Cal vs Louisville Prediction, Picks & Odds | 08 Nov 2025

College Football Betting Preview: California Golden Bears vs Louisville

California Golden Bears face Louisville at L&N Federal Credit Union Stadium, with kickoff scheduled for 19:00 on Saturday, November 8. Our betting preview features expert NCAAF predictions, picks, the latest betting odds and H2H stats.

Louisville Set for Big Win

We’re confident that Louisville can enjoy a big win when playing California Golden Bears, leading us to go against the spread at -18.5. This line makes plenty of appeal and there are odds of -110 available.

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Cal Bidding to Bounce Back After Loss

Cal have suffered back-to-back defeats, recently being beaten at home by Virginia Cavaliers 31-21 at California Memorial Stadium.

Louisville Cardinals have triumphed in their last three games. The latest of these was on the road where Virginia Tech Hokies were beaten 28-16 at Lane Stadium.

Quarterbacks

Jaron-Keawe Sagapolutele

206.5 Passing Yards

Over -114

Under -114

Miller Moss

273.5 Passing Yards

Over -114

Under -114

Cal vs Louisville Prediction & Picks

We cover the essential Cal vs Louisville betting angles, featuring our main match prediction, correct score pick, top player prop plays and a carefully crafted bet builder.

Game Prediction

There’s a case to be made for Louisville on the spread in this college football showdown. Our prediction is that the betting favorites can cover the -18.5 line at odds of -110 considering they should be superior.

We use the latest team news and injury updates to help shape the best possible CFB predictions. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.

Key Cal vs Louisville stats:

• The -18.5 line has been covered by Louisville in 9 of their last 20 games at home.

Louisville -18.5 Probability

Looking at the latest betting odds, our pick has a 52.4% chance of winning. Taking all factors into consideration, our experts think there’s a stronger chance of success and have a probability interval between 55-60%. The bet can be recommended for this precise reason.

In the quest to secure bigger odds, there’s the possibility of moving the line. There are plenty of choices when it comes to doing this, so you can choose the option that suits you.

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Best Bet

Louisville -18.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Miller Moss Over 273.5 Passing Yards -114

Miller Moss (Louisville) is available at -114 to record more than 273.5 passing yards. We’re tempted to back him to cover the QB Passing Yards line, with plenty of juice on offer.

Latest Miller Moss Player Prop Odds

Passing Yards

Over 273.5

-114

Under 273.5

-114

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Trond Grizzell Over 44.5 Receiving Yards -114

The odds for Trond Grizzell (Cal) to go accumulate over 44.5 receiving yards stand at -114. He looks capable of covering the line and that leads us to taking this Player Receiving Yards bet.

Latest Trond Grizzell Player Prop Odds

Receiving Yards

Over 44.5

-114

Under 44.5

-114

Correct Score Prediction

California 13 - 41 Louisville

There are some huge returns lying in wait if you can get the correct score right. With this in mind, we’ll have a play on Louisville to enjoy a 41-13 winning scoreline.

Cal vs Louisville Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Make Louisville Big Favorites

You might not get rich backing Louisville at -1250. However, the sportsbooks’ betting odds imply a 93% chance of winning this college game. For those wanting to back California, you will find +750 about the underdogs.

18.5 is the spread and 49.5 is the total points line. Football fans love the chance to get an alternative angle by going for a Total wager. If you’re going for Under 49.5, this outcome can be backed at -110.

Whether you are betting pre-game or in-game on college football, the best sportsbooks let you feast on a wide range of game lines and team props. The selections are practically endless, and it’s fantastic to have so many options.

Moneyline

Cal

+750

Louisville

-1250

Point Spread

Cal +18.5

-110

Louisville -18.5

-110

Total Points

Under 49.5

-110

Over 49.5

-110

Player Odds

Receiving Yards

Chris Bell (Louisville)

Over 86.5

-114

Under 86.5

-114

Jacob De Jesus (Cal)

Over 57.5

-114

Under 57.5

-114

Caullin Lacy (Louisville)

Over 53.5

-114

Under 53.5

-114

Trond Grizzell (Cal)

Over 44.5

-114

Under 44.5

-114

Mason Mini (Cal)

Over 31.5

-114

Under 31.5

-114

Rushing Yards

Kendrick Raphael (Cal)

Over 45.5

-114

Under 45.5

-114

Passing Yards

Miller Moss (Louisville)

Over 273.5

-114

Under 273.5

-114

Jaron-Keawe Sagapolutele (Cal)

Over 206.5

-114

Under 206.5

-114

Louisville Have Seven Wins in Their Last Ten Home Games

Louisville have a 7-3 record in their last 10 home games, putting up 37.30 points on average and giving up 23.00.

Cal own a 4-6 mark in their past 10 games away from home, putting up 20.60 points per contest and giving up 25.80.

Last 10 Games		W-L	P	PF	PA	O50.5	U50.5
Louisville Home Stats		7-3	60.30	37.30	23.00	7	3
Cal Away Stats		4-6	46.40	20.60	25.80	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O50.5 = Games Over 50.5 Points
• U50.5 = Games Under 50.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Cal Stats

Louisville Cardinals Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +18.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +18.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -18.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -18.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 48.40 pts in the previous 10 games
• Game Totals on the Road: An average of 46.40 pts in the previous 10 games on the road
• Over 50.5: Covered in 4 of the previous 10 games
• Over 50.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 23.40 pts and allowed 25.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.60 pts and allowed 25.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 56.00 pts in the previous 10 games
• Game Totals at Home: An average of 60.30 pts in the previous 10 home games
• Over 50.5: Covered in 7 of the previous 10 games
• Over 50.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 34.60 pts and allowed 21.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 37.30 pts and allowed 23.00 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Virginia	8	1	328	200	128	5-0	3-1	7W
Georgia Tech	8	1	324	208	116	5-0	3-1	1L
Louisville	7	1	270	166	104	4-1	3-0	3W
Pittsburgh	7	2	357	196	161	4-1	3-1	5W
Miami	6	2	258	125	133	5-1	1-1	1L
SMU	6	3	277	191	86	4-1	2-2	1W
Duke	5	3	283	225	58	2-2	3-1	1W
Wake Forest	5	3	194	174	20	3-2	2-1	1L
NC State	5	4	292	275	17	4-1	1-3	1W
California	5	4	221	226	-5	3-2	2-2	2L
Florida State	4	4	320	165	155	4-2	0-2	1W
Clemson	3	5	227	192	35	1-4	2-1	2L
North Carolina	3	5	155	177	-22	1-3	2-2	1W
Stanford	3	6	160	271	-111	3-1	0-5	2L
Virginia Tech	3	6	219	267	-48	2-4	1-2	1L
Syracuse	3	6	213	277	-64	2-3	1-3	5L
Boston College	1	8	224	300	-76	1-4	0-4	8L