Louisville vs SMU Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: Louisville vs SMU

Louisville square off against SMU at Gerald J. Ford Stadium, with kickoff scheduled for 12:00 on Saturday, November 22.

It’s time to side with SMU to record a victory over Louisville. They should have the upper hand and the -135 for our Moneyline prediction looks a good price.

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Louisville Cardinals have won three straight road games. Most recently, they lost 20-19 at home to Clemson Tigers at L&N Federal Credit Union Stadium.

SMU Mustangs have won three straight home games. In their last appearance, they won on the road, beating Boston College Eagles 45-13 at Alumni Stadium.

Head-to-Head Statistics

It was SMU who came out on top when they last played Louisville. At L&N Federal Credit Union Stadium, a 34-27 win was recorded.

Quarterbacks

Miller Moss

226.5 Passing Yards

Over -114

Under -114

Kevin Jennings

270.5 Passing Yards

Over -114

Under -114

Louisville vs SMU Prediction & Picks

Step into Louisville vs SMU with confidence as we bring you our expert match prediction, projected scoreline, best player prop picks and a custom-built bet builder.

Game Prediction

There are lots of reasons to support the pick that SMU will win this college football showdown. Therefore, we’re heading to the Moneyline where you can get -135.

We track all injuries that could impact each team before making our CFB picks. The form guide and latest stats also help the Sportsgambler.com team crunch the numbers ahead of the action.

Key Louisville vs SMU stats:

• SMU have won 17 of their last 20 games at home.
• SMU have won 8 of their last 10 games at home.
• SMU have won 3 consecutive games at home.
• Louisville have lost their last 2 games.

SMU Moneyline Probability

The top betting apps make it a 57.5% chance that our pick is settled as a winner. Taking all factors into consideration, our experts think there’s a stronger chance of success and have a probability interval between 60-65%. The wager can be recommended for this precise reason.

It’s worth considering all the options. If you’re looking for tastier odds about SMU to win and a certain number of points to be scored, then the Result & Total lines could be a good way forward.

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Our Game Prediction

SMU Moneyline @ -135 Bet Now

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Player Prop Picks

Top Pick: Kevin Jennings Over 270.5 Passing Yards -114

Kevin Jennings (SMU) can be backed at -114 to exceed 270.5 passing yards. There’s an opportunity to place a QB Passing Yards bet, with him capable of covering an appealing line.

Latest Kevin Jennings Player Prop Odds

Passing Yards

Over 270.5

-114

Under 270.5

-114

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Chris Bell Over 75.5 Receiving Yards -114

Chris Bell (Louisville) is priced at -114 to accumulate over 75.5 receiving yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this Player Receiving Yards pick.

Latest Chris Bell Player Prop Odds

Receiving Yards

Over 75.5

-114

Under 75.5

-114

Correct Score Prediction

Louisville 27 - 30 SMU

the Mustangs are available at massive odds to register a 30-27 victory and they might have the edge. This should be a close matchup and there won’t be much between the teams.

Louisville vs SMU Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

There are betting odds of -135 that SMU land victory, with Louisville alternatively at +116. This means the top sportsbooks give the visitors a 46% chance of winning.

The current spread is 2.5 and the total points line is 51.5. A Total bet relates to the number of points that will be scored overall. If you’re going for Under 51.5, this outcome can be backed at -110.

If you’re wagering on college football, we recommend heading to the best betting sites and scanning through the huge selection of team props and game lines. There’s the opportunity to bet pre-game and in-game.

Moneyline

Louisville

+116

SMU

-135

Point Spread

Louisville +2.5

-105

SMU -2.5

-115

Total Points

Under 51.5

-110

Over 51.5

-110

Receiving Yards

Jordan Hudson (SMU)

Over 76.5

-114

Under 76.5

-114

Chris Bell (Louisville)

Over 75.5

-114

Under 75.5

-114

Caullin Lacy (Louisville)

Over 51.5

-114

Under 51.5

-114

Romello Brinson (SMU)

Over 49.5

-114

Under 49.5

-114

Yamir Knight (SMU)

Over 41.5

-114

Under 41.5

-114

Rushing Yards

Keyjuan Brown (Louisville)

Over 88.5

-114

Under 88.5

-114

T.J. Harden (SMU)

Over 53.5

-114

Under 53.5

-114

Passing Yards

Kevin Jennings (SMU)

Over 270.5

-114

Under 270.5

-114

Miller Moss (Louisville)

Over 226.5

-114

Under 226.5

-114

Can SMU Keep Rolling at Home?

SMU have run off three consecutive wins at Gerald J. Ford Stadium. They have gone 9-1 across their last 10 home games, posting 41.00 points per contest while yielding 22.60.

Louisville have built a run of five consecutive road wins. They have eight wins and two losses in the last 10 road games, scoring 30.90 points per matchup and conceding 24.90.

Last 10 Games		W-L	P	PF	PA	O51.5	U51.5
SMU Home Stats		9-1	63.60	41.00	22.60	6	4
Louisville Away Stats		8-2	55.80	30.90	24.90	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O51.5 = Games Over 51.5 Points
• U51.5 = Games Under 51.5 Points

Latest regular season and playoff games stats.

Louisville Cardinals Stats

SMU Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 53.00 pts in the previous 10 games
• Game Totals on the Road: An average of 55.80 pts in the previous 10 games on the road
• Over 51.5: Covered in 6 of the previous 10 games
• Over 51.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 31.50 pts and allowed 21.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 30.90 pts and allowed 24.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 52.60 pts in the previous 10 games
• Game Totals at Home: An average of 59.30 pts in the previous 10 home games
• Over 51.5: Covered in 5 of the previous 10 games
• Over 51.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 32.20 pts and allowed 20.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 37.50 pts and allowed 21.80 pts in the last 10 home games

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