Sassuolo vs Lazio Prediction, Betting Tips, Lineups & Odds | 14 Sep 2025

Serie A Betting Preview: Sassuolo vs Lazio

Sassuolo host Lazio in this Italian Serie A encounter at Stadio Mapei, with kick-off set for 12:00 on Sunday 14 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

We’re Backing Lazio to Win

We’re keen to secure odds of +102 for an away win when Lazio face Sassuolo. There’s every chance that the visitors will have the edge and the Full-Time Result market offers plenty of value.

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Last H2H Encounter Ended in a 1-1 Draw

Sassuolo have lost back-to-back Serie A games. Away at Stadio Giovanni Zini, Cremonese recently beat them 3-2. Fabio Grosso's team enjoyed 58% possession and had five shots on target, with Andrea Pinamonti and Domenico Berardi scoring one goal apiece.

Lazio claimed a home victory in their previous game. A 4-0 win occurred against Hellas Verona at Stadio Olimpico. Le Aquile racked up six shots on goal and boasted 70% possession, while Matteo Guendouzi, Mattia Zaccagni, Valentin Castellanos and Boulaye Dia were on the scoresheet.

Head-to-Head Statistics

Lazio haven’t lost to Sassuolo in their past five games, with the last clash ending 1-1 at Stadio Olimpico. The 10 previous H2H meetings have involved six Lazio wins, one draw and three Sassuolo victories.

Serie A		G	W	D	L	GF	GA	GD	GD	P
7	Lazio	2	1	0	1	4	2	2	4:2	3
20	Sassuolo	2	0	0	2	2	5	-3	2:5	0

View Full Table

Sassuolo have 4 wins, 5 losses and 1 draw, averaging 1.8 goals from 5.0 shots on goal and 9.7 attempts. The Emilia-Romagna club have averaged 49.5% possession and 4.1 corners per game, with their opponents scoring 1.6 goals from 5.2 shots on goal, 10.6 attempts and 5.0 corners.

Top goalscorer Armand Lauriente has found the net 5 times, with Domenico Berardi, Simone Verdi, Daniel Boloca and Luca Moro scoring 2 each. Cristian Volpato is the top assists maker on 3.

Lazio have 4 victories, 2 defeats and 4 draws, averaging 4.9 shots on goal, 13.3 attempts and 1.4 goals. Le Aquile average 56.4% possession, 476.6 passes, 6.0 corners taken and 4.4 corners against them, while 0.9 goals have been conceded from 9.8 attempts and 3.6 shots on goal.

Pedro Rodriguez has scored 4, followed by Boulaye Dia on 3 and Valentin Castellanos with 2. Luca Pellegrini is top assists provider with 3, while Christos Mandas and Ivan Provedel have kept 3 clean sheets between them in the last 10 games.

Predicted & Confirmed Lineups

Sassuolo predicted lineup (4-3-3): Arijanet Muric (GK), Sebastian Walukiewicz, Jay Idzes, Tarik Muharemovic, Josh Doig, Ismaël Koné, Nemanja Matic, Aster Vranckx, Domenico Berardi, Andrea Pinamonti, Armand Lauriente.

Lazio predicted lineup (4-3-3): Ivan Provedel (GK), Adam Marusic, Mario Gila, Alessio Romagnoli, Nuno Tavares, Matteo Guendouzi, Danilo Cataldi, Fisayo Dele-Bashiru, Matteo Cancellieri, Valentín Castellanos, Mattia Zaccagni.

Sassuolo vs Lazio Prediction & Betting Tips

Take in the full Sassuolo vs Lazio betting outlook — from our expert match prediction and correct score pick to sharp corners advice, player prop insights and a bet builder tailored for value.

Match Prediction

We think Lazio stand a strong chance of victory when they compete in this Serie A game, with our pick providing lots of value. Secure the odds of +102 that the visitors are able to get the job done.

We take note of any injuries or suspensions affecting each side before going ahead with our football predictions. The Serie A form guide and stats also help the team at Sportsgambler.com crunch the numbers ahead of the action.

Key Sassuolo vs Lazio league stats:

• Lazio have won 6 of their last 10 games on the road.
• Lazio have won 3 of their last 5 games on the road.
• Sassuolo have lost 6 of their last 10 games against Lazio.

Lazio to Win Probability

If you go by the top bookies, there’s a 49.5% likelihood of our pick winning. However, our research has found that the actual probability is between 55-60%. It’s why we think it’s worth placing this bet.

If you think the price for Lazio to win is too short, then consider boosting your odds by pairing this selection with both teams to score on the Result & BTTS market.

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Our Match Prediction

Lazio To Win @ +102 Watch Live Bet Now

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Correct Score Prediction

Sassuolo 0 - 1 Lazio

An exciting bet could be a 1-0 victory in favor of Lazio at odds of +700. A correct score wager provides a fun alternative and a nice potential return on the cards.

Player Prop Picks

Top Pick: Mattia Zaccagni Under 0.5 Shots On Target -132

Mattia Zaccagni (Lazio) hasn’t recorded a shot on goal in seven of the past nine Serie A matches. We think he might fall short of the mark, with odds of -132 available when it comes to this Shots on Target bet.

Latest Mattia Zaccagni Player Prop Odds

Goalscorer

Anytime

+320

First

+700

Shots On Target

Over 0.5

-119

Under 0.5

-132

Shots

Over 1.5

-154

Under 1.5

-

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Valentín Castellanos To Score +195

Valentín Castellanos (Lazio) can be wagered at +195 to score. He looks like a value pick and we think that the odds offer plenty of appeal when it comes to wagering on Anytime Goalscorer.

Latest Valentín Castellanos Player Prop Odds

Goalscorer

Anytime

+195

First

+475

Shots On Target

Over 0.5

-222

Under 0.5

+112

Shots

Over 3.5

+130

Under 3.5

-

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Corners Prediction

Lazio Under 5.5 Corners -138

It’s been an average of 4.00 corners for Lazio in their past 5 away games, with Sassuolo conceding under 5.5 corners in the previous six matches. It stands to reason that the line won’t be reached and you can secure odds of -138 for this Lazio Team Corners bet.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Sassuolo

Total

9.10 4.10 5.00

Home

8.70 4.80 3.90

Away

8.60 3.30 5.30

Lazio

Total

10.40 6.00 4.40

Home

10.80 7.80 3.00

Away

10.30 4.50 5.80

Latest Corner Odds

Total Corners

Over 9.5

-149

Under 9.5

+106

Sassuolo Corners

Over 4.5

-100

Under 4.5

-138

Lazio Corners

Over 5.5

+110

Under 5.5

-150

Most Corners

1

+180

X

+650

2

-164

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Sassuolo vs Lazio Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Lazio Have the Shortest Odds to Win

With the bookies giving them a 50% probability of winning, Lazio might be a popular acca pick. Their current betting odds are +102 when it comes to triumphing in this Serie A clash. Sassuolo are operating at larger odds than the opposition and the underdogs can be wagered at +260.

Lazio are +102 on the Asian Handicap -0.5 which is like backing them on the Full-Time Result market. Alternatively, you can get -127 for Sassuolo +0.5 and get the draw on your side.

If you want to bet on the number of goals, you can get a similar price on Over or Under 2.5 Goals. BTTS betting is always a warm order and you can bet Yes at -143 on the Both Teams to Score market.

It’s fantastic to find hundreds of markets on offer for Serie A matches. You simply need to visit the best betting apps and select from the various football options that are presented.

Full-Time Result

1

+260

X

+245

2

+102

Half-Time Result

1

+295

X

+125

2

+155

Double Chance

1X

-133

12

-345

X2

-357

Draw No Bet

1

+155

2

-213

Asian Handicap

1 Hcp +0.5

-127

2 Hcp -0.5

+102

Total Goals

Under 2.5

-109

Over 2.5

-119

Both Teams to Score

Yes

-143

No

+105

Valentín Castellanos Top of First Goalscorer List

Favourite Valentín Castellanos is priced at +475 to be the first player to find the net. There’s also the opportunity to back him to score any time at odds of +195.

Valentín Castellanos (Lazio)

First

+195

Anytime

+475

Andrea Pinamonti (Sassuolo)

First

+255

Anytime

+600

Domenico Berardi (Sassuolo)

First

+280

Anytime

+650

Boulaye Dia (Lazio)

First

+290

Anytime

+650

Armand Laurienté (Sassuolo)

First

+290

Anytime

+650

Matteo Cancellieri (Lazio)

First

+310

Anytime

+700

Mattia Zaccagni (Lazio)

First

+320

Anytime

+700

Nicholas Pierini (Sassuolo)

First

+330

Anytime

+800

Gustav Isaksen (Lazio)

First

+370

Anytime

+900

Kristian Thorstvedt (Sassuolo)

First

+390

Anytime

+1000

Fisayo Dele-Bashiru (Lazio)

First

+440

Anytime

+1050

Matías Vecino (Lazio)

First

+550

Anytime

+1300

Alieu Fadera (Sassuolo)

First

+600

Anytime

+1400

Daniel Boloca (Sassuolo)

First

+700

Anytime

+1600

Aster Vranckx (Sassuolo)

First

+750

Anytime

+1900

Mattéo Guendouzi (Lazio)

First

+750

Anytime

+1900

Danilo Cataldi (Lazio)

First

+800

Anytime

+1800

Nicolò Rovella (Lazio)

First

+800

Anytime

+1800

Nuno Tavares (Lazio)

First

+800

Anytime

+2000

Mario Gila (Lazio)

First

+800

Anytime

+2000

Adam Marusic (Lazio)

First

+950

Anytime

+2200

Valentín Castellanos (Lazio)

Over 0.5

-222

Under 0.5

+112

Andrea Pinamonti (Sassuolo)

Over 0.5

-133

Under 0.5

-118

Boulaye Dia (Lazio)

Over 0.5

-132

Under 0.5

-118

Domenico Berardi (Sassuolo)

Over 0.5

-125

Under 0.5

-125

Matteo Cancellieri (Lazio)

Over 0.5

-125

Under 0.5

-125

Mattia Zaccagni (Lazio)

Over 0.5

-119

Under 0.5

-132

Armand Laurienté (Sassuolo)

Over 0.5

-112

Under 0.5

-139

Nicholas Pierini (Sassuolo)

Over 0.5

+102

Under 0.5

-159

Gustav Isaksen (Lazio)

Over 0.5

+102

Under 0.5

-161

Kristian Thorstvedt (Sassuolo)

Over 0.5

+133

Under 0.5

-213

Fisayo Dele-Bashiru (Lazio)

Over 0.5

+140

Under 0.5

-227

Matías Vecino (Lazio)

Over 0.5

+180

Under 0.5

-313

Alieu Fadera (Sassuolo)

Over 0.5

+220

Under 0.5

-400

Daniel Boloca (Sassuolo)

Over 0.5

+255

Under 0.5

-500

Mattéo Guendouzi (Lazio)

Over 0.5

+260

Under 0.5

-500

Aster Vranckx (Sassuolo)

Over 0.5

+290

Under 0.5

-588

Nuno Tavares (Lazio)

Over 0.5

+290

Under 0.5

-1000

Mario Gila (Lazio)

Over 0.5

+295

Under 0.5

-1000

Adam Marusic (Lazio)

Over 0.5

+320

Under 0.5

-1250

Valentín Castellanos (Lazio)

Over 3.5

+130

Under 3.5

-

Andrea Pinamonti (Sassuolo)

Over 2.5

+117

Under 2.5

-

Domenico Berardi (Sassuolo)

Over 2.5

+125

Under 2.5

-

Boulaye Dia (Lazio)

Over 1.5

-139

Under 1.5

-

Armand Laurienté (Sassuolo)

Over 1.5

-185

Under 1.5

-

Matteo Cancellieri (Lazio)

Over 1.5

-167

Under 1.5

-

Mattia Zaccagni (Lazio)

Over 1.5

-154

Under 1.5

-

Nicholas Pierini (Sassuolo)

Over 1.5

-128

Under 1.5

-

Gustav Isaksen (Lazio)

Over 1.5

-132

Under 1.5

-

Kristian Thorstvedt (Sassuolo)

Over 1.5

-102

Under 1.5

-

Alieu Fadera (Sassuolo)

Over 0.5

-200

Under 0.5

-

Daniel Boloca (Sassuolo)

Over 0.5

-154

Under 0.5

-

Nuno Tavares (Lazio)

Over 0.5

-147

Under 0.5

-

Mario Gila (Lazio)

Over 0.5

+102

Under 0.5

-

Adam Marusic (Lazio)

Over 0.5

-100

Under 0.5

-

Sassuolo Home Form Not Convincing

The previous three Sassuolo matches at Stadio Mapei have seen them beaten. I Neroverdi have managed six victories, three losses and one draw in the last 10 home matches, recording an average of 1.80 goals per game and conceding 1.00.

Lazio have recorded six victories, two draws and two defeats in the previous 10 away matches, netting an average of 1.30 goals per game and conceding 1.10.

Lazio enjoyed a 2-0 winning scoreline when last meeting Sassuolo at Stadio Mapei. The previous 5 H2H meetings at Stadio Mapei have involved Lazio winning three times and Sassuolo registering two victories.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Sassuolo Home Stats		6-1-3	2.80	1.80	1.00	2	8	3	7
Lazio Away Stats		6-2-2	2.40	1.30	1.10	5	5	3	7

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

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Sassuolo vs Lazio Lineups & Team News

Always review the Sassuolo vs Lazio team news before locking in your bets. We’ll share both predicted and confirmed lineups for Serie A along with the latest injury news.

Sassuolo Team Page Lazio Team Page