Illinois vs Indiana Prediction, Picks & Odds | 20 Sep 2025

College Football Betting Preview: Illinois vs Indiana

Illinois battle Indiana in this NCAAF Week 4 matchup at Memorial Stadium, with kickoff scheduled for 19:30 on Saturday 20 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Indiana Against The Spread Stand Out

Our prediction is to snap up the -110 that Indiana are able to cover the spread. The favorites are -6.5 in their clash against Illinois and the margin of victory could be a good deal more significant.

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Last H2H Saw Illini Triumph in Overtime

Illinois Fighting Illini made it three consecutive wins after a 38-0 home success over Western Michigan Broncos at Memorial Stadium.

Indiana Hoosiers were winners for the third straight time in their last game. Landing a 73-0 home victory against Indiana State Sycamores at Memorial Stadium.

Head-to-Head Statistics

Illini won the last matchup between the pair. Enjoying a 48-45 (OT) triumph when facing Indiana at Memorial Stadium.

Quarterbacks

Luke Altmyer

219.5 Passing Yards

Over -114

Under -114

Fernando Mendoza

250.5 Passing Yards

Over -114

Under -114

Illinois vs Indiana Prediction & Picks

Discover the top Illinois vs Indiana betting angles — from our trusted match prediction and likely score to the best prop plays and a customized bet builder.

Game Prediction

Bet on Indiana against the spread in order to get the best value. They should be able to cover a generous -6.5 line at -110 for this college football matchup.

To deliver the best possible college football picks, we start by locking in the team news and taking time to review the latest form. There’s also no shortage of data to crunch from the most up-to-date stats available.

Key Illinois vs Indiana stats:

• The -6.5 line has been covered by Indiana in 4 consecutive games at home.
• The -6.5 line has been covered by Indiana in 9 of their last 10 games at home.
• The -6.5 line has been covered by Indiana in 13 of their last 20 games.

Indiana -6.5 Probability

The top betting apps make it a 52.4% chance that our pick is settled as a winner. However, we think that the probability is close to 60% taking all factors into consideration. It is the reason why we are recommending this college wager.

If you want bigger odds, then you can move the line by selling points. Choose how many points to sell until you are happy with the juice available.

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Best Bet

Indiana -6.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Luke Altmyer Under 219.5 Passing Yards -114

Luke Altmyer (Illini) can be backed at -114 to have less than 219.5 passing yards. It’s reasonable to expect he may fall short, making the QB Passing Yards line appealing.

Latest Luke Altmyer Player Prop Odds

Passing Yards

Over 219.5

-114

Under 219.5

-114

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Hank Beatty Under 53.5 Receiving Yards -114

The odds for Hank Beatty (Illini) to finish with fewer than 53.5 receiving yards stand at -114. It’s reasonable to expect he may fall short, making the Player Receiving Yards line appealing.

Latest Hank Beatty Player Prop Odds

Receiving Yards

Over 53.5

-114

Under 53.5

-114

Correct Score Prediction

Illinois 23 - 35 Indiana

If you want to take a chance on a correct score, then the Hoosiers to achieve a 35-23 win could be along the right lines. There are huge odds for this particular outcome.

Illinois vs Indiana Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Make Indiana Likelier Winners

Indiana are -222 favorites and that means a 69% chance of winning this college game according to the Moneyline betting odds with the sportsbooks. Illinois are the underdogs at +180 and they’re regarded as least likely to win.

The spread is currently 6.5, with the total points line at 52.5. A Total bet relates to the number of points that will be scored overall. Those who wager Under 52.5 can get -110.

The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.

Moneyline

Illini

+180

Indiana

-222

Point Spread

Illini +6.5

-112

Indiana -6.5

-108

Total Points

Under 52.5

-110

Over 52.5

-110

Player Odds

Receiving Yards

Elijah Sarratt (Indiana)

Over 70.5

-114

Under 70.5

-114

Omar Cooper Jr. (Indiana)

Over 54.5

-114

Under 54.5

-114

Hank Beatty (Illini)

Over 53.5

-114

Under 53.5

-114

E.J. Williams Jr. (Indiana)

Over 27.5

-114

Under 27.5

-114

Rushing Yards

Roman Hemby (Indiana)

Over 72.5

-114

Under 72.5

-114

Kaden Feagin (Illini)

Over 60.5

-114

Under 60.5

-114

Kaelon Black (Indiana)

Over 58.5

-114

Under 58.5

-114

Passing Yards

Fernando Mendoza (Indiana)

Over 250.5

-114

Under 250.5

-114

Luke Altmyer (Illini)

Over 219.5

-114

Under 219.5

-114

Indiana Looking to Keep Rolling at Home

Indiana own a 10-0 mark in their past 10 home games, averaging 50.00 points on offense and surrendering 10.70 on defense.

Illinois have rattled off three road wins in a row. They have six wins and four losses in the last 10 road games, averaging 25.40 points scored and 27.00 points allowed.

In their most recent matchup at Memorial Stadium, Indiana got the better of Illini 23-20.

Last 10 Games		W-L	P	PF	PA	O52.5	U52.5
Indiana Home Stats		10-0	60.70	50.00	10.70	7	3
Illinois Away Stats		6-4	52.40	25.40	27.00	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O52.5 = Games Over 52.5 Points
• U52.5 = Games Under 52.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Illinois Fighting Illini Stats

Indiana Hoosiers Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 10 wins and 0 defeats in the last 10 home games

Point Spread

• +6.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +6.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -6.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -6.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

• Game Totals: An average of 50.10 pts in the previous 10 games
• Game Totals on the Road: An average of 52.40 pts in the previous 10 games on the road
• Over 52.5: Covered in 5 of the previous 10 games
• Over 52.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 31.70 pts and allowed 18.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 25.40 pts and allowed 27.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 54.50 pts in the previous 10 games
• Game Totals at Home: An average of 60.70 pts in the previous 10 home games
• Over 52.5: Covered in 6 of the previous 10 games
• Over 52.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 40.80 pts and allowed 13.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 50.00 pts and allowed 10.70 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	W	L	PF	PA	N. Pts	Home	Away	Strk
Illinois	3	0	135	22	113	2-0	1-0	3W
Penn State	3	0	132	17	115	3-0	0-0	3W
Washington	2	0	108	31	77	2-0	0-0	2W
Indiana	3	0	156	23	133	3-0	0-0	3W
Rutgers	3	0	139	58	81	3-0	0-0	3W
USC	3	0	165	50	115	2-0	1-0	3W
Oregon	3	0	162	30	132	2-0	1-0	3W
Ohio State	3	0	121	16	105	3-0	0-0	3W
Nebraska	3	0	147	24	123	2-0	1-0	3W
Michigan State	3	0	106	70	36	3-0	0-0	3W
Maryland	3	0	103	33	70	3-0	0-0	3W
Iowa	2	1	94	30	64	2-0	0-1	1W
Michigan	2	1	110	44	66	2-0	0-1	1W
Minnesota	2	1	103	37	66	2-0	0-1	1L
Purdue	2	1	82	50	32	2-1	0-0	1L
Wisconsin	2	1	73	48	25	2-0	0-1	1L
Northwestern	1	2	59	64	-5	1-1	0-1	1L
UCLA	0	3	43	108	-65	0-2	0-1	3L