Clemson vs South Carolina Prediction, Picks & Odds | 29 Nov 2025

College Football Betting Preview: Clemson vs South Carolina

Clemson battle South Carolina at Williams-Brice Stadium, with kickoff scheduled for 12:00 on Saturday, November 29.

The betting line makes lots of appeal considering it’s set at +2.5 and our prediction is that Clemson will cover this against South Carolina. There is -104 available for this outcome.

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Clemson Tigers claimed a home victory in their previous game. A 45-10 triumph against Furman Paladins at Memorial Stadium made it three straight wins.

South Carolina Gamecocks last game saw them claim a 51-7 home win over Coastal Carolina Chanticleers at Williams-Brice Stadium.

Head-to-Head Statistics

South Carolina won the last matchup between the pair. Enjoying a 17-14 triumph when facing Clemson at Memorial Stadium. The past 5 games between the teams have seen Clemson win three times.

Quarterbacks

Cade Klubnik

234.5 Passing Yards

Over -114

Under -114

LaNorris Sellers

219.5 Passing Yards

Over -114

Under -114

Clemson vs South Carolina Prediction & Picks

Get the edge with our Clemson vs South Carolina betting tips: a trusted match prediction, likely correct score outcome, key player prop picks and an expert-crafted bet builder.

Game Prediction

With Clemson capable of remaining close to the favorites, backing them against the spread could be the best way forward. -104 is available that the +2.5 is covered in this college football matchup.

We put solid research behind every CFB pick, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Clemson vs South Carolina stats:

• The +2.5 line has been covered by Clemson in 4 consecutive games.
• The +2.5 line has been covered by Clemson in 8 of their last 10 games on the road.
• The +2.5 line has been covered by Clemson in 13 of their last 20 games.
• The -2.5 line hasn’t been covered by South Carolina in 4 of their last 5 games.
• The -2.5 line hasn’t been covered by South Carolina in 7 of their last 10 games.
• The -2.5 line hasn’t been covered by South Carolina in 4 of their last 5 games against Clemson.

Clemson +2.5 Probability

Looking at the latest betting odds, our pick has a 51% chance of winning. After careful examination, our cappers calculate this probability to be somewhere between 55-60%. This is why we regard this as a value bet.

There are several wagering options to the spread and we particularly like the Winning Margin lines. It’s great whether you’re expecting things to be close or comprehensive.

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Our Game Prediction

Clemson +2.5 @ -104 Bet Now

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Player Prop Picks

Top Pick: Cade Klubnik Over 234.5 Passing Yards -114

You can back Cade Klubnik (Clemson) at -114 to rack up over 234.5 passing yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this QB Passing Yards pick.

Latest Cade Klubnik Player Prop Odds

Touchdown

Anytime

+320

First

+1800

Passing Yards

Over 234.5

-114

Under 234.5

-114

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T.J. Moore Anytime TD +180

T.J. Moore (Clemson) is priced at +180 to score a TD. We’ll have a play on this Anytime Touchdown Scorer wager as the betting odds look pretty attractive.

Latest T.J. Moore Player Prop Odds

Touchdown

Anytime

+180

First

+1000

Receiving Yards

Over 51.5

-114

Under 51.5

-114

Correct Score Prediction

Clemson 27 - 23 South Carolina

There’s every chance that this is going to be a close matchup and we’ll have a play on Clemson achieving a 27-23 winning scoreline. Hopefully this can go close.

Clemson vs South Carolina Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

South Carolina are on offer at -135 on the Moneyline if you want to back this team, with Clemson available at +118. According to the top sportsbooks, the home team have an implied probability of 57%.

The current spread is 2.5 and total points is 46.5. Football fans love the chance to get an alternative angle by going for a Total wager. Those that want to back Under 46.5 can find odds of -105 available.

You can find a wide range of team props and game lines for every college football matchup, with the best sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your wagers.

Moneyline

Clemson

+118

South Carolina

-135

Point Spread

Clemson +2.5

-104

South Carolina -2.5

-118

Total Points

Under 46.5

-105

Over 46.5

-115

Favorite Antonio Williams is now available at +650 to be the First Touchdown Scorer. You will find similar odds apply when it comes to him scoring the last TD.

Touchdown

Antonio Williams (Clemson)

First TD

+650

Anytime TD

+110

Rahsul Faison (South Carolina)

First TD

+700

Anytime TD

+115

Adam Randall (Clemson)

First TD

+700

Anytime TD

+120

LaNorris Sellers (South Carolina)

First TD

+800

Anytime TD

+125

Nyck Harbor (South Carolina)

First TD

+800

Anytime TD

+150

Matt Fuller (South Carolina)

First TD

+850

Anytime TD

+170

T.J. Moore (Clemson)

First TD

+1000

Anytime TD

+180

Jayden Sellers (South Carolina)

First TD

+1100

Anytime TD

+210

Gideon Davidson (Clemson)

First TD

+1300

Anytime TD

+230

Tristan Smith (Clemson)

First TD

+1600

Anytime TD

+300

Cade Klubnik (Clemson)

First TD

+1800

Anytime TD

+320

Donovan Murph (South Carolina)

First TD

+1800

Anytime TD

+350

Brady Hunt (South Carolina)

First TD

+2000

Anytime TD

+430

Vandrevius Jacobs (South Carolina)

First TD

+2000

Anytime TD

+440

Tyler Brown (Clemson)

First TD

+2500

Anytime TD

+500

Christian Bentancur (Clemson)

First TD

+2700

Anytime TD

+550

Receiving Yards

Antonio Williams (Clemson)

Over 58.5

-114

Under 58.5

-114

T.J. Moore (Clemson)

Over 51.5

-114

Under 51.5

-114

Nyck Harbor (South Carolina)

Over 48.5

-114

Under 48.5

-114

Jayden Sellers (South Carolina)

Over 41.5

-114

Under 41.5

-114

Vandrevius Jacobs (South Carolina)

Over 35.5

-114

Under 35.5

-114

Rushing Yards

Adam Randall (Clemson)

Over 55.5

-114

Under 55.5

-114

Rahsul Faison (South Carolina)

Over 28.5

-114

Under 28.5

-114

LaNorris Sellers (South Carolina)

Over 24.5

-114

Under 24.5

-114

Passing Yards

Cade Klubnik (Clemson)

Over 234.5

-114

Under 234.5

-114

LaNorris Sellers (South Carolina)

Over 219.5

-114

Under 219.5

-114

Clemson Lead Recent Head-to-Head Results at Williams-Brice Stadium

South Carolina own a 6-4 mark in their past 10 home games, scoring 29.70 points per contest and conceding 20.50.

Clemson have chalked up three straight wins on the road. They have eight wins and two losses in the last 10 games away from home, putting up 30.40 points on average and giving up 19.30.

The last time the teams met at Williams-Brice Stadium, Clemson defeated South Carolina 16-7. Across 3 head-to-head meetings at Williams-Brice Stadium, Clemson have come out on top each time.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
South Carolina Home Stats		6-4	50.20	29.70	20.50	7	3
Clemson Away Stats		8-2	49.70	30.40	19.30	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O46.5 = Games Over 46.5 Points
• U46.5 = Games Under 46.5 Points

Latest regular season and playoff games stats.

Clemson Tigers Stats

South Carolina Gamecocks Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 52.00 pts in the previous 10 games
• Game Totals on the Road: An average of 49.70 pts in the previous 10 games on the road
• Over 46.5: Covered in 6 of the previous 10 games
• Over 46.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 30.60 pts and allowed 21.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 30.40 pts and allowed 19.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 46.00 pts in the previous 10 games
• Game Totals at Home: An average of 50.70 pts in the previous 10 home games
• Over 46.5: Covered in 6 of the previous 10 games
• Over 46.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 23.40 pts and allowed 22.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.80 pts and allowed 18.90 pts in the last 10 home games

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