Michigan vs USC Prediction, Picks & Odds | 11 Oct 2025
College Football Betting Preview: Michigan vs USC
Michigan meet USC in this NCAAF Week 7 matchup at LA Memorial Coliseum, with kickoff scheduled for 19:30 on Saturday, October 11. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
The betting prediction is to back USC at -139. We think that Michigan are massively opposable, so this is the best angle of attack with our wager.
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Michigan Wolverines beat Wisconsin Badgers in their previous game, making it three straight victories. It was a 24-10 home win at Michigan Stadium.
USC Trojans have won three home games on the spin. On the road at Memorial Stadium in their last game, they were beaten 34-32 by Illinois Fighting Illini.
Head-to-Head Statistics
Michigan won the last matchup between the pair. Enjoying a 27-24 triumph when facing USC at Michigan Stadium.
Quarterbacks
Bryce Underwood
Jayden Maiava
Michigan vs USC Prediction & Picks
Gear up for Michigan vs USC with our comprehensive betting guide, featuring an expert match prediction, scoreline advice, top player props and a hand-picked bet builder.
Game Prediction
The best bet could be taking USC to simply achieve a victory in this college football battle. Our pick can be taken at -139 on the Moneyline which yields a potentially nice return.
Getting the lowdown on injuries and analyzing the form guide are key steps before making CFB predictions. We also put strong emphasis on stats, where a data-led approach often leads to smarter picks.
Key Michigan vs USC stats:
USC Moneyline Probability
According to the latest betting odds, our pick has a 58.1% chance of winning. However, our research has found that the actual probability is between 65-70%. This college wager can therefore be backed with confidence.
If you’re looking for greater odds, USC can be backed at a bigger price against the spread. Also consider the option of looking at the Result & Total and Double Result lines.
Check our complete list of betting promo codes, free bet deals and the latest welcome bonuses before wagering.
Player Prop Picks
Bryce Underwood (Michigan) is priced at -114 to finish with fewer than 185.5 passing yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the QB Passing Yards line.
The odds for Donaven McCulley (Michigan) to end with fewer than 51.5 receiving yards stand at -114. We’re confident he’ll fall short of the Player Receiving Yards line, as the total looks too high.
Same Game Parlay Picks
Our same game parlay has three options: USC to win, Under 56.5 points and Bryce Underwood (Michigan) to have Under 185.5 passing yards.
A same game parlay is an awesome way of cheering on different outcomes within the same football game. You can predict a number of outcomes and get bigger odds than a single wager. The odds can combine to great effect.
Correct Score Prediction
24
-
28
USC
There’s every chance that this is going to be a close matchup and we’ll have a play on the Trojans achieving a 28-24 winning scoreline. Hopefully this can go close.
Michigan vs USC Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
You can back USC at -143 to win against Michigan, with the latter trading at +120. The leading sportsbooks give the hosts a 59% chance of success.
The spread is 2.5 and the total points line is currently 57.5. A wager on the Totals allows football bettors to use the latest data to good effect. If you’re going for Under 57.5, this outcome can be backed at -106.
If you’re wagering on college football, we recommend heading to the best betting sites and scanning through the huge selection of team props and game lines. There’s the opportunity to bet pre-game and in-game.
Waymond Jordan is favorite to be First Touchdown Scorer at +490. If you want to back him to score the last TD, you can get similar odds.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
It’s good to consider all wagering options when it comes to college football and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.
USC Keep Cashing In at Home
USC have run off three consecutive wins at LA Memorial Coliseum. They have eight wins and two losses in the last 10 home games, scoring 44.00 points per contest and conceding 23.50.
Michigan have six wins and four losses in the last 10 games away from home, averaging 22.50 points scored and 16.80 points allowed.
| Last 10 Games | W-L | P | PF | PA | O56.5 | U56.5 | |
|---|---|---|---|---|---|---|---|
 USC Home Stats |
8-2 | 67.50 | 44.00 | 23.50 | 8 | 2 | |
 Michigan Away Stats |
6-4 | 39.30 | 22.50 | 16.80 | 1 | 9 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O56.5 = Games Over 56.5 Points
- U56.5 = Games Under 56.5 Points
Latest regular season and playoff games stats.
Michigan Wolverines Stats
USC Stats
- 7 wins and 3 defeats in the last 10 games
- 6 wins and 4 defeats in the last 10 games on the road
- +2.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +2.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road
- -2.5 Betting Line: Have covered the spread in 7 of the last 10 games
- -2.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games
- Game Totals: An average of 44.60 pts in the previous 10 games
- Game Totals on the Road: An average of 39.30 pts in the previous 10 games on the road
- Over 56.5: Covered in 2 of the previous 10 games
- Over 56.5 on the Road: Covered in 1 of the previous 10 games on the road
- Team Totals: Have scored an average of 27.80 pts and allowed 16.80 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 22.50 pts and allowed 16.80 pts in the last 10 games on the road
- Game Totals: An average of 63.40 pts in the previous 10 games
- Game Totals at Home: An average of 67.10 pts in the previous 10 home games
- Over 56.5: Covered in 6 of the previous 10 games
- Over 56.5 at Home: Covered in 8 of the previous 10 home games
- Team Totals: Have scored an average of 38.00 pts and allowed 25.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 43.30 pts and allowed 23.80 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
12 | 0 | 532 | 131 | 401 | 7-0 | 5-0 | 12W |
Ohio State
|
12 | 0 | 444 | 93 | 351 | 7-0 | 5-0 | 12W |
Oregon
|
11 | 1 | 458 | 178 | 280 | 6-1 | 5-0 | 6W |
|
Michigan
|
9 | 3 | 331 | 224 | 107 | 5-1 | 4-2 | 1L |
|
USC
|
9 | 3 | 438 | 269 | 169 | 7-0 | 2-3 | 1W |
Iowa
|
8 | 4 | 347 | 182 | 165 | 5-2 | 3-2 | 2W |
Illinois
|
8 | 4 | 352 | 279 | 73 | 6-1 | 2-3 | 1W |
Washington
|
8 | 4 | 405 | 233 | 172 | 5-2 | 3-2 | 1L |
Minnesota
|
7 | 5 | 279 | 281 | -2 | 7-0 | 0-5 | 1W |
Nebraska
|
7 | 5 | 351 | 276 | 75 | 4-3 | 3-2 | 2L |
Northwestern
|
6 | 6 | 270 | 251 | 19 | 5-2 | 1-4 | 1L |
Penn State
|
6 | 6 | 381 | 257 | 124 | 4-3 | 2-3 | 3W |
Rutgers
|
5 | 7 | 344 | 382 | -38 | 4-3 | 1-4 | 2L |
Wisconsin
|
4 | 8 | 154 | 259 | -105 | 4-3 | 0-5 | 1L |
Maryland
|
4 | 8 | 282 | 318 | -36 | 3-4 | 1-4 | 8L |
Michigan State
|
4 | 8 | 295 | 359 | -64 | 4-3 | 0-5 | 1W |
UCLA
|
3 | 9 | 218 | 401 | -183 | 2-4 | 1-5 | 5L |
Purdue
|
2 | 10 | 225 | 382 | -157 | 2-5 | 0-5 | 10L |
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