Indiana vs Purdue Prediction, Picks & Odds | 28 Nov 2025
College Football Betting Preview: Indiana vs Purdue
Indiana square off against Purdue at Ross-Ade Stadium, with kickoff scheduled for 19:30 on Friday, November 28.
We really fancy the chances of Indiana beating Purdue handsomely. That is why we are betting them at -28.5 on the spread at -110.
Indiana Hoosiers beat Wisconsin Badgers in their previous game, making it eleven straight victories. It was a 31-7 home win at Memorial Stadium.
Purdue Boilermakers have been beaten in their last nine games. On the road at Husky Stadium, Washington Huskies recently beat them 49-13.
Head-to-Head Statistics
These two teams last met at Memorial Stadium, with Indiana claiming the win. Beating Purdue by a 66-0 scoreline. The previous 5 H2H meetings have involved Purdue winning three times.
Indiana vs Purdue Prediction & Picks
Dive into our full Indiana vs Purdue betting preview, featuring an expert match prediction, a projected scoreline, top player prop bets and a bet builder designed for value.
Game Prediction
Indiana can finish well clear in this college football matchup and that means we’re going for the favorites against the spread. There is -110 on offer that they are able to cover the -28.5 betting line.
Team news and current form always play a key role in shaping our expert CFB predictions. We also dig into the latest stats and trends to help deliver the most accurate picks possible.
Key Indiana vs Purdue stats:
Indiana -28.5 Probability
The best sportsbooks make it a 52.4% chance that our pick is settled as a winner. Taking all factors into consideration, our experts think there’s a stronger chance of success and estimate the probability to be closer to 60%. This college bet can therefore be backed with confidence.
The Winning Margin lines allow you to bet on Indiana to secure a victory by a certain number of points. It’s a different wager and a viable alternative to the point spread.
Get extra value on your next wager with our list of betting offers—featuring welcome bonuses, free bets, and promotions.
Player Prop Picks
Fernando Mendoza (Indiana) is available at -114 to go over 249.5 passing yards. We can place a QB Passing Yards bet with confidence, as we expect him to cover the line.
You can back Roman Hemby (Indiana) at -114 to go beyond 72.5 rushing yards. He looks capable of covering the line and that leads us to taking this Player Rushing Yards bet.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Our same game parlay pick is Indiana -28.5 on the spread, Under 53.5 and Fernando Mendoza (Indiana) to go Over 249.5 passing yards.
There are many options when you place a same game parlay. You can go through the football lines and identify your favorite outcomes before combining the odds on the bet slip. Personalised betting doesn’t come any better.
Correct Score Prediction
41
-
3
Purdue
There’s lots of entertainment when it comes to a correct score wager. A play on the Hoosiers to achieve a 41-3 win should give bettors a good run for their money.
Indiana vs Purdue Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
Indiana are strong -10000 favorites to win this college game according to the Moneyline betting odds. The sportsbooks give them a 99% chance of claiming victory. Purdue are the underdogs at +2200 and they’re regarded as least likely to win.
The spread is currently 28.5, with the total points line at 54.5. Football bettors regularly enjoy the opportunity to wager on the Totals. Those that want to back Under 54.5 can find odds of -110 available.
The best betting apps offer a wide range of game lines and team props when it comes to most college football games. Make sure you look through all the available options before deciding which bet to place.
Roman Hemby is the favorite to be First Touchdown Scorer at +440. If you’re interested in backing him to score a TD at anytime, then the price is -208.
Touchdown
Receiving Yards
Rushing Yards
It’s possible to use stats to your advantage when it comes to college football micro betting, especially if you’re predicting outcomes such as the Next Drive Result. Check out the live player, score and team props and see if you can find an angle.
Can Purdue Stop the Rot at Home?
Purdue have lost four straight at Ross-Ade Stadium. They are 2-8 in their last 10 home games, putting up 18.30 points per contest and giving up 29.20.
Indiana have posted four consecutive wins on the road. They own a 7-3 mark in their past 10 games away from home, averaging 32.50 points scored and 21.60 points allowed.
Purdue beat Indiana 35-31 when they last met at Ross-Ade Stadium. The last 3 head-to-heads at Ross-Ade Stadium show Purdue with two wins, while Indiana have one to their name.
| Last 10 Games | W-L | P | PF | PA | O53.5 | U53.5 | |
|---|---|---|---|---|---|---|---|
 Purdue Home Stats |
2-8 | 47.50 | 18.30 | 29.20 | 2 | 8 | |
 Indiana Away Stats |
7-3 | 54.10 | 32.50 | 21.60 | 5 | 5 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O53.5 = Games Over 53.5 Points
- U53.5 = Games Under 53.5 Points
Latest regular season and playoff games stats.
Indiana Hoosiers Stats
Purdue Boilermakers Stats
- 10 wins and 0 defeats in the last 10 games
- 7 wins and 3 defeats in the last 10 games on the road
- -28.5 Betting Line: Have covered the spread in 5 of the last 10 games
- -28.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road
- +28.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +28.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games
- Game Totals: An average of 56.30 pts in the previous 10 games
- Game Totals on the Road: An average of 54.10 pts in the previous 10 games on the road
- Over 53.5: Covered in 5 of the previous 10 games
- Over 53.5 on the Road: Covered in 5 of the previous 10 games on the road
- Team Totals: Have scored an average of 44.90 pts and allowed 11.40 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 32.50 pts and allowed 21.60 pts in the last 10 games on the road
- Game Totals: An average of 51.70 pts in the previous 10 games
- Game Totals at Home: An average of 47.50 pts in the previous 10 home games
- Over 53.5: Covered in 3 of the previous 10 games
- Over 53.5 at Home: Covered in 2 of the previous 10 home games
- Team Totals: Have scored an average of 19.10 pts and allowed 32.60 pts in the last 10 games
- Team Totals at Home: Have scored an average of 18.30 pts and allowed 29.20 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
|
Indiana
|
13 | 0 | 545 | 141 | 404 | 7-0 | 6-0 | 13W |
Ohio State
|
12 | 1 | 454 | 106 | 348 | 7-1 | 5-0 | 1L |
Oregon
|
11 | 1 | 458 | 178 | 280 | 6-1 | 5-0 | 6W |
Michigan
|
9 | 3 | 331 | 224 | 107 | 5-1 | 4-2 | 1L |
USC
|
9 | 3 | 438 | 269 | 169 | 7-0 | 2-3 | 1W |
Iowa
|
8 | 4 | 347 | 182 | 165 | 5-2 | 3-2 | 2W |
Illinois
|
8 | 4 | 352 | 279 | 73 | 6-1 | 2-3 | 1W |
Washington
|
8 | 4 | 405 | 233 | 172 | 5-2 | 3-2 | 1L |
Minnesota
|
7 | 5 | 279 | 281 | -2 | 7-0 | 0-5 | 1W |
Nebraska
|
7 | 5 | 351 | 276 | 75 | 4-3 | 3-2 | 2L |
Northwestern
|
6 | 6 | 270 | 251 | 19 | 5-2 | 1-4 | 1L |
Penn State
|
6 | 6 | 381 | 257 | 124 | 4-3 | 2-3 | 3W |
Rutgers
|
5 | 7 | 344 | 382 | -38 | 4-3 | 1-4 | 2L |
Wisconsin
|
4 | 8 | 154 | 259 | -105 | 4-3 | 0-5 | 1L |
Maryland
|
4 | 8 | 282 | 318 | -36 | 3-4 | 1-4 | 8L |
Michigan State
|
4 | 8 | 295 | 359 | -64 | 4-3 | 0-5 | 1W |
UCLA
|
3 | 9 | 218 | 401 | -183 | 2-4 | 1-5 | 5L |
|
Purdue
|
2 | 10 | 225 | 382 | -157 | 2-5 | 0-5 | 10L |
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