Charlotte vs South Florida Prediction, Picks & Odds | 03 Oct 2025
College Football Betting Preview: Charlotte vs South Florida
Charlotte face off against South Florida in this NCAAF Week 6 matchup at Raymond James Stadium, with kickoff scheduled for 19:00 on Friday 3 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
USF to Run Riot?
We’d be surprised if South Florida don’t exceed a -27.5 spread against Charlotte. That is why the bet has to be for them to cover the line at -120.
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59-24 USF Victory in Previous H2H Meeting
Charlotte 49ers were beaten 28-17 at Jerry Richardson Stadium in their previous game, being turned over at home to Rice Owls.
South Florida last game was a 63-14 victory over South Carolina State Bulldogs at Raymond James Stadium. That means it’s now been two home wins on the spin.
Head-to-Head Statistics
It was South Florida who came out on top when they last played Charlotte. At Jerry Richardson Stadium, a 59-24 win was recorded.
Quarterbacks
Grayson Loftis
Byrum Brown
Charlotte vs South Florida Prediction & Picks
Discover the top Charlotte vs South Florida betting angles — from our trusted match prediction and likely score to the best prop plays and a customized bet builder.
Game Prediction
Our pick is that South Florida will get the better of their opponents by a significant margin in this college football matchup. With this in mind, let’s go for the favorites at -27.5 on the spread which is currently available at odds of -120.
We use the latest team news and injury updates to help shape the best possible CFB predictions. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.
Key Charlotte vs South Florida stats:
USF -27.5 Probability
The best betting apps imply that our pick has a 54.6% chance of winning. Based on our cappers in-depth research, we calculate the actual probability to be closer to 60%. That means we’re regarding it as a value bet.
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Best Bet
South Florida -27.5 @ -120
Player Prop Picks
The odds for Byrum Brown (South Florida) to exceed 250.5 passing yards are -114. We can place a QB Passing Yards bet with confidence, as we expect him to cover the line.
E. Jai Mason (South Florida) can be backed at -114 to go beyond 55.5 receiving yards. We’re confident in taking him to cover the Player Receiving Yards line and bettors can place this bet with confidence.
Same Game Parlay Picks
Take a same game parlay that incorporates South Florida to cover the -27.5 spread along with Over 55.5 points. We’ve also gone for Byrum Brown (South Florida) to have Over 250.5 passing yards.
A same game parlay is an awesome way of cheering on different outcomes within the same football game. You can predict a number of outcomes and get bigger odds than a single wager. The odds can combine to great effect.
Correct Score Prediction
13
-
49
South Florida
Rather than backing the Bulls to triumph, there’s the alternative to try your luck when it comes to the correct score lines. Take a chance on a 49-13 win in their favor.
Charlotte vs South Florida Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Books Taking No Chances With USF
South Florida are massive -10000 favorites. They are regarded as 99% likely to win this college game judging by the sportsbooks’ latest Moneyline odds. Charlotte are the underdogs at +2000 and they’re regarded as least likely to win.
27.5 is the spread and 55.5 is the total points line. Having a bet on the Totals is one of the most popular football wagers. There’s the chance to back Under 55.5 at -114.
The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.
Player Odds
Receiving Yards
Rushing Yards
Passing Yards
South Florida Racking Up the Home Wins
South Florida have rattled off three consecutive victories at Raymond James Stadium. They are 7-3 in their last 10 home games, averaging 34.30 points scored and 21.50 points allowed.
Charlotte own a 4-6 mark in their past 10 road games, putting up 21.20 points on average and giving up 33.60.
In their most recent matchup at Raymond James Stadium, South Florida got the better of Charlotte 48-14.
| Last 10 Games | W-L | P | PF | PA | O55.5 | U55.5 | |
|---|---|---|---|---|---|---|---|
 South Florida Home Stats |
7-3 | 55.80 | 34.30 | 21.50 | 5 | 5 | |
 Charlotte Away Stats |
4-6 | 54.80 | 21.20 | 33.60 | 7 | 3 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O55.5 = Games Over 55.5 Points
- U55.5 = Games Under 55.5 Points
Last 5 & H2H
Latest regular season and playoff games stats.
Charlotte 49ers Stats
South Florida Stats
- 3 wins and 7 defeats in the last 10 games
- 4 wins and 6 defeats in the last 10 games on the road
- +27.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +27.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -27.5 Betting Line: Have covered the spread in 3 of the last 10 games
- -27.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games
- Game Totals: An average of 56.10 pts in the previous 10 games
- Game Totals on the Road: An average of 54.80 pts in the previous 10 games on the road
- Over 55.5: Covered in 6 of the previous 10 games
- Over 55.5 on the Road: Covered in 7 of the previous 10 games on the road
- Team Totals: Have scored an average of 21.30 pts and allowed 34.80 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 21.20 pts and allowed 33.60 pts in the last 10 games on the road
- Game Totals: An average of 63.20 pts in the previous 10 games
- Game Totals at Home: An average of 55.80 pts in the previous 10 home games
- Over 55.5: Covered in 7 of the previous 10 games
- Over 55.5 at Home: Covered in 5 of the previous 10 home games
- Team Totals: Have scored an average of 36.90 pts and allowed 26.30 pts in the last 10 games
- Team Totals at Home: Have scored an average of 34.30 pts and allowed 21.50 pts in the last 10 home games
NCAAF Standings Select Season
| American Athletic | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Memphis
|
5 | 0 | 198 | 90 | 108 | 2-0 | 3-0 | 5W |
Navy
|
4 | 0 | 153 | 67 | 86 | 3-0 | 1-0 | 4W |
North Texas
|
5 | 0 | 224 | 100 | 124 | 3-0 | 2-0 | 5W |
Tulane
|
4 | 1 | 131 | 120 | 11 | 2-0 | 2-1 | 1W |
|
South Florida
|
3 | 1 | 127 | 86 | 41 | 2-0 | 1-1 | 1W |
East Carolina
|
3 | 2 | 152 | 67 | 85 | 2-1 | 1-1 | 1W |
Rice
|
3 | 2 | 102 | 102 | 0 | 1-1 | 2-1 | 1L |
Temple
|
2 | 2 | 124 | 104 | 20 | 1-1 | 1-1 | 2L |
UTSA
|
2 | 2 | 125 | 121 | 4 | 1-1 | 1-1 | 2W |
UAB
|
2 | 2 | 131 | 164 | -33 | 2-0 | 0-2 | 1L |
Tulsa
|
2 | 3 | 105 | 113 | -8 | 1-2 | 1-1 | 1L |
Army
|
1 | 3 | 95 | 124 | -29 | 0-2 | 1-1 | 2L |
|
Charlotte
|
1 | 3 | 73 | 117 | -44 | 1-3 | 0-0 | 1L |
Florida Atlantic
|
1 | 3 | 117 | 146 | -29 | 1-1 | 0-2 | 2L |
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