Eastern Michigan vs Buffalo Prediction, Picks & Odds | 04 Oct 2025

College Football Betting Preview: Eastern Michigan vs Buffalo

Eastern Michigan clash with Buffalo in this NCAAF Week 6 matchup at University of Buffalo Stadium, with kickoff scheduled for 15:30 on Saturday 4 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Buffalo Set for Big Win

There are odds of -104 that Buffalo cover the -10.5 line against Eastern Michigan. We think this is a more than generous spread for this betting prediction where there is plenty of value available.

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Buffalo 37-20 Winners When Teams Last Met

Eastern Michigan Eagles were beaten in their previous three road games and the latest was at Kelly/Shorts Stadium. Central Michigan Chippewas claimed a 24-13 win.

Buffalo Bulls have lost in back-to-back outings. In a recent home game at University of Buffalo Stadium, they were turned over 20-17 by UConn Huskies.

Head-to-Head Statistics

Buffalo had the edge in the most recent matchup between these teams. At Rynearson Stadium, they recorded a 37-20 win over Eastern Michigan. In the past 4 H2H meetings, Buffalo have won three.

Eastern Michigan vs Buffalo Prediction & Picks

Prepare for Eastern Michigan vs Buffalo with our expert betting guide featuring a trusted match prediction, a correct score recommendation and a well-crafted bet builder.

Game Prediction

There’s a case to be made for Buffalo on the spread in this college football showdown. Our prediction is that the betting favorites can cover the -10.5 line at odds of -104 considering they should be superior.

To deliver the best possible college football picks, we start by locking in the team news and taking time to review the latest form. There’s also no shortage of data to crunch from the most up-to-date stats available.

Key Eastern Michigan vs Buffalo stats:

• The +10.5 line hasn’t been covered by Eastern Michigan in 4 of their last 5 games on the road.
• The +10.5 line hasn’t been covered by Eastern Michigan in 3 consecutive games on the road.
• The -10.5 line has been covered by Buffalo in 3 of their last 4 games against Eastern Michigan.

Buffalo -10.5 Probability

Looking at the latest betting odds, our pick has a 51% chance of winning. In the opinion of our cappers, there’s actually a probability of success between 55-60%. That means we’re regarding it as a value bet.

If you want to pimp the odds about Buffalo covering the line, you might consider going down the Bet Builder route and combine your spread pick with other selections.

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Best Bet

Buffalo -10.5 @ -104 Bet Now

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Correct Score Prediction

Eastern Michigan 14 - 31 Buffalo

There are some huge returns lying in wait if you can get the correct score right. With this in mind, we’ll have a play on the Bulls to enjoy a 31-14 winning scoreline.

Eastern Michigan vs Buffalo Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Make Buffalo Big Favorites

The sportsbooks have Buffalo at -357 when it comes to the Moneyline betting, implying the market leaders are 78% likely to win this college game according to the latest odds. Eastern Michigan are trading at bigger odds than their opponents and they can be backed at +290.

The spread is currently 10.5, with the total points line at 54.5. The beauty of the Totals is that you only have to choose from one of two options. If you’re going for Under 54.5, this outcome can be backed at -110.

You’ll find a great variety of team props and game lines for most college football showdowns. The best betting apps provide a strong mix of pre-game and in-game options to suit your betting style.

Moneyline

EMU

+290

Buffalo

-357

Point Spread

EMU +10.5

-118

Buffalo -10.5

-104

Total Points

Under 54.5

-110

Over 54.5

-110

Player Props & Micro Betting

If you’re looking for an alternative to the main game lines, check out the player props instead. It’s great to bet on Quarterback Passing Yards, First Touchdown Scorer and Passing Touchdowns as potential options.

There are lots of exciting college football micro betting lines that are created and they are available in-game. Among them are whether a field goal will be scored and you simply bet whether the player will make it or miss.

Buffalo Hold Six Wins From Last Ten at Home

Buffalo are 6-4 in their last 10 home games, scoring 31.90 points per contest and conceding 20.50.

Eastern Michigan have suffered six defeats in a row away from home. They have three wins and seven losses in the last 10 games away from home, averaging 22.50 points scored and 29.80 points allowed.

Eastern Michigan earned a 24-11 win against Buffalo in the teams’ last meeting at University of Buffalo Stadium.

Last 10 Games		W-L	P	PF	PA	O54.5	U54.5
Buffalo Home Stats		6-4	52.40	31.90	20.50	2	8
Eastern Michigan Away Stats		3-7	52.30	22.50	29.80	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O54.5 = Games Over 54.5 Points
• U54.5 = Games Under 54.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Eastern Michigan Eagles Stats

Buffalo Bulls Stats

Moneyline

• 1 win and 9 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +10.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +10.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -10.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -10.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 55.20 pts in the previous 10 games
• Game Totals on the Road: An average of 52.30 pts in the previous 10 games on the road
• Over 54.5: Covered in 5 of the previous 10 games
• Over 54.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 21.70 pts and allowed 33.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 22.50 pts and allowed 29.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 52.80 pts in the previous 10 games
• Game Totals at Home: An average of 52.40 pts in the previous 10 home games
• Over 54.5: Covered in 4 of the previous 10 games
• Over 54.5 at Home: Covered in 2 of the previous 10 home games
• Team Totals: Have scored an average of 31.80 pts and allowed 21.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.90 pts and allowed 20.50 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Mid-American	W	L	PF	PA	N. Pts	Home	Away	Strk
Central Michigan	3	2	109	145	-36	2-0	1-2	2W
Ohio	3	2	144	136	8	3-0	0-2	2W
Toledo	3	2	179	62	117	3-0	0-2	1W
Bowling Green	2	3	106	129	-23	2-0	0-3	2L
Buffalo	2	3	120	98	22	1-2	1-1	2L
Western Michigan	2	3	97	121	-24	2-1	0-2	2W
Ball State	1	3	62	133	-71	1-0	0-3	1L
Kent State	1	3	73	176	-103	1-1	0-2	3L
Miami (OH)	1	3	93	103	-10	1-1	0-2	1W
Northern Illinois	1	3	41	81	-40	1-1	0-2	3L
Akron	1	4	82	161	-79	1-1	0-3	1L
Eastern Michigan	1	4	120	183	-63	1-1	0-3	1L
Massachusetts	0	4	49	158	-109	0-2	0-2	4L