Missouri vs Oklahoma Prediction, Picks & Odds | 22 Nov 2025
College Football Betting Preview: Missouri vs Oklahoma
Missouri square off against Oklahoma at Gaylord Family Memorial Stadium, with kickoff scheduled for 12:00 on Saturday, November 22.
Oklahoma and Missouri should be able to accumulate enough points for our prediction to win. We’re forecasting Over 41.5 and odds of -115 are available for this outcome.
Missouri Tigers won their previous game which was at home. It was a 49-27 triumph at Faurot Field against Mississippi State Bulldogs.
Oklahoma Sooners have triumphed in back-to-back games. The latest of these was on the road where Alabama Crimson Tide were beaten 23-21 at Bryant-Denny Stadium.
Head-to-Head Statistics
It was Missouri who came out on top when they last played Oklahoma. At Faurot Field, a 30-23 win was recorded.
Missouri vs Oklahoma Prediction & Picks
Get ahead of the game with our Missouri vs Oklahoma betting rundown, featuring our trusted match prediction, likely score outcome, standout player prop plays and a fully loaded bet builder.
Game Prediction
There are odds of -115 about Over 41.5 points and this looks generous for this college football showdown. The bar might have been set too low in terms of total.
Knowing which players are injured gives us a valuable edge when making college football predictions. After reviewing the form guide, we turn to the latest stats to shape our picks.
Key Missouri vs Oklahoma stats:
Over 41.5 Probability
The top betting apps make it a 53.5% chance that our pick is settled as a winner. However, our research has found that the actual probability is closer to 60%. It’s the reason why we are recommending this college bet.
If you’re confident with your Over pick but want more juice from your wager, then a Bet Builder can offer the chance to add in other selections for a bigger return.
Start wagering with a boost! Find the best welcome bonuses in our complete and updated betting offers guide.
Player Prop Picks
Matt Zollers (Missouri) can be backed at -114 to exceed 128.5 passing yards. He looks capable of covering the line and that leads us to taking this QB Passing Yards bet.
You can back Isaiah Sategna III (Missouri) at -114 to go beyond 70.5 receiving yards. We’re tempted to back him to cover the Player Receiving Yards line, with plenty of juice on offer.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Over 41.5, along with Oklahoma -7.5 on the spread and Matt Zollers (Missouri) to go Over 128.5 passing yards.
We recommend a same game parlay as it’s a great way of betting on a single event. Many football bettors like to create a personalised wager which reflects their predictions for how a game is going to play out.
Correct Score Prediction
21
-
30
Oklahoma
Rather than backing Oklahoma to triumph, there’s the alternative to try your luck when it comes to the correct score lines. Take a chance on a 30-21 win in their favor.
Missouri vs Oklahoma Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
The sportsbooks’ betting odds have Oklahoma as -263 favorites for this college game, implying that they are 72% likely to win. Missouri are the underdogs at +215 and they’re regarded as least likely to win.
There is a spread of 7.5 and total points has a line of 54.5. There are many ways to wager on football including the Totals. If you’re going for Over 54.5, then the odds are -110.
College football fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every clash on the coupon. Head to the top betting sites and find the best value picks.
There is -115 available that Ahmad Hardy scores a touchdown anytime. If you’re interested in the favorite to score the first TD, then you are able to secure +440.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
It’s good to consider all wagering options when it comes to college football and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.
Oklahoma With Six Wins in Previous Ten Home Games
Oklahoma have a 6-4 record in their last 10 home games, averaging 26.30 points on offense and surrendering 17.80 on defense.
Missouri have five wins and five losses in the last 10 road games, putting up 24.00 points per matchup and giving up 21.30.
| Last 10 Games | W-L | P | PF | PA | O41.5 | U41.5 | |
|---|---|---|---|---|---|---|---|
 Oklahoma Home Stats |
6-4 | 44.10 | 26.30 | 17.80 | 4 | 6 | |
 Missouri Away Stats |
5-5 | 45.30 | 24.00 | 21.30 | 6 | 4 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O41.5 = Games Over 41.5 Points
- U41.5 = Games Under 41.5 Points
Latest regular season and playoff games stats.
Missouri Tigers Stats
Oklahoma Sooners Stats
- 7 wins and 3 defeats in the last 10 games
- 5 wins and 5 defeats in the last 10 games on the road
- +7.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +7.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -7.5 Betting Line: Have covered the spread in 5 of the last 10 games
- -7.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games
- Game Totals: An average of 54.80 pts in the previous 10 games
- Game Totals on the Road: An average of 45.30 pts in the previous 10 games on the road
- Over 41.5: Covered in 8 of the previous 10 games
- Over 41.5 on the Road: Covered in 6 of the previous 10 games on the road
- Team Totals: Have scored an average of 34.90 pts and allowed 19.90 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 24.00 pts and allowed 21.30 pts in the last 10 games on the road
- Game Totals: An average of 43.10 pts in the previous 10 games
- Game Totals at Home: An average of 44.10 pts in the previous 10 home games
- Over 41.5: Covered in 5 of the previous 10 games
- Over 41.5 at Home: Covered in 4 of the previous 10 home games
- Team Totals: Have scored an average of 28.30 pts and allowed 14.80 pts in the last 10 games
- Team Totals at Home: Have scored an average of 26.30 pts and allowed 17.80 pts in the last 10 home games
| Southeastern | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Georgia
|
12 | 1 | 415 | 207 | 208 | 6-1 | 6-0 | 9W |
Ole Miss
|
11 | 1 | 447 | 241 | 206 | 8-0 | 3-1 | 5W |
Texas A&M
|
11 | 1 | 436 | 263 | 173 | 7-0 | 4-1 | 1L |
|
Oklahoma
|
10 | 2 | 317 | 167 | 150 | 6-1 | 4-1 | 4W |
Vanderbilt
|
10 | 2 | 473 | 263 | 210 | 7-0 | 3-2 | 3W |
Alabama
|
10 | 3 | 406 | 226 | 180 | 6-2 | 4-1 | 1L |
Texas
|
9 | 3 | 355 | 237 | 118 | 7-0 | 2-3 | 2W |
|
Missouri
|
8 | 4 | 386 | 233 | 153 | 6-2 | 2-2 | 1W |
Tennessee
|
8 | 4 | 489 | 345 | 144 | 5-3 | 3-1 | 1L |
LSU
|
7 | 5 | 262 | 220 | 42 | 6-1 | 1-4 | 1L |
Kentucky
|
5 | 7 | 276 | 317 | -41 | 4-3 | 1-4 | 2L |
Auburn
|
5 | 7 | 321 | 248 | 73 | 3-4 | 2-3 | 1L |
Mississippi State
|
5 | 7 | 366 | 350 | 16 | 3-4 | 2-3 | 3L |
Florida
|
4 | 8 | 259 | 288 | -29 | 4-3 | 0-5 | 1W |
South Carolina
|
4 | 8 | 272 | 265 | 7 | 4-4 | 0-4 | 1L |
Arkansas
|
2 | 10 | 395 | 406 | -11 | 2-5 | 0-5 | 10L |
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