Duke vs UConn Prediction, Picks & Odds | 08 Nov 2025

College Football Betting Preview: Duke vs UConn

Duke face UConn at Rentschler Field, with kickoff scheduled for 15:30 on Saturday, November 8. Our betting preview features expert NCAAF predictions, picks, the latest betting odds and H2H stats.

UConn to Give Duke a Tough Test

The best bet could involve backing UConn against the spread. There’s an attractive +9.5 available at -110 that the underdogs cover the line against Duke and that has to be our prediction.

Thinking we’re on the right side of the line? Learn more about BetMGM in our comprehensive review, then access the latest promo code to add more value.

Duke Too Good for UConn in Previous Matchup

Duke Blue Devils won their previous game 46-45. This victory at Memorial Stadium against Clemson Tigers was their third road win on the spin.

UConn Huskies won their last game 38-19, making it four home wins on the bounce. This was recorded at Rentschler Field against UAB Blazers.

Head-to-Head Statistics

Duke won the most recent matchup between these teams. A 26-21 victory was registered against UConn at Wallace Wade Stadium.

Duke vs UConn Prediction & Picks

Our Duke vs UConn betting outlook has it all, including a trusted match forecast, our predicted score, top player prop picks and a hand-picked bet builder.

Game Prediction

We’re really sweet on UConn putting up a fight in this college football matchup and that compels us to bet the underdogs against the spread. You can get -110 when it comes to the +9.5 that is available.

The college football picks at Sportsgambler.com are always guided by the latest team news, injury updates and overall form. Once we've reviewed that, we dive into the most relevant stats to confidently recommend every pick.

Key Duke vs UConn stats:

• The +9.5 line has been covered by UConn in 20 consecutive games.
• The -9.5 line hasn’t been covered by Duke in 14 of their last 20 games on the road.
• The -9.5 line hasn’t been covered by Duke in 6 of their last 10 games.
• The -9.5 line hasn’t been covered by Duke in 2 consecutive games.

UConn +9.5 Probability

If you go by the best sportsbooks, our pick has a 52.4% prospect of winning. However, we have this figure between 55-60% based on our in-depth research. That means we are regarding it as a value wager.

As a wagering alternative, you can choose to buy or sell points when it comes to your spread pick. Buy if you want a safer bet and sell to get more juice from the line.

Check our complete list of betting promo codes, free bet deals and the latest welcome bonuses before wagering.

Best Bet

UConn +9.5 @ -110 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Player Prop Picks

Top Pick: Darian Mensah Under 281.5 Passing Yards -114

Darian Mensah (Duke) is available at -114 to have less than 281.5 passing yards. It’s reasonable to expect he may fall short, making the QB Passing Yards line appealing.

Latest Darian Mensah Player Prop Odds

Passing Yards

Over 281.5

-114

Under 281.5

-114

---

Cooper Barkate Under 77.5 Receiving Yards -114

Cooper Barkate (Duke) is available at -114 to finish with fewer than 77.5 receiving yards. The line looks too high and we’re confident he’ll fall short of the Player Receiving Yards total.

Latest Cooper Barkate Player Prop Odds

Receiving Yards

Over 77.5

-114

Under 77.5

-114

Correct Score Prediction

Duke 30 - 28 UConn

Duke are available at massive odds to register a 30-28 victory and they might have the edge. This should be a close matchup and there won’t be much between the teams.

Duke vs UConn Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Duke Big Favorites According to Latest Odds

Duke are -345 favorites and that means a 78% chance of winning this college game according to the Moneyline betting odds with the sportsbooks. UConn are trading at bigger odds than their opponents and they can be backed at +280.

The current spread is 9.5 and the total points line is 63.5. Football fans love the chance to get an alternative angle by going for a Total wager. If you fancy Under 63.5, then the odds are -114.

You can find a nice selection of game lines and team props for every college football game, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your bets.

Moneyline

Duke

-345

UConn

+280

Point Spread

Duke -9.5

-110

UConn +9.5

-110

Total Points

Under 63.5

-114

Over 63.5

-106

Player Odds

Receiving Yards

Skyler Bell (UConn)

Over 126.5

-114

Under 126.5

-114

Cooper Barkate (Duke)

Over 77.5

-114

Under 77.5

-114

Que'Sean Brown (Duke)

Over 57.5

-114

Under 57.5

-114

Rushing Yards

Nate Sheppard (Duke)

Over 73.5

-114

Under 73.5

-114

Cam Edwards (UConn)

Over 71.5

-114

Under 71.5

-114

Can UConn Keep Rolling at Home?

UConn are riding six consecutive victories at Rentschler Field. They have gone 9-1 across their last 10 home games, averaging 37.40 points scored and 16.40 points allowed.

Duke have chalked up three straight wins on the road. They have a 6-4 record in their last 10 road games, scoring 31.80 points per contest and conceding 28.50.

In their last matchup at Rentschler Field, Duke came out on top 41-7 against UConn.

Last 10 Games		W-L	P	PF	PA	O63.5	U63.5
UConn Home Stats		9-1	53.80	37.40	16.40	1	9
Duke Away Stats		6-4	60.30	31.80	28.50	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O63.5 = Games Over 63.5 Points
• U63.5 = Games Under 63.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Duke Blue Devils Stats

UConn Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• -9.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -9.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• +9.5 Betting Line: Have covered the spread in the last 10 games
• +9.5 Betting Line at Home: Have covered the spread in the last 10 home games

Total Points

• Game Totals: An average of 62.00 pts in the previous 10 games
• Game Totals on the Road: An average of 60.30 pts in the previous 10 games on the road
• Over 63.5: Covered in 5 of the previous 10 games
• Over 63.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 32.60 pts and allowed 29.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 31.80 pts and allowed 28.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 58.80 pts in the previous 10 games
• Game Totals at Home: An average of 53.80 pts in the previous 10 home games
• Over 63.5: Covered in 3 of the previous 10 games
• Over 63.5 at Home: Covered in 1 of the previous 10 home games
• Team Totals: Have scored an average of 35.90 pts and allowed 22.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 37.40 pts and allowed 16.40 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Independents I-A	W	L	PF	PA	N. Pts	Home	Away	Strk
Notre Dame	6	2	299	159	140	4-1	2-1	6W
UConn	6	3	332	215	117	4-0	2-3	1W

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Virginia	8	1	328	200	128	5-0	3-1	7W
Georgia Tech	8	1	324	208	116	5-0	3-1	1L
Louisville	7	1	270	166	104	4-1	3-0	3W
Pittsburgh	7	2	357	196	161	4-1	3-1	5W
Miami	6	2	258	125	133	5-1	1-1	1L
SMU	6	3	277	191	86	4-1	2-2	1W
Duke	5	3	283	225	58	2-2	3-1	1W
Wake Forest	5	3	194	174	20	3-2	2-1	1L
NC State	5	4	292	275	17	4-1	1-3	1W
California	5	4	221	226	-5	3-2	2-2	2L
Florida State	4	4	320	165	155	4-2	0-2	1W
Clemson	3	5	227	192	35	1-4	2-1	2L
North Carolina	3	5	155	177	-22	1-3	2-2	1W
Stanford	3	6	160	271	-111	3-1	0-5	2L
Virginia Tech	3	6	219	267	-48	2-4	1-2	1L
Syracuse	3	6	213	277	-64	2-3	1-3	5L
Boston College	1	8	224	300	-76	1-4	0-4	8L