EFL Cup Betting Preview: Liverpool vs Southampton

Premier League team Liverpool host Championship club Southampton in this EFL Cup match at Anfield, with kick-off set for 15:00 on Tuesday 23 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and confirmed lineups.

Reds Look Set for a Big Win

Liverpool -2.25 are available at -116 on the Asian Handicap and we need a three-goal winning margin to land a full return. However, we get half our stake returned if the favourites win by two goals against Southampton.

Backing the Asian Handicap play? Check the updated BetMGM promo code and read our comprehensive site review before you place your wager.

8 Triumphs for Liverpool in Previous 10 H2H Clashes

Liverpool were winners last time out. Landing a 2-1 Premier League home triumph against Everton at Anfield. The Merseyside club had most of the ball recording 57% possession and three shots on target, with Ryan Gravenberch and Hugo Ekitike scoring one goal apiece.

Southampton were defeated in their previous game. On their travels, they suffered a 3-1 Championship loss against Hull City at MKM Stadium. The Saints had four shots on goal and enjoyed 71% possession, with Adam Armstrong on the scoresheet.

In the last round of the EFL Cup, Southampton overcame Norwich City 3-0 away.

Head-to-Head Statistics

Liverpool have won three on the spin against Southampton. In the last encounter, Liverpool claimed a 3-1 Premier League victory when hosting at Anfield. The past 10 H2H matches have involved eight Liverpool wins, one Southampton victory and one draw.

Liverpool – Last 10 League & EFL Cup Games

Liverpool have 6 wins, 2 losses and 2 draws, averaging 2.2 goals from 4.7 shots on goal and 15.2 attempts. The Merseyside side have averaged 60.7% possession, 506.1 passes and 5.9 corners per game, with their opponents scoring 1.5 goals from 4.3 shots on goal, 11.3 attempts and 3.6 corners.

Top goalscorer Mohamed Salah has found the net 4 times, with Hugo Ekitike and Cody Gakpo scoring 3 each. Cody Gakpo and Dominik Szoboszlai have been top assistors on 3, with goalkeeper Alisson Becker keeping 2 clean sheets.

Southampton – Last 6 League & EFL Cup Games

Southampton have 1 victory, 2 defeats and 3 draws, with an average of 1.2 goals from 15.2 attempts and 4.5 shots on goal. Will Still's men average 61.2% possession, 6.2 corners awarded and 3.5 corners against them, while conceding 1.5 goals from 11.5 attempts and 2.8 shots on goal.

Ryan Manning has scored 2 goals, followed by Adam Armstrong, Cameron Archer, Taylor Harwood-Bellis and Jay Robinson on 1. Ryan Fraser has been the top assist maker with 2 in the last 6 games.

Liverpool vs Southampton Prediction & Betting Tips

Join us as we dissect the best Liverpool vs Southampton betting tips — from our expert match prediction and correct score advice to a sharp corners pick, top player prop insights and a ready-made bet builder.

Match Prediction

We’re going for Liverpool -2.25 in the expectation that the favourites achieve a win with something to spare. The EFL Cup encounter should go in their favour and we’ll take the odds of -116.

Our football experts are keen to follow the latest form and understand any patterns that emerge. The same applies to injuries that could affect key players. Combined with the best EFL Cup stats, there is plenty of information to make a verdict.

Key Liverpool vs Southampton EFL Cup & league stats:

The -2.25 line has been covered by Liverpool in 3 of their last 20 games at home.

Liverpool -2.25 Probability

The best betting apps make it a 53.8% chance that our pick is settled as a winner. However, our tipsters research has found that the actual probability is closer to 60%. This is why we can recommend this wager.

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Our Match Prediction

Liverpool Asian Hcp -2.25 @ -116 Bet Now

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Published 21:08, 21 September 2025

Correct Score Prediction

Liverpool

4 - 0 Southampton logo

Southampton

Liverpool are available at +750 to secure a 4-0 victory. Many bettors enjoy a correct score wager and there are some nice potential returns to be had.

Latest Correct Score Odds

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Player Prop Picks

Top Pick: Federico Chiesa Under 0.5 Shots On Target +120

Federico Chiesa (Liverpool) hasn’t managed a shot on goal in three straight matches. There’s a reasonable prospect that he will fall short of the mark, with odds of +120 on offer that he doesn’t cover the Shots on Target line.

Latest Federico Chiesa Player Prop Odds

Goalscorer

Shots On Target

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Hugo Ekitike to Score +105

Hugo Ekitike (Liverpool) has been among the goals in three of his past five matches. When it comes to him scoring, we think that the +105 available is attractive when betting on the Anytime Goalscorer market.

Latest Hugo Ekitike Player Prop Odds

Goalscorer

Shots On Target

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Corners Prediction

Liverpool Under 7.5 Corners -150

In their past three home games, Liverpool have not covered the 7.5 corners line, while the previous ten Southampton matches have involved them conceding under 7.5 corners. There’s a chance to go under the Liverpool Team Corners line and we’re confident this will happen, with odds of -150 on offer.

EFL Cup & League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Liverpool

Total

9.50 5.90 3.60

Home

11.00 6.70 4.30

Away

9.60 5.90 3.70

Southampton

Total

8.40 5.00 3.40

Home

9.80 5.80 4.00

Away

8.14 4.43 3.71

Latest Corner Odds

Total Corners

Liverpool Corners

Southampton Corners

Most Corners

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Bet Builder Tips

Asian Handicap Liverpool -2.25 -116

Both Team To Score No -135

Shots On Target Federico Chiesa Under 0.5 +120

Our bet builder picks are Liverpool on the Asian Handicap at -2.25, No on the Both Teams to Score market and Federico Chiesa (Liverpool) failing to record a shot on target.

Placing a bet builder means you can have various selections for one football match. Bettors enjoy creating a tailored wager based on their predictions for how a match is likely to turn out.

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Liverpool vs Southampton Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Betting Sites Make Liverpool Massive Favourites

Liverpool are gigantic -714 favourites to land a victory in this EFL Cup clash. On the basis of the latest odds, the bookmakers afford them a 88% chance of claiming a win. Southampton are the rank outsiders at +1600 which suggests a low likelihood of winning.

There’s a nice alternative in the form of the Half-Time Result market. This allows you to back Liverpool at -222 to lead at the break or alternatively opt for Southampton at +850. The draw is the third option at +230.

Over 2.5 Goals is the market leader and that means three or more goals are predicted. Both Teams to Score No is available at -135 for anyone expecting at least one side to draw a blank.

There are hundreds of markets from which to select your preferred wager when it comes to EFL Cup games. The best football betting sites push the boat out to provide lots of choice.

Full-Time Result

Half-Time Result

Draw No Bet

Asian Handicap

Total Goals

Both Teams to Score

Mohamed Salah Heads First Goalscorer Market

There’s the chance to back Mohamed Salah at +330 to be the First Goalscorer. He’s the favourite and available at similar odds to find the net last instead.

Player Goals

Mohamed Salah (Liverpool)

Hugo Ekitike (Liverpool)

Alexander Isak (Liverpool)

Federico Chiesa (Liverpool)

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Player Shots On Target

Rio Ngumoha (Liverpool)

Federico Chiesa (Liverpool)

Cody Gakpo (Liverpool)

Florian Wirtz (Liverpool)

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Last 5 Games

Liverpool

Southampton

Head to Head

Liverpool vs Southampton

Team Stats

Latest EFL Cup and domestic league stats. Full Time Result, Goals, Corners and Possession.

Liverpool Stats

Southampton Stats

Full-Time Result

6 wins, 2 defeats and 2 draws in the previous 10 matches
8 wins and 2 draws in the previous 10 home matches

Full-Time Result

1 win, 2 defeats and 3 draws in the previous 6 matches
1 defeat and 2 draws in the previous 3 away matches

Goals

An average of 2.20 goals scored and 1.50 conceded in the previous 10 matches
An average of 2.30 goals scored and 0.90 conceded in the previous 10 home matches
An average of 3.70 goals per game in the previous 10 matches
An average of 3.20 goals per game in the previous 10 home matches
BTTS Yes in 8 of the previous 10 matches
BTTS Yes in 7 of the previous 10 home matches
Over 2.5 Goals in 7 of the previous 10 matches
Over 2.5 Goals in 6 of the previous 10 home matches

Goals

An average of 1.17 goals scored and 1.50 conceded in the previous 6 matches
An average of 1.33 goals scored and 2.00 conceded in the previous 3 away matches
An average of 2.67 goals per game in the previous 6 matches
An average of 3.33 goals per game in the previous 3 away matches
BTTS Yes in 5 of the previous 6 matches
BTTS Yes in 3 of the previous 3 away matches
Over 2.5 Goals in 4 of the previous 6 matches
Over 2.5 Goals in 2 of the previous 3 away matches

Corners

An average of 5.90 corners awarded and 3.60 corners conceded in the last 10 matches
An average of 6.70 corners awarded and 3.60 corners against in the last 10 home matches
An average of 9.50 corners awarded in the last 10 matches
An average of 10.30 corners awarded in the last 10 home matches
Had the most corners in 6 and least corners in 3 of the last 10 matches
Had the most corners in 8 and least corners in 2 of the last 10 home matches

Corners

An average of 6.17 corners awarded and 3.50 corners conceded in the last 6 matches
An average of 5.33 corners awarded and 3.00 corners against in the last 3 away matches
An average of 9.67 corners awarded in the last 6 matches
An average of 8.33 corners awarded in the last 3 away matches
Had the most corners in 6 and least corners in 0 of the last 6 matches
Had the most corners in 3 and least corners in 0 of the last 3 away matches

Possession

An average of 60.70% possession in the last 10 matches
An average of 60.80% possession in the last 10 home matches
Most possession in 9 of the last 10 matches
Most possession in 9 of the last 10 home matches

Possession

An average of 61.17% possession in the last 6 matches
An average of 55.67% possession in the last 3 away matches
Most possession in 4 of the last 6 matches
Most possession in 1 of the last 3 away matches

Liverpool vs Southampton Lineups & Team News

Double-check the Liverpool vs Southampton team news before placing your bets. We’ll share the predicted and confirmed lineups for the EFL Cup together with updated injury news.