Boston College vs Louisville Prediction, Picks & Odds | 25 Oct 2025
College Football Betting Preview: Boston College vs Louisville
Boston College meet Louisville in this NCAAF Week 9 matchup at L&N Federal Credit Union Stadium, with kickoff scheduled for 19:30 on Saturday, October 25. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
We strongly fancy the chances of Louisville beating Boston College handsomely. That is why we’re having a bet on them at -25.5 on the spread at -110.
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Boston College Eagles have suffered six straight defeats, recently being beaten at home by UConn Huskies 38-23 at Alumni Stadium.
Louisville Cardinals won last time out by a 24-21 scoreline. It was on the road against Miami Hurricanes at Hard Rock Stadium.
Head-to-Head Statistics
Louisville have claimed victories in the last two matchups against Boston College. At L&N Federal Credit Union Stadium, the scoreline was 56-28 and then we saw 31-27 at Alumni Stadium. It’s been four Louisville wins in the past 6 games between these teams.
Boston College vs Louisville Prediction & Picks
Take on Boston College vs Louisville with our in-depth betting analysis, featuring an expert match prediction, scoreline advice, key player props and a value-driven bet builder.
Game Prediction
Louisville can finish well clear in this college football battle and that means we’re going for them against the spread. There is -110 on offer that the favorites are able to cover a -25.5 line.
We keep a close eye on team news and our CFB handicappers stay sharp by tracking the latest form and lineups. You’ll also find a full set of stats that offer valuable insight and help shape smarter predictions ahead of the action.
Key Boston College vs Louisville stats:
Louisville -25.5 Probability
The top sportsbooks are estimating that there is a 52.4% likelihood of this pick winning. In the opinion of our analysts, there’s actually a probability of success closer to 60%. This college bet can therefore be backed with confidence.
If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your spread pick. It all comes down to how confident you feel.
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Player Prop Picks
Miller Moss (Louisville) can be backed at -114 to rack up over 290.5 passing yards. We feel confident that he’ll cover the QB Passing Yards line, which looks generous.
You can place a bet on Caullin Lacy (Louisville) at -114 to go beyond 44.5 receiving yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this Player Receiving Yards pick.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Louisville -25.5 on the spread, combined with Over 54.5 and Miller Moss (Louisville) to have Over 290.5 passing yards.
A football same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big return from a small stake.
Correct Score Prediction
14
-
45
Louisville
Should you want a wager that can land a big return, then look no further than the correct score lines. Bet on Louisville to win 45-14 and leverage a massive payout if this happens.
Boston College vs Louisville Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
At betting odds of -5000 with the sportsbooks, Louisville are regarded as 98% likely to win this college game. Boston College are trading at bigger odds than their opponents and they can be backed at +1500.
There is a spread of 25.5 and total points has a line of 54.5. The beauty of the Totals is that you only have to choose from one of two options. Those that want to back Under 54.5 can find odds of -110 available.
The best betting apps provide tons of game lines and team props for nearly every college football matchup. Take a few moments to browse all the markets so you can place a bet that matches your insight.
Those interested in favorite Isaac Brown to score the first touchdown are able to get +270. If the Anytime TD angle makes appeal, then this is -313.
Touchdown
Receiving Yards
Rushing Yards
You don’t have to wait for the final outcome when it comes to college football micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.
Louisville Have Won Last Three Head-to-Head Meetings at L&N Federal Credit Union Stadium
Louisville are 7-3 in their last 10 home games, putting up 39.70 points on average and giving up 20.60.
Boston College have lost eight straight on the road. They have one win and nine losses in the last 10 games on the road, putting up 21.00 points per contest and giving up 30.80.
Louisville defeated Boston College 56-28 in their last meeting at L&N Federal Credit Union Stadium. Across the previous 3 head-to-head meetings at L&N Federal Credit Union Stadium, Louisville have prevailed every time.
| Last 10 Games | W-L | P | PF | PA | O54.5 | U54.5 | |
|---|---|---|---|---|---|---|---|
 Louisville Home Stats |
7-3 | 60.30 | 39.70 | 20.60 | 7 | 3 | |
 Boston College Away Stats |
1-9 | 51.80 | 21.00 | 30.80 | 4 | 6 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O54.5 = Games Over 54.5 Points
- U54.5 = Games Under 54.5 Points
Latest regular season and playoff games stats.
Boston College Stats
Louisville Cardinals Stats
- 3 wins and 7 defeats in the last 10 games
- 1 win and 9 defeats in the last 10 games on the road
- +25.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +25.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road
- -25.5 Betting Line: Have covered the spread in 3 of the last 10 games
- -25.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games
- Game Totals: An average of 58.10 pts in the previous 10 games
- Game Totals on the Road: An average of 51.80 pts in the previous 10 games on the road
- Over 54.5: Covered in 6 of the previous 10 games
- Over 54.5 on the Road: Covered in 4 of the previous 10 games on the road
- Team Totals: Have scored an average of 28.00 pts and allowed 30.10 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 21.00 pts and allowed 30.80 pts in the last 10 games on the road
- Game Totals: An average of 57.30 pts in the previous 10 games
- Game Totals at Home: An average of 60.30 pts in the previous 10 home games
- Over 54.5: Covered in 7 of the previous 10 games
- Over 54.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 35.20 pts and allowed 22.10 pts in the last 10 games
- Team Totals at Home: Have scored an average of 39.70 pts and allowed 20.60 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Virginia
|
10 | 3 | 418 | 267 | 151 | 6-2 | 4-1 | 1L |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
|
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
Duke
|
8 | 5 | 442 | 373 | 69 | 3-3 | 5-2 | 3W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
|
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
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