Indiana vs Purdue Prediction, Picks & Odds | 28 Nov 2025

College Football Betting Preview: Indiana vs Purdue

Indiana square off against Purdue at Ross-Ade Stadium, with kickoff scheduled for 19:30 on Friday, November 28.

We really fancy the chances of Indiana beating Purdue handsomely. That is why we are betting them at -28.5 on the spread at -110.

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Indiana Hoosiers beat Wisconsin Badgers in their previous game, making it eleven straight victories. It was a 31-7 home win at Memorial Stadium.

Purdue Boilermakers have been beaten in their last nine games. On the road at Husky Stadium, Washington Huskies recently beat them 49-13.

Head-to-Head Statistics

These two teams last met at Memorial Stadium, with Indiana claiming the win. Beating Purdue by a 66-0 scoreline. The previous 5 H2H meetings have involved Purdue winning three times.

Indiana vs Purdue Prediction & Picks

Dive into our full Indiana vs Purdue betting preview, featuring an expert match prediction, a projected scoreline, top player prop bets and a bet builder designed for value.

Game Prediction

Indiana can finish well clear in this college football matchup and that means we’re going for the favorites against the spread. There is -110 on offer that they are able to cover the -28.5 betting line.

Team news and current form always play a key role in shaping our expert CFB predictions. We also dig into the latest stats and trends to help deliver the most accurate picks possible.

Key Indiana vs Purdue stats:

• The -28.5 line has been covered by Indiana in 5 of their last 10 games.

Indiana -28.5 Probability

The best sportsbooks make it a 52.4% chance that our pick is settled as a winner. Taking all factors into consideration, our experts think there’s a stronger chance of success and estimate the probability to be closer to 60%. This college bet can therefore be backed with confidence.

The Winning Margin lines allow you to bet on Indiana to secure a victory by a certain number of points. It’s a different wager and a viable alternative to the point spread.

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Our Game Prediction

Indiana -28.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Fernando Mendoza Over 249.5 Passing Yards -114

Fernando Mendoza (Indiana) is available at -114 to go over 249.5 passing yards. We can place a QB Passing Yards bet with confidence, as we expect him to cover the line.

Latest Fernando Mendoza Player Prop Odds

Passing Yards

Over 249.5

-114

Under 249.5

-114

Rushing Yards

Over 25.5

-114

Under 25.5

-114

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Roman Hemby Over 72.5 Rushing Yards -114

You can back Roman Hemby (Indiana) at -114 to go beyond 72.5 rushing yards. He looks capable of covering the line and that leads us to taking this Player Rushing Yards bet.

Latest Roman Hemby Player Prop Odds

Rushing Yards

Over 72.5

-114

Under 72.5

-114

Correct Score Prediction

Indiana 41 - 3 Purdue

There’s lots of entertainment when it comes to a correct score wager. A play on the Hoosiers to achieve a 41-3 win should give bettors a good run for their money.

Indiana vs Purdue Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Indiana are strong -10000 favorites to win this college game according to the Moneyline betting odds. The sportsbooks give them a 99% chance of claiming victory. Purdue are the underdogs at +2400 and they’re regarded as least likely to win.

The spread is currently 28.5, with the total points line at 53.5. Football bettors regularly enjoy the opportunity to wager on the Totals. Those that want to back Under 53.5 can find odds of -108 available.

The best betting apps offer a wide range of game lines and team props when it comes to most college football games. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Indiana

-10000

Purdue

+2400

Point Spread

Indiana -28.5

-110

Purdue +28.5

-110

Total Points

Under 53.5

-108

Over 53.5

-112

Receiving Yards

Omar Cooper Jr. (Indiana)

Over 73.5

-114

Under 73.5

-114

Elijah Sarratt (Indiana)

Over 71.5

-114

Under 71.5

-114

Michael Jackson III (Purdue)

Over 40.5

-114

Under 40.5

-114

Nitro Tuggle (Purdue)

Over 33.5

-114

Under 33.5

-114

E.J. Williams Jr. (Indiana)

Over 31.5

-114

Under 31.5

-114

Rushing Yards

Roman Hemby (Indiana)

Over 72.5

-114

Under 72.5

-114

Kaelon Black (Indiana)

Over 58.5

-114

Under 58.5

-114

Antonio Harris (Purdue)

Over 37.5

-114

Under 37.5

-114

Fernando Mendoza (Indiana)

Over 25.5

-114

Under 25.5

-114

Can Purdue Stop the Rot at Home?

Purdue have lost four straight at Ross-Ade Stadium. They are 2-8 in their last 10 home games, putting up 18.30 points per contest and giving up 29.20.

Indiana have posted four consecutive wins on the road. They own a 7-3 mark in their past 10 games away from home, averaging 32.50 points scored and 21.60 points allowed.

Purdue beat Indiana 35-31 when they last met at Ross-Ade Stadium. The last 3 head-to-heads at Ross-Ade Stadium show Purdue with two wins, while Indiana have one to their name.

Last 10 Games		W-L	P	PF	PA	O53.5	U53.5
Purdue Home Stats		2-8	47.50	18.30	29.20	2	8
Indiana Away Stats		7-3	54.10	32.50	21.60	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O53.5 = Games Over 53.5 Points
• U53.5 = Games Under 53.5 Points

Latest regular season and playoff games stats.

Indiana Hoosiers Stats

Purdue Boilermakers Stats

Moneyline

• 10 wins and 0 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 1 win and 9 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 home games

Point Spread

• -28.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -28.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +28.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +28.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 56.30 pts in the previous 10 games
• Game Totals on the Road: An average of 54.10 pts in the previous 10 games on the road
• Over 53.5: Covered in 5 of the previous 10 games
• Over 53.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 44.90 pts and allowed 11.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 32.50 pts and allowed 21.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 51.70 pts in the previous 10 games
• Game Totals at Home: An average of 47.50 pts in the previous 10 home games
• Over 53.5: Covered in 3 of the previous 10 games
• Over 53.5 at Home: Covered in 2 of the previous 10 home games
• Team Totals: Have scored an average of 19.10 pts and allowed 32.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 18.30 pts and allowed 29.20 pts in the last 10 home games

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