Kentucky vs Vanderbilt Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: Kentucky vs Vanderbilt

Kentucky battle Vanderbilt at FirstBank Stadium, with kickoff scheduled for 15:30 on Saturday, November 22.

We are confident that Vanderbilt will cover the spread. -8.5 seems a more than generous line and you can get -110 that they will win by a bigger margin when playing Kentucky.

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Kentucky Wildcats claimed a home victory in their previous game. A 42-10 triumph against Tennessee Tech Golden Eagles at Kroger Field made it three straight wins.

Vanderbilt Commodores were winners last time out. Their 45-38 (OT) victory against Auburn Tigers at FirstBank Stadium was their sixth straight home triumph.

Head-to-Head Statistics

Vanderbilt won the most recent matchup between these teams. A 20-13 victory was registered against Kentucky at Kroger Field. The previous 6 H2H meetings have involved Kentucky winning four times.

Quarterbacks

Cutter Boley

201.5 Passing Yards

Over -114

Under -114

Diego Pavia

243.5 Passing Yards

Over -114

Under -114

Kentucky vs Vanderbilt Prediction & Picks

Be fully equipped for Kentucky vs Vanderbilt with our betting guide, offering a key match prediction, a correct score recommendation, top player prop picks and a bet builder tailored for value.

Game Prediction

It’s great to see Vanderbilt given a -8.5 line on the spread at -110 as we’re expecting a bigger margin of victory in this college football matchup.

The handicappers at Sportsgambler.com stay on top of the latest injuries, while recent form also shapes our CFB predictions. We combine this insight with up-to-date stats for sharper picks

Key Kentucky vs Vanderbilt stats:

• The +8.5 line hasn’t been covered by Kentucky in 4 of their last 5 games on the road.
• The +8.5 line hasn’t been covered by Kentucky in 2 of their last 3 games on the road this season.

Vandy -8.5 Probability

Based on the odds from the top sportsbooks, our pick has a 52.4% chance of winning. However, our analysts have this figure between 55-60% based on their in-depth research. The bet can be recommended for this precise reason.

There’s the chance to sell points and that means moving the line until you’re happy with your spread pick. It means a riskier bet but a bigger return on the odds available.

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Our Game Prediction

Vanderbilt -8.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Cutter Boley Under 201.5 Passing Yards -114

The odds for Cutter Boley (Kentucky) to finish with fewer than 201.5 passing yards are -114. He is likely to fall short of the line, making this QB Passing Yards bet an appealing option.

Latest Cutter Boley Player Prop Odds

Passing Yards

Over 201.5

-114

Under 201.5

-114

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Seth McGowan Under 58.5 Rushing Yards -114

You can place a bet on Seth McGowan (Kentucky) at -114 to end with fewer than 58.5 rushing yards. The line looks too high and we’re confident he’ll fall short of the Player Rushing Yards total.

Latest Seth McGowan Player Prop Odds

Rushing Yards

Over 58.5

-114

Under 58.5

-114

Correct Score Prediction

Kentucky 17 - 35 Vanderbilt

For those looking to get more bang for their buck, consider a correct score wager on the Commodores. Backing them to win 35-17 means you can land a potential monster return.

Kentucky vs Vanderbilt Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Vanderbilt are regarded as having a 78% chance of winning this college game according to the latest betting odds. The sportsbooks have priced them up at -345. For those wanting to back Kentucky, you will find +280 about the underdogs.

The spread is 8.5 and the total points line is currently 54.5. There is no denying the popularity of wagering on the Totals. Those who wager Under 54.5 can get -110.

The best betting apps offer a wide range of game lines and team props when it comes to most college football games. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Kentucky

+280

Vanderbilt

-345

Point Spread

Kentucky +8.5

-110

Vanderbilt -8.5

-110

Total Points

Under 54.5

-110

Over 54.5

-110

Receiving Yards

Eli Stowers (Vanderbilt)

Over 62.5

-114

Under 62.5

-114

Kendrick Law (Kentucky)

Over 53.5

-114

Under 53.5

-114

Junior Sherrill (Vanderbilt)

Over 46.5

-114

Under 46.5

-114

Rushing Yards

Seth McGowan (Kentucky)

Over 58.5

-114

Under 58.5

-114

Diego Pavia (Vanderbilt)

Over 52.5

-114

Under 52.5

-114

Sedrick Alexander (Vanderbilt)

Over 40.5

-114

Under 40.5

-114

Passing Yards

Diego Pavia (Vanderbilt)

Over 243.5

-114

Under 243.5

-114

Cutter Boley (Kentucky)

Over 201.5

-114

Under 201.5

-114

Vanderbilt Racking Up the Home Wins

Vanderbilt have reeled off six straight wins at FirstBank Stadium. They have seven wins and three losses in the last 10 home games, averaging 34.10 points scored and 23.60 points allowed.

Kentucky own a 4-6 mark in their past 10 road games, averaging 18.50 points on offense and surrendering 24.80 on defense.

Kentucky defeated Vanderbilt 45-28 the last time they played at FirstBank Stadium. Across 3 head-to-head meetings at FirstBank Stadium, Kentucky have come out on top each time.

Last 10 Games		W-L	P	PF	PA	O54.5	U54.5
Vanderbilt Home Stats		7-3	57.70	34.10	23.60	5	5
Kentucky Away Stats		4-6	43.30	18.50	24.80	2	8

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O54.5 = Games Over 54.5 Points
• U54.5 = Games Under 54.5 Points

Latest regular season and playoff games stats.

Kentucky Wildcats Stats

Vanderbilt Commodores Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +8.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +8.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -8.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -8.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 49.00 pts in the previous 10 games
• Game Totals on the Road: An average of 43.30 pts in the previous 10 games on the road
• Over 54.5: Covered in 2 of the previous 10 games
• Over 54.5 on the Road: Covered in 2 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.90 pts and allowed 23.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 18.50 pts and allowed 24.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 60.50 pts in the previous 10 games
• Game Totals at Home: An average of 60.10 pts in the previous 10 home games
• Over 54.5: Covered in 6 of the previous 10 games
• Over 54.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 38.30 pts and allowed 22.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 35.20 pts and allowed 24.90 pts in the last 10 home games

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