Atlético Nacional vs São Paulo Prediction, Betting Tips, Lineups & Odds | 12 Aug 2025

Copa Libertadores Betting Preview: Atlético Nacional vs São Paulo

Colombian Categoria Primera A club Atlético Nacional host Brazilian Série A side São Paulo in the first leg of this Copa Libertadores round of 16 tie at Estadio Atanasio Girardot, with kick-off set for 21:30 on Tuesday 12 August. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats and team news.

Can São Paulo Keep the Scores Close?

When São Paulo clash against Atlético Nacional, we will take the former at -115 on the Asian Handicap +0.25. With our stake divided between 0 and +0.5, the visitors look as though they can land a return by swerving defeat.

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Both Teams Victorious in Last Game

Atlético Nacional beat Alianza Petrolera 3-0 at home in their last game. Los Verdolagas recorded 56% possession and had six shots on target, with Facundo Batista, Juan Zapata and Andrés Sarmiento on the scoresheet.

São Paulo won their previous game, beating Vitória at home. It was a 2-0 Série A triumph. Tricolor Paulista managed four shots on goal and enjoyed 57% possession, with Damian Bobadilla and Sabino finding the net.

Copa Libertadores		G	W	D	L	GF	GA	GD	GD	P
1	São Paulo	6	4	2	0	10	4	6	10:4	14
2	Atlético Nacional	6	3	0	3	7	6	1	7:6	9

View Full Table

Confirmed Lineups

Atlético Nacional confirmed lineup (4-2-3-1): David Ospina (GK), Felipe Roman, Juan Jose Arias, William Tesillo, Camilo Candido, Jorman Campuzano, Juan Zapata, Marino Hinestroza, Edwin Cardona, Marlos Moreno, Alfredo Morelos.

São Paulo confirmed lineup (3-5-2): Rafael (GK), Nahuel Ferraresi, Sabino, Alan Franco, Cedric Soares, Alisson, Damian Bobadilla, Marcos Antonio, Enzo Hernan Diaz, Luciano Neves, Andre.

Atlético Nacional vs São Paulo Prediction & Betting Tips

Discover the top Atlético Nacional vs São Paulo betting angles — from our trusted match prediction and likely score to the best prop plays and a customized bet builder.

Match Prediction

Wager on São Paulo +0.25 on the Asian Handicap at -115 for this Copa Libertadores game. We’re keen on their prospects of outperforming their match winner price and this wager looks like good value.

It’s always a case of checking out the latest Copa Libertadores team news to make expert football predictions. Then we get to work when it comes to unearthing the stats that are the most valuable.

Key Atlético Nacional vs São Paulo Copa Libertadores & league stats:

• The +0.25 line has been covered by São Paulo in 6 consecutive games.
• The +0.25 line has been covered by São Paulo in 15 of their last 20 games.
• The +0.25 line has been covered by São Paulo in 7 of their last 10 games.
• The -0.25 line hasn’t been covered by Nacional in 3 of their last 5 games.
• The -0.25 line hasn’t been covered by Nacional in 11 of their last 20 games.

São Paulo +0.25 Probability

The best betting apps make it a 53.5% chance that our pick is settled as a winner. However, we have this number closer to 60% based on our in-depth research. This is why we can recommend this wager.

There are different options to wager on São Paulo, with Winning Margin a great alternative. Select the fixed interval and get paid out if you’re correct.

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Our Match Prediction

São Paulo Asian Hcp +0.25 @ -115 Bet Now

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Correct Score Prediction

Nacional 0 - 1 São Paulo

We’re betting on São Paulo to secure a 1-0 winning scoreline. Odds of +650 can be taken and it’s great fun to predict a correct score and hopefully land a winner.

Player Prop Picks

Top Pick: Aldemir Ferreira Under 0.5 Shots On Target -159

Aldemir Ferreira (São Paulo) can be backed to not record a shot on goal at -159. We’ll take a chance with this Shots on Target pick as the betting odds look pretty attractive.

Latest Aldemir Ferreira Player Prop Odds

Goalscorer

Anytime

+480

First

+850

Shots On Target

Over 0.5

+110

Under 0.5

-154

Shots

Over 1.5

-115

Under 1.5

-

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André Oliveira Silva To Score +430

André Oliveira Silva (São Paulo) can be backed at +430 to score. The odds that he will be an Anytime Goalscorer look attractive based on the evidence and we’ll plump for him to find the net.

Latest André Oliveira Silva Player Prop Odds

Goalscorer

Anytime

+450

First

+800

Shots On Target

Over 0.5

+107

Under 0.5

-152

Shots

Over 1.5

-147

Under 1.5

-

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Atlético Nacional vs São Paulo Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Nacional Trading at Shorter Odds Than São Paulo

Favourites Atlético Nacional are regarded as the likeliest winners for this Copa Libertadores clash. The +110 about them triumphing means a 48% chance of coming out on top based on their current betting odds. At +295, São Paulo are regarded as having a lower probability of winning.

There’s the option to get some insurance on your bet by going down the Draw No Bet route. This allows you to back Nacional at -227 with a safety net or alternatively opt for São Paulo at +155.

The Total Goals odds suggest that Under 2.5 is the likelier outcome in this contest. If you anticipate that a minimum of one side can manage a clean sheet, you might want to take the -175 about Both Teams to Score No.

If you visit one of the recommended betting sites, it’s fantastic to access hundreds of markets for whichever Copa Libertadores game appeals. Scan through the choices and pick your football wager.

Full-Time Result

1

+110

X

+210

2

+295

Half-Time Result

1

+195

X

-105

2

+350

Double Chance

1X

-370

12

-263

X2

-133

Draw No Bet

1

-227

2

+155

Asian Handicap

1 Hcp -0.25

-137

2 Hcp +0.25

-104

Total Goals

Under 2.5

-227

Over 2.5

+180

Both Teams to Score

Yes

+123

No

-175

Alfredo Morelos Favourite to Be First Goalscorer

You will find Alfredo Morelos at +340 to be First Goalscorer which makes him the favourite. There’s the chance to get +150 that he finds the net at anytime.

Alfredo Morelos (Nacional)

First

+150

Anytime

+340

Edwin Cardona (Nacional)

First

+340

Anytime

+650

Marino Hinestroza (Nacional)

First

+370

Anytime

+650

Luciano da Rocha (São Paulo)

First

+380

Anytime

+700

Gonzalo Tapia (São Paulo)

First

+420

Anytime

+750

André Oliveira Silva (São Paulo)

First

+450

Anytime

+800

Aldemir Ferreira (São Paulo)

First

+480

Anytime

+850

Dairon Asprilla (Nacional)

First

+500

Anytime

+950

Jonathan Calleri (São Paulo)

First

+525

Anytime

+1000

Oscar (São Paulo)

First

+575

Anytime

+1150

Mateus Uribe (Nacional)

First

+900

Anytime

+1800

Andrés Felipe Román (Nacional)

First

+950

Anytime

+2200

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

First

+1000

Anytime

+1900

Juan Manuel Zapata (Nacional)

First

+1050

Anytime

+2000

Jorman Campuzano (Nacional)

First

+1050

Anytime

+2000

Damián Bobadilla (São Paulo)

First

+1200

Anytime

+2000

Luiz Gustavo (São Paulo)

First

+1200

Anytime

+2200

Alfredo Morelos (Nacional)

Over 0.5

-222

Under 0.5

+128

Luciano da Rocha (São Paulo)

Over 0.5

-149

Under 0.5

+106

Marino Hinestroza (Nacional)

Over 0.5

-132

Under 0.5

-110

Edwin Cardona (Nacional)

Over 0.5

-118

Under 0.5

-122

Gonzalo Tapia (São Paulo)

Over 0.5

+105

Under 0.5

-152

André Oliveira Silva (São Paulo)

Over 0.5

+107

Under 0.5

-152

Aldemir Ferreira (São Paulo)

Over 0.5

+110

Under 0.5

-154

Jonathan Calleri (São Paulo)

Over 0.5

+133

Under 0.5

-192

Oscar (São Paulo)

Over 0.5

+163

Under 0.5

-238

Dairon Asprilla (Nacional)

Over 0.5

+165

Under 0.5

-244

Damián Bobadilla (São Paulo)

Over 0.5

+205

Under 0.5

-333

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

Over 0.5

+290

Under 0.5

-500

Mateus Uribe (Nacional)

Over 0.5

+340

Under 0.5

-625

Luiz Gustavo (São Paulo)

Over 0.5

+360

Under 0.5

-667

Andrés Felipe Román (Nacional)

Over 0.5

+375

Under 0.5

-1111

Juan Manuel Zapata (Nacional)

Over 0.5

+380

Under 0.5

-714

Jorman Campuzano (Nacional)

Over 0.5

+380

Under 0.5

-769

Alfredo Morelos (Nacional)

Over 2.5

-164

Under 2.5

-

Marino Hinestroza (Nacional)

Over 2.5

-106

Under 2.5

-

Luciano da Rocha (São Paulo)

Over 2.5

+110

Under 2.5

-

Edwin Cardona (Nacional)

Over 2.5

+128

Under 2.5

-

Dairon Asprilla (Nacional)

Over 1.5

+140

Under 1.5

-

Oscar (São Paulo)

Over 1.5

+145

Under 1.5

-

Jonathan Calleri (São Paulo)

Over 1.5

-100

Under 1.5

-

Aldemir Ferreira (São Paulo)

Over 1.5

-115

Under 1.5

-

André Oliveira Silva (São Paulo)

Over 1.5

-147

Under 1.5

-

Gonzalo Tapia (São Paulo)

Over 1.5

-120

Under 1.5

-

Mateus Uribe (Nacional)

Over 0.5

-108

Under 0.5

-

Andrés Felipe Román (Nacional)

Over 0.5

-120

Under 0.5

-

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

Over 0.5

-204

Under 0.5

-

Juan Manuel Zapata (Nacional)

Over 0.5

-143

Under 0.5

-

Jorman Campuzano (Nacional)

Over 0.5

+112

Under 0.5

-

Damián Bobadilla (São Paulo)

Over 0.5

-179

Under 0.5

-

Luiz Gustavo (São Paulo)

Over 0.5

+110

Under 0.5

-

Latest Copa Libertadores and domestic league stats. Full Time Result, Goals, Corners and Possession.

Atlético Nacional Stats

São Paulo Stats

Full-Time Result

• 5 wins, 3 defeats and 2 draws in the previous 10 matches
• 5 wins, 3 defeats and 2 draws in the previous 10 home matches

Full-Time Result

• 5 wins, 4 defeats and 1 draw in the previous 10 matches
• 2 wins, 4 defeats and 4 draws in the previous 10 away matches

Goals

• An average of 1.60 goals scored and 1.00 conceded in the previous 10 matches
• An average of 1.90 goals scored and 1.00 conceded in the previous 10 home matches
• An average of 2.60 goals per game in the previous 10 matches
• An average of 2.90 goals per game in the previous 10 home matches
• BTTS Yes in 7 of the previous 10 matches
• BTTS Yes in 6 of the previous 10 home matches
• Over 2.5 Goals in 7 of the previous 10 matches
• Over 2.5 Goals in 7 of the previous 10 home matches

Goals

• An average of 1.40 goals scored and 1.30 conceded in the previous 10 matches
• An average of 1.00 goals scored and 1.30 conceded in the previous 10 away matches
• An average of 2.70 goals per game in the previous 10 matches
• An average of 2.30 goals per game in the previous 10 away matches
• BTTS Yes in 5 of the previous 10 matches
• BTTS Yes in 6 of the previous 10 away matches
• Over 2.5 Goals in 5 of the previous 10 matches
• Over 2.5 Goals in 5 of the previous 10 away matches

Atlético Nacional vs São Paulo Lineups & Team News

Always review the Nacional vs São Paulo team news before locking in your bets. We’ll bring you both the expected and confirmed lineups for the Copa Libertadores, along with current injury news.