Michigan vs USC Prediction, Picks & Odds | 11 Oct 2025

By Joshua Davis, NCAAF Analyst | Published: 15 hours ago | 4 min read

Michigan Wolverines

American Football NCAAF LA Memorial Coliseum Sat 11 Oct 19:30

Southern California Trojans (USC)

Prediction
SGP Picks
Odds
Player Props
Stats
Standings

College Football Betting Preview: Michigan vs USC

Michigan meet USC in this NCAAF Week 7 matchup at LA Memorial Coliseum, with kickoff scheduled for 19:30 on Saturday 11 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

USC Look a Great Bet to Win

The betting prediction is to back USC at -139. We think that Michigan are massively opposable, so this is the best angle of attack with our wager.

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27-24 Victory for Michigan in Pair’s Last Battle

Michigan Wolverines beat Wisconsin Badgers in their previous game, making it three straight victories. It was a 24-10 home win at Michigan Stadium.

USC Trojans have won three home games on the spin. On the road at Memorial Stadium in their last game, they were beaten 34-32 by Illinois Fighting Illini.

Head-to-Head Statistics

Michigan won the last matchup between the pair. Enjoying a 27-24 triumph when facing USC at Michigan Stadium.

Quarterbacks

Bryce Underwood

Jayden Maiava

Michigan vs USC Prediction & Picks

Gear up for Michigan vs USC with our comprehensive betting guide, featuring an expert match prediction, scoreline advice, top player props and a hand-picked bet builder.

Game Prediction

The best bet could be taking USC to simply achieve a victory in this college football battle. Our pick can be taken at -139 on the Moneyline which yields a potentially nice return.

Getting the lowdown on injuries and analyzing the form guide are key steps before making CFB predictions. We also put strong emphasis on stats, where a data-led approach often leads to smarter picks.

Key Michigan vs USC stats:

USC have won 4 consecutive games at home.
USC have won 8 of their last 10 games at home.
USC have won 13 of their last 20 games at home.
Michigan have lost 3 of their last 5 games on the road.

USC Moneyline Probability

According to the latest betting odds, our pick has a 58.1% chance of winning. However, our research has found that the actual probability is between 65-70%. This college wager can therefore be backed with confidence.

Looking for Bigger Odds?

If you’re looking for greater odds, USC can be backed at a bigger price against the spread. Also consider the option of looking at the Result & Total and Double Result lines.

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Best Bet

USC Moneyline @ -139 Bet Now

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Published 02:26, 10 October 2025

Player Prop Picks

Top Pick: Bryce Underwood Under 185.5 Passing Yards -114

Bryce Underwood (Michigan) is priced at -114 to finish with fewer than 185.5 passing yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the QB Passing Yards line.

Latest Bryce Underwood Player Prop Odds

Touchdown

Passing Yards

Rushing Yards

Donaven McCulley Under 51.5 Receiving Yards -114

The odds for Donaven McCulley (Michigan) to end with fewer than 51.5 receiving yards stand at -114. We’re confident he’ll fall short of the Player Receiving Yards line, as the total looks too high.

Latest Donaven McCulley Player Prop Odds

Touchdown

Receiving Yards

Same Game Parlay Picks

Moneyline USC

Totals Under 56.5

Passing Yards Bryce Underwood Under 185.5

Our same game parlay has three options: USC to win, Under 56.5 points and Bryce Underwood (Michigan) to have Under 185.5 passing yards.

A same game parlay is an awesome way of cheering on different outcomes within the same football game. You can predict a number of outcomes and get bigger odds than a single wager. The odds can combine to great effect.

Bet Boosts

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Correct Score Prediction

Michigan

24 - 28 USC logo

USC

There’s every chance that this is going to be a close matchup and we’ll have a play on the Trojans achieving a 28-24 winning scoreline. Hopefully this can go close.

Michigan vs USC Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Latest Odds Suggest a Close Encounter

You can back USC at -139 to win against Michigan, with the latter trading at +118. The leading sportsbooks give the hosts a 58% chance of success.

The spread is 2.5 and the total points line is currently 56.5. A wager on the Totals allows football bettors to use the latest data to good effect. If you’re going for Under 56.5, this outcome can be backed at -108.

If you’re wagering on college football, we recommend heading to the best betting sites and scanning through the huge selection of team props and game lines. There’s the opportunity to bet pre-game and in-game.

Moneyline

Point Spread

Total Points

Justice Haynes Favorite to Score First Touchdown

Justice Haynes is favorite to be First Touchdown Scorer at +440. If you want to back him to score the last TD, you can get similar odds.

Touchdown

Justice Haynes (Michigan)

Waymond Jordan (USC)

Makai Lemon (USC)

Eli Sanders (USC)

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Receiving Yards

Makai Lemon (USC)

Donaven McCulley (Michigan)

Ja'Kobi Lane (USC)

Andrew Marsh (Michigan)

View More View Less

Rushing Yards

Justice Haynes (Michigan)

Waymond Jordan (USC)

Jordan Marshall (Michigan)

Bryce Underwood (Michigan)

Passing Yards

Jayden Maiava (USC)

Bryce Underwood (Michigan)

Best Betting Offers

LA Memorial Coliseum

USC Keep Cashing In at Home

USC have run off three consecutive wins at LA Memorial Coliseum. They have eight wins and two losses in the last 10 home games, scoring 44.00 points per contest and conceding 23.50.

Michigan have six wins and four losses in the last 10 games away from home, averaging 22.50 points scored and 16.80 points allowed.

Last 10 Games		W-L	P	PF	PA	O56.5	U56.5
USC Home Stats		8-2	67.50	44.00	23.50	8	2
Michigan Away Stats		6-4	39.30	22.50	16.80	1	9

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O56.5 = Games Over 56.5 Points
U56.5 = Games Under 56.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Michigan

NCAAF: 04/10 Wisconsin10 Michigan 24
NCAAF: 20/09 Michigan30 Nebraska 27
NCAAF: 13/09 Central Michigan3 Michigan 63
NCAAF: 07/09 Michigan13 Oklahoma 24
NCAAF: 31/08 New Mexico17 Michigan 34

USC

NCAAF: 27/09 USC32 Illinois 34
NCAAF: 21/09 Michigan State31 USC 45
NCAAF: 13/09 USC33 Purdue 17
NCAAF: 07/09 Georgia Southern20 USC 59
NCAAF: 31/08 Missouri State13 USC 73

Head to Head

Michigan vs USC

NCAAF: 21/09 2024 USC 24 Michigan 27

Team Stats

Latest regular season and playoff games stats.

Michigan Wolverines Stats

USC Stats

Moneyline

7 wins and 3 defeats in the last 10 games
6 wins and 4 defeats in the last 10 games on the road

Moneyline

7 wins and 3 defeats in the last 10 games
8 wins and 2 defeats in the last 10 home games

Point Spread

+2.5 Betting Line: Have covered the spread in 7 of the last 10 games
+2.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

-2.5 Betting Line: Have covered the spread in 7 of the last 10 games
-2.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

Game Totals: An average of 44.60 pts in the previous 10 games
Game Totals on the Road: An average of 39.30 pts in the previous 10 games on the road
Over 56.5: Covered in 2 of the previous 10 games
Over 56.5 on the Road: Covered in 1 of the previous 10 games on the road
Team Totals: Have scored an average of 27.80 pts and allowed 16.80 pts in the last 10 games
Team Totals on the Road: Have scored an average of 22.50 pts and allowed 16.80 pts in the last 10 games on the road

Total Points

Game Totals: An average of 63.40 pts in the previous 10 games
Game Totals at Home: An average of 67.10 pts in the previous 10 home games
Over 56.5: Covered in 6 of the previous 10 games
Over 56.5 at Home: Covered in 8 of the previous 10 home games
Team Totals: Have scored an average of 38.00 pts and allowed 25.40 pts in the last 10 games
Team Totals at Home: Have scored an average of 43.30 pts and allowed 23.80 pts in the last 10 home games

NCAAF Standings Select Season

Big Ten	W	L	PF	PA	N. Pts	Home	Away	Strk
Indiana	5	0	239	48	191	4-0	1-0	5W
Oregon	5	0	233	61	172	3-0	2-0	5W
Ohio State	5	0	187	25	162	4-0	1-0	5W
Illinois	5	1	222	144	78	3-0	2-1	2W
Maryland	4	1	150	67	83	3-1	1-0	1L
Michigan	4	1	164	81	83	3-0	1-1	3W
Nebraska	4	1	212	81	131	3-1	1-0	1W
USC	4	1	242	115	127	3-0	1-1	1L
Washington	4	1	197	99	98	2-1	2-0	1W
Penn State	3	2	193	89	104	3-1	0-1	2L
Rutgers	3	2	195	127	68	3-1	0-1	2L
Iowa	3	2	147	78	69	2-1	1-1	1L
Northwestern	3	2	118	85	33	3-1	0-1	2W
Minnesota	3	2	137	107	30	3-0	0-2	1L
Michigan State	3	2	164	153	11	3-0	0-2	2L
Purdue	2	3	139	149	-10	2-2	0-1	3L
Wisconsin	2	3	93	99	-6	2-1	0-2	3L
UCLA	1	4	99	162	-63	1-2	0-2	1W