Napoli vs Pisa Prediction, Betting Tips, Lineups & Odds | 22 Sep 2025

Serie A Betting Preview: Napoli vs Pisa

Napoli host Pisa in this Italian Serie A clash at Diego Armando Maradona, with kick-off set for 14:45 on Monday 22 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Will Pisa Keep the Scoreline Respectable?

You can wager Pisa +1.5 on the Asian Handicap when playing Napoli. This means getting odds of -104 and a return is on the cards if the underdogs are able to win, draw or lose by a single goal.

Betting on our Asian Handicap selection? Access the updated BetMGM promo code and read our expert review of the platform before locking in your bet.

Two Teams Defeated in Last Game

Napoli won last time out by a 3-1 scoreline. On the road against Fiorentina at Stadio Artemio Franchi, they made it three wins on the spin. Gli Azzurri enjoyed 47% possession and had eight shots on target, while Kevin De Bruyne, Rasmus Hoejlund and Sam Beukema got among the goals.

Four days ago, Napoli were beaten 2-0 when facing Manchester City away in the Champions League.

Pisa have lost in back-to-back Serie A outings. In a recent home game at Stadio Romeo Anconetani, they were turned over 1-0 by Udinese. The Tuscany side recorded two shots on goal and had 51% possession.

Serie A		G	W	D	L	GF	GA	GD	GD	P
1	Napoli	10	7	1	2	16	8	8	16:8	22
17	Pisa	10	0	6	4	7	14	-7	7:14	6

View Full Table

Napoli have 8 wins and 2 draws, averaging 1.7 goals from 5.2 shots on goal and 14.2 attempts. Antonio Conte's side have averaged 61.0% possession, 534.9 passes and 5.4 corners per match, conceding 0.3 goals and 3.6 corners from 1.5 shots on goal and 8.3 attempts.

Scott McTominay leads the way with 7 goals, Romelu Lukaku has 3, with Kevin De Bruyne and Giacomo Raspadori scoring 2. Matteo Politano is the leading assists maker with 3, while goalie Alex Meret has 8 clean sheets.

Pisa have 4 victories, 4 defeats and 2 draws, averaging 3.4 shots on goal, 10.4 attempts and 1.2 goals. I Nerazzurri average 46.7% possession, 4.3 corners taken and 5.0 corners against them, while 1.1 goals have been conceded from 9.3 attempts and 3.1 shots on goal.

The top scorers have been Stefano Moreo, Idrissa Toure, Alexander Lind and Matteo Tramoni, with 2 goals apiece. Stefano Moreo has managed 2 assists in the last 10 games.

Confirmed Lineups

Napoli confirmed lineup (4-1-4-1): Alex Meret (GK), Giovanni Di Lorenzo, Sam Beukema, Alessandro Buongiorno, Leonardo Spinazzola, Billy Gilmour, Matteo Politano, Eljif Elmas, Kevin De Bruyne, Scott McTominay, Rasmus Hoejlund.

Pisa confirmed lineup (3-5-2): Adrian Semper (GK), Simone Canestrelli, Antonio Caracciolo, Mateus Lusuardi, Mehdi Leris, Marius Marin, Michel Aebischer, Ebenezer Akinsanmiro, Giovanni Bonfanti, M'Bala Nzola, Stefano Moreo.

Napoli vs Pisa Prediction & Betting Tips

Step into Napoli vs Pisa with confidence as we bring you our main match prediction, projected scoreline, key corners betting angle, best player prop picks and a custom-built bet builder.

Match Prediction

Pisa +1.5 on the Asian Handicap are a great betting option at -104 on the basis that they can perform well as underdogs for this Serie A encounter. We’re expecting the game to be close.

Plenty of research goes into our football picks. It begins by focusing on the latest Serie A form and knowing the injury situation. The important numbers can then be utilised to help complete the picture.

Key Napoli vs Pisa league stats:

• The +1.5 line has been covered by Pisa in 3 consecutive games.
• The -1.5 line hasn’t been covered by Napoli in 15 of their last 20 games.
• The -1.5 line hasn’t been covered by Napoli in 7 of their last 10 games at home.

Pisa +1.5 Probability

The betting apps are estimating that there is a 51% likelihood of this pick landing a return. Taking all factors into consideration, our experts think there’s a stronger chance of success and estimate the probability to be closer to 60%. The bet can be recommended for this precise reason.

If you want to land a big potential return from a small stake, then a Bet Builder could be the way to go. Back Pisa to cover the line in a combination with other selections.

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Our Match Prediction

Pisa Asian Hcp +1.5 @ -104 Bet Now

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Correct Score Prediction

Napoli 1 - 0 Pisa

We’ve picked out a correct score of 1-0 being landed by Napoli. You can secure odds of +500 and this provides an alternative way to place a wager.

Player Prop Picks

Top Pick: Matteo Politano Over 2.5 Shots +130

Matteo Politano (Napoli) has recorded over 2.5 shots in three consecutive Serie A matches. He certainly looks capable of covering the line when it comes to this player prop and odds of +130 are currently on offer.

Latest Matteo Politano Player Prop Odds

Goalscorer

Anytime

+360

First

+850

Shots On Target

Over 0.5

-102

Under 0.5

-156

Shots

Over 2.5

+132

Under 2.5

-

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Scott McTominay to Score +180

Scott McTominay (Napoli) has netted five goals in his past five Serie A home games. Considering the numbers, we think that odds of +180 offer plenty of appeal when it comes to wagering on Anytime Goalscorer.

Latest Scott McTominay Player Prop Odds

Goalscorer

Anytime

+190

First

+440

Shots On Target

Over 0.5

-227

Under 0.5

+145

Shots

Over 2.5

-109

Under 2.5

-

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Corners Prediction

Pisa Over 2.5 Corners -120

Pisa have been awarded an average of 5.00 corners in the past five games, while Napoli have yielded a corner average of 3.60 in their previous ten matches. There are odds of -120 available when it comes to this Team Corners bet and we think Pisa can cover the line.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Napoli

Total

9.00 5.40 3.60

Home

10.20 6.90 3.30

Away

8.60 3.90 4.70

Pisa

Total

9.30 4.30 5.00

Home

8.40 5.60 2.80

Away

7.90 3.50 4.40

Latest Corner Odds

Total Corners

Over 9.5

-130

Under 9.5

-108

Napoli Corners

Over 6.5

-132

Under 6.5

-108

Pisa Corners

Over 2.5

-137

Under 2.5

-103

Most Corners

1

-667

X

+1000

2

+575

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Napoli vs Pisa Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Bookies Running Scared of Napoli Win

Napoli are overwhelming -333 favourites to win this Serie A clash based on the latest betting odds. The bookmakers afford them a 77% probability of claiming the spoils. Pisa are the +1000 underdogs, while the draw can also be backed as an alternative.

If you fancy Napoli to be leading at the interval, then you can secure odds of -127. Alternatively, there’s the chance to wager on Pisa at +700 on the Half-Time Result, with the draw trading at +145.

You’re able to back Over 2.5 Goals or Under 2.5 Goals at roughly the same price right now. If you’re expecting at least one team to keep a clean sheet, you might be interested in the -189 about Both Teams to Score No.

There are hundreds of markets which means lots of options to find a football bet for the latest Serie A match. The best betting sites leave no stone unturned to provide a first-class service.

Full-Time Result

1

-333

X

+400

2

+1000

Half-Time Result

1

-127

X

+145

2

+700

Double Chance

1X

-2500

12

-588

X2

+225

Draw No Bet

1

-1429

2

+600

Asian Handicap

1 Hcp -1.5

-108

2 Hcp +1.5

-115

Total Goals

Under 2.5

-110

Over 2.5

-116

Both Teams to Score

Yes

+138

No

-189

Lorenzo Lucca Favourite to Find the Net First

Lorenzo Lucca is the market leader to be First Goalscorer at +270 while there’s also the chance to back him to find the net at -104.

Lorenzo Lucca (Napoli)

First

-104

Anytime

+270

Rasmus Højlund (Napoli)

First

+145

Anytime

+350

Scott McTominay (Napoli)

First

+190

Anytime

+440

Kevin De Bruyne (Napoli)

First

+220

Anytime

+500

Eljif Elmas (Napoli)

First

+280

Anytime

+650

Matteo Politano (Napoli)

First

+360

Anytime

+850

Miguel Gutiérrez (Napoli)

First

+410

Anytime

+950

Matteo Tramoni (Pisa)

First

+500

Anytime

+1100

Stefano Moreo (Pisa)

First

+575

Anytime

+1300

Frank Anguissa (Napoli)

First

+650

Anytime

+1600

Billy Gilmour (Napoli)

First

+700

Anytime

+1700

Mathías Olivera (Napoli)

First

+700

Anytime

+2000

Stanislav Lobotka (Napoli)

First

+750

Anytime

+1900

Leonardo Spinazzola (Napoli)

First

+750

Anytime

+2000

Juan Jesus (Napoli)

First

+800

Anytime

+2000

Giovanni Di Lorenzo (Napoli)

First

+800

Anytime

+2000

Idrissa Touré (Pisa)

First

+1000

Anytime

+2200

Rasmus Højlund (Napoli)

Over 0.5

-244

Under 0.5

+120

Scott McTominay (Napoli)

Over 0.5

-227

Under 0.5

+145

Kevin De Bruyne (Napoli)

Over 0.5

-189

Under 0.5

+118

Eljif Elmas (Napoli)

Over 0.5

-125

Under 0.5

-123

Lorenzo Lucca (Napoli)

Over 1.5

-102

Under 1.5

-192

Matteo Politano (Napoli)

Over 0.5

-102

Under 0.5

-156

Matteo Tramoni (Pisa)

Over 0.5

+115

Under 0.5

-182

Miguel Gutiérrez (Napoli)

Over 0.5

+130

Under 0.5

-204

Stefano Moreo (Pisa)

Over 0.5

+143

Under 0.5

-303

Frank Anguissa (Napoli)

Over 0.5

+230

Under 0.5

-435

Billy Gilmour (Napoli)

Over 0.5

+250

Under 0.5

-476

Idrissa Touré (Pisa)

Over 0.5

+260

Under 0.5

-526

Mathías Olivera (Napoli)

Over 0.5

+275

Under 0.5

-833

Leonardo Spinazzola (Napoli)

Over 0.5

+280

Under 0.5

-909

Giovanni Di Lorenzo (Napoli)

Over 0.5

+290

Under 0.5

-909

Juan Jesus (Napoli)

Over 0.5

+300

Under 0.5

-1000

Stanislav Lobotka (Napoli)

Over 0.5

+320

Under 0.5

-667

Lorenzo Lucca (Napoli)

Over 4.5

+107

Under 4.5

-

Rasmus Højlund (Napoli)

Over 2.5

-125

Under 2.5

-

Scott McTominay (Napoli)

Over 2.5

-109

Under 2.5

-

Kevin De Bruyne (Napoli)

Over 2.5

-135

Under 2.5

-

Eljif Elmas (Napoli)

Over 2.5

+130

Under 2.5

-

Matteo Politano (Napoli)

Over 2.5

+132

Under 2.5

-

Miguel Gutiérrez (Napoli)

Over 1.5

+112

Under 1.5

-

Matteo Tramoni (Pisa)

Over 1.5

+102

Under 1.5

-

Stefano Moreo (Pisa)

Over 1.5

+120

Under 1.5

-

Frank Anguissa (Napoli)

Over 1.5

-102

Under 1.5

-

Mathías Olivera (Napoli)

Over 0.5

-137

Under 0.5

-

Leonardo Spinazzola (Napoli)

Over 0.5

-149

Under 0.5

-

Juan Jesus (Napoli)

Over 0.5

-125

Under 0.5

-

Giovanni Di Lorenzo (Napoli)

Over 0.5

-133

Under 0.5

-

Napoli Difficult to Beat on Home Soil

Napoli are unbeaten over their previous ten games at Diego Armando Maradona. Gli Azzurri have seven wins and three draws in the last 10 home games, scoring an average of 1.80 goals per match and conceding 0.70.

Pisa have recorded four victories, three draws and three defeats in the previous 10 away matches, netting an average of 1.30 goals per game and conceding 0.90.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Napoli Home Stats		7-3-0	2.50	1.80	0.70	5	5	6	4
Pisa Away Stats		4-3-3	2.20	1.30	0.90	4	6	5	5

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

Napoli vs Pisa Lineups & Team News

Be smart with your bets — check the Napoli vs Pisa team news beforehand. We’ll offer the predicted and confirmed Serie A lineups along with the latest injury developments.

Napoli Team Page Pisa Team Page