Illinois vs Indiana Prediction, Picks & Odds | 20 Sep 2025
College Football Betting Preview: Illinois vs Indiana
Illinois battle Indiana in this NCAAF Week 4 matchup at Memorial Stadium, with kickoff scheduled for 19:30 on Saturday, September 20. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
Our prediction is to snap up the -110 that Indiana are able to cover the spread. The favorites are -6.5 in their clash against Illinois and the margin of victory could be a good deal more significant.
Jumping on our side of the line? Unlock the latest BetMGM promo code and dive into our full review of the sportsbook before you make your selection.
Illinois Fighting Illini made it three consecutive wins after a 38-0 home success over Western Michigan Broncos at Memorial Stadium.
Indiana Hoosiers were winners for the third straight time in their last game. Landing a 73-0 home victory against Indiana State Sycamores at Memorial Stadium.
Head-to-Head Statistics
Illini won the last matchup between the pair. Enjoying a 48-45 (OT) triumph when facing Indiana at Memorial Stadium.
Quarterbacks
Luke Altmyer
Fernando Mendoza
Illinois vs Indiana Prediction & Picks
Discover the top Illinois vs Indiana betting angles — from our trusted match prediction and likely score to the best prop plays and a customized bet builder.
Game Prediction
Bet on Indiana against the spread in order to get the best value. They should be able to cover a generous -6.5 line at -110 for this college football matchup.
To deliver the best possible college football picks, we start by locking in the team news and taking time to review the latest form. There’s also no shortage of data to crunch from the most up-to-date stats available.
Key Illinois vs Indiana stats:
Indiana -6.5 Probability
The top betting apps make it a 52.4% chance that our pick is settled as a winner. However, we think that the probability is close to 60% taking all factors into consideration. It is the reason why we are recommending this college wager.
If you want bigger odds, then you can move the line by selling points. Choose how many points to sell until you are happy with the juice available.
Searching for betting perks? Explore our bonus guide for the freshest sportsbook promo codes, free bets, and offers today.
Player Prop Picks
Luke Altmyer (Illini) can be backed at -114 to have less than 219.5 passing yards. It’s reasonable to expect he may fall short, making the QB Passing Yards line appealing.
The odds for Hank Beatty (Illini) to finish with fewer than 53.5 receiving yards stand at -114. It’s reasonable to expect he may fall short, making the Player Receiving Yards line appealing.
Same Game Parlay Picks
Take a same game parlay that incorporates Indiana to cover the -6.5 spread along with Over 52.5 points. We’ve also gone for Luke Altmyer (Illinois) to have Under 219.5 passing yards.
The same game parlay option allows you to combine different outcomes within the same game. You need all your predictions to be correct although bettors love to place a tailored football bet on the event which interests them most.
Correct Score Prediction
23
-
35
Indiana
If you want to take a chance on a correct score, then the Hoosiers to achieve a 35-23 win could be along the right lines. There are huge odds for this particular outcome.
Illinois vs Indiana Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Indiana are -263 favorites and that means a 72% chance of winning this college game according to the Moneyline betting odds with the sportsbooks. Illinois are the underdogs at +210 and they’re regarded as least likely to win.
The spread is currently 6.5, with the total points line at 51.5. A Total bet relates to the number of points that will be scored overall. Those who wager Under 51.5 can get -110.
The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.
Elijah Sarratt is available at -120 when it comes to Anytime Touchdown Scorer. The favorite is now priced at odds of +550 to score the first TD.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Micro betting is something that’s really popular with bettors, with college football fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.
Indiana Looking to Keep Rolling at Home
Indiana own a 10-0 mark in their past 10 home games, averaging 50.00 points on offense and surrendering 10.70 on defense.
Illinois have rattled off three road wins in a row. They have six wins and four losses in the last 10 road games, averaging 25.40 points scored and 27.00 points allowed.
In their most recent matchup at Memorial Stadium, Indiana got the better of Illini 23-20.
| Last 10 Games | W-L | P | PF | PA | O52.5 | U52.5 | |
|---|---|---|---|---|---|---|---|
 Indiana Home Stats |
10-0 | 60.70 | 50.00 | 10.70 | 7 | 3 | |
 Illinois Away Stats |
6-4 | 52.40 | 25.40 | 27.00 | 6 | 4 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O52.5 = Games Over 52.5 Points
- U52.5 = Games Under 52.5 Points
Latest regular season and playoff games stats.
Illinois Fighting Illini Stats
Indiana Hoosiers Stats
- 8 wins and 2 defeats in the last 10 games
- 6 wins and 4 defeats in the last 10 games on the road
- +6.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +6.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -6.5 Betting Line: Have covered the spread in 7 of the last 10 games
- -6.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games
- Game Totals: An average of 50.10 pts in the previous 10 games
- Game Totals on the Road: An average of 52.40 pts in the previous 10 games on the road
- Over 52.5: Covered in 5 of the previous 10 games
- Over 52.5 on the Road: Covered in 6 of the previous 10 games on the road
- Team Totals: Have scored an average of 31.70 pts and allowed 18.40 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 25.40 pts and allowed 27.00 pts in the last 10 games on the road
- Game Totals: An average of 54.50 pts in the previous 10 games
- Game Totals at Home: An average of 60.70 pts in the previous 10 home games
- Over 52.5: Covered in 6 of the previous 10 games
- Over 52.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 40.80 pts and allowed 13.70 pts in the last 10 games
- Team Totals at Home: Have scored an average of 50.00 pts and allowed 10.70 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
|
Indiana
|
12 | 0 | 532 | 131 | 401 | 7-0 | 5-0 | 12W |
Ohio State
|
12 | 0 | 444 | 93 | 351 | 7-0 | 5-0 | 12W |
Oregon
|
11 | 1 | 458 | 178 | 280 | 6-1 | 5-0 | 6W |
Michigan
|
9 | 3 | 331 | 224 | 107 | 5-1 | 4-2 | 1L |
USC
|
9 | 3 | 438 | 269 | 169 | 7-0 | 2-3 | 1W |
Iowa
|
8 | 4 | 347 | 182 | 165 | 5-2 | 3-2 | 2W |
|
Illinois
|
8 | 4 | 352 | 279 | 73 | 6-1 | 2-3 | 1W |
Washington
|
8 | 4 | 405 | 233 | 172 | 5-2 | 3-2 | 1L |
Minnesota
|
7 | 5 | 279 | 281 | -2 | 7-0 | 0-5 | 1W |
Nebraska
|
7 | 5 | 351 | 276 | 75 | 4-3 | 3-2 | 2L |
Northwestern
|
6 | 6 | 270 | 251 | 19 | 5-2 | 1-4 | 1L |
Penn State
|
6 | 6 | 381 | 257 | 124 | 4-3 | 2-3 | 3W |
Rutgers
|
5 | 7 | 344 | 382 | -38 | 4-3 | 1-4 | 2L |
Wisconsin
|
4 | 8 | 154 | 259 | -105 | 4-3 | 0-5 | 1L |
Maryland
|
4 | 8 | 282 | 318 | -36 | 3-4 | 1-4 | 8L |
Michigan State
|
4 | 8 | 295 | 359 | -64 | 4-3 | 0-5 | 1W |
UCLA
|
3 | 9 | 218 | 401 | -183 | 2-4 | 1-5 | 5L |
Purdue
|
2 | 10 | 225 | 382 | -157 | 2-5 | 0-5 | 10L |
George Washington
Army
Predictions
12:00 - Tue 02 Dec
DFB-Pokal
Hertha BSC
Kaiserslautern
Predictions
12:00 - Tue 02 Dec
DFB-Pokal
Borussia Monchengladbach
St Pauli
Predictions
12:00 - Tue 02 Dec
NCAAB
Charleston Southern
UT Martin
Predictions
13:00 - Tue 02 Dec
Copa del Rey
Racing de Ferrol
Huesca
Predictions
14:30 - Tue 02 Dec
Premier League
Bournemouth
Everton
Predictions