Santos vs São Paulo Prediction, Betting Tips, Lineups & Odds | 21 Sep 2025

Série A Betting Preview: Santos vs São Paulo

Santos host São Paulo in this Brazilian Série A encounter, with kick-off set for 19:30 on Sunday 21 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Back São Paulo to Frustrate Santos

When São Paulo clash against Santos, we will take the former at -106 on the Asian Handicap +0.25. With our stake divided between 0 and +0.5, the visitors look as though they can land a return by swerving defeat.

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2-1 Victory for São Paulo in Previous H2H Clash

Santos drew away from home in their last game. A 1-1 scoreline was played out against Atlético Mineiro. The Fish had the majority of the ball boasting 56% possession and five shots on target, with Tiquinho Soares being the goalscorer.

São Paulo claimed a home win in their previous Série A game. A 1-0 victory occurred against Botafogo. Hernan Crespo's side enjoyed 48% possession and three shots on goal, with Juan Dinenno scoring the winner seven minutes after kick-off.

On Thursday night, São Paulo were beaten 2-0 when facing LDU Quito away in the Copa Libertadores.

Head-to-Head Statistics

São Paulo have not lost to Santos in the past three meetings. Their last clash saw São Paulo land a 2-1 home win. The previous 10 H2H games have resulted in four draws and three wins apiece.

Série A		G	W	D	L	GF	GA	GD	GD	P
7	São Paulo	23	9	8	6	27	23	4	27:23	35
16	Santos	22	6	5	11	21	32	-11	21:32	23

View Full Table

Santos have 3 wins, 4 losses and 3 draws, averaging 1.0 goals from 3.7 shots on goal and 8.3 attempts. The Fish have averaged 49.2% possession and 3.4 corners per game, with the opposition getting 1.8 goals from 5.4 shots on goal, 10.8 attempts and 6.0 corners.

Neymar is the top goalscorer with 3, Alvaro Barreal has 2, with Tiquinho Soares and two other players on 1. The leading assistor is Guilherme Augusto with 2.

São Paulo have 7 victories, 1 defeat and 2 draws, with an average of 1.7 goals from 4.7 shots on goal and 9.9 attempts. Hernan Crespo's men have averaged 55.0% possession, 6.2 corners taken and 3.9 corners against, while conceding 0.7 goals from 2.5 shots on goal and 5.9 attempts.

Luciano Neves is top of the team’s scoring charts with 3, while Gonzalo Tapia, Damian Bobadilla, Robert Arboleda and Andre have 2. Nahuel Ferraresi and Luciano Neves have managed 3 assists in the last 10 games.

Predicted & Confirmed Lineups

Santos predicted lineup (4-3-1-2): Gabriel Brazão (GK), Mayke, Adonis Frías, Luan Peres, Gonzalo Escobar, Joao Schmidt, Zé Rafael, Victor Hugo, Benjamín Rollheiser, Guilherme Augusto, Lautaro Diaz.

São Paulo predicted lineup (3-5-2): Rafael (GK), Rafael Toloi, Robert Arboleda, Alan Franco, Cedric Soares, Damián Bobadilla, Pablo Maia, Marcos Antônio, Enzo Díaz, Emiliano Rigoni, Luciano.

Santos vs São Paulo Prediction & Betting Tips

This Santos vs São Paulo betting guide features sharp analysis across major markets, including a match prediction, correct score bet, corner kick insight, valuable player prop picks and a strategic bet builder.

Match Prediction

We’ll side with São Paulo +0.25 for this Série A clash, with an attractive -106 available. Our verdict is that they’ll perform strongly and the Asian Handicap line looks generous for this outcome.

We’re always focused on the Série A form guide to identify the latest betting trends. When it comes to key players getting injured, that can also have a bearing. The latest stats provide even more information to make a football prediction.

Key Santos vs São Paulo league stats:

• The +0.25 line has been covered by São Paulo in 9 of their last 10 games.
• The +0.25 line has been covered by São Paulo in 4 of their last 5 games.
• The -0.25 line hasn’t been covered by Santos in 4 consecutive games.
• The -0.25 line hasn’t been covered by Santos in 7 of their last 10 games.
• The -0.25 line hasn’t been covered by Santos in 14 of their last 20 games.
• The -0.25 line hasn’t been covered by Santos in 3 consecutive games against São Paulo.

São Paulo +0.25 Probability

According to the best betting sites, our pick has a 51.5% chance of landing a return. However, our experts have this number between 55-60% based on their in-depth research. This is why we regard this as a value bet.

It’s good to consider every option and you can opt to take a larger price when it comes to your pick. Proceed with moving the line until you’re satisfied with the odds.

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Our Match Prediction

São Paulo Asian Hcp +0.25 @ -106 Watch Live Bet Now

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Correct Score Prediction

Santos 0 - 1 São Paulo

There’s the option to wager on São Paulo to win by a 1-0 scoreline. Odds of +700 are on offer and this is a correct score bet that should provide plenty of entertainment.

Player Prop Picks

Top Pick: Damián Bobadilla To Score +900

Damián Bobadilla (São Paulo) can be wagered at +900 to be among the goals. We think this is the pick of the player props, with generous odds available when it comes to backing him to score at any time.

Latest Damián Bobadilla Player Prop Odds

Goalscorer

Anytime

+900

First

+1800

Shots On Target

Over 0.5

+210

Under 0.5

-370

Shots

Over 1.5

+160

Under 1.5

-

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Corners Prediction

São Paulo Over 4.5 Corners -100

In their past four away matches, São Paulo have covered the 4.5 corners line, with Santos conceding 6.00 corners on average in their last 10 games. The number of São Paulo corners might be larger than the line implies and that means a bet at odds of -100.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Santos

Total

9.40 3.40 6.00

Home

10.60 5.50 5.10

Away

10.10 3.00 7.10

São Paulo

Total

10.10 6.20 3.90

Home

9.60 5.30 4.30

Away

10.50 4.70 5.80

Latest Corner Odds

Total Corners

Over 9.5

-123

Under 9.5

-114

Santos Corners

Over 5.5

+120

Under 5.5

-163

São Paulo Corners

Over 4.5

-100

Under 4.5

-138

Most Corners

1

-137

X

+650

2

+150

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Santos vs São Paulo Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Latest Odds Suggest a Close Encounter

With the bookmakers affording them a 46% chance of winning, Santos might be a popular accumulator selection. Their betting odds are +116 when it comes to this Série A encounter. For those wanting to back São Paulo, you will find +260 about this outsider.

There’s sometimes a case for betting on the Draw No Bet market, with Santos available at -200 for those who want insurance on their bet. The same applies to opponents São Paulo at +143.

The Total Goals price implies that Under 2.5 is the most likely result in this contest. The Both Teams to Score No wager is -149 and it’s perfect if you anticipate that one side or more will fail to score by the full-time whistle.

The best football betting sites are on hand to provide lots of choice to bettors. It’s now the case that you can select from hundreds of markets for all of the Série A matches.

Full-Time Result

1

+116

X

+205

2

+260

Half-Time Result

1

+185

X

-100

2

+320

Double Chance

1X

-370

12

-294

X2

-159

Draw No Bet

1

-200

2

+143

Asian Handicap

1 Hcp -0.25

-118

2 Hcp +0.25

-106

Total Goals

Under 2.5

-189

Over 2.5

+145

Both Teams to Score

Yes

+105

No

-149

Neymar Favourite to Score the First Goal

Favourite Neymar is now available at +340 to be the First Goalscorer. You will find similar odds apply when it comes to him scoring the last goal.

Neymar (Santos)

First

+165

Anytime

+340

Luciano da Rocha (São Paulo)

First

+295

Anytime

+600

'Guilherme' dos Santos (Santos)

First

+340

Anytime

+700

Tiquinho Soares (Santos)

First

+360

Anytime

+750

Aldemir Ferreira (São Paulo)

First

+390

Anytime

+850

Álvaro Barreal (Santos)

First

+400

Anytime

+850

Lautaro Díaz (Santos)

First

+450

Anytime

+900

Emiliano Rigoni (São Paulo)

First

+500

Anytime

+1100

Oscar (São Paulo)

First

+525

Anytime

+1050

Benjamín Rollheiser (Santos)

First

+550

Anytime

+1150

Damián Bobadilla (São Paulo)

First

+900

Anytime

+1800

João Victor de Souza Menezes (Santos)

First

+900

Anytime

+1800

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

First

+900

Anytime

+1800

José Vivian "Zé Rafael" (Santos)

First

+950

Anytime

+2000

Luciano da Rocha (São Paulo)

Over 0.5

-200

Under 0.5

+114

'Guilherme' dos Santos (Santos)

Over 0.5

-132

Under 0.5

-119

Aldemir Ferreira (São Paulo)

Over 0.5

-116

Under 0.5

-147

Tiquinho Soares (Santos)

Over 0.5

-105

Under 0.5

-149

Álvaro Barreal (Santos)

Over 0.5

+110

Under 0.5

-172

Lautaro Díaz (Santos)

Over 0.5

+128

Under 0.5

-204

Neymar (Santos)

Over 1.5

+130

Under 1.5

-208

Oscar (São Paulo)

Over 0.5

+133

Under 0.5

-213

Emiliano Rigoni (São Paulo)

Over 0.5

+140

Under 0.5

-233

Benjamín Rollheiser (Santos)

Over 0.5

+155

Under 0.5

-250

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

Over 0.5

+163

Under 0.5

-270

Damián Bobadilla (São Paulo)

Over 0.5

+210

Under 0.5

-370

João Victor de Souza Menezes (Santos)

Over 0.5

+300

Under 0.5

-625

José Vivian "Zé Rafael" (Santos)

Over 0.5

+300

Under 0.5

-625

Neymar (Santos)

Over 3.5

+110

Under 3.5

-

Luciano da Rocha (São Paulo)

Over 2.5

-152

Under 2.5

-

'Guilherme' dos Santos (Santos)

Over 2.5

-128

Under 2.5

-

Tiquinho Soares (Santos)

Over 2.5

+145

Under 2.5

-

Aldemir Ferreira (São Paulo)

Over 2.5

+140

Under 2.5

-

Álvaro Barreal (Santos)

Over 1.5

-147

Under 1.5

-

Lautaro Díaz (Santos)

Over 1.5

-154

Under 1.5

-

Emiliano Rigoni (São Paulo)

Over 1.5

+115

Under 1.5

-

Oscar (São Paulo)

Over 1.5

-100

Under 1.5

-

Benjamín Rollheiser (Santos)

Over 1.5

-118

Under 1.5

-

Damián Bobadilla (São Paulo)

Over 1.5

+160

Under 1.5

-

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

Over 1.5

+123

Under 1.5

-

João Victor de Souza Menezes (Santos)

Over 0.5

-116

Under 0.5

-

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Santos vs São Paulo Lineups & Team News

Avoid surprises — review the Santos vs São Paulo team news before you bet. We’ll share both predicted and confirmed lineups for Série A along with the latest injury news.

Santos Team Page São Paulo Team Page