Buffalo vs Central Michigan Prediction, Picks & Odds | 12 Nov 2025

College Football Betting Preview: Buffalo vs Central Michigan

Buffalo battle Central Michigan at Kelly/Shorts Stadium, with kickoff scheduled for 19:00 on Wednesday, November 12. Our betting preview features expert NCAAF predictions, picks, the latest betting odds and H2H stats.

CMU to Triumph?

We are going to bet against Buffalo with our betting prediction. The best way of doing this is by siding with their opponents and we really like the -106 about Central Michigan winning on the Moneyline.

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Buffalo Overcame CMU in Previous Clash

Buffalo Bulls have won three road games on the spin, triumphing 28-3 in their previous appearance. This was against Bowling Green Falcons at Doyt L. Perry Stadium.

Central Michigan Chippewas have won three consecutive games at home. In their last appearance, they suffered a 24-21 road defeat against Western Michigan Broncos at Waldo Stadium.

Head-to-Head Statistics

Buffalo had the edge in the most recent matchup between these teams. At University of Buffalo Stadium, they recorded a 37-13 win over Central Michigan. The past 3 games between the teams have seen Buffalo win two times.

Buffalo vs Central Michigan Prediction & Picks

Step into Buffalo vs Central Michigan with confidence, armed with our expert match prediction, likely scoreline and a custom-built bet builder for maximum value.

Game Prediction

The -106 about Central Michigan look really attractive when it comes to the Moneyline. We think their opponents can be beaten in this college football matchup, so this is our pick.

The college football picks at Sportsgambler.com are always guided by the latest team news, injury updates and overall form. Once we've reviewed that, we dive into the most relevant stats to confidently recommend every pick.

Key Buffalo vs Central Michigan stats:

• Central Michigan have won 4 consecutive games at home.
• Central Michigan have won 7 of their last 10 games at home.
• Central Michigan have won 13 of their last 20 games at home.

CMU Moneyline Probability

The best sportsbooks make it a 51.5% chance that our pick is settled as a winner. Taking all factors into consideration, our experts think there’s a stronger chance of success and estimate the probability to be closer to 60%. The bet can be recommended for this precise reason.

If you’re looking for greater odds, CMU can be backed at a bigger price against the spread. Also consider the option of looking at the Result & Total and Double Result lines.

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Best Bet

Central Michigan Moneyline @ -106 Bet Now

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Correct Score Prediction

Buffalo 21 - 24 Central Michigan

There are massive odds available when it comes to the Chippewas claiming a 24-21 victory. A close battle is anticipated between two evenly-matched teams.

Buffalo vs Central Michigan Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Predicting a Close Encounter

If you want to bet on Central Michigan, then Moneyline odds of -106 are on offer, although Buffalo are a -110 chance. In the eyes of the leading sportsbooks, the home team are regarded as 52% likely to claim a victory.

The spread currently stands at 1.5 and the total points line is 42.5. Having a bet on the Totals is one of the most popular football wagers. Those who wager Under 42.5 can get -110.

If you’re getting ready to place a college football bet, head over to one of the top betting apps and explore the wide variety of game lines and team props. Take your time to spot the most appealing opportunities.

Moneyline

Buffalo

-110

CMU

-106

Point Spread

Buffalo +1.5

-120

CMU -1.5

-102

Total Points

Under 42.5

-110

Over 42.5

-110

Player Props & Micro Betting

There is regularly value to be found from betting the quarterback and player props with the best online gambling sites. You can find lots of ways to back for or against a specific player lining up for one of the two teams.

Micro betting is something that’s really popular with bettors, with college football fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.

Central Michigan Racking Up the Home Wins

Central Michigan are riding four consecutive victories at Kelly/Shorts Stadium. They have seven wins and three losses in the last 10 games at home, averaging 30.70 points scored and 19.70 points allowed.

Buffalo have chalked up three consecutive victories on their travels. They own a 7-3 mark in their past 10 games on the road, posting 24.30 points per contest while yielding 24.60.

When the teams last met at Kelly/Shorts Stadium, Central Michigan beat Buffalo 31-27.

Last 10 Games		W-L	P	PF	PA	O42.5	U42.5
Central Michigan Home Stats		7-3	50.40	30.70	19.70	7	3
Buffalo Away Stats		7-3	48.90	24.30	24.60	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O42.5 = Games Over 42.5 Points
• U42.5 = Games Under 42.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Buffalo Bulls Stats

Central Michigan Chippewas Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +1.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +1.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -1.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -1.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 43.20 pts in the previous 10 games
• Game Totals on the Road: An average of 48.90 pts in the previous 10 games on the road
• Over 42.5: Covered in 4 of the previous 10 games
• Over 42.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 24.90 pts and allowed 18.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 24.30 pts and allowed 24.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 47.30 pts in the previous 10 games
• Game Totals at Home: An average of 50.40 pts in the previous 10 home games
• Over 42.5: Covered in 6 of the previous 10 games
• Over 42.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 23.30 pts and allowed 24.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 30.70 pts and allowed 19.70 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Mid-American	W	L	PF	PA	N. Pts	Home	Away	Strk
Ohio	6	3	258	218	40	5-0	1-3	3W
Buffalo	5	4	223	176	47	2-3	3-1	1W
Miami (OH)	5	4	228	195	33	3-1	2-3	1L
Western Michigan	5	4	201	171	30	4-1	1-3	1W
Central Michigan	5	4	217	216	1	3-0	2-4	1L
Toledo	5	4	296	131	165	5-0	0-4	1W
Ball State	4	5	148	251	-103	4-0	0-5	1W
Akron	4	6	213	271	-58	3-2	1-4	2W
Kent State	3	6	162	309	-147	3-1	0-5	1L
Eastern Michigan	3	7	244	317	-73	3-2	0-5	1W
Bowling Green	3	7	185	258	-73	3-2	0-5	4L
Northern Illinois	2	7	110	219	-109	2-2	0-5	1L
UMass	0	9	102	331	-229	0-4	0-5	9L