Northern Illinois vs Mississippi State Prediction, Picks & Odds | 20 Sep 2025

College Football Betting Preview: Northern Illinois vs Mississippi State

Northern Illinois square off against Mississippi State in this NCAAF Week 4 matchup at Davis Wade Stadium, with kickoff scheduled for 16:15 on Saturday, September 20. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

We’ve smashed into Northern Illinois +22.5 and this spread wager at odds of -115 means we need them to avoid a heavy defeat against Mississippi State.

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Northern Illinois Huskies suffered a defeat in their previous game. A 20-9 scoreline occurred on the road at Solider Field against Maryland Terrapins.

Mississippi State Bulldogs were winners for the third straight time in their last game. Landing a 63-0 home victory against Alcorn State Braves at Davis Wade Stadium.

Northern Illinois vs Mississippi State Prediction & Picks

The Northern Illinois vs Mississippi State betting tips feature sharp analysis across major markets, including a key match prediction, correct score guidance and a ready-made bet builder.

Game Prediction

Our pick is that Northern Illinois might not be beaten heavily in this college football battle. The underdogs have been afforded a generous +22.5 and we recommend backing them at odds of -115.

We put solid research behind every CFB pick, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Northern Illinois vs Mississippi State stats:

• The +22.5 line has been covered by Northern Illinois in 20 consecutive games.
• The -22.5 line hasn’t been covered by Mississippi State in 17 of their last 20 games.
• The -22.5 line hasn’t been covered by Mississippi State in 8 of their last 10 games.

NIU +22.5 Probability

The top betting apps are suggesting that our pick has a 53.5% chance of delivering a return. In the opinion of our cappers, there’s actually a probability of success closer to 60%. It’s why we think it’s worth placing this college bet.

If you’re hunting for tastier odds and feel confident your selection is going to perform well, then consider moving the line and land a bigger potential payout.

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Our Game Prediction

Northern Illinois +22.5 @ -115 Bet Now

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Correct Score Prediction

Northern Illinois 17 - 35 MS State

For those looking to get more bang for their buck, consider a correct score wager on Mississippi State. Backing them to win 35-17 means you can land a potential monster return.

Northern Illinois vs Mississippi State Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

With an estimated 97% chance of winning, the sportsbooks are taking no chances with their -3333 betting odds about Mississippi State triumphing in this college game. Northern Illinois are trading at bigger odds than their opponents and they can be backed at +1200.

The current spread is 23.5 and total points is 48.5. Having a bet on the Totals is one of the most popular football wagers. If you’re going for Under 48.5, this outcome can be backed at -110.

The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.

Moneyline

NIU

+1200

MS State

-3333

Point Spread

NIU +23.5

-110

MS State -23.5

-110

Total Points

Under 48.5

-110

Over 48.5

-110

If you have a view on Player Interceptions, Passing Attempts or Longest Pass Completion, then the player prop betting could be up your street. It’s a great way of wagering on a player or quarterback to perform well.

Micro betting provides a rollercoaster ride for college football bettors. It can be great to enjoy the live lines, with the opportunity to wager on the Next Scoring Play. Watch the live action before deciding which way to go.

Mississippi State Home Record Reads Six Defeats From Last Ten

Mississippi State have a 4-6 record in their last 10 home games, posting 30.90 points per contest while yielding 28.10.

Northern Illinois are 5-5 in their last 10 games away from home, putting up 22.90 points per contest and giving up 22.20.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Mississippi State Home Stats		4-6	59.00	30.90	28.10	8	2
Northern Illinois Away Stats		5-5	45.10	22.90	22.20	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Latest regular season and playoff games stats.

Northern Illinois Huskies Stats

Mississippi State Bulldogs Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• +22.5 Betting Line: Have covered the spread in the last 10 games
• +22.5 Betting Line on the Road: Have covered the spread in the last 10 games on the road

Point Spread

• -22.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -22.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 38.80 pts in the previous 10 games
• Game Totals on the Road: An average of 45.10 pts in the previous 10 games on the road
• Over 48.5: Covered in 1 of the previous 10 games
• Over 48.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 20.60 pts and allowed 18.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 22.90 pts and allowed 22.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 58.20 pts in the previous 10 games
• Game Totals at Home: An average of 59.00 pts in the previous 10 home games
• Over 48.5: Covered in 7 of the previous 10 games
• Over 48.5 at Home: Covered in 8 of the previous 10 home games
• Team Totals: Have scored an average of 29.40 pts and allowed 28.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 30.90 pts and allowed 28.10 pts in the last 10 home games

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