Jacksonville State vs Southern Miss Prediction, Picks & Odds | 27 Sep 2025

College Football Betting Preview: Jacksonville State vs Southern Miss

Jacksonville State square off against Southern Miss in this NCAAF Week 5 matchup at M.M. Roberts Stadium, with kickoff scheduled for 19:00 on Saturday 27 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Can Jax State Keep the Scores Close?

Jacksonville State look a great pick at +3.5 on the spread. They could beat Southern Miss and the -105 about this selection makes plenty of appeal.

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Jax State Won 44-7 in Teams’ Previous H2H

Jacksonville State have lost their previous two on the road. Their most recent game was at home at Burgess Snow Field at AmFirst Stadium where they recorded a 45-10 victory over Murray State Racers.

Southern Mississippi Golden Eagles have landed two home wins on the spin. It was a road defeat to Louisiana Tech Bulldogs in their last game, losing 30-20 at Joe Aillet Stadium.

Head-to-Head Statistics

The last matchup between Jax State and Southern Miss saw the former win. It was a 44-7 scoreline at Burgess Snow Field at AmFirst Stadium.

Jacksonville State vs Southern Miss Prediction & Picks

We cover the essential Jacksonville State vs Southern Miss betting angles, featuring our main match prediction, correct score guidance and a carefully crafted bet builder.

Game Prediction

We’re sweet on Jacksonville State putting up a fight in this college football showdown and that compels us to back the underdogs against the spread. You can get -105 when it comes to the +3.5 that is available.

Knowing which players are injured gives us a valuable edge when making college football predictions. After reviewing the form guide, we turn to the latest stats to shape our picks.

Key Jacksonville State vs Southern Miss stats:

• The +3.5 line has been covered by Jacksonville State in 8 of their last 10 games.
• The +3.5 line has been covered by Jacksonville State in 16 of their last 20 games.
• The -3.5 line hasn’t been covered by Southern Miss in 8 of their last 10 games.
• The -3.5 line hasn’t been covered by Southern Miss in 16 of their last 20 games.

Jax State +3.5 Probability

The top sportsbooks are estimating that there is a 51.3% likelihood of this pick winning. However, we think that the probability sits between 55-60% taking all factors into consideration. It’s why we think it’s worth placing this college bet.

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Best Bet

Jax State +3.5 @ -105 Bet Now

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Correct Score Prediction

Jax State 27 - 24 Southern Miss

There’s every chance that this is going to be a close matchup and we’ll have a play on the Gamecocks achieving a 27-24 winning scoreline. Hopefully this can go close.

Jacksonville State vs Southern Miss Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Southern Miss Likely to Win According to Latest Odds

Southern Miss are regarded as having a 65% chance of winning this college game according to the latest betting odds. The sportsbooks have priced them up at -185. Jacksonville State are trading at bigger odds than their opponents and they can be backed at +152.

The spread is 3.5 and the total points line is currently 55.5. The beauty of the Totals is that you only have to choose from one of two options. If you want to bet Under 55.5, there are odds of -110.

If you’re planning to place a college football wager, visit the best betting apps and check out the huge selection of available team props and game lines. Find the odds and betting lines which are the most attractive.

Moneyline

Jax State

+152

Southern Miss

-185

Point Spread

Jax State +3.5

-102

Southern Miss -3.5

-120

Total Points

Under 55.5

-110

Over 55.5

-110

Player Props & Micro Betting

The gambling sites also allow you to place player prop bets such as Quarterback Passing Yards and First/Last Touchdown Scorer. This means you can focus on an individual player’s performance rather than wager on the actual outcome of the game in question.

An increasing number of bettors are now enjoying micro betting on college football and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Southern Miss Home Record Reads Seven Losses in Previous Ten Matches

Southern Miss have a 3-7 record in their last 10 home games, scoring 22.70 points per contest and conceding 30.90.

Jacksonville State have endured three straight defeats on the road. They own a 4-6 mark in their past 10 games on the road, putting up 29.80 points per contest and giving up 29.60.

Last 10 Games		W-L	P	PF	PA	O55.5	U55.5
Southern Miss Home Stats		3-7	53.60	22.70	30.90	4	6
Jacksonville State Away Stats		4-6	59.40	29.80	29.60	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O55.5 = Games Over 55.5 Points
• U55.5 = Games Under 55.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Jacksonville State Stats

Southern Mississippi Golden Eagles Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 55.00 pts in the previous 10 games
• Game Totals on the Road: An average of 59.40 pts in the previous 10 games on the road
• Over 55.5: Covered in 6 of the previous 10 games
• Over 55.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 31.80 pts and allowed 23.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 29.80 pts and allowed 29.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 56.00 pts in the previous 10 games
• Game Totals at Home: An average of 53.60 pts in the previous 10 home games
• Over 55.5: Covered in 5 of the previous 10 games
• Over 55.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 19.60 pts and allowed 36.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 22.70 pts and allowed 30.90 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Sun Belt	W	L	PF	PA	N. Pts	Home	Away	Strk
Texas State	3	1	145	100	45	2-0	1-1	1W
Appalachian State	2	1	76	62	14	1-0	1-1	1L
James Madison	2	1	90	51	39	1-0	1-1	1W
Old Dominion	2	1	113	59	54	1-0	1-1	2W
UL Monroe	2	1	60	98	-38	1-0	1-1	1W
Coastal Carolina	2	2	58	106	-48	1-1	1-1	1W
Georgia Southern	2	2	120	152	-32	2-0	0-2	2W
Marshall	2	2	107	101	6	1-1	1-1	2W
Southern Miss	2	2	113	106	7	2-1	0-1	1L
Troy State	2	2	82	92	-10	1-1	1-1	1W
Georgia State	1	3	81	192	-111	1-1	0-2	1L
Arkansas State	1	3	93	132	-39	1-1	0-2	3L
Louisiana	1	3	87	110	-23	1-1	0-2	2L
South Alabama	1	3	104	123	-19	1-2	0-1	3L

Conference USA	W	L	PF	PA	N. Pts	Home	Away	Strk
Delaware Blue Hens	3	1	124	105	19	2-0	1-1	2W
Louisiana Tech	3	1	110	57	53	3-0	0-1	2W
Western Kentucky	3	1	148	91	57	3-0	0-1	1W
New Mexico St	2	1	54	66	-12	2-0	0-1	1L
FIU	2	2	96	109	-13	2-1	0-1	1L
Jacksonville State	2	2	123	92	31	2-0	0-2	1W
Kennesaw State	2	2	73	100	-27	2-0	0-2	2W
Missouri State	2	2	86	131	-45	1-1	1-1	1W
Liberty	1	3	78	95	-17	1-1	0-2	3L
M. Tennessee	1	3	66	131	-65	0-2	1-1	1L
UTEP	1	3	93	103	-10	1-1	0-2	2L
Sam Houston	0	4	65	171	-106	0-1	0-3	4L