Michigan State vs Indiana Prediction, Picks & Odds | 18 Oct 2025
College Football Betting Preview: Michigan State vs Indiana
Michigan State lock horns with Indiana in this NCAAF Week 8 matchup at Memorial Stadium, with kickoff scheduled for 15:30 on Saturday 18 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
Roll the Dice on Teams Scoring Over 52.5
Over 52.5 points are expected to be scored when Indiana and Michigan State meet, with this prediction available at odds of -115 and this looks like a value bet.
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47-10 Win for Indiana in Pair’s Previous Clash
Michigan State Spartans have been defeated in three straight games. They were recently beaten at home to UCLA Bruins by a 38-13 scoreline at Spartan Stadium.
Indiana Hoosiers won their last game 30-20, making it six on the bounce. This was a road victory at Autzen Stadium against Oregon Ducks.
Head-to-Head Statistics
Indiana won the last matchup between the pair. Enjoying a 47-10 triumph when facing Michigan State at Spartan Stadium. Each team has landed three wins in the previous 6 games between these teams.
Michigan State vs Indiana Prediction & Picks
Get ready for Michigan State vs Indiana with all the betting angles covered, from an expert match prediction and correct score advice to player props and a custom bet builder.
Game Prediction
We’re confident that Over 52.5 is the value play at -115. We’re expecting these college football teams to rack up the points, so a total wager could be the way forward.
The CFB handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.
Key Michigan State vs Indiana stats:
Over 52.5 Probability
If you go by the top betting apps, there’s a 53.5% chance that our pick is settled as a winner. However, our research has found that the actual probability is closer to 60%. That means we’re regarding it as a value bet.
Want more juice from your Over wager on the Totals? Bigger odds can be found if you move the line and go for a riskier bet. You can choose from a range of options.
Ready to boost your bet? Explore a huge selection of welcome bonuses in our regularly updated betting offers guide.
Best Bet
Over 52.5 Points @ -115
Player Prop Picks
The odds for Fernando Mendoza (Indiana) to go over 270.5 passing yards are -114. We feel confident that he’ll cover the QB Passing Yards line, which looks generous.
You can back Nick Marsh (Indiana) at -114 to rack up over 50.5 receiving yards. The line for him on the Overs looks attractive and bettors can get plenty of juice from this Player Receiving Yards wager.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Over 52.5, along with Indiana -27.5 on the spread and Fernando Mendoza (Indiana) to go Over 270.5 passing yards.
A football same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big return from a small stake.
Correct Score Prediction
10
-
45
Indiana
There’s a massive payout on the cards should you correctly predict the correct score. We’re siding with the Hoosiers to enjoy a 45-10 victory which will hopefully go close.
Michigan State vs Indiana Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Books Have Indiana as Heavy Favorites
At betting odds of -5000 with the sportsbooks, Indiana are regarded as 98% likely to win this college game. If you’re looking for an alternative angle, Michigan State are trading at +1600.
The spread is currently 26.5, with the total points line at 49.5. Football fans love the chance to get an alternative angle by going for a Total wager. If you fancy Over 49.5, this outcome can be backed at -110.
The top sportsbooks cover every college football matchup with a great mix of game lines and team props. Whether you prefer to bet before kickoff or during the action, make sure to explore all available options.
Elijah Sarratt Favorite to Score First TD
Elijah Sarratt is favorite to be First Touchdown Scorer at +290. If you want to back him to score the last TD, you can get similar odds.
Touchdown
Receiving Yards
Rushing Yards
Micro Betting
There are lots of exciting college football micro betting lines that are created and they are available in-game. Among them are whether a field goal will be scored and you simply bet whether the player will make it or miss.
Indiana Locked In at Home
Indiana have ten wins and zero loss in the last 10 home games, averaging 48.60 points on offense and surrendering 11.40 on defense.
Michigan State have dropped six consecutive away games. They have two wins and eight losses in the last 10 games away from home, posting 18.60 points per contest while yielding 30.90.
In their last matchup at Memorial Stadium, Michigan State came out on top 24-21 against Indiana.
| Last 10 Games | W-L | P | PF | PA | O52.5 | U52.5 | |
|---|---|---|---|---|---|---|---|
 Indiana Home Stats |
10-0 | 60.00 | 48.60 | 11.40 | 7 | 3 | |
 Michigan State Away Stats |
2-8 | 49.50 | 18.60 | 30.90 | 3 | 7 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O52.5 = Games Over 52.5 Points
- U52.5 = Games Under 52.5 Points
Last 5 & H2H
Latest regular season and playoff games stats.
Michigan State Spartans Stats
Indiana Hoosiers Stats
- 4 wins and 6 defeats in the last 10 games
- 2 wins and 8 defeats in the last 10 games on the road
- +27.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +27.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road
- -27.5 Betting Line: Have covered the spread in 4 of the last 10 games
- -27.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games
- Game Totals: An average of 57.50 pts in the previous 10 games
- Game Totals on the Road: An average of 49.50 pts in the previous 10 games on the road
- Over 52.5: Covered in 7 of the previous 10 games
- Over 52.5 on the Road: Covered in 3 of the previous 10 games on the road
- Team Totals: Have scored an average of 24.10 pts and allowed 33.40 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 18.60 pts and allowed 30.90 pts in the last 10 games on the road
- Game Totals: An average of 53.50 pts in the previous 10 games
- Game Totals at Home: An average of 60.00 pts in the previous 10 home games
- Over 52.5: Covered in 5 of the previous 10 games
- Over 52.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 38.70 pts and allowed 14.80 pts in the last 10 games
- Team Totals at Home: Have scored an average of 48.60 pts and allowed 11.40 pts in the last 10 home games
NCAAF Standings Select Season
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
|
Indiana
|
7 | 0 | 307 | 81 | 226 | 5-0 | 2-0 | 7W |
Ohio State
|
7 | 0 | 255 | 41 | 214 | 4-0 | 3-0 | 7W |
Oregon
|
6 | 1 | 309 | 101 | 208 | 3-1 | 3-0 | 1W |
Nebraska
|
5 | 2 | 252 | 136 | 116 | 3-1 | 2-1 | 1L |
Washington
|
5 | 2 | 242 | 142 | 100 | 3-1 | 2-1 | 1L |
Northwestern
|
5 | 2 | 159 | 106 | 53 | 4-1 | 1-1 | 4W |
USC
|
5 | 2 | 297 | 162 | 135 | 4-0 | 1-2 | 1L |
Minnesota
|
5 | 2 | 188 | 133 | 55 | 5-0 | 0-2 | 2W |
Michigan
|
5 | 2 | 201 | 119 | 82 | 4-0 | 1-2 | 1W |
Iowa
|
5 | 2 | 209 | 102 | 107 | 3-1 | 2-1 | 2W |
Illinois
|
5 | 2 | 238 | 178 | 60 | 3-1 | 2-1 | 1L |
Maryland
|
4 | 3 | 198 | 121 | 77 | 3-2 | 1-1 | 3L |
|
Michigan State
|
3 | 4 | 190 | 229 | -39 | 3-1 | 0-3 | 4L |
Penn State
|
3 | 4 | 238 | 136 | 102 | 3-2 | 0-2 | 4L |
Rutgers
|
3 | 4 | 224 | 221 | 3 | 3-2 | 0-2 | 4L |
UCLA
|
3 | 4 | 157 | 192 | -35 | 2-2 | 1-2 | 3W |
Purdue
|
2 | 5 | 159 | 195 | -36 | 2-2 | 0-3 | 5L |
Wisconsin
|
2 | 5 | 93 | 170 | -77 | 2-3 | 0-2 | 5L |
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