Boston College vs Louisville Prediction, Picks & Odds | 25 Oct 2025

College Football Betting Preview: Boston College vs Louisville

Boston College meet Louisville in this NCAAF matchup at L&N Federal Credit Union Stadium, with kickoff scheduled for 19:30 on Saturday 25 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Louisville Primed for Massive Win

We strongly fancy the chances of Louisville beating Boston College handsomely. That is why we’re having a bet on them at -25.5 on the spread at -110.

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Louisville Claimed 31-27 Victory in Last H2H

Boston College Eagles have suffered six straight defeats, recently being beaten at home by UConn Huskies 38-23 at Alumni Stadium.

Louisville Cardinals won last time out by a 24-21 scoreline. It was on the road against Miami Hurricanes at Hard Rock Stadium.

Head-to-Head Statistics

Louisville have claimed victories in the last two matchups against Boston College. At L&N Federal Credit Union Stadium, the scoreline was 56-28 and then we saw 31-27 at Alumni Stadium. It’s been four Louisville wins in the past 6 games between these teams.

Boston College vs Louisville Prediction & Picks

Take on Boston College vs Louisville with our in-depth betting analysis, featuring an expert match prediction, scoreline advice, key player props and a value-driven bet builder.

Game Prediction

Louisville can finish well clear in this college football battle and that means we’re going for them against the spread. There is -110 on offer that the favorites are able to cover a -25.5 line.

We keep a close eye on team news and our CFB handicappers stay sharp by tracking the latest form and lineups. You’ll also find a full set of stats that offer valuable insight and help shape smarter predictions ahead of the action.

Key Boston College vs Louisville stats:

• The -25.5 line has been covered by Louisville in 4 of their last 10 games at home.

Louisville -25.5 Probability

The top sportsbooks are estimating that there is a 52.4% likelihood of this pick winning. In the opinion of our analysts, there’s actually a probability of success closer to 60%. This college bet can therefore be backed with confidence.

If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your spread pick. It all comes down to how confident you feel.

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Best Bet

Louisville -25.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Miller Moss Over 290.5 Passing Yards -114

Miller Moss (Louisville) can be backed at -114 to rack up over 290.5 passing yards. We feel confident that he’ll cover the QB Passing Yards line, which looks generous.

Latest Miller Moss Player Prop Odds

Passing Yards

Over 290.5

-114

Under 290.5

-114

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Caullin Lacy Over 44.5 Receiving Yards -114

You can place a bet on Caullin Lacy (Louisville) at -114 to go beyond 44.5 receiving yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this Player Receiving Yards pick.

Latest Caullin Lacy Player Prop Odds

Receiving Yards

Over 47.5

-114

Under 47.5

-114

Correct Score Prediction

Boston College 14 - 45 Louisville

Should you want a wager that can land a big return, then look no further than the correct score lines. Bet on Louisville to win 45-14 and leverage a massive payout if this happens.

Boston College vs Louisville Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Louisville Win on the Cards According to the Books

At betting odds of -5000 with the sportsbooks, Louisville are regarded as 98% likely to win this college game. Boston College are trading at bigger odds than their opponents and they can be backed at +1600.

There is a spread of 25.5 and total points has a line of 54.5. The beauty of the Totals is that you only have to choose from one of two options. Those that want to back Under 54.5 can find odds of -110 available.

The best betting apps provide tons of game lines and team props for nearly every college football matchup. Take a few moments to browse all the markets so you can place a bet that matches your insight.

Moneyline

BC

+1600

Louisville

-5000

Point Spread

BC +25.5

-110

Louisville -25.5

-110

Total Points

Under 54.5

-110

Over 54.5

-110

Player Odds

Receiving Yards

Chris Bell (Louisville)

Over 99.5

-114

Under 99.5

-114

Caullin Lacy (Louisville)

Over 47.5

-114

Under 47.5

-114

Rushing Yards

Isaac Brown (Louisville)

Over 105.5

-114

Under 105.5

-114

Louisville Have Won Last Three Head-to-Head Meetings at L&N Federal Credit Union Stadium

Louisville are 7-3 in their last 10 home games, putting up 39.70 points on average and giving up 20.60.

Boston College have lost eight straight on the road. They have one win and nine losses in the last 10 games on the road, putting up 21.00 points per contest and giving up 30.80.

Louisville defeated Boston College 56-28 in their last meeting at L&N Federal Credit Union Stadium. Across the previous 3 head-to-head meetings at L&N Federal Credit Union Stadium, Louisville have prevailed every time.

Last 10 Games		W-L	P	PF	PA	O54.5	U54.5
Louisville Home Stats		7-3	60.30	39.70	20.60	7	3
Boston College Away Stats		1-9	51.80	21.00	30.80	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O54.5 = Games Over 54.5 Points
• U54.5 = Games Under 54.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Boston College Stats

Louisville Cardinals Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +25.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +25.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -25.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -25.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 58.10 pts in the previous 10 games
• Game Totals on the Road: An average of 51.80 pts in the previous 10 games on the road
• Over 54.5: Covered in 6 of the previous 10 games
• Over 54.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 28.00 pts and allowed 30.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.00 pts and allowed 30.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 57.30 pts in the previous 10 games
• Game Totals at Home: An average of 60.30 pts in the previous 10 home games
• Over 54.5: Covered in 7 of the previous 10 games
• Over 54.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 35.20 pts and allowed 22.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 39.70 pts and allowed 20.60 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Georgia Tech	7	0	247	144	103	4-0	3-0	7W
Virginia	6	1	280	163	117	5-0	1-1	5W
Louisville	5	1	204	126	78	3-1	2-0	1W
Miami	5	1	196	92	104	4-1	1-0	1L
California	5	2	166	153	13	3-1	2-1	1W
Pittsburgh	5	2	269	142	127	3-1	2-1	3W
SMU	5	2	239	158	81	3-1	2-1	3W
Wake Forest	4	2	174	120	54	2-2	2-0	2W
Duke	4	3	237	180	57	2-2	2-1	1L
NC State	4	3	210	186	24	3-1	1-2	1L
Clemson	3	4	182	146	36	1-3	2-1	1L
Florida State	3	4	278	158	120	3-2	0-2	4L
Stanford	3	4	133	194	-61	3-0	0-4	1W
Syracuse	3	4	187	209	-22	2-2	1-2	3L
North Carolina	2	4	112	150	-38	1-2	1-2	3L
Virginia Tech	2	5	161	205	-44	1-3	1-2	2L
Boston College	1	6	190	237	-47	1-3	0-3	6L