São Paulo vs Atlético Nacional Prediction, Betting Tips, Lineups & Odds | 19 Aug 2025

Copa Libertadores Betting Preview: São Paulo vs Atlético Nacional

Brazilian Série A outfit São Paulo host Colombian Categoría Primera A side Atlético Nacional in the second leg of this Copa Libertadores round of 16 tie at Estádio do Morumbi, with kick-off set for 20:30 on Tuesday 19 August. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and confirmed lineups.

We’re Backing São Paulo To Claim Victory

São Paulo look like a standout bet when it comes to the Full-Time Result market. There are odds of -128 that the home team overcome Atlético Nacional and we’re confident that this is a value play.

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Goalless Draw in First Leg

São Paulo played Sport Recife on their travels in their last game. It was a 2-2 Série A draw. Tricolor Paulista had seven shots on target and enjoyed 67% possession, while Lucas Moura and Maik Gomes each scored one goal.

Atlético Nacional drew their previous game which was at home in the Primera A. The action ended 2-2 against Fortaleza.

Head-to-Head Statistics

The first leg ended 0-0 as Nacional and São Paulo cancelled each other out. The Colombians enjoyed 55% possession and managed the game’s only effort on target.

Copa Libertadores		G	W	D	L	GF	GA	GD	GD	P
1	São Paulo	6	4	2	0	10	4	6	10:4	14
2	Atlético Nacional	6	3	0	3	7	6	1	7:6	9

View Full Table

Confirmed Lineups

São Paulo confirmed lineup (3-5-2): Rafael (GK), Nahuel Ferraresi, Alan Franco, Sabino, Cedric Soares, Damian Bobadilla, Marcos Antonio, Rodriguinho, Enzo Hernan Diaz, Luciano Neves, Andre.

Atlético Nacional confirmed lineup (4-2-3-1): David Ospina (GK), Felipe Roman, Juan Jose Arias, William Tesillo, Camilo Candido, Juan Zapata, Jorman Campuzano, Marino Hinestroza, Edwin Cardona, Marlos Moreno, Alfredo Morelos.

São Paulo vs Atlético Nacional Prediction & Betting Tips

Our São Paulo vs Atlético Nacional betting tips provide expert coverage of all major angles, including our main match prediction, top player prop picks, correct score recommendation and best bet builder insights.

Match Prediction

It’s great to get attractive odds of -128 for a home win in this Copa Libertadores encounter. We think that São Paulo will have the upper hand and this could be the best way of getting value.

The team news that filters through can have a knock-on effect as far as the Copa Libertadores odds are concerned. We use this information along with the form guide, while the latest stats are also taken into consideration when making football predictions.

Key São Paulo vs Atlético Nacional Copa Libertadores & league stats:

• São Paulo have won 4 of their last 5 games at home.
• São Paulo have won 6 of their last 10 games at home.
• São Paulo have won 3 consecutive games at home.

São Paulo to Win Probability

Based on the odds from the best betting apps, our pick carries a 56.2% chance of winning. However, our experts have this number between 60-65% based on their in-depth research. This is why we can recommend this wager.

Those looking for tastier odds about a win for São Paulo can take a look at the Match Result & Total market. You can combine your match winner pick with an Under / Over goals prediction for more juice.

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Our Match Prediction

São Paulo To Win @ -128 Bet Now

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Correct Score Prediction

São Paulo 2 - 0 Nacional

We’ve picked out a correct score of 2-0 being landed by São Paulo. You can secure odds of +600 and this provides an alternative way to place a wager.

Player Prop Picks

Top Pick: Gonzalo Tapia Over 0.5 Shots On Target -154

Gonzalo Tapia (São Paulo) can be wagered at -154 to finish with a minimum of one shot on goal. It’s really hard to rule him out at an attractive price for the Shots on Target betting market.

Latest Gonzalo Tapia Player Prop Odds

Goalscorer

Anytime

+280

First

+525

Shots On Target

Over 0.5

-172

Under 0.5

+120

Shots

Over 2.5

-116

Under 2.5

-

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André Oliveira Silva To Score +285

André Oliveira Silva (São Paulo) can be wagered to be on the scoresheet at +285. The odds that he will be an Anytime Goalscorer look attractive based on the evidence and we’ll plump for him to find the net.

Latest André Oliveira Silva Player Prop Odds

Goalscorer

Anytime

+290

First

+525

Shots On Target

Over 0.5

-172

Under 0.5

+120

Shots

Over 2.5

-120

Under 2.5

-

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São Paulo vs Atlético Nacional Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Latest Full-Time Odds Suggest São Paulo Victory

São Paulo are forecasted to have a 53% chance of triumphing in this Copa Libertadores encounter according to the bookmakers. It leads to their latest betting odds being -115. At +375, Atlético Nacional are regarded as having a lower probability of winning.

São Paulo are -115 when it comes to the Asian Handicap -0.5 which is the same as backing them on the 1x2 market. If you instead want to bet on Nacional +0.5 at -108, you also get paid out if it’s a draw.

For the Total Goals market, Under 2.5 is the shortest price for this interesting contest. The Both Teams to Score No bet is -179 and it’s ideal if you think at least one side will not score during the ninety minutes.

The top football betting sites are on hand to provide lots of choice to bettors. It’s now the case that you can select from hundreds of markets for all of the Copa Libertadores games.

Full-Time Result

1

-115

X

+225

2

+375

Half-Time Result

1

+165

X

-100

2

+410

Double Chance

1X

-500

12

-278

X2

-106

Draw No Bet

1

-333

2

+205

Asian Handicap

1 Hcp -0.5

-115

2 Hcp +0.5

-108

Total Goals

Under 2.5

-208

Over 2.5

+165

Both Teams to Score

Yes

+128

No

-179

Luciano da Rocha Heads First Goalscorer Market

Favourite Luciano da Rocha is +450 to be the First Goalscorer, while similar odds apply when it comes to him scoring the last goal.

Luciano da Rocha (São Paulo)

First

+235

Anytime

+450

Gonzalo Tapia (São Paulo)

First

+280

Anytime

+525

André Oliveira Silva (São Paulo)

First

+290

Anytime

+525

Alfredo Morelos (Nacional)

First

+295

Anytime

+600

Aldemir Ferreira (São Paulo)

First

+330

Anytime

+600

Edwin Cardona (Nacional)

First

+340

Anytime

+650

Oscar (São Paulo)

First

+400

Anytime

+750

Lucas Moura (São Paulo)

First

+440

Anytime

+850

Marino Hinestroza (Nacional)

First

+575

Anytime

+1150

Damián Bobadilla (São Paulo)

First

+650

Anytime

+1300

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

First

+650

Anytime

+1300

Dairon Asprilla (Nacional)

First

+800

Anytime

+1600

Robert Arboleda (São Paulo)

First

+800

Anytime

+2000

Cédric Soares (São Paulo)

First

+1050

Anytime

+2000

Pablo Maia (São Paulo)

First

+1050

Anytime

+2000

Marcos Antônio Silva Santos (São Paulo)

First

+1050

Anytime

+2200

Wendell (São Paulo)

First

+1050

Anytime

+2200

Alisson Castro (São Paulo)

First

+1150

Anytime

+2200

Gonzalo Tapia (São Paulo)

Over 0.5

-172

Under 0.5

+120

André Oliveira Silva (São Paulo)

Over 0.5

-172

Under 0.5

+120

Alfredo Morelos (Nacional)

Over 0.5

-172

Under 0.5

+102

Aldemir Ferreira (São Paulo)

Over 0.5

-161

Under 0.5

+112

Edwin Cardona (Nacional)

Over 0.5

-123

Under 0.5

-115

Oscar (São Paulo)

Over 0.5

-100

Under 0.5

-143

Marino Hinestroza (Nacional)

Over 0.5

+105

Under 0.5

-149

Lucas Moura (São Paulo)

Over 0.5

+108

Under 0.5

-154

Luciano da Rocha (São Paulo)

Over 1.5

+155

Under 1.5

-222

Damián Bobadilla (São Paulo)

Over 0.5

+160

Under 0.5

-233

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

Over 0.5

+170

Under 0.5

-250

Dairon Asprilla (Nacional)

Over 0.5

+200

Under 0.5

-303

Marcos Antônio Silva Santos (São Paulo)

Over 0.5

+300

Under 0.5

-526

Pablo Maia (São Paulo)

Over 0.5

+320

Under 0.5

-556

Alisson Castro (São Paulo)

Over 0.5

+320

Under 0.5

-588

Robert Arboleda (São Paulo)

Over 0.5

+325

Under 0.5

-833

Wendell (São Paulo)

Over 0.5

+340

Under 0.5

-625

Cédric Soares (São Paulo)

Over 0.5

+360

Under 0.5

-667

Luciano da Rocha (São Paulo)

Over 3.5

-103

Under 3.5

-

Gonzalo Tapia (São Paulo)

Over 2.5

-116

Under 2.5

-

André Oliveira Silva (São Paulo)

Over 2.5

-120

Under 2.5

-

Alfredo Morelos (Nacional)

Over 2.5

-141

Under 2.5

-

Aldemir Ferreira (São Paulo)

Over 2.5

-102

Under 2.5

-

Edwin Cardona (Nacional)

Over 2.5

+123

Under 2.5

-

Marino Hinestroza (Nacional)

Over 2.5

+123

Under 2.5

-

Dairon Asprilla (Nacional)

Over 1.5

+155

Under 1.5

-

Rodrigo Almeida Mendonca "Rodriguinho" (São Paulo)

Over 1.5

-108

Under 1.5

-

Damián Bobadilla (São Paulo)

Over 1.5

+116

Under 1.5

-

Lucas Moura (São Paulo)

Over 1.5

-133

Under 1.5

-

Oscar (São Paulo)

Over 1.5

-141

Under 1.5

-

Robert Arboleda (São Paulo)

Over 0.5

+102

Under 0.5

-

Cédric Soares (São Paulo)

Over 0.5

+104

Under 0.5

-

Pablo Maia (São Paulo)

Over 0.5

-118

Under 0.5

-

Marcos Antônio Silva Santos (São Paulo)

Over 0.5

-152

Under 0.5

-

Wendell (São Paulo)

Over 0.5

-102

Under 0.5

-

Alisson Castro (São Paulo)

Over 0.5

-156

Under 0.5

-

Latest Copa Libertadores and domestic league stats. Full Time Result, Goals, Corners and Possession.

São Paulo Stats

Atlético Nacional Stats

Full-Time Result

• 5 wins, 3 defeats and 2 draws in the previous 10 matches
• 5 wins, 2 defeats and 3 draws in the previous 10 home matches

Full-Time Result

• 5 wins, 2 defeats and 3 draws in the previous 10 matches
• 3 wins, 3 defeats and 4 draws in the previous 10 away matches

Goals

• An average of 1.60 goals scored and 1.30 conceded in the previous 10 matches
• An average of 1.30 goals scored and 0.90 conceded in the previous 10 home matches
• An average of 2.90 goals per game in the previous 10 matches
• An average of 2.20 goals per game in the previous 10 home matches
• BTTS Yes in 6 of the previous 10 matches
• BTTS Yes in 5 of the previous 10 home matches
• Over 2.5 Goals in 6 of the previous 10 matches
• Over 2.5 Goals in 4 of the previous 10 home matches

Goals

• An average of 1.70 goals scored and 1.00 conceded in the previous 10 matches
• An average of 1.00 goals scored and 0.90 conceded in the previous 10 away matches
• An average of 2.70 goals per game in the previous 10 matches
• An average of 1.90 goals per game in the previous 10 away matches
• BTTS Yes in 7 of the previous 10 matches
• BTTS Yes in 6 of the previous 10 away matches
• Over 2.5 Goals in 7 of the previous 10 matches
• Over 2.5 Goals in 5 of the previous 10 away matches

São Paulo vs Atlético Nacional Lineups & Team News

Be smart with your bets — check the São Paulo vs Nacional team news beforehand. We’ll provide the predicted and confirmed lineups for the Copa Libertadores along with up-to-date injury news.