Kansas vs Iowa State Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: Kansas vs Iowa State

Kansas square off against Iowa State at Jack Trice Stadium, with kickoff scheduled for 12:00 on Saturday, November 22.

Don’t miss the opportunity to side with Iowa State on the spread at -3.5. On the face of it, this seems a generous line and odds of -110 can be backed in their clash against Kansas.

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Kansas Jayhawks have been beaten in successive road games and the latest was at Arizona Stadium. Arizona Wildcats claimed a 24-20 win.

Iowa State Cyclones have suffered back-to-back home defeats. In their last game, they beat Texas Christian Horned Frogs 20-17 on the road at Amon G. Carter Stadium.

Head-to-Head Statistics

Kansas triumphed 45-36 when they last played Iowa State. This head-to-head was played at David Booth Kansas Memorial Stadium. The past 6 games H2H record shows that both teams have three wins.

Quarterbacks

Jalon Daniels

198.5 Passing Yards

Over -114

Under -114

Rocco Becht

236.5 Passing Yards

Over -114

Under -114

Kansas vs Iowa State Prediction & Picks

Discover our expert Kansas vs Iowa State betting tips, featuring a key match prediction, correct score suggestion, top player prop picks and bet builder advice. Scroll down for full analysis.

Game Prediction

It’s great to see Iowa State given a -3.5 line on the spread at -110 as we’re expecting a bigger margin of victory in this college football matchup.

Our CFB predictions are always well-researched, starting with a combination of the latest team news and current form. Once we’ve got a solid read on the matchup, we layer in the key data to back it up.

Key Kansas vs Iowa State stats:

• The +3.5 line hasn’t been covered by Kansas in 4 of their last 5 games on the road.
• The +3.5 line hasn’t been covered by Kansas in 3 of their last 4 games on the road this season.
• The +3.5 line hasn’t been covered by Kansas in 2 consecutive games on the road.

Iowa State -3.5 Probability

The best sportsbooks make it a 52.4% chance that our pick is settled as a winner. Our cappers think there’s a stronger chance of success and calculate the probability to be 55-60%. This is why we regard this as a value bet.

Selling points can be a fantastic option and allows bettors to enjoy a bigger return on the same selection. For a more conservative spread pick, you can alternatively buy points.

Get more from your bets with our detailed guide, featuring the best free bets and generous welcome bonuses.

Our Game Prediction

Iowa State -3.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Rocco Becht Over 236.5 Passing Yards -114

You can back Rocco Becht (Iowa State) at -114 to top 236.5 passing yards. With confidence, we can back him to cover the generous QB Passing Yards line, as all the signs point to him reaching the expected total.

Latest Rocco Becht Player Prop Odds

Passing Yards

Over 236.5

-114

Under 236.5

-114

Rushing Yards

Over 14.5

-114

Under 14.5

-114

Correct Score Prediction

Kansas 21 - 30 Iowa State

There’s the chance to back the Cyclones in lots of different ways and this includes predicting the correct winning score. We’ll go for a 30-21 triumph in their favor.

Kansas vs Iowa State Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

With the sportsbooks giving them a 64% probability of winning this college game, Iowa State might be a popular parlay pick. That is reflected in their -175 Moneyline betting odds. If you’re looking for an alternative angle, Kansas are trading at +148.

The spread is calculated to be 3.5, while total points comes in at 55.5. The Totals offers football bettors an alternative way of getting involved. If you fancy Under 55.5, then the odds are -110.

There are a wide range of game lines and team props when it comes to most college football matchups and we recommend visiting the best betting apps to find the wager that matches your view on the game.

Moneyline

Kansas

+148

Iowa State

-175

Point Spread

Kansas +3.5

-110

Iowa State -3.5

-110

Total Points

Under 55.5

-110

Over 55.5

-110

Receiving Yards

Emmanuel Henderson Jr. (Kansas)

Over 49.5

-114

Under 49.5

-114

Chase Sowell (Iowa State)

Over 46.5

-114

Under 46.5

-114

Brett Eskildsen (Iowa State)

Over 36.5

-114

Under 36.5

-114

Cam Pickett (Kansas)

Over 34.5

-114

Under 34.5

-114

Boden Groen (Kansas)

Over 25.5

-114

Under 25.5

-114

Rushing Yards

Carson Hansen (Iowa State)

Over 103.5

-114

Under 103.5

-114

Jalon Daniels (Kansas)

Over 37.5

-114

Under 37.5

-114

Rocco Becht (Iowa State)

Over 14.5

-114

Under 14.5

-114

Passing Yards

Rocco Becht (Iowa State)

Over 236.5

-114

Under 236.5

-114

Jalon Daniels (Kansas)

Over 198.5

-114

Under 198.5

-114

Iowa State Own Seven Wins From Last Ten at Home

Iowa State have seven wins and three losses in the last 10 home games, posting 32.20 points per contest while yielding 21.60.

Kansas have gone 2-8 across their last 10 games away from home, averaging 23.20 points scored and 30.50 points allowed.

Kansas beat Iowa State 28-21 when they last met at Jack Trice Stadium. Over the previous 3 head-to-head clashes at Jack Trice Stadium, Iowa State have collected two victories, while Kansas have one.

Last 10 Games		W-L	P	PF	PA	O55.5	U55.5
Iowa State Home Stats		7-3	53.80	32.20	21.60	4	6
Kansas Away Stats		2-8	53.70	23.20	30.50	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O55.5 = Games Over 55.5 Points
• U55.5 = Games Under 55.5 Points

Latest regular season and playoff games stats.

Kansas Jayhawks Stats

Iowa State Cyclones Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 55.40 pts in the previous 10 games
• Game Totals on the Road: An average of 53.70 pts in the previous 10 games on the road
• Over 55.5: Covered in 5 of the previous 10 games
• Over 55.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 30.20 pts and allowed 25.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 23.20 pts and allowed 30.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.60 pts in the previous 10 games
• Game Totals at Home: An average of 53.80 pts in the previous 10 home games
• Over 55.5: Covered in 3 of the previous 10 games
• Over 55.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 27.10 pts and allowed 21.50 pts in the last 10 games
• Team Totals at Home: Have scored an average of 32.20 pts and allowed 21.60 pts in the last 10 home games

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