Cal vs Louisville Prediction, Picks & Odds | 08 Nov 2025
College Football Betting Preview: Cal vs Louisville
Cal face Louisville at L&N Federal Credit Union Stadium, with kickoff scheduled for 19:00 on Saturday, November 8. Our betting preview features expert NCAAF predictions, picks, the latest betting odds and H2H stats.
We’re confident that Louisville can enjoy a big win when playing Cal, leading us to go against the spread at -18.5. This line makes plenty of appeal and there are odds of -110 available.
Cal have suffered back-to-back defeats, recently being beaten at home by Virginia Cavaliers 31-21 at California Memorial Stadium.
Louisville Cardinals have triumphed in their last three games. The latest of these was on the road where Virginia Tech Hokies were beaten 28-16 at Lane Stadium.
Quarterbacks
Jaron-Keawe Sagapolutele
Miller Moss
Cal vs Louisville Prediction & Picks
We cover the essential Cal vs Louisville betting angles, featuring our main match prediction, correct score pick, top player prop plays and a carefully crafted bet builder.
Game Prediction
There’s a case to be made for Louisville on the spread in this college football showdown. Our prediction is that the betting favorites can cover the -18.5 line at odds of -110 considering they should be superior.
We use the latest team news and injury updates to help shape the best possible CFB predictions. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.
Key Cal vs Louisville stats:
Louisville -18.5 Probability
Looking at the latest betting odds, our pick has a 52.4% chance of winning. Taking all factors into consideration, our experts think there’s a stronger chance of success and have a probability interval between 55-60%. The bet can be recommended for this precise reason.
In the quest to secure bigger odds, there’s the possibility of moving the line. There are plenty of choices when it comes to doing this, so you can choose the option that suits you.
Thinking of betting? Browse our detailed guide for the best current offers, including free bets and the latest bonuses.
Player Prop Picks
Miller Moss (Louisville) is available at -114 to record more than 273.5 passing yards. We’re tempted to back him to cover the QB Passing Yards line, with plenty of juice on offer.
The odds for Trond Grizzell (Cal) to go accumulate over 44.5 receiving yards stand at -114. He looks capable of covering the line and that leads us to taking this Player Receiving Yards bet.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Our same game parlay pick is Louisville -18.5 on the spread, Over 50.5 and Miller Moss (Louisville) to have Over 273.5 passing yards.
We recommend a same game parlay as it’s a great way of betting on a single event. Many football bettors like to create a personalised wager which reflects their predictions for how a game is going to play out.
Correct Score Prediction
13
-
41
Louisville
There are some huge returns lying in wait if you can get the correct score right. With this in mind, we’ll have a play on Louisville to enjoy a 41-13 winning scoreline.
Cal vs Louisville Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
You might not get rich backing Louisville at -909. However, the sportsbooks’ betting odds imply a 90% chance of winning this college game. For those wanting to back California, you will find +640 about the underdogs.
18.5 is the spread and 48.5 is the total points line. Football fans love the chance to get an alternative angle by going for a Total wager. If you’re going for Under 48.5, this outcome can be backed at -110.
Whether you are betting pre-game or in-game on college football, the best sportsbooks let you feast on a wide range of game lines and team props. The selections are practically endless, and it’s fantastic to have so many options.
Receiving Yards
Rushing Yards
Passing Yards
Louisville Have Seven Wins in Their Last Ten Home Games
Louisville have a 7-3 record in their last 10 home games, putting up 37.30 points on average and giving up 23.00.
Cal own a 4-6 mark in their past 10 games away from home, putting up 20.60 points per contest and giving up 25.80.
| Last 10 Games | W-L | P | PF | PA | O50.5 | U50.5 | |
|---|---|---|---|---|---|---|---|
 Louisville Home Stats |
7-3 | 60.30 | 37.30 | 23.00 | 7 | 3 | |
 Cal Away Stats |
4-6 | 46.40 | 20.60 | 25.80 | 3 | 7 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O50.5 = Games Over 50.5 Points
- U50.5 = Games Under 50.5 Points
Latest regular season and playoff games stats.
Cal Stats
Louisville Cardinals Stats
- 5 wins and 5 defeats in the last 10 games
- 4 wins and 6 defeats in the last 10 games on the road
- +18.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +18.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road
- -18.5 Betting Line: Have covered the spread in 3 of the last 10 games
- -18.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games
- Game Totals: An average of 48.40 pts in the previous 10 games
- Game Totals on the Road: An average of 46.40 pts in the previous 10 games on the road
- Over 50.5: Covered in 4 of the previous 10 games
- Over 50.5 on the Road: Covered in 3 of the previous 10 games on the road
- Team Totals: Have scored an average of 23.40 pts and allowed 25.00 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 20.60 pts and allowed 25.80 pts in the last 10 games on the road
- Game Totals: An average of 56.00 pts in the previous 10 games
- Game Totals at Home: An average of 60.30 pts in the previous 10 home games
- Over 50.5: Covered in 7 of the previous 10 games
- Over 50.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 34.60 pts and allowed 21.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 37.30 pts and allowed 23.00 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Virginia
|
10 | 3 | 418 | 267 | 151 | 6-2 | 4-1 | 1L |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
|
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
Duke
|
8 | 5 | 442 | 373 | 69 | 3-3 | 5-2 | 3W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
|
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
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