Santos vs São Paulo Prediction, Betting Tips, Lineups & Odds | 21 Sep 2025

Série A Betting Preview: Santos vs São Paulo

Santos host São Paulo in this Brazilian Série A encounter, with kick-off set for 19:30 on Sunday 21 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Back São Paulo to Frustrate Santos

When São Paulo clash against Santos, we will take the former at -106 on the Asian Handicap +0.25. With our stake divided between 0 and +0.5, the visitors look as though they can land a return by swerving defeat.

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2-1 Victory for São Paulo in Previous H2H Clash

Santos drew away from home in their last game. A 1-1 scoreline was played out against Atlético Mineiro. The Fish had the majority of the ball boasting 56% possession and five shots on target, with Tiquinho Soares being the goalscorer.

São Paulo claimed a home win in their previous Série A game. A 1-0 victory occurred against Botafogo. Hernan Crespo's side enjoyed 48% possession and three shots on goal, with Juan Dinenno scoring the winner seven minutes after kick-off.

On Thursday night, São Paulo were beaten 2-0 when facing LDU Quito away in the Copa Libertadores.

Head-to-Head Statistics

São Paulo have not lost to Santos in the past three meetings. Their last clash saw São Paulo land a 2-1 home win. The previous 10 H2H games have resulted in four draws and three wins apiece.

Série A		G	W	D	L	GF	GA	GD	GD	P
8	São Paulo	32	12	9	11	37	35	2	37:35	45
17	Santos	31	8	9	14	31	45	-14	31:45	33

View Full Table

Santos have 3 wins, 4 losses and 3 draws, averaging 1.0 goals from 3.7 shots on goal and 8.3 attempts. The Fish have averaged 49.2% possession and 3.4 corners per game, with the opposition getting 1.8 goals from 5.4 shots on goal, 10.8 attempts and 6.0 corners.

Neymar is the top goalscorer with 3, Alvaro Barreal has 2, with Tiquinho Soares and two other players on 1. The leading assistor is Guilherme Augusto with 2.

São Paulo have 7 victories, 1 defeat and 2 draws, with an average of 1.7 goals from 4.7 shots on goal and 9.9 attempts. Hernan Crespo's men have averaged 55.0% possession, 6.2 corners taken and 3.9 corners against, while conceding 0.7 goals from 2.5 shots on goal and 5.9 attempts.

Luciano Neves is top of the team’s scoring charts with 3, while Gonzalo Tapia, Damian Bobadilla, Robert Arboleda and Andre have 2. Nahuel Ferraresi and Luciano Neves have managed 3 assists in the last 10 games.

Confirmed Lineups

Santos confirmed lineup (4-2-3-1): Gabriel Brazao (GK), Mayke, Adonis Frias, Luan Peres, Gonzalo Escobar, Joao Schmidt, Ze Rafael, Victor Hugo, Benjamin Rollheiser, Guilherme Augusto, Lautaro Diaz.

São Paulo confirmed lineup (4-4-2): Young (GK), Felipe Negrucci, Rafael Toloi, Sabino, Mailton, Alisson, Luan Santos, Wendell, Rodriguinho, Ferreira, Juan Dinenno.

Santos vs São Paulo Prediction & Betting Tips

This Santos vs São Paulo betting guide features sharp analysis across major markets, including a match prediction, correct score bet, corner kick insight, valuable player prop picks and a strategic bet builder.

Match Prediction

We’ll side with São Paulo +0.25 for this Série A clash, with an attractive -106 available. Our verdict is that they’ll perform strongly and the Asian Handicap line looks generous for this outcome.

We’re always focused on the Série A form guide to identify the latest betting trends. When it comes to key players getting injured, that can also have a bearing. The latest stats provide even more information to make a football prediction.

Key Santos vs São Paulo league stats:

• The +0.25 line has been covered by São Paulo in 9 of their last 10 games.
• The +0.25 line has been covered by São Paulo in 4 of their last 5 games.
• The -0.25 line hasn’t been covered by Santos in 4 consecutive games.
• The -0.25 line hasn’t been covered by Santos in 7 of their last 10 games.
• The -0.25 line hasn’t been covered by Santos in 14 of their last 20 games.
• The -0.25 line hasn’t been covered by Santos in 3 consecutive games against São Paulo.

São Paulo +0.25 Probability

According to the best betting sites, our pick has a 51.5% chance of landing a return. However, our experts have this number between 55-60% based on their in-depth research. This is why we regard this as a value bet.

It’s good to consider every option and you can opt to take a larger price when it comes to your pick. Proceed with moving the line until you’re satisfied with the odds.

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Our Match Prediction

São Paulo Asian Hcp +0.25 @ -106 Bet Now

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Correct Score Prediction

Santos 0 - 1 São Paulo

There’s the option to wager on São Paulo to win by a 1-0 scoreline. Odds of +650 are on offer and this is a correct score bet that should provide plenty of entertainment.

Player Prop Picks

Top Pick: Aldemir Ferreira Under 0.5 Shots On Target -143

Aldemir Ferreira (São Paulo) can be wagered at -143 to fail to have a shot on goal. The odds look attractive based on the evidence and we’ll take a chance on him on the Shots on Target market.

Latest Aldemir Ferreira Player Prop Odds

Goalscorer

Anytime

+400

First

+850

Shots On Target

Over 0.5

-111

Under 0.5

-141

Shots

Over 1.5

-179

Under 1.5

-

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Juan Dinenno To Score +575

Juan Dinenno (São Paulo) is available at +575 to be among the goals. He looks like a value pick and we think that the odds offer plenty of appeal when it comes to wagering on Anytime Goalscorer.

Latest Juan Dinenno Player Prop Odds

Goalscorer

Anytime

+575

First

+1050

Shots On Target

Over 0.5

+150

Under 0.5

-250

Shots

Over 1.5

+120

Under 1.5

-

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Corners Prediction

São Paulo Over 4.5 Corners -100

In their past four away matches, São Paulo have covered the 4.5 corners line, with Santos conceding 6.00 corners on average in their last 10 games. The number of São Paulo corners might be larger than the line implies and that means a bet at odds of -100.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Santos

Total

9.40 3.40 6.00

Home

10.60 5.50 5.10

Away

10.10 3.00 7.10

São Paulo

Total

10.10 6.20 3.90

Home

9.60 5.30 4.30

Away

10.50 4.70 5.80

Latest Corner Odds

Total Corners

Over 9.5

-123

Under 9.5

-115

Santos Corners

Over 4.5

-150

Under 4.5

+110

São Paulo Corners

Over 4.5

-100

Under 4.5

-138

Most Corners

1

-122

X

+650

2

+138

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Santos vs São Paulo Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Latest Odds Suggest a Close Encounter

This Série A encounter sees Santos available at +133 and São Paulo priced at +230 for the victory. If you want to back the game to finish level, the bookies have odds of +200 about the draw.

There’s sometimes a case for betting on the Draw No Bet market, with Santos available at -167 for those who want insurance on their bet. The same applies to opponents São Paulo at +123.

The Total Goals price implies that Under 2.5 is the most likely result in this contest. The Both Teams to Score No wager is -149 and it’s perfect if you anticipate that one side or more will fail to score by the full-time whistle.

The best football betting sites are on hand to provide lots of choice to bettors. It’s now the case that you can select from hundreds of markets for all of the Série A matches.

Full-Time Result

1

+133

X

+200

2

+230

Half-Time Result

1

+200

X

-100

2

+300

Double Chance

1X

-333

12

-286

X2

-182

Draw No Bet

1

-167

2

+123

Asian Handicap

1 Hcp -0.25

-103

2 Hcp +0.25

-120

Total Goals

Under 2.5

-192

Over 2.5

+148

Both Teams to Score

Yes

+105

No

-149

Neymar Favourite to Score the First Goal

Favourite Neymar is now available at +340 to be the First Goalscorer. You will find similar odds apply when it comes to him scoring the last goal.

Neymar (Santos)

First

+165

Anytime

+340

Luciano da Rocha (São Paulo)

First

+300

Anytime

+600

'Guilherme' dos Santos (Santos)

First

+350

Anytime

+700

Tiquinho Soares (Santos)

First

+360

Anytime

+700

Gonzalo Tapia (São Paulo)

First

+380

Anytime

+750

Aldemir Ferreira (São Paulo)

First

+400

Anytime

+850

Álvaro Barreal (Santos)

First

+410

Anytime

+850

Lautaro Díaz (Santos)

First

+475

Anytime

+950

Emiliano Rigoni (São Paulo)

First

+540

Anytime

+1100

Oscar (São Paulo)

First

+550

Anytime

+1150

Juan Dinenno (São Paulo)

First

+575

Anytime

+1050

Benjamín Rollheiser (Santos)

First

+575

Anytime

+1200

Damián Bobadilla (São Paulo)

First

+900

Anytime

+1800

João Victor de Souza Menezes (Santos)

First

+900

Anytime

+1800

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

First

+950

Anytime

+1800

José Vivian "Zé Rafael" (Santos)

First

+1000

Anytime

+1900

Luciano da Rocha (São Paulo)

Over 0.5

-175

Under 0.5

+110

'Guilherme' dos Santos (Santos)

Over 0.5

-137

Under 0.5

-115

Gonzalo Tapia (São Paulo)

Over 0.5

-115

Under 0.5

-137

Aldemir Ferreira (São Paulo)

Over 0.5

-111

Under 0.5

-141

Tiquinho Soares (Santos)

Over 0.5

-108

Under 0.5

-143

Álvaro Barreal (Santos)

Over 0.5

+110

Under 0.5

-172

Lautaro Díaz (Santos)

Over 0.5

+128

Under 0.5

-204

Neymar (Santos)

Over 1.5

+130

Under 1.5

-208

Oscar (São Paulo)

Over 0.5

+138

Under 0.5

-227

Emiliano Rigoni (São Paulo)

Over 0.5

+150

Under 0.5

-244

Juan Dinenno (São Paulo)

Over 0.5

+150

Under 0.5

-250

Benjamín Rollheiser (Santos)

Over 0.5

+155

Under 0.5

-250

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

Over 0.5

+170

Under 0.5

-294

Damián Bobadilla (São Paulo)

Over 0.5

+205

Under 0.5

-370

João Victor de Souza Menezes (Santos)

Over 0.5

+290

Under 0.5

-625

José Vivian "Zé Rafael" (Santos)

Over 0.5

+310

Under 0.5

-625

Neymar (Santos)

Over 3.5

+110

Under 3.5

-

Luciano da Rocha (São Paulo)

Over 2.5

-127

Under 2.5

-

'Guilherme' dos Santos (Santos)

Over 2.5

-133

Under 2.5

-

Tiquinho Soares (Santos)

Over 2.5

+145

Under 2.5

-

Gonzalo Tapia (São Paulo)

Over 1.5

-172

Under 1.5

-

Aldemir Ferreira (São Paulo)

Over 1.5

-179

Under 1.5

-

Álvaro Barreal (Santos)

Over 1.5

-152

Under 1.5

-

Lautaro Díaz (Santos)

Over 1.5

-164

Under 1.5

-

Emiliano Rigoni (São Paulo)

Over 1.5

+120

Under 1.5

-

Oscar (São Paulo)

Over 1.5

+106

Under 1.5

-

Juan Dinenno (São Paulo)

Over 1.5

+120

Under 1.5

-

Benjamín Rollheiser (Santos)

Over 1.5

-119

Under 1.5

-

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

Over 1.5

+130

Under 1.5

-

Damián Bobadilla (São Paulo)

Over 0.5

-250

Under 0.5

-

João Victor de Souza Menezes (Santos)

Over 0.5

-118

Under 0.5

-

José Vivian "Zé Rafael" (Santos)

Over 0.5

-130

Under 0.5

-

Santos vs São Paulo Lineups & Team News

Avoid surprises — review the Santos vs São Paulo team news before you bet. We’ll share both predicted and confirmed lineups for Série A along with the latest injury news.

Santos Team Page São Paulo Team Page