Duke vs Syracuse Prediction, Picks & Odds | 27 Sep 2025

By Joshua Davis, NCAAF Analyst | Published: 5 hours ago | 4 min read

Duke Blue Devils

American Football NCAAF JMA Wireless Dome Sat 27 Sep 12:00

Syracuse Orange

Prediction
Bet Builder
Odds
Player Props
Stats
Standings

College Football Betting Preview: Duke vs Syracuse

Duke face off against Syracuse in this NCAAF Week 5 matchup at JMA Wireless Dome, with kickoff scheduled for 12:00 on Saturday 27 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Can Syracuse Stay Close to the Favorites?

We’re confident that Syracuse can push for a victory and the +5.5 about them on the spread makes lots of appeal. Take -115 that they cover the line against Duke.

Confident in the spread bet? Don’t place it before unlocking the best BetMGM promo code and reading our in-depth site review.

Duke 38-24 Winners in Previous H2H Matchup

Duke Blue Devils won their previous game which was at home. It was a 45-33 triumph at Wallace Wade Stadium against North Carolina State Wolfpack.

Syracuse Orange won last time out by a 34-21 scoreline. On the road against Clemson Tigers at Memorial Stadium, they made it three wins on the spin.

Head-to-Head Statistics

Duke won the last matchup between the pair. Enjoying a 38-24 triumph when facing Syracuse at JMA Wireless Dome.

Duke vs Syracuse Prediction & Picks

We dive into the best Duke vs Syracuse betting angles, including an expert match prediction, correct score forecast, top player prop bets and a value-focused bet builder.

Game Prediction

We’re very confident of Syracuse staying close to the favorites in this college football battle, with our pick being that they’ll cover the spread. The +5.5 looks more than generous at -115.

We only make our college football picks after confirming the latest team news. Studying recent form and digging into the most relevant stats also helps us build a complete picture.

Key Duke vs Syracuse stats:

The +5.5 line has been covered by Syracuse in 9 consecutive games at home.
The +5.5 line has been covered by Syracuse in 15 of their last 20 games.
The -5.5 line hasn’t been covered by Duke in 6 of their last 10 games.
The -5.5 line hasn’t been covered by Duke in 3 of their last 5 games.
The -5.5 line hasn’t been covered by Duke in 2 consecutive games on the road.

Syracuse +5.5 Probability

If you go by the best sportsbooks, our pick has a 53.5% prospect of winning. However, our cappers have this figure closer to 60% based on their in-depth research. This is why we can recommend this college bet.

Looking for Bigger Odds?

If you want a viable alternative to backing Syracuse on the spread, then the Winning Margin lines could be up your street. Choose from a wide range of options.

Take full advantage of our betting promo codes. Browse our up-to-date guide featuring top bonuses and exclusive offers.

Best Bet

Syracuse +5.5 @ -115 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Published 18:26, 25 September 2025

Player Prop Picks

Top Pick: Darian Mensah Under 280.5 Passing Yards -114

Darian Mensah (Duke) is priced at -114 to have less than 280.5 passing yards. We’re confident he’ll fall short of the QB Passing Yards line, as the total looks too high.

Latest Darian Mensah Player Prop Odds

Touchdown

Passing Yards

Will Nixon Anytime TD -110

You can back Will Nixon (Syracuse) at -110 to hit paydirt. We’ll have a play on this Anytime Touchdown Scorer bet, which could hopefully result in him taking it to the house.

Latest Will Nixon Player Prop Odds

Touchdown

Same Game Parlay Picks

Spread Syracuse +5.5

Totals Over 60.5

Passing Yards Darian Mensah Under 280.5

We’ve compiled a same game parlay that includes Syracuse +5.5 on the spread, combined with Over 60.5 and Darian Mensah (Duke) to have Under 280.5 passing yards.

Many betting sites now allow you to place a same game parlay on each individual football game. It means that you can create a personalised wager at bigger odds, with there generally being no limit as to the number of picks.

Bet Boosts

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Duke

30 - 34 Syracuse logo

Syracuse

We’ll roll the dice and go for Syracuse to register a 34-30 victory. We don’t think that there will be too much between the teams and we’re happy to take the huge odds.

Duke vs Syracuse Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Have Duke as Favorites

Duke have the shortest price to win this college game, with the sportsbooks giving them a 68% probability due to their -213 Moneyline betting odds. Syracuse are the underdogs at +176 and they’re regarded as least likely to win.

The current spread is 4.5 and total points is 60.5. Football bettors regularly enjoy the opportunity to wager on the Totals. If you fancy Under 60.5, then the odds are -105.

There are a wide range of game lines and team props when it comes to most college football matchups and we recommend visiting the best betting apps to find the wager that matches your view on the game.

Moneyline

Point Spread

Total Points

Yasin Willis Favorite to Score First TD

Favorite Yasin Willis is priced at +600 to be the first player to score a touchdown. There’s also the chance to back him to score a TD at anytime at odds of -141.

Touchdown

Yasin Willis (Syracuse)

Will Nixon (Syracuse)

Nate Sheppard (Duke)

Cooper Barkate (Duke)

View More View Less

Receiving Yards

Cooper Barkate (Duke)

Que'Sean Brown (Duke)

Johntay Cook (Syracuse)

Justus Ross-Simmons (Syracuse)

View More View Less

Rushing Yards

Yasin Willis (Syracuse)

Nate Sheppard (Duke)

Anderson Castle (Duke)

Best Betting Offers

JMA Wireless Dome

Syracuse Looking to Keep Rolling at Home

Syracuse have rattled off six consecutive victories at JMA Wireless Dome. They own a 8-2 mark in their past 10 home games, putting up 33.90 points per contest and giving up 27.20.

Duke are 4-6 in their last 10 road games, averaging 28.70 points scored and 31.30 points allowed.

In their most recent matchup at JMA Wireless Dome, Duke got the better of Syracuse 38-24.

Last 10 Games		W-L	P	PF	PA	O60.5	U60.5
Syracuse Home Stats		8-2	61.10	33.90	27.20	3	7
Duke Away Stats		4-6	60.00	28.70	31.30	5	5

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O60.5 = Games Over 60.5 Points
U60.5 = Games Under 60.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Duke

NCAAF: 20/09 NC State33 Duke 45
NCAAF: 14/09 Duke27 Tulane 34
NCAAF: 06/09 Illinois45 Duke 19
NCAAF: 29/08 Elon17 Duke 45
NCAAF Bowls: 03/01 Duke20 Ole Miss 52

Syracuse

NCAAF: 20/09 Syracuse34 Clemson 21
NCAAF: 13/09 Colgate24 Syracuse 66
NCAAF: 06/09 UConn20 Syracuse 27
NCAAF: 30/08 Syracuse26 Tennessee 45
NCAAF Bowls: 28/12 Syracuse52 Washington State 35

Head to Head

Duke vs Syracuse

NCAAF: 10/10 2020 Duke 38 Syracuse 24
NCAAF: 16/11 2019 Syracuse 49 Duke 6

Team Stats

Latest regular season and playoff games stats.

Duke Blue Devils Stats

Syracuse Orange Stats

Moneyline

5 wins and 5 defeats in the last 10 games
4 wins and 6 defeats in the last 10 games on the road

Moneyline

8 wins and 2 defeats in the last 10 games
8 wins and 2 defeats in the last 10 home games

Point Spread

-5.5 Betting Line: Have covered the spread in 4 of the last 10 games
-5.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

+5.5 Betting Line: Have covered the spread in 8 of the last 10 games
+5.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

Game Totals: An average of 62.30 pts in the previous 10 games
Game Totals on the Road: An average of 60.00 pts in the previous 10 games on the road
Over 60.5: Covered in 6 of the previous 10 games
Over 60.5 on the Road: Covered in 5 of the previous 10 games on the road
Team Totals: Have scored an average of 29.70 pts and allowed 32.60 pts in the last 10 games
Team Totals on the Road: Have scored an average of 28.70 pts and allowed 31.30 pts in the last 10 games on the road

Total Points

Game Totals: An average of 68.00 pts in the previous 10 games
Game Totals at Home: An average of 61.10 pts in the previous 10 home games
Over 60.5: Covered in 6 of the previous 10 games
Over 60.5 at Home: Covered in 3 of the previous 10 home games
Team Totals: Have scored an average of 38.00 pts and allowed 30.00 pts in the last 10 games
Team Totals at Home: Have scored an average of 33.90 pts and allowed 27.20 pts in the last 10 home games

NCAAF Standings Select Season

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Florida State	3	0	174	30	144	3-0	0-0	3W
Georgia Tech	4	0	155	77	78	3-0	1-0	4W
Louisville	3	0	119	48	71	3-0	0-0	3W
Miami	4	0	147	46	101	4-0	0-0	4W
California	3	1	96	66	30	2-0	1-1	1L
NC State	3	1	126	117	9	2-0	1-1	1L
Syracuse	3	1	153	110	43	2-0	1-1	3W
Virginia	3	1	182	78	104	3-0	0-1	2W
Pittsburgh	2	1	130	57	73	2-0	0-1	1L
Wake Forest	2	1	76	53	23	2-1	0-0	1L
Duke	2	2	136	129	7	2-1	0-1	1W
North Carolina	2	2	84	91	-7	1-1	1-1	1L
SMU	2	2	139	106	33	1-1	1-1	1L
Boston College	1	2	126	82	44	1-0	0-2	2L
Clemson	1	3	79	91	-12	1-2	0-1	2L
Stanford	1	3	73	118	-45	1-0	0-3	1L
Virginia Tech	1	3	95	119	-24	1-2	0-1	1W