Lazio vs Roma Prediction, Betting Tips, Lineups & Odds | 21 Sep 2025

Serie A Betting Preview: Lazio vs Roma

Fierce rivals Lazio and Roma lock horns in the Derby della Capitale at Stadio Olimpico, with kick-off set for 06:30 on Sunday 21 September. Our Italian Serie A betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Lazio and Roma to Cancel Each Other Out

We can make an argument for betting Under 2.5 when it comes to Total Goals. The stats imply that Lazio and Roma could fall short of this total and the price of -159 looks a value one.

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Last H2H Saw Game End 1-1

Lazio lost away from home in their last game. Sassuolo won 1-0 at Stadio Mapei. Maurizio Sarri's team had the majority of the ball boasting 59% possession and three shots on target.

Roma were beaten 1-0 in their previous game, being turned over at home to Torino at Stadio Olimpico. I Giallorossi recorded an impressive 73% of possession and had five shots on goal.

Head-to-Head Statistics

Roma have not lost to Lazio in the past three games, with the last clash seeing a 1-1 draw played out at Stadio Olimpico. The past 10 H2H games have seen each team land four wins and there’s been two draws.

Serie A		G	W	D	L	GF	GA	GD	GD	P
6	Roma	3	2	0	1	2	1	1	2:1	6
12	Lazio	3	1	0	2	4	3	1	4:3	3

View Full Table

3 wins, 3 losses and 4 draws, averaging 1.3 goals from 13.7 attempts and 4.9 shots on goal. Lazio have had 58.1% possession, 497.9 passes and 6.3 corners per match. On average, they have conceded 1.0 goals from 9.8 attempts and 3.7 shots on goal, while their opponents have earned 3.6 corners.

Pedro Rodriguez is the top scorer with 4 goals, while Boulaye Dia has 3 and Valentin Castellanos 2. Luca Pellegrini is the top assists maker on 3, with goalkeepers Christos Mandas and Ivan Provedel managing 3 clean sheets between them.

Roma have 7 victories, 2 defeats and 1 draw, averaging 13.0 attempts, 4.6 shots on goal and 1.2 goals. I Giallorossi average 52.4% possession, 456.8 passes, 4.7 corners awarded and 4.5 corners against them, while 0.5 goals have been conceded from 3.5 shots on goal and 11.3 attempts.

Matias Soule has scored 3 goals, followed by Leandro Paredes and Bryan Cristante on 2. Matias Soule has been chief assist maker on 4, with Mile Svilar recording 6 clean sheets in the previous 10 games.

Predicted & Confirmed Lineups

Lazio predicted lineup (4-3-3): Ivan Provedel (GK), Adam Marusic, Mario Gila, Alessio Romagnoli, Nuno Tavares, Matteo Guendouzi, Nicolò Rovella, Fisayo Dele-Bashiru, Matteo Cancellieri, Valentín Castellanos, Mattia Zaccagni.

Roma predicted lineup (3-4-2-1): Mile Svilar (GK), Mario Hermoso, Gianluca Mancini, Evan NDicka, Wesley, Manu Koné, Bryan Cristante, Angeliño, Matias Soule, Stephan El Shaarawy, Evan Ferguson.

Lazio vs Roma Prediction & Betting Tips

Our expert Lazio vs Roma tips include betting advice on all fronts — from a main match prediction and player prop picks to corners guidance, a correct score selection and a ready-made bet builder.

Match Prediction

We could be set for a low-scoring Serie A encounter. We will therefore bet on Under 2.5 which can be backed at an eye-catching price of -159, with defences set to be on top for the most part.

Sportsgambler.com has plenty of Serie A insights and that includes getting the team news immediately. The recent form will also help deliver our expert football predictions and we ensure that the most relevant stats are used to good effect.

Key Lazio vs Roma league stats:

• The 2.5 line hasn’t been covered in 7 of the last 10 Lazio games.
• The 2.5 line hasn’t been covered in 3 of the last 5 Lazio games.
• The 2.5 line hasn’t been covered in the last 4 Roma games.
• The 2.5 line hasn’t been covered in 8 of the last 10 Roma games.
• The 2.5 line hasn’t been covered in 15 of the last 20 Roma games.
• The 2.5 line hasn’t been covered in the last 7 games between these teams.

Under 2.5 Probability

According to the top bookmakers, our pick has a 61.3% chance of landing a return. However, our research has found that the actual probability is between 65-70%. This is why we regard this as a value bet.

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Our Match Prediction

Under 2.5 Goals @ -159 Watch Live Bet Now

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Correct Score Prediction

Lazio 1 - 1 Roma

There are odds of +460 that the two teams play out a 1-1 scoreline. The correct score option is popular due to the potential return that can be achieved.

Player Prop Picks

Top Pick: Mattia Zaccagni Over 0.5 Shots On Target -100

Mattia Zaccagni (Lazio) has totalled at least one shot on goal in back-to-back Serie A games. We’ve decided to back him on the Overs for Shots on Target, with this line looking attractive at odds of -100.

Latest Mattia Zaccagni Player Prop Odds

Goalscorer

Anytime

+410

First

+1000

Shots On Target

Over 0.5

+102

Under 0.5

-161

Shots

Over 1.5

-133

Under 1.5

-

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Bryan Cristante to Score +650

Bryan Cristante (Roma) has racked up two goals in his past ten Serie A games. We think there’s value in backing him for an Anytime Goalscorer prop bet at +650 which will hopefully see him find the net.

Latest Bryan Cristante Player Prop Odds

Goalscorer

Anytime

+650

First

+1400

Shots On Target

Over 0.5

+225

Under 0.5

-417

Shots

Over 0.5

-185

Under 0.5

-

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Corners Prediction

Lazio Over 4.5 Corners -159

We’ve seen an average of 8.00 Lazio corners in the past five home games. We think that the value can be landed by betting on Team Corners and you can get -159 that Lazio go over the line.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Lazio

Total

9.90 6.30 3.60

Home

10.80 7.80 3.00

Away

10.20 4.60 5.60

Roma

Total

9.20 4.70 4.50

Home

8.00 4.50 3.50

Away

9.70 5.90 3.80

Latest Corner Odds

Total Corners

Over 9.5

-119

Under 9.5

-119

Lazio Corners

Over 4.5

-138

Under 4.5

-100

Roma Corners

Over 3.5

-163

Under 3.5

+120

Most Corners

1

-130

X

+650

2

+143

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Lazio vs Roma Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Betting Sites Predicting a Close-Run Battle

Roma are +150 with the bookies to get the better of Lazio, with the latter having betting odds of +195. If you want to back the draw to be landed in this Serie A encounter, this can be wagered at +205.

Roma -0.25 on the Asian Handicap can be backed at +112. It means your stake is split between 0 and -0.5, with a full payout if they beat Lazio. Half your stake is refunded if we see a draw.

Under 2.5 Goals is operating at the shortest price for those anticipating two or less goals. Both Teams to Score is a two-way market and, in terms of price, there’s not much to split Yes and No.

The best football betting sites are on hand to provide lots of choice to bettors. It’s now the case that you can select from hundreds of markets for all of the Serie A matches.

Full-Time Result

1

+195

X

+205

2

+150

Half-Time Result

1

+255

X

+106

2

+210

Double Chance

1X

-200

12

-278

X2

-263

Draw No Bet

1

-100

2

-137

Asian Handicap

1 Hcp +0.25

-141

2 Hcp -0.25

+112

Total Goals

Under 2.5

-159

Over 2.5

+123

Both Teams to Score

Yes

-114

No

-119

Valentín Castellanos is the First Goalscorer Favourite

Favourite Valentín Castellanos is +550 to be the First Goalscorer, while similar odds apply when it comes to him scoring the last goal.

Valentín Castellanos (Lazio)

First

+245

Anytime

+550

Evan Ferguson (Roma)

First

+270

Anytime

+525

Stephan El Shaarawy (Roma)

First

+360

Anytime

+650

Boulaye Dia (Lazio)

First

+380

Anytime

+850

Matteo Cancellieri (Lazio)

First

+400

Anytime

+900

Matías Soulé (Roma)

First

+410

Anytime

+900

Mattia Zaccagni (Lazio)

First

+410

Anytime

+1000

Gustav Isaksen (Lazio)

First

+500

Anytime

+1200

Lorenzo Pellegrini (Roma)

First

+575

Anytime

+1200

Fisayo Dele-Bashiru (Lazio)

First

+600

Anytime

+1300

Bryan Cristante (Roma)

First

+650

Anytime

+1400

Kouadio Kone (Roma)

First

+700

Anytime

+1400

Matías Vecino (Lazio)

First

+750

Anytime

+1700

Evan Ndicka (Roma)

First

+900

Anytime

+2200

Mattéo Guendouzi (Lazio)

First

+1000

Anytime

+2200

Nicolò Rovella (Lazio)

First

+1000

Anytime

+2200

Danilo Cataldi (Lazio)

First

+1050

Anytime

+2000

Valentín Castellanos (Lazio)

Over 0.5

-278

Under 0.5

+133

Evan Ferguson (Roma)

Over 0.5

-128

Under 0.5

-123

Boulaye Dia (Lazio)

Over 0.5

-108

Under 0.5

-147

Matteo Cancellieri (Lazio)

Over 0.5

-100

Under 0.5

-159

Mattia Zaccagni (Lazio)

Over 0.5

+102

Under 0.5

-161

Stephan El Shaarawy (Roma)

Over 0.5

+123

Under 0.5

-200

Matías Soulé (Roma)

Over 0.5

+125

Under 0.5

-200

Gustav Isaksen (Lazio)

Over 0.5

+125

Under 0.5

-200

Fisayo Dele-Bashiru (Lazio)

Over 0.5

+160

Under 0.5

-263

Lorenzo Pellegrini (Roma)

Over 0.5

+200

Under 0.5

-357

Matías Vecino (Lazio)

Over 0.5

+220

Under 0.5

-400

Bryan Cristante (Roma)

Over 0.5

+225

Under 0.5

-417

Kouadio Kone (Roma)

Over 0.5

+250

Under 0.5

-476

Mattéo Guendouzi (Lazio)

Over 0.5

+300

Under 0.5

-625

Evan Ndicka (Roma)

Over 0.5

+340

Under 0.5

-1429

Valentín Castellanos (Lazio)

Over 3.5

+117

Under 3.5

-

Evan Ferguson (Roma)

Over 2.5

+138

Under 2.5

-

Matías Soulé (Roma)

Over 2.5

+110

Under 2.5

-

Stephan El Shaarawy (Roma)

Over 1.5

+123

Under 1.5

-

Boulaye Dia (Lazio)

Over 1.5

-125

Under 1.5

-

Matteo Cancellieri (Lazio)

Over 1.5

-135

Under 1.5

-

Mattia Zaccagni (Lazio)

Over 1.5

-133

Under 1.5

-

Gustav Isaksen (Lazio)

Over 1.5

-111

Under 1.5

-

Fisayo Dele-Bashiru (Lazio)

Over 1.5

+155

Under 1.5

-

Lorenzo Pellegrini (Roma)

Over 0.5

-233

Under 0.5

-

Bryan Cristante (Roma)

Over 0.5

-185

Under 0.5

-

Kouadio Kone (Roma)

Over 0.5

-154

Under 0.5

-

Evan Ndicka (Roma)

Over 0.5

+104

Under 0.5

-

Past Seven H2H Stadio Olimpico Meetings Have Seen Lazio Unbeaten

Lazio have racked up seven draws, two wins and one loss in the previous 10 home games, netting an average of 1.50 goals per match and conceding 1.00.

Roma have eight wins, one draw and one loss in the last 10 away games, scoring an average of 1.20 goals per match and conceding 0.40.

When the sides last met at Stadio Olimpico, Lazio drew 1-1 with Roma. We’ve seen four of 7 H2H meetings at Stadio Olimpico go the way of Lazio, with three draws also taking place.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Lazio Home Stats		2-7-1	2.50	1.50	1.00	3	7	7	3
Roma Away Stats		8-1-1	1.60	1.20	0.40	2	8	3	7

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

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Lazio vs Roma Lineups & Team News

Make sure you're up to date on the Lazio vs Roma team news before betting. Get the latest predicted and confirmed Serie A lineups and injury news right here.

Lazio Team Page Roma Team Page