Louisville vs Virginia Tech Prediction, Picks & Odds | 01 Nov 2025
College Football Betting Preview: Louisville vs Virginia Tech
Louisville go up against Virginia Tech in this NCAAF matchup at Lane Stadium, with kickoff scheduled for 14:00 on Saturday, November 1. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
We’d be surprised if Louisville don’t exceed a -10.5 spread against Virginia Tech. That is why the wager has to be the favorites to cover the line at -112.
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Louisville Cardinals beat Boston College Eagles in their previous game, making it back-to-back victories. It was a 38-24 home win at L&N Federal Credit Union Stadium.
Virginia Tech Hokies last game saw them claim a 42-34 home win over Cal at Lane Stadium.
Head-to-Head Statistics
Louisville beat Virginia Tech in their last head-to-head matchup. It was a 34-3 scoreline at L&N Federal Credit Union Stadium.
Quarterbacks
Miller Moss
Kyron Drones
Louisville vs Virginia Tech Prediction & Picks
We’ve lined up expert Louisville vs Virginia Tech betting tips, from our match prediction and correct score call to player prop picks and best bet builder advice. Read on for the full breakdown.
Game Prediction
We’re sweet on the favorites who are -10.5 on the spread. Louisville should enjoy a huge win in this college football matchup and cover the line at -112.
Our team of college football handicappers track current injuries closely. Combined with recent form, this helps us identify the best value odds. A data-led approach backed by key stats and the latest team news keeps our analysis sharp.
Key Louisville vs Virginia Tech stats:
Louisville -10.5 Probability
Looking at the latest betting odds, our pick has a 52.9% chance of winning. In the opinion of our cappers, there’s actually a probability of success between 55-60%. This is why we regard this as a value bet.
If you’re hunting for bigger odds, then a Bet Builder could be the perfect way to go. Combine Louisville to cover the line with other picks until you’re happy with the overall price.
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Player Prop Picks
You can back Miller Moss (Louisville) at -114 to accumulate over 273.5 passing yards. He looks capable of covering the line and that leads us to taking this QB Passing Yards bet.
You can back Marcellous Hawkins (Virginia Tech) at -114 to exceed 57.5 rushing yards. We're confident in him covering the Player Rushing Yards line and hitting our Over bet.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Louisville -10.5 on the spread, combined with Over 53.5 and Miller Moss (Louisville) to have Over 273.5 passing yards.
A same game parlay allows bettors to place a multiple wager on the same football game. You can go through the available betting lines and cherry-pick the outcomes that you think will happen. The odds for each selection are then combined together.
Correct Score Prediction
38
-
21
Virginia Tech
There are stacks of correct score lines available and we’re looking at Louisville to achieve a winning scoreline of 38-21 where a massive potential return is on the cards.
Louisville vs Virginia Tech Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
The favorites are 82% likely to win according to the sportsbooks’ latest Money Line odds, with Louisville priced at -455 to triumph in this college game. If you’re looking for an alternative angle, Virginia Tech are trading at +350.
The spread is currently 10.5, with the total points line at 52.5. The Totals offers football bettors an alternative way of getting involved. There’s the chance to back Under 52.5 at -110.
College football bettors are spoilt for choice thanks to the huge selection of team props and game lines which are available for every matchup on the coupon. Head to the top sportsbooks and find the best value wagers.
Isaac Brown is the First Touchdown Scorer favorite at +320. Alternatively, there’s the opportunity to simply back him to score a TD anytime at -270.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
An increasing number of bettors are now enjoying micro betting on college football and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.
Virginia Tech Sitting on Five Wins in Previous Ten at Home
Virginia Tech own a 5-5 mark in their past 10 home games, averaging 28.60 points on offense and surrendering 25.30 on defense.
Louisville have put together four consecutive victories on the road. They have seven wins and three losses in the last 10 road games, putting up 30.90 points on average and giving up 27.50.
| Last 10 Games | W-L | P | PF | PA | O53.5 | U53.5 | |
|---|---|---|---|---|---|---|---|
 Virginia Tech Home Stats |
5-5 | 53.90 | 28.60 | 25.30 | 5 | 5 | |
 Louisville Away Stats |
7-3 | 58.40 | 30.90 | 27.50 | 8 | 2 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O53.5 = Games Over 53.5 Points
- U53.5 = Games Under 53.5 Points
Latest regular season and playoff games stats.
Louisville Cardinals Stats
Virginia Tech Stats
- 9 wins and 1 defeat in the last 10 games
- 7 wins and 3 defeats in the last 10 games on the road
- -10.5 Betting Line: Have covered the spread in 6 of the last 10 games
- -10.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road
- +10.5 Betting Line: Have covered the spread in 5 of the last 10 games
- +10.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 56.20 pts in the previous 10 games
- Game Totals on the Road: An average of 58.40 pts in the previous 10 games on the road
- Over 53.5: Covered in 7 of the previous 10 games
- Over 53.5 on the Road: Covered in 8 of the previous 10 games on the road
- Team Totals: Have scored an average of 35.50 pts and allowed 20.70 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 30.90 pts and allowed 27.50 pts in the last 10 games on the road
- Game Totals: An average of 53.00 pts in the previous 10 games
- Game Totals at Home: An average of 52.40 pts in the previous 10 home games
- Over 53.5: Covered in 5 of the previous 10 games
- Over 53.5 at Home: Covered in 5 of the previous 10 home games
- Team Totals: Have scored an average of 25.00 pts and allowed 28.00 pts in the last 10 games
- Team Totals at Home: Have scored an average of 27.30 pts and allowed 25.10 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Virginia
|
10 | 3 | 418 | 267 | 151 | 6-2 | 4-1 | 1L |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
|
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
Duke
|
8 | 5 | 442 | 373 | 69 | 3-3 | 5-2 | 3W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
|
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
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