Louisville vs Virginia Tech Prediction, Picks & Odds | 01 Nov 2025

College Football Betting Preview: Louisville vs Virginia Tech

Louisville go up against Virginia Tech in this NCAAF matchup at Lane Stadium, with kickoff scheduled for 15:00 on Saturday 1 November. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Louisville Expected to Win Big

We’d be surprised if Louisville don’t exceed a -10.5 spread against Virginia Tech. That is why the wager has to be the favorites to cover the line at -112.

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34-3 Win for Louisville in Last H2H Battle

Louisville Cardinals beat Boston College Eagles in their previous game, making it back-to-back victories. It was a 38-24 home win at L&N Federal Credit Union Stadium.

Virginia Tech Hokies last game saw them claim a 42-34 home win over Cal at Lane Stadium.

Head-to-Head Statistics

Louisville beat Virginia Tech in their last head-to-head matchup. It was a 34-3 scoreline at L&N Federal Credit Union Stadium.

Quarterbacks

Miller Moss

273.5 Passing Yards

Over -114

Under -114

Kyron Drones

175.5 Passing Yards

Over -114

Under -114

Louisville vs Virginia Tech Prediction & Picks

We’ve lined up expert Louisville vs Virginia Tech betting tips, from our match prediction and correct score call to player prop picks and best bet builder advice. Read on for the full breakdown.

Game Prediction

We’re sweet on the favorites who are -10.5 on the spread. Louisville should enjoy a huge win in this college football matchup and cover the line at -112.

Our team of college football handicappers track current injuries closely. Combined with recent form, this helps us identify the best value odds. A data-led approach backed by key stats and the latest team news keeps our analysis sharp.

Key Louisville vs Virginia Tech stats:

• The -10.5 line has been covered by Louisville in 6 of their last 10 games.
• The -10.5 line has been covered by Louisville in 4 of their last 7 games this season.

Louisville -10.5 Probability

Looking at the latest betting odds, our pick has a 52.9% chance of winning. In the opinion of our cappers, there’s actually a probability of success between 55-60%. This is why we regard this as a value bet.

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Best Bet

Louisville -10.5 @ -112 Bet Now

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Player Prop Picks

Top Pick: Miller Moss Over 273.5 Passing Yards -114

You can back Miller Moss (Louisville) at -114 to accumulate over 273.5 passing yards. He looks capable of covering the line and that leads us to taking this QB Passing Yards bet.

Latest Miller Moss Player Prop Odds

Passing Yards

Over 273.5

-114

Under 273.5

-114

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Marcellous Hawkins Over 57.5 Rushing Yards -114

You can back Marcellous Hawkins (Virginia Tech) at -114 to exceed 57.5 rushing yards. We're confident in him covering the Player Rushing Yards line and hitting our Over bet.

Latest Marcellous Hawkins Player Prop Odds

Rushing Yards

Over 57.5

-114

Under 57.5

-114

Correct Score Prediction

Louisville 38 - 21 Virginia Tech

There are stacks of correct score lines available and we’re looking at Louisville to achieve a winning scoreline of 38-21 where a massive potential return is on the cards.

Louisville vs Virginia Tech Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Louisville Win on the Cards According to the Books

The favorites are 81% likely to win according to the sportsbooks’ latest Money Line odds, with Louisville priced at -417 to triumph in this college game. If you’re looking for an alternative angle, Virginia Tech are trading at +330.

The spread is currently 10.5, with the total points line at 53.5. The Totals offers football bettors an alternative way of getting involved. There’s the chance to back Under 53.5 at -110.

College football bettors are spoilt for choice thanks to the huge selection of team props and game lines which are available for every matchup on the coupon. Head to the top sportsbooks and find the best value wagers.

Moneyline

Louisville

-417

Virginia Tech

+330

Point Spread

Louisville -10.5

-112

Virginia Tech +10.5

-108

Total Points

Under 53.5

-110

Over 53.5

-110

Player Odds

Receiving Yards

Chris Bell (Louisville)

Over 91.5

-114

Under 91.5

-114

Caullin Lacy (Louisville)

Over 46.5

-114

Under 46.5

-114

Takye Heath (Virginia Tech)

Over 41.5

-114

Under 41.5

-114

Ayden Greene (Virginia Tech)

Over 32.5

-114

Under 32.5

-114

Rushing Yards

Isaac Brown (Louisville)

Over 88.5

-114

Under 88.5

-114

Marcellous Hawkins (Virginia Tech)

Over 57.5

-114

Under 57.5

-114

Kyron Drones (Virginia Tech)

Over 47.5

-114

Under 47.5

-114

Passing Yards

Miller Moss (Louisville)

Over 273.5

-114

Under 273.5

-114

Kyron Drones (Virginia Tech)

Over 175.5

-114

Under 175.5

-114

Virginia Tech Sitting on Five Wins in Previous Ten at Home

Virginia Tech own a 5-5 mark in their past 10 home games, averaging 28.60 points on offense and surrendering 25.30 on defense.

Louisville have put together four consecutive victories on the road. They have seven wins and three losses in the last 10 road games, putting up 30.90 points on average and giving up 27.50.

Last 10 Games		W-L	P	PF	PA	O53.5	U53.5
Virginia Tech Home Stats		5-5	53.90	28.60	25.30	5	5
Louisville Away Stats		7-3	58.40	30.90	27.50	8	2

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O53.5 = Games Over 53.5 Points
• U53.5 = Games Under 53.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Louisville Cardinals Stats

Virginia Tech Stats

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -10.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -10.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road

Point Spread

• +10.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +10.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 56.20 pts in the previous 10 games
• Game Totals on the Road: An average of 58.40 pts in the previous 10 games on the road
• Over 53.5: Covered in 7 of the previous 10 games
• Over 53.5 on the Road: Covered in 8 of the previous 10 games on the road
• Team Totals: Have scored an average of 35.50 pts and allowed 20.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 30.90 pts and allowed 27.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 53.00 pts in the previous 10 games
• Game Totals at Home: An average of 52.40 pts in the previous 10 home games
• Over 53.5: Covered in 5 of the previous 10 games
• Over 53.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 25.00 pts and allowed 28.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 27.30 pts and allowed 25.10 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Georgia Tech	8	0	288	160	128	5-0	3-0	8W
Virginia	7	1	297	179	118	5-0	2-1	6W
Louisville	6	1	242	150	92	4-1	2-0	2W
Miami	6	1	238	99	139	5-1	1-0	1W
Pittsburgh	6	2	322	176	146	4-1	2-1	4W
Wake Forest	5	2	187	132	55	3-2	2-0	3W
California	5	3	200	195	5	3-1	2-2	1L
SMU	5	3	251	171	80	3-1	2-2	1L
Duke	4	3	237	180	57	2-2	2-1	1L
NC State	4	4	244	239	5	3-1	1-3	2L
Clemson	3	4	182	146	36	1-3	2-1	1L
Florida State	3	4	278	158	120	3-2	0-2	4L
Stanford	3	5	140	236	-96	3-0	0-5	1L
Syracuse	3	5	203	250	-47	2-2	1-3	4L
Virginia Tech	3	5	203	239	-36	2-3	1-2	1W
North Carolina	2	5	128	167	-39	1-3	1-2	4L
Boston College	1	7	214	275	-61	1-3	0-4	7L