Michigan State vs Iowa Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: Michigan State vs Iowa

Michigan State battle Iowa at Kinnick Stadium, with kickoff scheduled for 15:30 on Saturday, November 22.

Iowa and Michigan State should be able to accumulate enough points for our prediction to win. We’re forecasting Over 42.5 and odds of -108 are available for this outcome.

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Michigan State Spartans have been defeated in seven straight games. They were recently beaten at home to Penn State Nittany Lions by a 28-10 scoreline at Spartan Stadium.

Iowa Hawkeyes have been defeated in back-to-back games. On the road at LA Memorial Coliseum, USC Trojans recently beat them 26-21.

Head-to-Head Statistics

Michigan State triumphed 32-20 when they last played Iowa. This head-to-head was played at Spartan Stadium. Iowa have triumphed in two of the previous 3 clashes between these teams.

Michigan State vs Iowa Prediction & Picks

Get the edge with our Michigan State vs Iowa betting tips: our expert match prediction, most likely correct score outcome and a bet builder tailored for value.

Game Prediction

There’s juice available when it comes to backing Over 42.5 points in this college football showdown and that’s the betting angle we’re pursuing. Our pick is priced up at -108 which looks worth taking.

Our CFB predictions are rooted in solid team news and up-to-date form for each team. We also dig deep to uncover the most relevant stats that help guide and strengthen our picks.

Key Michigan State vs Iowa stats:

• The 42.5 line has been covered in the last 5 Michigan State games on the road.
• The 42.5 line has been covered in 8 of the last 10 Michigan State games.
• The 42.5 line has been covered in 13 of the last 20 Michigan State games.
• The 42.5 line has been covered in 6 of the last 10 Iowa games at home.
• The 42.5 line has been covered in 3 of the last 5 Iowa games.

Over 42.5 Probability

According to the latest betting odds, our pick has a 51.8% chance of winning. After careful examination, our analysts calculate this probability to be somewhere between 55-60%. It is the reason why we are recommending this college wager.

There are several ways to increase the odds if you’re wanting to wager on Overs and one of them is betting on the Result & Total lines where you also predict a team to win.

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Our Game Prediction

Over 42.5 Points @ -108 Bet Now

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Correct Score Prediction

Michigan State 14 - 34 Iowa

Correct score betting might be tough to predict but there’s a tasty potential return if you get it right. We’ll try Iowa to achieve a 34-14 victory at massive odds.

Michigan State vs Iowa Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The latest Moneyline betting odds give Iowa a 91% chance of winning this college game which means they’re overwhelming -1000 favorites with the sportsbooks. Michigan State are trading at bigger odds than their opponents and they can be backed at +660.

The current spread is 16.5 and the total points line is 42.5. Football fans love the chance to get an alternative angle by going for a Total wager. The Over 42.5 selection is available to back at -108.

There are a wide range of game lines and team props when it comes to most college football matchups and we recommend visiting the best betting apps to find the wager that matches your view on the game.

Moneyline

MSU

+660

Iowa

-1000

Point Spread

MSU +16.5

-104

Iowa -16.5

-118

Total Points

Under 42.5

-112

Over 42.5

-108

We’re fond of the quarterback and player props as an alternative to betting on the game lines. The gambling sites will have Player Kicking Points, Longest Rushing Attempt and Rushing Yards among the choices and you can take a view.

Micro betting is something that’s really popular with bettors, with college football fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.

Iowa With Eight Wins in Past Ten Home Games

Iowa have gone 8-2 across their last 10 home games, putting up 31.30 points per contest and giving up 12.90.

Michigan State have been beaten in eight straight games away from home. They have two wins and eight losses in the last 10 games on the road, scoring 20.40 points per contest and conceding 30.50.

The most recent Kinnick Stadium meeting saw Iowa claim a 26-16 win over Michigan State.

Last 10 Games		W-L	P	PF	PA	O42.5	U42.5
Iowa Home Stats		8-2	44.20	31.30	12.90	6	4
Michigan State Away Stats		2-8	50.90	20.40	30.50	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O42.5 = Games Over 42.5 Points
• U42.5 = Games Under 42.5 Points

Latest regular season and playoff games stats.

Michigan State Spartans Stats

Iowa Hawkeyes Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +16.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +16.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -16.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -16.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 55.10 pts in the previous 10 games
• Game Totals on the Road: An average of 50.90 pts in the previous 10 games on the road
• Over 42.5: Covered in 8 of the previous 10 games
• Over 42.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 24.00 pts and allowed 31.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.40 pts and allowed 30.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 43.60 pts in the previous 10 games
• Game Totals at Home: An average of 44.20 pts in the previous 10 home games
• Over 42.5: Covered in 5 of the previous 10 games
• Over 42.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 28.70 pts and allowed 14.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.30 pts and allowed 12.90 pts in the last 10 home games

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