Massachusetts vs Missouri Prediction, Picks & Odds | 27 Sep 2025

College Football Betting Preview: Massachusetts vs Missouri

Massachusetts lock horns with Missouri in this NCAAF Week 5 matchup at Faurot Field, with kickoff scheduled for 19:30 on Saturday 27 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

We Could See Lots of Points Scored

We think that 55.5 is a more than generous total for Over backers when Missouri meet Massachusetts. Take the -105 that we see the teams combine to good effect.

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Teams’ Last Matchup Saw 45-3 Mizzou Win

Massachusetts Minutemen were beaten in their previous three games and the latest was on the road at Kinnick Stadium. Iowa Hawkeyes claimed a 47-7 win.

Missouri Tigers won their last game 29-20, making it four victories on the bounce. This was a home win at Faurot Field against South Carolina Gamecocks.

Head-to-Head Statistics

Missouri had the edge in the most recent matchup between these teams. At Warren McGuirk Alumni Stadium, they recorded a 45-3 win over Massachusetts.

Massachusetts vs Missouri Prediction & Picks

Step into Massachusetts vs Missouri with confidence, armed with our expert match prediction, likely scoreline and a custom-built bet builder for maximum value.

Game Prediction

The total line looks to be on the low side at 55.5. There’s a strong chance that these college football rivals will conspire to go above the line and we’re backing Over at -105.

Our team of college football handicappers track current injuries closely. Combined with recent form, this helps us identify the best value odds. A data-led approach backed by key stats and the latest team news keeps our analysis sharp.

Key Massachusetts vs Missouri stats:

• The 55.5 line has been covered in 3 of the last 4 Missouri games this season.
• The 55.5 line has been covered in 3 of the last 5 Missouri games.

Over 55.5 Probability

Looking at the latest betting odds, our pick has a 51.3% chance of winning. After careful examination, our cappers calculate this probability to be somewhere between 55-60%. It's therefore regarded as a value wager.

If you want to go Over on the Totals at tastier odds, then you can combine this selection with other picks in a Bet Builder until you’re happy with the potential return.

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Best Bet

Over 55.5 Points @ -105 Bet Now

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Correct Score Prediction

Massachusetts 13 - 52 Missouri

If you want to achieve a big return from your stake, then it’s worth checking out the correct score lines. the Tigers to achieve a 52-13 victory is on offer at massive odds.

Massachusetts vs Missouri Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Not Expecting a Competitive Game

The Moneyline betting odds might not be available with some sportsbooks as there’s a big underdog in the form of Massachusetts. However, the Spread can provide some great alternative wagering options.

The spread is calculated to be 44.5, while total points comes in at 55.5. Having a bet on the Totals is one of the most popular football wagers. If you're keen on Over 55.5, this selection is available at -115.

The best betting apps offer a wide range of game lines and team props when it comes to most college football games. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Massachusetts

-

Missouri

-

Point Spread

Massachusetts +44.5

-110

Missouri -44.5

-110

Total Points

Under 55.5

-105

Over 55.5

-115

Player Props & Micro Betting

Should you be more interested in a specific individual who is competing, check out the gambling sites’ prop bets where you can pick out player and quarterback lines that focus on performance rather than the game result.

You don’t have to wait for the final outcome when it comes to college football micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.

Missouri Building a Fortress at Home

Missouri have ten wins and zero loss in the last 10 home games, averaging 35.80 points on offense and surrendering 17.60 on defense.

Massachusetts have been beaten eight consecutive times away from home. They have one win and nine losses in the last 10 games away from home, posting 16.00 points per contest while yielding 40.60.

Last 10 Games		W-L	P	PF	PA	O55.5	U55.5
Missouri Home Stats		10-0	53.40	35.80	17.60	4	6
Massachusetts Away Stats		1-9	56.60	16.00	40.60	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O55.5 = Games Over 55.5 Points
• U55.5 = Games Under 55.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Massachusetts Minutemen Stats

Missouri Tigers Stats

Moneyline

• 1 win and 9 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 10 wins and 0 defeats in the last 10 home games

Point Spread

• +44.5 Betting Line: Have covered the spread in the last 10 games
• +44.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -44.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -44.5 Betting Line at Home: Have covered the spread in 1 of the last 10 home games

Total Points

• Game Totals: An average of 60.60 pts in the previous 10 games
• Game Totals on the Road: An average of 56.60 pts in the previous 10 games on the road
• Over 55.5: Covered in 4 of the previous 10 games
• Over 55.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 21.80 pts and allowed 38.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 16.00 pts and allowed 40.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 56.10 pts in the previous 10 games
• Game Totals at Home: An average of 54.70 pts in the previous 10 home games
• Over 55.5: Covered in 5 of the previous 10 games
• Over 55.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 33.80 pts and allowed 22.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 34.70 pts and allowed 20.00 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Southeastern	W	L	PF	PA	N. Pts	Home	Away	Strk
Georgia	3	0	117	54	63	2-0	1-0	3W
LSU	4	0	116	37	79	3-0	1-0	4W
Mississippi State	4	0	159	47	112	3-0	1-0	4W
Missouri	4	0	184	67	117	4-0	0-0	4W
Oklahoma	4	0	125	36	89	3-0	1-0	4W
Ole Miss	4	0	179	75	104	3-0	1-0	4W
Texas A&M	3	0	127	86	41	2-0	1-0	3W
Vanderbilt	4	0	190	51	139	2-0	2-0	4W
Auburn	3	1	128	66	62	2-0	1-1	1L
Tennessee	3	1	214	111	103	3-1	0-0	1W
Texas	3	1	127	31	96	3-0	0-1	3W
Alabama	2	1	128	45	83	2-0	0-1	2W
Kentucky	2	1	95	69	26	2-1	0-0	1W
Arkansas	2	2	174	94	80	2-0	0-2	2L
South Carolina	2	2	89	81	8	2-1	0-1	2L
Florida	1	3	88	64	24	1-1	0-2	3L

Mid-American	W	L	PF	PA	N. Pts	Home	Away	Strk
Bowling Green	2	2	86	94	-8	2-0	0-2	1L
Buffalo	2	2	103	78	25	1-1	1-1	1L
Central Michigan	2	2	85	132	-47	1-0	1-2	1W
Ohio	2	2	109	116	-7	2-0	0-2	1W
Toledo	2	2	134	59	75	2-0	0-2	1L
Northern Illinois	1	2	38	75	-37	1-0	0-2	2L
Akron	1	3	79	116	-37	1-1	0-2	1W
Ball State	1	3	62	133	-71	1-0	0-3	1L
Eastern Michigan	1	3	107	159	-52	1-1	0-2	1W
Kent State	1	3	73	176	-103	1-1	0-2	3L
Western Michigan	1	3	50	107	-57	1-1	0-2	1W
Massachusetts	0	3	43	116	-73	0-2	0-1	3L
Miami (OH)	0	3	55	103	-48	0-1	0-2	3L