Missouri vs Oklahoma Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: Missouri vs Oklahoma

Missouri square off against Oklahoma at Gaylord Family Memorial Stadium, with kickoff scheduled for 12:00 on Saturday, November 22.

Oklahoma and Missouri should be able to accumulate enough points for our prediction to win. We’re forecasting Over 41.5 and odds of -115 are available for this outcome.

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Missouri Tigers won their previous game which was at home. It was a 49-27 triumph at Faurot Field against Mississippi State Bulldogs.

Oklahoma Sooners have triumphed in back-to-back games. The latest of these was on the road where Alabama Crimson Tide were beaten 23-21 at Bryant-Denny Stadium.

Head-to-Head Statistics

It was Missouri who came out on top when they last played Oklahoma. At Faurot Field, a 30-23 win was recorded.

Quarterbacks

Matt Zollers

128.5 Passing Yards

Over -114

Under -114

John Mateer

217.5 Passing Yards

Over -114

Under -114

Missouri vs Oklahoma Prediction & Picks

Get ahead of the game with our Missouri vs Oklahoma betting rundown, featuring our trusted match prediction, likely score outcome, standout player prop plays and a fully loaded bet builder.

Game Prediction

There are odds of -115 about Over 41.5 points and this looks generous for this college football showdown. The bar might have been set too low in terms of total.

Knowing which players are injured gives us a valuable edge when making college football predictions. After reviewing the form guide, we turn to the latest stats to shape our picks.

Key Missouri vs Oklahoma stats:

• The 41.5 line has been covered in 8 of the last 10 Missouri games.
• The 41.5 line has been covered in 16 of the last 20 Missouri games.
• The 41.5 line has been covered in the last 2 Missouri games.
• The 41.5 line has been covered in the last 3 Oklahoma games.
• The 41.5 line has been covered in 12 of the last 20 Oklahoma games at home.

Over 41.5 Probability

The top betting apps make it a 53.5% chance that our pick is settled as a winner. However, our research has found that the actual probability is closer to 60%. It’s the reason why we are recommending this college bet.

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Our Game Prediction

Over 41.5 Points @ -115 Bet Now

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Player Prop Picks

Top Pick: Matt Zollers Over 128.5 Passing Yards -114

Matt Zollers (Missouri) can be backed at -114 to exceed 128.5 passing yards. He looks capable of covering the line and that leads us to taking this QB Passing Yards bet.

Latest Matt Zollers Player Prop Odds

Passing Yards

Over 128.5

-114

Under 128.5

-114

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Isaiah Sategna III Over 70.5 Receiving Yards -114

You can back Isaiah Sategna III (Missouri) at -114 to go beyond 70.5 receiving yards. We’re tempted to back him to cover the Player Receiving Yards line, with plenty of juice on offer.

Latest Isaiah Sategna III Player Prop Odds

Receiving Yards

Over 70.5

-114

Under 70.5

-114

Correct Score Prediction

Missouri 21 - 30 Oklahoma

Rather than backing Oklahoma to triumph, there’s the alternative to try your luck when it comes to the correct score lines. Take a chance on a 30-21 win in their favor.

Missouri vs Oklahoma Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The sportsbooks’ betting odds have Oklahoma as -294 favorites for this college game, implying that they are 75% likely to win. Missouri are the underdogs at +235 and they’re regarded as least likely to win.

There is a spread of 7.5 and total points has a line of 41.5. There are many ways to wager on football including the Totals. If you’re going for Over 41.5, then the odds are -115.

College football fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every clash on the coupon. Head to the top betting sites and find the best value picks.

Moneyline

Missouri

+235

Oklahoma

-294

Point Spread

Missouri +7.5

-120

Oklahoma -7.5

-102

Total Points

Under 41.5

-105

Over 41.5

-115

Receiving Yards

Isaiah Sategna III (Oklahoma)

Over 70.5

-114

Under 70.5

-114

Deion Burks (Oklahoma)

Over 42.5

-114

Under 42.5

-114

Jaren Kanak (Oklahoma)

Over 30.5

-114

Under 30.5

-114

Kevin Coleman Jr. (Missouri)

Over 26.5

-114

Under 26.5

-114

Rushing Yards

Ahmad Hardy (Missouri)

Over 112.5

-114

Under 112.5

-114

John Mateer (Oklahoma)

Over 32.5

-114

Under 32.5

-114

Passing Yards

John Mateer (Oklahoma)

Over 217.5

-114

Under 217.5

-114

Matt Zollers (Missouri)

Over 128.5

-114

Under 128.5

-114

Oklahoma With Six Wins in Previous Ten Home Games

Oklahoma have a 6-4 record in their last 10 home games, averaging 26.30 points on offense and surrendering 17.80 on defense.

Missouri have five wins and five losses in the last 10 road games, putting up 24.00 points per matchup and giving up 21.30.

Last 10 Games		W-L	P	PF	PA	O41.5	U41.5
Oklahoma Home Stats		6-4	44.10	26.30	17.80	4	6
Missouri Away Stats		5-5	45.30	24.00	21.30	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O41.5 = Games Over 41.5 Points
• U41.5 = Games Under 41.5 Points

Latest regular season and playoff games stats.

Missouri Tigers Stats

Oklahoma Sooners Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +7.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +7.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -7.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -7.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 54.80 pts in the previous 10 games
• Game Totals on the Road: An average of 45.30 pts in the previous 10 games on the road
• Over 41.5: Covered in 8 of the previous 10 games
• Over 41.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 34.90 pts and allowed 19.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 24.00 pts and allowed 21.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 43.10 pts in the previous 10 games
• Game Totals at Home: An average of 44.10 pts in the previous 10 home games
• Over 41.5: Covered in 5 of the previous 10 games
• Over 41.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 28.30 pts and allowed 14.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.30 pts and allowed 17.80 pts in the last 10 home games

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