Clemson vs South Carolina Prediction, Picks & Odds | 29 Nov 2025
College Football Betting Preview: Clemson vs South Carolina
Clemson battle South Carolina at Williams-Brice Stadium, with kickoff scheduled for 12:00 on Saturday, November 29.
The betting line makes lots of appeal considering it’s set at +2.5 and our prediction is that Clemson will cover this against South Carolina. There is -104 available for this outcome.
Clemson Tigers claimed a home victory in their previous game. A 45-10 triumph against Furman Paladins at Memorial Stadium made it three straight wins.
South Carolina Gamecocks last game saw them claim a 51-7 home win over Coastal Carolina Chanticleers at Williams-Brice Stadium.
Head-to-Head Statistics
South Carolina won the last matchup between the pair. Enjoying a 17-14 triumph when facing Clemson at Memorial Stadium. The past 5 games between the teams have seen Clemson win three times.
Quarterbacks
Cade Klubnik
LaNorris Sellers
Clemson vs South Carolina Prediction & Picks
Get the edge with our Clemson vs South Carolina betting tips: a trusted match prediction, likely correct score outcome, key player prop picks and an expert-crafted bet builder.
Game Prediction
With Clemson capable of remaining close to the favorites, backing them against the spread could be the best way forward. -104 is available that the +2.5 is covered in this college football matchup.
We put solid research behind every CFB pick, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.
Key Clemson vs South Carolina stats:
Clemson +2.5 Probability
Looking at the latest betting odds, our pick has a 51% chance of winning. After careful examination, our cappers calculate this probability to be somewhere between 55-60%. This is why we regard this as a value bet.
There are several wagering options to the spread and we particularly like the Winning Margin lines. It’s great whether you’re expecting things to be close or comprehensive.
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Player Prop Picks
You can back Cade Klubnik (Clemson) at -114 to rack up over 234.5 passing yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this QB Passing Yards pick.
T.J. Moore (Clemson) is priced at +180 to score a TD. We’ll have a play on this Anytime Touchdown Scorer wager as the betting odds look pretty attractive.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Take a same game parlay that incorporates Clemson to cover the +2.5 spread along with Over 46.5 points. We’ve also gone for Cade Klubnik (Clemson) to have Over 234.5 passing yards.
The same game parlay option allows you to combine different outcomes within the same game. You need all your predictions to be correct although bettors love to place a tailored football bet on the event which interests them most.
Correct Score Prediction
27
-
23
South Carolina
There’s every chance that this is going to be a close matchup and we’ll have a play on Clemson achieving a 27-23 winning scoreline. Hopefully this can go close.
Clemson vs South Carolina Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
South Carolina are on offer at +170 on the Moneyline if you want to back this team, with Clemson available at -204. According to the top sportsbooks, the home team have an implied probability of 37%.
The current spread is 5.5 and total points is 53.5. Football fans love the chance to get an alternative angle by going for a Total wager. Those that want to back Under 53.5 can find odds of -110 available.
You can find a wide range of team props and game lines for every college football matchup, with the best sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your wagers.
Favorite Antonio Williams is now available at +700 to be the First Touchdown Scorer. You will find similar odds apply when it comes to him scoring the last TD.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
You don’t have to wait for the final outcome when it comes to college football micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.
Clemson Lead Recent Head-to-Head Results at Williams-Brice Stadium
South Carolina own a 6-4 mark in their past 10 home games, scoring 29.70 points per contest and conceding 20.50.
Clemson have chalked up three straight wins on the road. They have eight wins and two losses in the last 10 games away from home, putting up 30.40 points on average and giving up 19.30.
The last time the teams met at Williams-Brice Stadium, Clemson defeated South Carolina 16-7. Across 3 head-to-head meetings at Williams-Brice Stadium, Clemson have come out on top each time.
| Last 10 Games | W-L | P | PF | PA | O46.5 | U46.5 | |
|---|---|---|---|---|---|---|---|
 South Carolina Home Stats |
6-4 | 50.20 | 29.70 | 20.50 | 7 | 3 | |
 Clemson Away Stats |
8-2 | 49.70 | 30.40 | 19.30 | 5 | 5 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O46.5 = Games Over 46.5 Points
- U46.5 = Games Under 46.5 Points
Latest regular season and playoff games stats.
Clemson Tigers Stats
South Carolina Gamecocks Stats
- 6 wins and 4 defeats in the last 10 games
- 8 wins and 2 defeats in the last 10 games on the road
- +2.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +2.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road
- -2.5 Betting Line: Have covered the spread in 3 of the last 10 games
- -2.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 52.00 pts in the previous 10 games
- Game Totals on the Road: An average of 49.70 pts in the previous 10 games on the road
- Over 46.5: Covered in 6 of the previous 10 games
- Over 46.5 on the Road: Covered in 5 of the previous 10 games on the road
- Team Totals: Have scored an average of 30.60 pts and allowed 21.40 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 30.40 pts and allowed 19.30 pts in the last 10 games on the road
- Game Totals: An average of 46.00 pts in the previous 10 games
- Game Totals at Home: An average of 50.70 pts in the previous 10 home games
- Over 46.5: Covered in 6 of the previous 10 games
- Over 46.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 23.40 pts and allowed 22.60 pts in the last 10 games
- Team Totals at Home: Have scored an average of 31.80 pts and allowed 18.90 pts in the last 10 home games
| Southeastern | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Georgia
|
12 | 1 | 415 | 207 | 208 | 6-1 | 6-0 | 9W |
Ole Miss
|
11 | 1 | 447 | 241 | 206 | 8-0 | 3-1 | 5W |
Texas A&M
|
11 | 1 | 436 | 263 | 173 | 7-0 | 4-1 | 1L |
Oklahoma
|
10 | 2 | 317 | 167 | 150 | 6-1 | 4-1 | 4W |
Vanderbilt
|
10 | 2 | 473 | 263 | 210 | 7-0 | 3-2 | 3W |
Alabama
|
10 | 3 | 406 | 226 | 180 | 6-2 | 4-1 | 1L |
Texas
|
9 | 3 | 355 | 237 | 118 | 7-0 | 2-3 | 2W |
Missouri
|
8 | 4 | 386 | 233 | 153 | 6-2 | 2-2 | 1W |
Tennessee
|
8 | 4 | 489 | 345 | 144 | 5-3 | 3-1 | 1L |
LSU
|
7 | 5 | 262 | 220 | 42 | 6-1 | 1-4 | 1L |
Kentucky
|
5 | 7 | 276 | 317 | -41 | 4-3 | 1-4 | 2L |
Auburn
|
5 | 7 | 321 | 248 | 73 | 3-4 | 2-3 | 1L |
Mississippi State
|
5 | 7 | 366 | 350 | 16 | 3-4 | 2-3 | 3L |
Florida
|
4 | 8 | 259 | 288 | -29 | 4-3 | 0-5 | 1W |
|
South Carolina
|
4 | 8 | 272 | 265 | 7 | 4-4 | 0-4 | 1L |
Arkansas
|
2 | 10 | 395 | 406 | -11 | 2-5 | 0-5 | 10L |
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Virginia
|
10 | 3 | 418 | 267 | 151 | 6-2 | 4-1 | 1L |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
Duke
|
8 | 5 | 442 | 373 | 69 | 3-3 | 5-2 | 3W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
|
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
Macarthur
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