Buffalo vs Massachusetts Prediction, Picks & Odds | 18 Oct 2025


College Football Betting Preview: Buffalo vs Massachusetts
Buffalo face off against Massachusetts in this NCAAF Week 8 matchup at Warren McGuirk Alumni Stadium, with kickoff scheduled for 14:30 on Saturday 18 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
Buffalo to Win Big
Go for the favorites on the spread in order to get the best value. Buffalo should be able to cover a line of -16.5 at odds of -115 when they take on Massachusetts.
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Buffalo Beat Massachusetts in Pair’s Previous Clash
Buffalo Bulls claimed a victory in their previous game. A 31-30 home win occurred against Eastern Michigan Eagles at University of Buffalo Stadium.
Massachusetts Minutemen have been beaten in their last six games. On the road at Dix Stadium, Kent State Golden Flashes recently beat them 42-6.
Head-to-Head Statistics
These two teams last met at University of Buffalo Stadium, with Buffalo claiming the win. Beating Massachusetts by a 34-3 scoreline.
Buffalo vs Massachusetts Prediction & Picks
This expert Buffalo vs Massachusetts betting breakdown features our match prediction, a correct score pick and a carefully constructed bet builder to guide your wagers.
Game Prediction
We’d be surprised if the favorites don’t exceed a -16.5 spread in this college football battle. That is why the wager has to be Buffalo to cover the line at -115.
Injuries can influence the outcome and our CFB handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the matchup might unfold.
Key Buffalo vs Massachusetts stats:
Buffalo -16.5 Probability
According to the best betting apps, there’s a 53.5% chance that our pick is settled as a winner. Our cappers think there’s a stronger chance of success and calculate the probability to be closer to 60%. This is why we can recommend this college wager.
Selling points can be a great alternative and allows bettors to enjoy a bigger return on the same selection. For a more conservative pick, you can alternatively buy points.
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Best Bet
Buffalo -16.5 @ -115
Same Game Parlay Picks
Take a same game parlay that incorporates Buffalo to cover the -16.5 spread along with Over 46.5 points. Add in Touchdown as first score method.
A same game parlay allows bettors to place a multiple wager on the same football game. You can go through the available betting lines and cherry-pick the outcomes that you think will happen. The odds for each selection are then combined together.
Correct Score Prediction
Buffalo vs Massachusetts Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Buffalo Big Favorites According to Latest Odds
With an estimated 87% chance of winning, the sportsbooks are taking no chances with their -667 betting odds about Buffalo triumphing in this college game. Massachusetts are the underdogs at +490 and they’re regarded as least likely to win.
The spread is currently 16.5, with the total points line at 46.5. The Totals offers football bettors an alternative way of getting involved. There’s the chance to back Under 46.5 at -110.
If you’re wagering on college football, we recommend heading to the best betting sites and scanning through the huge selection of team props and game lines. There’s the opportunity to bet pre-game and in-game.




Player Props & Micro Betting
Prop bets don’t involve betting on a team to win and instead might look at a player’s individual performance. For example, the number of Passing Yards a quarterback might have or the number of Touchdowns a player might score.
An increasing number of bettors are now enjoying micro betting on college football and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Can Massachusetts Avoid Yet Another Home Defeat?
Massachusetts have been beaten five times in a row at Warren McGuirk Alumni Stadium. They own a 2-8 mark in their past 10 home games, scoring 22.00 points per contest and conceding 31.40.
Buffalo have five wins and five losses in the last 10 games on the road, averaging 19.70 points scored and 28.30 points allowed.
When the teams last met at Warren McGuirk Alumni Stadium, Buffalo beat Massachusetts 34-7.
Last 10 Games | W-L | P | PF | PA | O46.5 | U46.5 | |
---|---|---|---|---|---|---|---|
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2-8 | 53.40 | 22.00 | 31.40 | 7 | 3 | |
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5-5 | 48.00 | 19.70 | 28.30 | 5 | 5 |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O46.5 = Games Over 46.5 Points
- U46.5 = Games Under 46.5 Points
Last 5 & H2H
Latest regular season and playoff games stats.


- 7 wins and 3 defeats in the last 10 games
- 5 wins and 5 defeats in the last 10 games on the road
- -16.5 Betting Line: Have covered the spread in 4 of the last 10 games
- -16.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road
- +16.5 Betting Line: Have covered the spread in 3 of the last 10 games
- +16.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 51.80 pts in the previous 10 games
- Game Totals on the Road: An average of 48.00 pts in the previous 10 games on the road
- Over 46.5: Covered in 6 of the previous 10 games
- Over 46.5 on the Road: Covered in 5 of the previous 10 games on the road
- Team Totals: Have scored an average of 30.80 pts and allowed 21.00 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 19.70 pts and allowed 28.30 pts in the last 10 games on the road
- Game Totals: An average of 58.20 pts in the previous 10 games
- Game Totals at Home: An average of 53.40 pts in the previous 10 home games
- Over 46.5: Covered in 9 of the previous 10 games
- Over 46.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 17.50 pts and allowed 40.70 pts in the last 10 games
- Team Totals at Home: Have scored an average of 22.00 pts and allowed 31.40 pts in the last 10 home games
NCAAF Standings Select Season
Mid-American | W | L | PF | PA | N. Pts | Home | Away | Strk |
---|---|---|---|---|---|---|---|---|
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4 | 3 | 179 | 149 | 30 | 2-2 | 2-1 | 2W |
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4 | 3 | 158 | 179 | -21 | 2-0 | 2-3 | 1W |
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4 | 3 | 182 | 154 | 28 | 2-1 | 2-2 | 4W |
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4 | 3 | 206 | 177 | 29 | 4-0 | 0-3 | 1W |
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4 | 3 | 247 | 100 | 147 | 4-0 | 0-3 | 1W |
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4 | 3 | 160 | 124 | 36 | 3-1 | 1-2 | 4W |
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3 | 4 | 124 | 217 | -93 | 3-0 | 0-4 | 1W |
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3 | 4 | 140 | 179 | -39 | 3-1 | 0-3 | 1L |
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2 | 5 | 125 | 271 | -146 | 2-1 | 0-4 | 1L |
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2 | 6 | 145 | 245 | -100 | 2-2 | 0-4 | 2L |
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2 | 6 | 196 | 268 | -72 | 2-1 | 0-5 | 1L |
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1 | 6 | 86 | 170 | -84 | 1-2 | 0-4 | 6L |
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0 | 7 | 79 | 249 | -170 | 0-4 | 0-3 | 7L |

















