Lazio vs Roma Prediction, Betting Tips, Lineups & Odds | 21 Sep 2025

Serie A Betting Preview: Lazio vs Roma

Fierce rivals Lazio and Roma lock horns in the Derby della Capitale at Stadio Olimpico, with kick-off set for 06:30 on Sunday 21 September. Our Italian Serie A betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Lazio and Roma to Cancel Each Other Out

We can make an argument for betting Under 2.5 when it comes to Total Goals. The stats imply that Lazio and Roma could fall short of this total and the price of -159 looks a value one.

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Last H2H Saw Game End 1-1

Lazio lost away from home in their last game. Sassuolo won 1-0 at Stadio Mapei. Maurizio Sarri's team had the majority of the ball boasting 59% possession and three shots on target.

Roma were beaten 1-0 in their previous game, being turned over at home to Torino at Stadio Olimpico. I Giallorossi recorded an impressive 73% of possession and had five shots on goal.

Head-to-Head Statistics

Roma have not lost to Lazio in the past three games, with the last clash seeing a 1-1 draw played out at Stadio Olimpico. The past 10 H2H games have seen each team land four wins and there’s been two draws.

Serie A		G	W	D	L	GF	GA	GD	GD	P
4	Roma	10	7	0	3	10	5	5	10:5	21
8	Lazio	10	4	3	3	13	7	6	13:7	15

View Full Table

3 wins, 3 losses and 4 draws, averaging 1.3 goals from 13.7 attempts and 4.9 shots on goal. Lazio have had 58.1% possession, 497.9 passes and 6.3 corners per match. On average, they have conceded 1.0 goals from 9.8 attempts and 3.7 shots on goal, while their opponents have earned 3.6 corners.

Pedro Rodriguez is the top scorer with 4 goals, while Boulaye Dia has 3 and Valentin Castellanos 2. Luca Pellegrini is the top assists maker on 3, with goalkeepers Christos Mandas and Ivan Provedel managing 3 clean sheets between them.

Roma have 7 victories, 2 defeats and 1 draw, averaging 13.0 attempts, 4.6 shots on goal and 1.2 goals. I Giallorossi average 52.4% possession, 456.8 passes, 4.7 corners awarded and 4.5 corners against them, while 0.5 goals have been conceded from 3.5 shots on goal and 11.3 attempts.

Matias Soule has scored 3 goals, followed by Leandro Paredes and Bryan Cristante on 2. Matias Soule has been chief assist maker on 4, with Mile Svilar recording 6 clean sheets in the previous 10 games.

Confirmed Lineups

Lazio confirmed lineup (4-3-3): Ivan Provedel (GK), Adam Marusic, Mario Gila, Alessio Romagnoli, Nuno Tavares, Matteo Guendouzi, Nicolo Rovella, Fisayo Dele-Bashiru, Pedro Rodriguez, Boulaye Dia, Mattia Zaccagni.

Roma confirmed lineup (4-4-2): Mile Svilar (GK), Mehmet Zeki Celik, Gianluca Mancini, Evan N'Dicka, Devyne Rensch, Manu Kone, Bryan Cristante, Angelino, Lorenzo Pellegrini, Matias Soule, Evan Ferguson.

Lazio vs Roma Prediction & Betting Tips

Our expert Lazio vs Roma tips include betting advice on all fronts — from a main match prediction and player prop picks to corners guidance, a correct score selection and a ready-made bet builder.

Match Prediction

We could be set for a low-scoring Serie A encounter. We will therefore bet on Under 2.5 which can be backed at an eye-catching price of -159, with defences set to be on top for the most part.

Sportsgambler.com has plenty of Serie A insights and that includes getting the team news immediately. The recent form will also help deliver our expert football predictions and we ensure that the most relevant stats are used to good effect.

Key Lazio vs Roma league stats:

• The 2.5 line hasn’t been covered in 7 of the last 10 Lazio games.
• The 2.5 line hasn’t been covered in 3 of the last 5 Lazio games.
• The 2.5 line hasn’t been covered in the last 4 Roma games.
• The 2.5 line hasn’t been covered in 8 of the last 10 Roma games.
• The 2.5 line hasn’t been covered in 15 of the last 20 Roma games.
• The 2.5 line hasn’t been covered in the last 7 games between these teams.

Under 2.5 Probability

According to the top bookmakers, our pick has a 61.3% chance of landing a return. However, our research has found that the actual probability is between 65-70%. This is why we regard this as a value bet.

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Our Match Prediction

Under 2.5 Goals @ -159 Bet Now

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Correct Score Prediction

Lazio 1 - 1 Roma

There are odds of +450 that the two teams play out a 1-1 scoreline. The correct score option is popular due to the potential return that can be achieved.

Player Prop Picks

Top Pick: Mattia Zaccagni Over 0.5 Shots On Target -100

Mattia Zaccagni (Lazio) has totalled at least one shot on goal in back-to-back Serie A games. We’ve decided to back him on the Overs for Shots on Target, with this line looking attractive at odds of -100.

Latest Mattia Zaccagni Player Prop Odds

Goalscorer

Anytime

+390

First

+900

Shots On Target

Over 0.5

-106

Under 0.5

-182

Shots

Over 1.5

-147

Under 1.5

-

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Bryan Cristante to Score +650

Bryan Cristante (Roma) has racked up two goals in his past ten Serie A games. We think there’s value in backing him for an Anytime Goalscorer prop bet at +650 which will hopefully see him find the net.

Latest Bryan Cristante Player Prop Odds

Goalscorer

Anytime

+650

First

+1400

Shots On Target

Over 0.5

+225

Under 0.5

-417

Shots

Over 0.5

-192

Under 0.5

-

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Corners Prediction

Lazio Over 4.5 Corners -159

We’ve seen an average of 8.00 Lazio corners in the past five home games. We think that the value can be landed by betting on Team Corners and you can get -159 that Lazio go over the line.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Lazio

Total

9.90 6.30 3.60

Home

10.80 7.80 3.00

Away

10.20 4.60 5.60

Roma

Total

9.20 4.70 4.50

Home

8.00 4.50 3.50

Away

9.70 5.90 3.80

Latest Corner Odds

Total Corners

Over 9.5

-118

Under 9.5

-120

Lazio Corners

Over 4.5

-138

Under 4.5

-100

Roma Corners

Over 3.5

-163

Under 3.5

+120

Most Corners

1

-135

X

+650

2

+148

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Lazio vs Roma Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Betting Sites Predicting a Close-Run Battle

Roma are +160 with the bookies to get the better of Lazio, with the latter having betting odds of +185. If you want to back the draw to be landed in this Serie A encounter, this can be wagered at +205.

Roma -0.25 on the Asian Handicap can be backed at +120. It means your stake is split between 0 and -0.5, with a full payout if they beat Lazio. Half your stake is refunded if we see a draw.

Under 2.5 Goals is operating at the shortest price for those anticipating two or less goals. Both Teams to Score is a two-way market and, in terms of price, there’s not much to split Yes and No.

The best football betting sites are on hand to provide lots of choice to bettors. It’s now the case that you can select from hundreds of markets for all of the Serie A matches.

Full-Time Result

1

+185

X

+205

2

+160

Half-Time Result

1

+245

X

+107

2

+215

Double Chance

1X

-213

12

-278

X2

-244

Draw No Bet

1

-106

2

-128

Asian Handicap

1 Hcp +0.25

-149

2 Hcp -0.25

+120

Total Goals

Under 2.5

-156

Over 2.5

+120

Both Teams to Score

Yes

-115

No

-118

Valentín Castellanos is the First Goalscorer Favourite

Favourite Valentín Castellanos is +550 to be the First Goalscorer, while similar odds apply when it comes to him scoring the last goal.

Valentín Castellanos (Lazio)

First

+245

Anytime

+550

Evan Ferguson (Roma)

First

+260

Anytime

+525

Matías Soulé (Roma)

First

+350

Anytime

+750

Boulaye Dia (Lazio)

First

+350

Anytime

+800

Pedro Rodríguez Ledesma (Lazio)

First

+360

Anytime

+800

Stephan El Shaarawy (Roma)

First

+370

Anytime

+700

Mattia Zaccagni (Lazio)

First

+390

Anytime

+900

Matteo Cancellieri (Lazio)

First

+410

Anytime

+900

Gustav Isaksen (Lazio)

First

+500

Anytime

+1100

Fisayo Dele-Bashiru (Lazio)

First

+510

Anytime

+1200

Lorenzo Pellegrini (Roma)

First

+575

Anytime

+1200

Bryan Cristante (Roma)

First

+650

Anytime

+1400

Kouadio Kone (Roma)

First

+750

Anytime

+1500

Matías Vecino (Lazio)

First

+750

Anytime

+1700

Mattéo Guendouzi (Lazio)

First

+900

Anytime

+2200

Nicolò Rovella (Lazio)

First

+900

Anytime

+2200

Devyne Rensch (Roma)

First

+950

Anytime

+2000

Evan Ndicka (Roma)

First

+950

Anytime

+2200

Danilo Cataldi (Lazio)

First

+1050

Anytime

+2200

Valentín Castellanos (Lazio)

Over 0.5

-278

Under 0.5

+133

Evan Ferguson (Roma)

Over 0.5

-141

Under 0.5

-137

Boulaye Dia (Lazio)

Over 0.5

-120

Under 0.5

-161

Pedro Rodríguez Ledesma (Lazio)

Over 0.5

-116

Under 0.5

-167

Mattia Zaccagni (Lazio)

Over 0.5

-106

Under 0.5

-182

Matías Soulé (Roma)

Over 0.5

-100

Under 0.5

-156

Matteo Cancellieri (Lazio)

Over 0.5

+105

Under 0.5

-164

Gustav Isaksen (Lazio)

Over 0.5

+125

Under 0.5

-200

Stephan El Shaarawy (Roma)

Over 0.5

+128

Under 0.5

-204

Fisayo Dele-Bashiru (Lazio)

Over 0.5

+145

Under 0.5

-313

Lorenzo Pellegrini (Roma)

Over 0.5

+200

Under 0.5

-357

Bryan Cristante (Roma)

Over 0.5

+225

Under 0.5

-417

Matías Vecino (Lazio)

Over 0.5

+225

Under 0.5

-417

Kouadio Kone (Roma)

Over 0.5

+250

Under 0.5

-476

Mattéo Guendouzi (Lazio)

Over 0.5

+290

Under 0.5

-909

Nicolò Rovella (Lazio)

Over 0.5

+300

Under 0.5

-1000

Devyne Rensch (Roma)

Over 0.5

+350

Under 0.5

-833

Evan Ndicka (Roma)

Over 0.5

+350

Under 0.5

-1429

Valentín Castellanos (Lazio)

Over 3.5

+123

Under 3.5

-

Matías Soulé (Roma)

Over 2.5

-103

Under 2.5

-

Evan Ferguson (Roma)

Over 2.5

+130

Under 2.5

-

Matteo Cancellieri (Lazio)

Over 1.5

-133

Under 1.5

-

Fisayo Dele-Bashiru (Lazio)

Over 1.5

+145

Under 1.5

-

Gustav Isaksen (Lazio)

Over 1.5

-111

Under 1.5

-

Mattia Zaccagni (Lazio)

Over 1.5

-147

Under 1.5

-

Stephan El Shaarawy (Roma)

Over 1.5

+128

Under 1.5

-

Pedro Rodríguez Ledesma (Lazio)

Over 1.5

-159

Under 1.5

-

Boulaye Dia (Lazio)

Over 1.5

-141

Under 1.5

-

Lorenzo Pellegrini (Roma)

Over 0.5

-238

Under 0.5

-

Bryan Cristante (Roma)

Over 0.5

-192

Under 0.5

-

Kouadio Kone (Roma)

Over 0.5

-164

Under 0.5

-

Mattéo Guendouzi (Lazio)

Over 0.5

-143

Under 0.5

-

Nicolò Rovella (Lazio)

Over 0.5

-147

Under 0.5

-

Devyne Rensch (Roma)

Over 0.5

+105

Under 0.5

-

Evan Ndicka (Roma)

Over 0.5

+105

Under 0.5

-

Past Seven H2H Stadio Olimpico Meetings Have Seen Lazio Unbeaten

Lazio have racked up seven draws, two wins and one loss in the previous 10 home games, netting an average of 1.50 goals per match and conceding 1.00.

Roma have eight wins, one draw and one loss in the last 10 away games, scoring an average of 1.20 goals per match and conceding 0.40.

When the sides last met at Stadio Olimpico, Lazio drew 1-1 with Roma. We’ve seen four of 7 H2H meetings at Stadio Olimpico go the way of Lazio, with three draws also taking place.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Lazio Home Stats		2-7-1	2.50	1.50	1.00	3	7	7	3
Roma Away Stats		8-1-1	1.60	1.20	0.40	2	8	3	7

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

Lazio vs Roma Lineups & Team News

Make sure you're up to date on the Lazio vs Roma team news before betting. Get the latest predicted and confirmed Serie A lineups and injury news right here.

Lazio Team Page Roma Team Page