Iowa State vs Arkansas State Prediction, Picks & Odds | 13 Sep 2025

College Football Betting Preview: Iowa State vs Arkansas State

Iowa State face Arkansas State in this NCAAF matchup at Centennial Bank Stadium, with kickoff scheduled for 16:00 on Saturday 13 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Side With Arkansas State and Take a Big Line

We’ll take a chance on the underdogs and back Arkansas State with a +21.5 points start. They should be able to cover the line against Iowa State at odds of -105.

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52-7 Victory for Iowa State in Pair’s Previous H2H

Iowa State Cyclones have won their previous three games. The latest was a 16-13 home triumph at Jack Trice Stadium against Iowa Hawkeyes.

Arkansas State Red Wolves suffered a defeat in their last game. A 56-14 scoreline occurred on the road at War Memorial Stadium Arkansas against Arkansas Razorbacks.

Head-to-Head Statistics

It was a 52-7 win for Iowa State at Jack Trice Stadium when they last played Arkansas State.

Iowa State vs Arkansas State Prediction & Picks

Get fully prepped for Iowa State vs Arkansas State with our betting guide, featuring our expert match pick, predicted scoreline and a value-focused bet builder. Read on for the full breakdown.

Game Prediction

It’s all about Arkansas State to stay ahead of the curve against the big favorites. The spread of +21.5 looks more than generous at -105 for this college football pick.

We track all injuries that could impact each team before making our CFB picks. The form guide and latest stats also help the Sportsgambler.com team crunch the numbers ahead of the action.

Key Iowa State vs Arkansas State stats:

• The +21.5 line has been covered by Arkansas State in 12 consecutive games at home.
• The +21.5 line has been covered by Arkansas State in 16 of their last 20 games.
• The -21.5 line hasn’t been covered by Iowa State in 9 consecutive games on the road.
• The -21.5 line hasn’t been covered by Iowa State in 19 of their last 20 games on the road.

Arkansas State +21.5 Probability

The best sportsbooks make it a 51.3% chance that our pick is settled as a winner. After careful examination, our cappers calculate this probability to be somewhere between 55-60%. It is the reason why we are recommending this college wager.

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Best Bet

Arkansas State +21.5 @ -105 Bet Now

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Correct Score Prediction

Iowa State 38 - 21 Arkansas State

There’s a massive payout on the cards should you correctly predict the correct score. We’re siding with the Cyclones to enjoy a 38-21 victory which will hopefully go close.

Iowa State vs Arkansas State Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Iowa State Heavy Favorites in Eyes of the Books

The sportsbooks are taking no chances with their Moneyline odds of -2500 about Iowa State which reflects they have a 96% chance of winning this college game. At +1100, Arkansas State are regarded as having a lower probability of winning.

The current spread is 21.5 and total points is 55.5. A wager on the Totals allows football bettors to use the latest data to good effect. The Over 55.5 selection is available to back at -110.

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Moneyline

Iowa State

-2500

Arkansas State

+1100

Point Spread

Iowa State -21.5

-115

Arkansas State +21.5

-105

Total Points

Under 55.5

-110

Over 55.5

-110

Player Props & Micro Betting

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Arkansas State Have Picked Up Eight Wins in Past Ten at Home

Arkansas State own a 8-2 mark in their past 10 home games, scoring 34.70 points per contest and conceding 26.20.

Iowa State have a 8-2 record in their last 10 games away from home, putting up 30.70 points on average and giving up 26.30.

Last 10 Games		W-L	P	PF	PA	O55.5	U55.5
Arkansas State Home Stats		8-2	60.90	34.70	26.20	5	5
Iowa State Away Stats		8-2	57.00	30.70	26.30	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O55.5 = Games Over 55.5 Points
• U55.5 = Games Under 55.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Iowa State Cyclones Stats

Arkansas State Red Wolves Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• -21.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -21.5 Betting Line on the Road: Have covered the spread in 1 of the last 10 games on the road

Point Spread

• +21.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +21.5 Betting Line at Home: Have covered the spread in the last 10 home games

Total Points

• Game Totals: An average of 56.90 pts in the previous 10 games
• Game Totals on the Road: An average of 57.00 pts in the previous 10 games on the road
• Over 55.5: Covered in 5 of the previous 10 games
• Over 55.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 30.80 pts and allowed 26.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 30.70 pts and allowed 26.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 63.40 pts in the previous 10 games
• Game Totals at Home: An average of 60.90 pts in the previous 10 home games
• Over 55.5: Covered in 7 of the previous 10 games
• Over 55.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 28.70 pts and allowed 34.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 34.70 pts and allowed 26.20 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Sun Belt	W	L	PF	PA	N. Pts	Home	Away	Strk
Appalachian State	2	0	54	24	30	1-0	1-0	2W
Texas State	2	0	95	63	32	1-0	1-0	2W
Coastal Carolina	1	1	20	48	-28	1-0	0-1	1W
James Madison	1	1	59	38	21	1-0	0-1	1L
Old Dominion	1	1	68	33	35	1-0	0-1	1W
Arkansas State	1	1	56	80	-24	1-0	0-1	1L
Louisiana	1	1	46	24	22	1-1	0-0	1W
UL Monroe	1	1	29	73	-44	1-0	0-1	1L
South Alabama	1	1	69	54	15	1-1	0-0	1L
Southern Miss	1	1	55	54	1	1-1	0-0	1W
Troy State	1	1	54	47	7	1-0	0-1	1L
Georgia Southern	0	2	34	101	-67	0-0	0-2	2L
Georgia State	0	2	23	101	-78	0-1	0-1	2L
Marshall	0	2	27	66	-39	0-1	0-1	2L

Big 12	W	L	PF	PA	N. Pts	Home	Away	Strk
Arizona	2	0	88	9	79	2-0	0-0	2W
BYU	2	0	96	3	93	2-0	0-0	2W
Houston	2	0	62	9	53	1-0	1-0	2W
Iowa State	3	0	95	41	54	2-0	1-0	3W
TCU	1	0	48	14	34	0-0	1-0	1W
Texas Tech	2	0	129	21	108	2-0	0-0	2W
UCF	2	0	85	17	68	2-0	0-0	2W
Utah	2	0	106	19	87	1-0	1-0	2W
Kansas	2	1	108	56	52	2-0	0-1	1L
Baylor	1	1	72	83	-11	0-1	1-0	1W
Cincinnati	1	1	51	40	11	1-1	0-0	1W
Colorado	1	1	51	34	17	1-1	0-0	1W
Oklahoma State	1	1	30	76	-46	1-0	0-1	1L
West Virginia	1	1	55	20	35	1-0	0-1	1L
Kansas State	1	2	80	83	-3	1-2	0-0	1L