Duke vs Syracuse Prediction, Picks & Odds | 27 Sep 2025
College Football Betting Preview: Duke vs Syracuse
Duke face off against Syracuse in this NCAAF Week 5 matchup at JMA Wireless Dome, with kickoff scheduled for 12:00 on Saturday, September 27. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
We’re confident that Syracuse can push for a victory and the +5.5 about them on the spread makes lots of appeal. Take -115 that they cover the line against Duke.
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Duke Blue Devils won their previous game which was at home. It was a 45-33 triumph at Wallace Wade Stadium against North Carolina State Wolfpack.
Syracuse Orange won last time out by a 34-21 scoreline. On the road against Clemson Tigers at Memorial Stadium, they made it three wins on the spin.
Head-to-Head Statistics
Duke won the last matchup between the pair. Enjoying a 38-24 triumph when facing Syracuse at JMA Wireless Dome.
Quarterbacks
Darian Mensah
Rickie Collins
Duke vs Syracuse Prediction & Picks
We dive into the best Duke vs Syracuse betting angles, including an expert match prediction, correct score forecast, top player prop bets and a value-focused bet builder.
Game Prediction
We’re very confident of Syracuse staying close to the favorites in this college football battle, with our pick being that they’ll cover the spread. The +5.5 looks more than generous at -115.
We only make our college football picks after confirming the latest team news. Studying recent form and digging into the most relevant stats also helps us build a complete picture.
Key Duke vs Syracuse stats:
Syracuse +5.5 Probability
If you go by the best sportsbooks, our pick has a 53.5% prospect of winning. However, our cappers have this figure closer to 60% based on their in-depth research. This is why we can recommend this college bet.
If you want a viable alternative to backing Syracuse on the spread, then the Winning Margin lines could be up your street. Choose from a wide range of options.
Take full advantage of our betting promo codes. Browse our up-to-date guide featuring top bonuses and exclusive offers.
Player Prop Picks
Darian Mensah (Duke) is priced at -114 to have less than 280.5 passing yards. We’re confident he’ll fall short of the QB Passing Yards line, as the total looks too high.
You can back Will Nixon (Syracuse) at -110 to hit paydirt. We’ll have a play on this Anytime Touchdown Scorer bet, which could hopefully result in him taking it to the house.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Syracuse +5.5 on the spread, combined with Over 60.5 and Darian Mensah (Duke) to have Under 280.5 passing yards.
Many betting sites now allow you to place a same game parlay on each individual football game. It means that you can create a personalised wager at bigger odds, with there generally being no limit as to the number of picks.
Correct Score Prediction
30
-
34
Syracuse
We’ll roll the dice and go for Syracuse to register a 34-30 victory. We don’t think that there will be too much between the teams and we’re happy to take the huge odds.
Duke vs Syracuse Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Duke have the shortest price to win this college game, with the sportsbooks giving them a 65% probability due to their -189 Moneyline betting odds. Syracuse are the underdogs at +155 and they’re regarded as least likely to win.
The current spread is 4.5 and total points is 60.5. Football bettors regularly enjoy the opportunity to wager on the Totals. If you fancy Under 60.5, then the odds are -115.
There are a wide range of game lines and team props when it comes to most college football matchups and we recommend visiting the best betting apps to find the wager that matches your view on the game.
Favorite Yasin Willis is priced at +600 to be the first player to score a touchdown. There’s also the chance to back him to score a TD at anytime at odds of -135.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Micro betting is something that’s really popular with bettors, with college football fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.
Syracuse Looking to Keep Rolling at Home
Syracuse have rattled off six consecutive victories at JMA Wireless Dome. They own a 8-2 mark in their past 10 home games, putting up 33.90 points per contest and giving up 27.20.
Duke are 4-6 in their last 10 road games, averaging 28.70 points scored and 31.30 points allowed.
In their most recent matchup at JMA Wireless Dome, Duke got the better of Syracuse 38-24.
| Last 10 Games | W-L | P | PF | PA | O60.5 | U60.5 | |
|---|---|---|---|---|---|---|---|
 Syracuse Home Stats |
8-2 | 61.10 | 33.90 | 27.20 | 3 | 7 | |
 Duke Away Stats |
4-6 | 60.00 | 28.70 | 31.30 | 5 | 5 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O60.5 = Games Over 60.5 Points
- U60.5 = Games Under 60.5 Points
Latest regular season and playoff games stats.
Duke Blue Devils Stats
Syracuse Orange Stats
- 5 wins and 5 defeats in the last 10 games
- 4 wins and 6 defeats in the last 10 games on the road
- -5.5 Betting Line: Have covered the spread in 4 of the last 10 games
- -5.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road
- +5.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +5.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games
- Game Totals: An average of 62.30 pts in the previous 10 games
- Game Totals on the Road: An average of 60.00 pts in the previous 10 games on the road
- Over 60.5: Covered in 6 of the previous 10 games
- Over 60.5 on the Road: Covered in 5 of the previous 10 games on the road
- Team Totals: Have scored an average of 29.70 pts and allowed 32.60 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 28.70 pts and allowed 31.30 pts in the last 10 games on the road
- Game Totals: An average of 68.00 pts in the previous 10 games
- Game Totals at Home: An average of 61.10 pts in the previous 10 home games
- Over 60.5: Covered in 6 of the previous 10 games
- Over 60.5 at Home: Covered in 3 of the previous 10 home games
- Team Totals: Have scored an average of 38.00 pts and allowed 30.00 pts in the last 10 games
- Team Totals at Home: Have scored an average of 33.90 pts and allowed 27.20 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Virginia
|
10 | 2 | 398 | 240 | 158 | 6-1 | 4-1 | 2W |
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
|
Duke
|
7 | 5 | 415 | 353 | 62 | 3-3 | 4-2 | 2W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
|
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
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