Iowa State vs Oklahoma State Prediction, Picks & Odds | 29 Nov 2025

College Football Betting Preview: Iowa State vs Oklahoma State

Iowa State battle Oklahoma State at Boone Pickens Stadium, with kickoff scheduled for 12:00 on Saturday, November 29.

We’re predicting that Iowa State will beat Oklahoma State by a significant margin. With this in mind, let’s go for the favorites at -13.5 on the spread which is currently on offer at -110.

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Iowa State Cyclones beat Kansas Jayhawks in their previous game, making it back-to-back victories. It was a 38-14 home win at Jack Trice Stadium.

Oklahoma State Cowboys lost on the road in their last game, making it ten straight defeats. UCF Knights won 17-14 at Acrisure Bounce House.

Head-to-Head Statistics

It was a 34-27 win for Iowa State at Jack Trice Stadium when they last played Oklahoma State. Oklahoma State have won three of the previous 5 H2H meetings.

Iowa State vs Oklahoma State Prediction & Picks

Gear up for Iowa State vs Oklahoma State with our betting guide, featuring an expert match prediction, scoreline advice and a hand-picked bet builder. Explore each section below for detailed insights.

Game Prediction

We’d be surprised if the favorites don’t exceed a -13.5 spread in this college football battle. That is why the wager has to be Iowa State to cover the line at -110.

Sportsgambler.com brings strong college football expertise, built on knowing the team news as soon as it’s confirmed. Recent form plays a big part in our CFB picks and we always back it up with the most relevant stats.

Key Iowa State vs Oklahoma State stats:

• The +13.5 line hasn’t been covered by Oklahoma State in 7 of their last 10 games.
• The +13.5 line hasn’t been covered by Oklahoma State in 7 of their last 11 games this season.

Iowa State -13.5 Probability

The top betting apps make it a 52.4% chance that our pick is settled as a winner. However, our cappers think that the probability sits between 55-60% taking all factors into consideration. This college wager can therefore be backed with confidence.

A Bet Builder provides you with the opportunity to combine Iowa State on the spread with other picks. For every additional selection, the price is boosted.

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Our Game Prediction

Iowa State -13.5 @ -110 Bet Now

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Correct Score Prediction

Iowa State 38 - 17 Oklahoma State

For those wanting a big return from a small stake, consider the correct score lines. For example, the Cyclones can be backed to win 38-17 at enormous betting odds.

Iowa State vs Oklahoma State Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The latest Moneyline betting odds give Iowa State a 85% chance of winning this college game which means they’re overwhelming -588 favorites with the sportsbooks. If you’re looking for an alternative angle, Oklahoma State are trading at +450.

The spread currently stands at 13.5 and the total points line is 46.5. A wager on the Totals allows football bettors to use the latest data to good effect. Those who wager Under 46.5 can get -115.

Consider every angle when placing your college football wagers. The best betting sites have a huge selection of team props and game lines and it’s all about finding a bet which matches your prediction of the game.

Moneyline

Iowa State

-588

Oklahoma State

+450

Point Spread

Iowa State -13.5

-110

Oklahoma State +13.5

-110

Total Points

Under 46.5

-115

Over 46.5

-105

There is regularly value to be found from betting the quarterback and player props with the best online gambling sites. You can find lots of ways to back for or against a specific player lining up for one of the two teams.

Micro betting is an exciting way to wager on college football. There are a huge range of live lines and it’s a simple case of predicting what is going to happen next. Field Goal Outcome, Next Drive Result and Next Play Result are often among the options.

Oklahoma State Home Record Includes Five Straight Defeats

Oklahoma State have been handed five consecutive losses at Boone Pickens Stadium. They have one win and nine losses in the last 10 home games, averaging 20.80 points scored and 33.10 points allowed.

Iowa State own a 6-4 mark in their past 10 games on the road, posting 27.10 points per contest while yielding 29.10.

Oklahoma State beat Iowa State 20-14 when the teams last met at Boone Pickens Stadium.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
Oklahoma State Home Stats		1-9	53.90	20.80	33.10	6	4
Iowa State Away Stats		6-4	56.20	27.10	29.10	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O46.5 = Games Over 46.5 Points
• U46.5 = Games Under 46.5 Points

Latest regular season and playoff games stats.

Iowa State Cyclones Stats

Oklahoma State Cowboys Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 0 wins and 10 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 home games

Point Spread

• -13.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -13.5 Betting Line on the Road: Have not covered the spread in any of the last 10 games on the road

Point Spread

• +13.5 Betting Line: Have covered the spread in 3 of the last 10 games
• +13.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 49.30 pts in the previous 10 games
• Game Totals on the Road: An average of 56.20 pts in the previous 10 games on the road
• Over 46.5: Covered in 5 of the previous 10 games
• Over 46.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 28.50 pts and allowed 20.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 27.10 pts and allowed 29.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 50.30 pts in the previous 10 games
• Game Totals at Home: An average of 53.90 pts in the previous 10 home games
• Over 46.5: Covered in 6 of the previous 10 games
• Over 46.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 13.00 pts and allowed 37.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 20.80 pts and allowed 33.10 pts in the last 10 home games

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