread

Villanova -4.5

-114

USC +4.5

-106

Total Points

Under 150.5

-110

Over 150.5

-110

Player Props & Micro Betting

As an alternative to the game lines, check out the player prop bets that are available. It’s especially great if you have a view when it comes to Turnovers, Steals, Blocks and Points, while there are lots of other options.

For those looking to enjoy a thrilling in-game wager, college basketball micro betting could be up your street. You are now able to wager on the Next Field Goal, with the options being for a two-pointer or a three-pointer.

Last 5 & H2H

Latest regular season and playoff games stats.

Villanova Stats

USC Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games

Moneyline

• 3 wins and 7 defeats in the last 10 games

Point Spread

• -5.5 Betting Line: Have covered the spread in 4 of the last 10 games

Point Spread

• +5.5 Betting Line: Have covered the spread in 6 of the last 10 games

Total Points

• Game Totals: An average of 136.40 pts in the previous 10 games
• Over 151.5: Has not been covered in any of the previous 10 games
• Team Totals: Have scored an average of 69.50 pts and allowed 66.90 pts in the last 10 games

Total Points

• Game Totals: An average of 157.40 pts in the previous 10 games
• Over 151.5: Covered in 6 of the previous 10 games
• Team Totals: Have scored an average of 77.70 pts and allowed 79.70 pts in the last 10 games

NCAAB Regular Season Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	Overall	PF	PA	N. Pts	Home	Away	Strk
Illinois	0-0	0	0	0	0-0	0-0	-
Indiana	0-0	0	0	0	0-0	0-0	-
Iowa	0-0	0	0	0	0-0	0-0	-
Maryland	0-0	0	0	0	0-0	0-0	-
Michigan	0-0	0	0	0	0-0	0-0	-
Minnesota	0-0	0	0	0	0-0	0-0	-
Nebraska	0-0	0	0	0	0-0	0-0	-
Northwestern	0-0	0	0	0	0-0	0-0	-
Oregon	0-0	0	0	0	0-0	0-0	-
Penn State	0-0	0	0	0	0-0	0-0	-
Purdue	0-0	0	0	0	0-0	0-0	-
Rutgers	0-0	0	0	0	0-0	0-0	-
USC	0-0	0	0	0	0-0	0-0	-
UCLA	0-0	0	0	0	0-0	0-0	-
Washington	0-0	0	0	0	0-0	0-0	-
Wisconsin	0-0	0	0	0	0-0	0-0	-

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
Butler	0-0	0	0	0	0-0	0-0	-
UConn	0-0	0	0	0	0-0	0-0	-
Creighton	0-0	0	0	0	0-0	0-0	-
DePaul	0-0	0	0	0	0-0	0-0	-
Georgetown	0-0	0	0	0	0-0	0-0	-
Marquette	0-0	0	0	0	0-0	0-0	-
St. John's	0-0	0	0	0	0-0	0-0	-
Villanova	0-0	0	0	0	0-0	0-0	-
Xavier	0-0	0	0	0	0-0	0-0	-

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak