Illinois vs Duke Prediction, Picks & Odds | 06 Sep 2025
College Football Betting Preview: Illinois vs Duke
Illinois lock horns with Duke in this NCAAF Week 2 matchup at Wallace Wade Stadium, with kickoff scheduled for 12:00 on Saturday, September 6. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
If you agree that Duke can push Illinois to the wire, then back the underdogs against the spread here. The +3.5 makes lots of appeal at -122.
Confident in our spread pick? Unlock the current BetMGM promo code and take a moment to read our in-depth site review before you commit to your play.
Illinois Fighting Illini previous game saw them claim a 52-3 home win over Western Illinois Leathernecks at Memorial Stadium.
Duke Blue Devils last game saw them claim a 45-17 home win over Elon Phoenix at Wallace Wade Stadium.
Quarterbacks
Luke Altmyer
Darian Mensah
Illinois vs Duke Prediction & Picks
Be fully equipped for Illinois vs Duke with our betting guide, offering a key match prediction, a correct score recommendation, top player prop picks and a bet builder tailored for value.
Game Prediction
With Duke being given a line of +3.5 to overcome in this college football matchup, our pick is that the underdogs can cover this. There’s the chance to get -122 for this outcome.
We use the latest team news and injury updates to help shape the best possible CFB predictions. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.
Key Illinois vs Duke stats:
Duke +3.5 Probability
When you look at the latest odds, our pick has a 54.9% chance of delivering a return. However, our analysts have this number closer to 60% based on their in-depth research. It is the reason why we are recommending this college wager.
If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your spread pick. It all comes down to how confident you feel.
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Player Prop Picks
Darian Mensah (Duke) is priced at -114 to go beyond 253.5 passing yards. We’re happy to take him to cover the QB Passing Yards line and bettors can place this wager with confidence.
The odds for Hank Beatty (Illini) to record more than 36.5 receiving yards are -114. He looks capable of covering the line and that leads us to taking this Player Receiving Yards bet.
Same Game Parlay Picks
Get in the game with a same game parlay. Our picks are Duke to cover the +3.5 spread, Over 49.5 on the total and Darian Mensah (Duke) to go Over 253.5 passing yards.
A football same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big return from a small stake.
Correct Score Prediction
27
-
28
Duke
Don’t pass up the opportunity to have a speculative bet on Duke to land a 28-27 win. We don’t think that there will be too much between the teams.
Illinois vs Duke Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Illinois are -141 favorites and that means a 58% chance of winning this college game according to the Moneyline betting odds with the sportsbooks. At +116, Duke are regarded as having a lower probability of winning.
The spread is currently 2.5, with the total points line at 49.5. The Totals offers football bettors an alternative way of getting involved. If you want to bet Under 49.5, there are odds of -118.
If you’re betting on college football, we recommend heading to the top betting apps and scanning through the many team props and game lines. There’s a chance to wager pre-game and in-game.
Those interested in favorite Aidan Laughery to score the first touchdown are able to get +600. If the Anytime TD angle makes appeal, then this is -100.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
It’s good to consider all wagering options when it comes to college football and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.
Duke With Nine Wins in Past Ten Home Games
Duke are 9-1 in their last 10 home games, averaging 27.00 points on offense and surrendering 18.30 on defense.
Illini own a 5-5 mark in their past 10 games on the road, scoring 23.20 points per contest and conceding 28.50.
| Last 10 Games | W-L | P | PF | PA | O49.5 | U49.5 | |
|---|---|---|---|---|---|---|---|
 Duke Home Stats |
9-1 | 45.30 | 27.00 | 18.30 | 3 | 7 | |
 Illinois Away Stats |
5-5 | 51.70 | 23.20 | 28.50 | 7 | 3 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O49.5 = Games Over 49.5 Points
- U49.5 = Games Under 49.5 Points
Latest regular season and playoff games stats.
Illinois Fighting Illini Stats
Duke Blue Devils Stats
- 7 wins and 3 defeats in the last 10 games
- 5 wins and 5 defeats in the last 10 games on the road
- -3.5 Betting Line: Have covered the spread in 6 of the last 10 games
- -3.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road
- +3.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +3.5 Betting Line at Home: Have covered the spread in the last 10 home games
- Game Totals: An average of 52.60 pts in the previous 10 games
- Game Totals on the Road: An average of 51.70 pts in the previous 10 games on the road
- Over 49.5: Covered in 5 of the previous 10 games
- Over 49.5 on the Road: Covered in 7 of the previous 10 games on the road
- Team Totals: Have scored an average of 29.10 pts and allowed 23.50 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 23.20 pts and allowed 28.50 pts in the last 10 games on the road
- Game Totals: An average of 53.80 pts in the previous 10 games
- Game Totals at Home: An average of 45.30 pts in the previous 10 home games
- Over 49.5: Covered in 5 of the previous 10 games
- Over 49.5 at Home: Covered in 3 of the previous 10 home games
- Team Totals: Have scored an average of 26.40 pts and allowed 27.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 27.00 pts and allowed 18.30 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Virginia
|
10 | 2 | 398 | 240 | 158 | 6-1 | 4-1 | 2W |
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
|
Duke
|
7 | 5 | 415 | 353 | 62 | 3-3 | 4-2 | 2W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
12 | 0 | 532 | 131 | 401 | 7-0 | 5-0 | 12W |
Ohio State
|
12 | 0 | 444 | 93 | 351 | 7-0 | 5-0 | 12W |
Oregon
|
11 | 1 | 458 | 178 | 280 | 6-1 | 5-0 | 6W |
Michigan
|
9 | 3 | 331 | 224 | 107 | 5-1 | 4-2 | 1L |
USC
|
9 | 3 | 438 | 269 | 169 | 7-0 | 2-3 | 1W |
Iowa
|
8 | 4 | 347 | 182 | 165 | 5-2 | 3-2 | 2W |
|
Illinois
|
8 | 4 | 352 | 279 | 73 | 6-1 | 2-3 | 1W |
Washington
|
8 | 4 | 405 | 233 | 172 | 5-2 | 3-2 | 1L |
Minnesota
|
7 | 5 | 279 | 281 | -2 | 7-0 | 0-5 | 1W |
Nebraska
|
7 | 5 | 351 | 276 | 75 | 4-3 | 3-2 | 2L |
Northwestern
|
6 | 6 | 270 | 251 | 19 | 5-2 | 1-4 | 1L |
Penn State
|
6 | 6 | 381 | 257 | 124 | 4-3 | 2-3 | 3W |
Rutgers
|
5 | 7 | 344 | 382 | -38 | 4-3 | 1-4 | 2L |
Wisconsin
|
4 | 8 | 154 | 259 | -105 | 4-3 | 0-5 | 1L |
Maryland
|
4 | 8 | 282 | 318 | -36 | 3-4 | 1-4 | 8L |
Michigan State
|
4 | 8 | 295 | 359 | -64 | 4-3 | 0-5 | 1W |
UCLA
|
3 | 9 | 218 | 401 | -183 | 2-4 | 1-5 | 5L |
Purdue
|
2 | 10 | 225 | 382 | -157 | 2-5 | 0-5 | 10L |
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