LSU vs Ole Miss Prediction, Picks & Odds | 27 Sep 2025
College Football Betting Preview: LSU vs Ole Miss
LSU battle Ole Miss in this NCAAF Week 5 matchup at Vaught-Hemingway Stadium, with kickoff scheduled for 15:30 on Saturday 27 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
Let’s Gamble on Ole Miss
The best bet could be taking Ole Miss to simply achieve a victory over LSU. Our prediction can be taken at -118 on the Moneyline which yields a potentially nice return.
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Overtime Win for LSU in Last H2H
LSU Tigers have won their previous four games. The latest was a 56-10 home triumph at Tiger Stadium against SE Louisiana.
Ole Miss were winners for the fourth straight time in their last game. Landing a 45-10 home victory against Tulane Green Wave at Vaught-Hemingway Stadium.
Head-to-Head Statistics
LSU won the last matchup between the pair. Enjoying a 29-26 (OT) triumph when facing Ole Miss at Tiger Stadium. The past 6 H2H games have seen LSU land four wins.
Quarterbacks
Garrett Nussmeier
Trinidad Chambliss
LSU vs Ole Miss Prediction & Picks
Prepare for LSU vs Ole Miss with our expert betting guide featuring a trusted match prediction, likely scoreline, key player props and a well-crafted bet builder.
Game Prediction
The visiting team look opposable on the Moneyline, so we’re going to make Ole Miss our pick for this college football showdown. You can currently get -118 for this selection which looks value.
We put solid research behind every CFB pick, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.
Key LSU vs Ole Miss stats:
Ole Miss Moneyline Probability
The top sportsbooks imply that our pick has a 54.1% prospect of winning. In the opinion of our cappers, there’s actually a probability of success closer to 60%. This college wager can therefore be backed with confidence.
Ole Miss can be backed in many different ways and you might find the odds more attractive when you check out the Spread or the Result & Total lines.
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Best Bet
Ole Miss Moneyline @ -118
Player Prop Picks
You can back Trinidad Chambliss (Ole Miss) at -114 to exceed 260.5 passing yards. We can place a QB Passing Yards bet with confidence, as we expect him to cover the line.
Same Game Parlay Picks
Back a same game parlay featuring Ole Miss on the moneyline combined with Under 56.5 points. We’ve also gone for Trinidad Chambliss (Ole Miss) to go Over 260.5 passing yards.
The same game parlay option is fantastic for football bettors wanting a personalised multi-leg wager on the same game. It’s especially good if you have a strong opinion on the likely outcomes and the odds for each selection are combined.
Correct Score Prediction
20
-
27
Ole Miss
If you want to achieve a big return from your stake, then it’s worth checking out the correct score lines. the Rebels to achieve a 27-20 victory is on offer at massive odds.
LSU vs Ole Miss Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Books Anticipating a Close Contest
Ole Miss are available at Moneyline odds of -122, while opponents LSU can be backed at +102. There is a 55% chance of the hosts winning according to the top sportsbooks.
The spread is currently 1.5, with the total points line at 56.5. There are many ways to wager on football including the Totals. If you fancy Under 56.5, then the odds are -105.
If you’re getting ready to place a college football bet, head over to one of the top betting apps and explore the wide variety of game lines and team props. Take your time to spot the most appealing opportunities.
Kewan Lacy Favorite to Be First Touchdown Scorer
Kewan Lacy is available at -200 when it comes to Anytime Touchdown Scorer. The favorite is now priced at odds of +420 to score the first TD.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Ole Miss Keep Delivering at Home
Ole Miss have put together six consecutive victories at Vaught-Hemingway Stadium. They have gone 9-1 across their last 10 home games, scoring 42.60 points per contest and conceding 12.60.
LSU have gone 5-5 across their last 10 games games on the road, scoring 31.70 points per contest and conceding 31.30.
Ole Miss defeated LSU 55-49 in their last meeting at Vaught-Hemingway Stadium. Looking back at the past 3 head-to-head meetings at Vaught-Hemingway Stadium, Ole Miss have posted two victories, with LSU earning one.
| Last 10 Games | W-L | P | PF | PA | O56.5 | U56.5 | |
|---|---|---|---|---|---|---|---|
 Ole Miss Home Stats |
9-1 | 55.20 | 42.60 | 12.60 | 4 | 6 | |
 LSU Away Stats |
5-5 | 63.00 | 31.70 | 31.30 | 6 | 4 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O56.5 = Games Over 56.5 Points
- U56.5 = Games Under 56.5 Points
Last 5 & H2H
Latest regular season and playoff games stats.
LSU Tigers Stats
Ole Miss Stats
- 7 wins and 3 defeats in the last 10 games
- 5 wins and 5 defeats in the last 10 games on the road
- +1.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +1.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road
- -1.5 Betting Line: Have covered the spread in 9 of the last 10 games
- -1.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games
- Game Totals: An average of 48.20 pts in the previous 10 games
- Game Totals on the Road: An average of 63.00 pts in the previous 10 games on the road
- Over 56.5: Covered in 3 of the previous 10 games
- Over 56.5 on the Road: Covered in 6 of the previous 10 games on the road
- Team Totals: Have scored an average of 27.30 pts and allowed 20.90 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 31.70 pts and allowed 31.30 pts in the last 10 games on the road
- Game Totals: An average of 57.90 pts in the previous 10 games
- Game Totals at Home: An average of 54.80 pts in the previous 10 home games
- Over 56.5: Covered in 4 of the previous 10 games
- Over 56.5 at Home: Covered in 4 of the previous 10 home games
- Team Totals: Have scored an average of 39.10 pts and allowed 18.80 pts in the last 10 games
- Team Totals at Home: Have scored an average of 40.20 pts and allowed 14.60 pts in the last 10 home games
NCAAF Standings Select Season
| Southeastern | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Georgia
|
3 | 0 | 117 | 54 | 63 | 2-0 | 1-0 | 3W |
|
LSU
|
4 | 0 | 116 | 37 | 79 | 3-0 | 1-0 | 4W |
Mississippi State
|
4 | 0 | 159 | 47 | 112 | 3-0 | 1-0 | 4W |
Missouri
|
4 | 0 | 184 | 67 | 117 | 4-0 | 0-0 | 4W |
Oklahoma
|
4 | 0 | 125 | 36 | 89 | 3-0 | 1-0 | 4W |
|
Ole Miss
|
4 | 0 | 179 | 75 | 104 | 3-0 | 1-0 | 4W |
Texas A&M
|
3 | 0 | 127 | 86 | 41 | 2-0 | 1-0 | 3W |
Vanderbilt
|
4 | 0 | 190 | 51 | 139 | 2-0 | 2-0 | 4W |
Auburn
|
3 | 1 | 128 | 66 | 62 | 2-0 | 1-1 | 1L |
Tennessee
|
3 | 1 | 214 | 111 | 103 | 3-1 | 0-0 | 1W |
Texas
|
3 | 1 | 127 | 31 | 96 | 3-0 | 0-1 | 3W |
Alabama
|
2 | 1 | 128 | 45 | 83 | 2-0 | 0-1 | 2W |
Kentucky
|
2 | 1 | 95 | 69 | 26 | 2-1 | 0-0 | 1W |
Arkansas
|
2 | 2 | 174 | 94 | 80 | 2-0 | 0-2 | 2L |
South Carolina
|
2 | 2 | 89 | 81 | 8 | 2-1 | 0-1 | 2L |
Florida
|
1 | 3 | 88 | 64 | 24 | 1-1 | 0-2 | 3L |
Florida State
Virginia
Betting Tips
21:00 - Fri 26 Sep
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22:30 - Fri 26 Sep
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12:00 - Sat 27 Sep
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13:30 - Sat 27 Sep
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