Illinois vs Duke Prediction, Picks & Odds | 06 Sep 2025

College Football Betting Preview: Illinois vs Duke

Illinois lock horns with Duke in this NCAAF Week 2 matchup at Wallace Wade Stadium, with kickoff scheduled for 12:00 on Saturday 6 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Back Duke to Cause Illini Problems

If you agree that Duke can push Illinois to the wire, then back the underdogs against the spread here. The +3.5 makes lots of appeal at -122.

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Each Team Bidding to Secure Another Win

Illinois Fighting Illini previous game saw them claim a 52-3 home win over Western Illinois Leathernecks at Memorial Stadium.

Duke Blue Devils last game saw them claim a 45-17 home win over Elon Phoenix at Wallace Wade Stadium.

Quarterbacks

Luke Altmyer

215.5 Passing Yards

Over -114

Under -114

Darian Mensah

253.5 Passing Yards

Over -114

Under -114

Illinois vs Duke Prediction & Picks

Be fully equipped for Illinois vs Duke with our betting guide, offering a key match prediction, a correct score recommendation, top player prop picks and a bet builder tailored for value.

Game Prediction

With Duke being given a line of +3.5 to overcome in this college football matchup, our pick is that the underdogs can cover this. There’s the chance to get -122 for this outcome.

We use the latest team news and injury updates to help shape the best possible CFB predictions. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.

Key Illinois vs Duke stats:

• The +3.5 line has been covered by Duke in 11 consecutive games at home.
• The +3.5 line has been covered by Duke in 19 of their last 20 games at home.
• The -3.5 line hasn’t been covered by Illinois in 7 of their last 10 games on the road.
• The -3.5 line hasn’t been covered by Illinois in 13 of their last 20 games on the road.

Duke +3.5 Probability

When you look at the latest odds, our pick has a 54.9% chance of delivering a return. However, our analysts have this number closer to 60% based on their in-depth research. It is the reason why we are recommending this college wager.

If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your spread pick. It all comes down to how confident you feel.

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Best Bet

Duke +3.5 @ -122 Bet Now

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Player Prop Picks

Top Pick: Darian Mensah Over 253.5 Passing Yards -114

Darian Mensah (Duke) is priced at -114 to go beyond 253.5 passing yards. We’re happy to take him to cover the QB Passing Yards line and bettors can place this wager with confidence.

Latest Darian Mensah Player Prop Odds

Passing Yards

Over 253.5

-114

Under 253.5

-114

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Hank Beatty Over 36.5 Receiving Yards -114

The odds for Hank Beatty (Illini) to record more than 36.5 receiving yards are -114. He looks capable of covering the line and that leads us to taking this Player Receiving Yards bet.

Latest Hank Beatty Player Prop Odds

Receiving Yards

Over 36.5

-114

Under 36.5

-114

Correct Score Prediction

Illinois 27 - 28 Duke

Don’t pass up the opportunity to have a speculative bet on Duke to land a 28-27 win. We don’t think that there will be too much between the teams.

Illinois vs Duke Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Illini Could Have the Edge Say the Books

Illinois are -149 favorites and that means a 60% chance of winning this college game according to the Moneyline betting odds with the sportsbooks. At +125, Duke are regarded as having a lower probability of winning.

The spread is currently 2.5, with the total points line at 49.5. The Totals offers football bettors an alternative way of getting involved. If you want to bet Under 49.5, there are odds of -110.

If you’re betting on college football, we recommend heading to the top betting apps and scanning through the many team props and game lines. There’s a chance to wager pre-game and in-game.

Moneyline

Illini

-149

Duke

+125

Point Spread

Illini -2.5

-122

Duke +2.5

-100

Total Points

Under 49.5

-110

Over 49.5

-110

Player Odds

Receiving Yards

Cooper Barkate (Duke)

Over 51.5

-114

Under 51.5

-114

Que'Sean Brown (Duke)

Over 50.5

-114

Under 50.5

-114

Sahmir Hagans (Duke)

Over 37.5

-114

Under 37.5

-114

Hank Beatty (Illini)

Over 36.5

-114

Under 36.5

-114

Hudson Clement (Illini)

Over 25.5

-114

Under 25.5

-114

Rushing Yards

Aidan Laughery (Illini)

Over 50.5

-114

Under 50.5

-114

Kaden Feagin (Illini)

Over 47.5

-114

Under 47.5

-114

Jaquez Moore (Duke)

Over 37.5

-114

Under 37.5

-114

Passing Yards

Darian Mensah (Duke)

Over 253.5

-114

Under 253.5

-114

Luke Altmyer (Illini)

Over 215.5

-114

Under 215.5

-114

Duke With Nine Wins in Past Ten Home Games

Duke are 9-1 in their last 10 home games, averaging 27.00 points on offense and surrendering 18.30 on defense.

Illini own a 5-5 mark in their past 10 games on the road, scoring 23.20 points per contest and conceding 28.50.

Last 10 Games		W-L	P	PF	PA	O49.5	U49.5
Duke Home Stats		9-1	45.30	27.00	18.30	3	7
Illinois Away Stats		5-5	51.70	23.20	28.50	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O49.5 = Games Over 49.5 Points
• U49.5 = Games Under 49.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Illinois Fighting Illini Stats

Duke Blue Devils Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• -3.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -3.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +3.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +3.5 Betting Line at Home: Have covered the spread in the last 10 home games

Total Points

• Game Totals: An average of 52.60 pts in the previous 10 games
• Game Totals on the Road: An average of 51.70 pts in the previous 10 games on the road
• Over 49.5: Covered in 5 of the previous 10 games
• Over 49.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 29.10 pts and allowed 23.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 23.20 pts and allowed 28.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 53.80 pts in the previous 10 games
• Game Totals at Home: An average of 45.30 pts in the previous 10 home games
• Over 49.5: Covered in 5 of the previous 10 games
• Over 49.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 26.40 pts and allowed 27.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 27.00 pts and allowed 18.30 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Boston College	1	0	66	10	56	1-0	0-0	1W
NC State	1	0	24	17	7	1-0	0-0	1W
Wake Forest	1	0	10	9	1	1-0	0-0	1W
Virginia	1	0	48	7	41	1-0	0-0	1W
SMU	1	0	42	13	29	1-0	0-0	1W
California	1	0	34	15	19	0-0	1-0	1W
Pittsburgh	1	0	61	9	52	1-0	0-0	1W
Miami	1	0	27	24	3	1-0	0-0	1W
Louisville	1	0	51	17	34	1-0	0-0	1W
Georgia Tech	1	0	27	20	7	0-0	1-0	1W
Florida State	1	0	31	17	14	1-0	0-0	1W
Duke	1	0	45	17	28	1-0	0-0	1W
Clemson	0	1	10	17	-7	0-1	0-0	1L
North Carolina	0	1	14	48	-34	0-1	0-0	1L
Stanford	0	1	20	23	-3	0-0	0-1	1L
Syracuse	0	1	26	45	-19	0-0	0-1	1L
Virginia Tech	0	1	11	24	-13	0-0	0-1	1L

Big Ten	W	L	PF	PA	N. Pts	Home	Away	Strk
Illinois	1	0	52	3	49	1-0	0-0	1W
Indiana	1	0	27	14	13	1-0	0-0	1W
Wisconsin	1	0	17	0	17	1-0	0-0	1W
Washington	1	0	38	21	17	1-0	0-0	1W
USC	1	0	73	13	60	1-0	0-0	1W
Rutgers	1	0	34	31	3	1-0	0-0	1W
Purdue	1	0	31	0	31	1-0	0-0	1W
Penn State	1	0	46	11	35	1-0	0-0	1W
Oregon	1	0	59	13	46	1-0	0-0	1W
Ohio State	1	0	14	7	7	1-0	0-0	1W
Nebraska	1	0	20	17	3	0-0	1-0	1W
Minnesota	1	0	23	10	13	1-0	0-0	1W
Michigan	1	0	34	17	17	1-0	0-0	1W
Michigan State	1	0	23	6	17	1-0	0-0	1W
Maryland	1	0	39	7	32	1-0	0-0	1W
Iowa	1	0	34	7	27	1-0	0-0	1W
Northwestern	0	1	3	23	-20	0-0	0-1	1L
UCLA	0	1	10	43	-33	0-1	0-0	1L