Louisville vs SMU Prediction, Picks & Odds | 22 Nov 2025
College Football Betting Preview: Louisville vs SMU
Louisville square off against SMU at Gerald J. Ford Stadium, with kickoff scheduled for 12:00 on Saturday, November 22.
It’s time to side with SMU to record a victory over Louisville. They should have the upper hand and the -135 for our Moneyline prediction looks a good price.
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Louisville Cardinals have won three straight road games. Most recently, they lost 20-19 at home to Clemson Tigers at L&N Federal Credit Union Stadium.
SMU Mustangs have won three straight home games. In their last appearance, they won on the road, beating Boston College Eagles 45-13 at Alumni Stadium.
Head-to-Head Statistics
It was SMU who came out on top when they last played Louisville. At L&N Federal Credit Union Stadium, a 34-27 win was recorded.
Quarterbacks
Miller Moss
Kevin Jennings
Louisville vs SMU Prediction & Picks
Step into Louisville vs SMU with confidence as we bring you our expert match prediction, projected scoreline, best player prop picks and a custom-built bet builder.
Game Prediction
There are lots of reasons to support the pick that SMU will win this college football showdown. Therefore, we’re heading to the Moneyline where you can get -135.
We track all injuries that could impact each team before making our CFB picks. The form guide and latest stats also help the Sportsgambler.com team crunch the numbers ahead of the action.
Key Louisville vs SMU stats:
SMU Moneyline Probability
The top betting apps make it a 57.5% chance that our pick is settled as a winner. Taking all factors into consideration, our experts think there’s a stronger chance of success and have a probability interval between 60-65%. The wager can be recommended for this precise reason.
It’s worth considering all the options. If you’re looking for tastier odds about SMU to win and a certain number of points to be scored, then the Result & Total lines could be a good way forward.
Get more from your bets with our detailed guide, featuring the best free bets and generous welcome bonuses.
Player Prop Picks
Kevin Jennings (SMU) can be backed at -114 to exceed 270.5 passing yards. There’s an opportunity to place a QB Passing Yards bet, with him capable of covering an appealing line.
Chris Bell (Louisville) is priced at -114 to accumulate over 75.5 receiving yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this Player Receiving Yards pick.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Get in the game with this same game parlay. Our selections are SMU on the moneyline, Over 51.5 on the total and Kevin Jennings (SMU) to have Over 270.5 passing yards.
A same game parlay is an awesome way of cheering on different outcomes within the same football game. You can predict a number of outcomes and get bigger odds than a single wager. The odds can combine to great effect.
Correct Score Prediction
27
-
30
SMU
the Mustangs are available at massive odds to register a 30-27 victory and they might have the edge. This should be a close matchup and there won’t be much between the teams.
Louisville vs SMU Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
There are betting odds of -189 that SMU land victory, with Louisville alternatively at +158. This means the top sportsbooks give the visitors a 39% chance of winning.
The current spread is 4.5 and the total points line is 48.5. A Total bet relates to the number of points that will be scored overall. If you’re going for Under 48.5, this outcome can be backed at -105.
If you’re wagering on college football, we recommend heading to the best betting sites and scanning through the huge selection of team props and game lines. There’s the opportunity to bet pre-game and in-game.
T.J. Harden is the market leader to be First TD Scorer at +600. Alternatively, there’s the opportunity to back him to register a touchdown at any stage at -100.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
You don’t have to wait for the final outcome when it comes to college football micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.
Can SMU Keep Rolling at Home?
SMU have run off three consecutive wins at Gerald J. Ford Stadium. They have gone 9-1 across their last 10 home games, posting 41.00 points per contest while yielding 22.60.
Louisville have built a run of five consecutive road wins. They have eight wins and two losses in the last 10 road games, scoring 30.90 points per matchup and conceding 24.90.
| Last 10 Games | W-L | P | PF | PA | O51.5 | U51.5 | |
|---|---|---|---|---|---|---|---|
 SMU Home Stats |
9-1 | 63.60 | 41.00 | 22.60 | 6 | 4 | |
 Louisville Away Stats |
8-2 | 55.80 | 30.90 | 24.90 | 7 | 3 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O51.5 = Games Over 51.5 Points
- U51.5 = Games Under 51.5 Points
Latest regular season and playoff games stats.
Louisville Cardinals Stats
SMU Stats
- 7 wins and 3 defeats in the last 10 games
- 8 wins and 2 defeats in the last 10 games on the road
- +2.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +2.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road
- -2.5 Betting Line: Have covered the spread in 7 of the last 10 games
- -2.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games
- Game Totals: An average of 53.00 pts in the previous 10 games
- Game Totals on the Road: An average of 55.80 pts in the previous 10 games on the road
- Over 51.5: Covered in 6 of the previous 10 games
- Over 51.5 on the Road: Covered in 7 of the previous 10 games on the road
- Team Totals: Have scored an average of 31.50 pts and allowed 21.50 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 30.90 pts and allowed 24.90 pts in the last 10 games on the road
- Game Totals: An average of 52.60 pts in the previous 10 games
- Game Totals at Home: An average of 59.30 pts in the previous 10 home games
- Over 51.5: Covered in 5 of the previous 10 games
- Over 51.5 at Home: Covered in 6 of the previous 10 home games
- Team Totals: Have scored an average of 32.20 pts and allowed 20.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 37.50 pts and allowed 21.80 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Virginia
|
10 | 3 | 418 | 267 | 151 | 6-2 | 4-1 | 1L |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
|
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
|
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
Duke
|
8 | 5 | 442 | 373 | 69 | 3-3 | 5-2 | 3W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
Belmont
UIC
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