Ohio State vs Purdue Prediction, Picks & Odds | 08 Nov 2025
College Football Betting Preview: Ohio State vs Purdue
Ohio State battle Purdue at Ross-Ade Stadium, with kickoff scheduled for 13:00 on Saturday, November 8. Our betting preview features expert NCAAF predictions, picks, the latest betting odds and H2H stats.
Go for the favorites on the spread in order to get the best value. Ohio State should be able to cover a line of -29.5 at odds of -115 when they take on Purdue.
Ohio State Buckeyes beat Penn State Nittany Lions in their previous game, making it eight straight victories. It was a 38-14 home win at Ohio Stadium.
Purdue Boilermakers have suffered defeat in their last seven games. Most recently, a 21-16 scoreline occurred on the road at Michigan Stadium against Michigan Wolverines.
Head-to-Head Statistics
Ohio State won the last matchup between the pair. Enjoying a 45-0 triumph when facing Purdue at Ohio Stadium. It’s been a succession of Ohio State wins in the past 3 H2H meetings.
Ohio State vs Purdue Prediction & Picks
Be fully equipped for Ohio State vs Purdue with our betting guide, offering a key match prediction, a correct score recommendation, top player prop picks and a bet builder tailored for value.
Game Prediction
We’re predicting that this could be a one-sided college football affair. Our best bet is to take Ohio State at -115 to cover a -29.5 betting line on the spread.
Our CFB predictions are always well-researched, starting with a combination of the latest team news and current form. Once we’ve got a solid read on the matchup, we layer in the key data to back it up.
Key Ohio State vs Purdue stats:
Ohio State -29.5 Probability
According to the top sportsbooks, there’s a 53.5% likelihood of our pick landing a return. Taking all factors into consideration, our experts think there’s a stronger chance of success and estimate the probability to be closer to 60%. This is why we regard this as a value bet.
In the hunt for bigger odds, you might be interested to know that you can move the betting line. There’s extra juice depending on how risky you want your bet to be.
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Player Prop Picks
You can back Julian Sayin (Ohio State) at -114 to go over 293.5 passing yards. He looks capable of covering the line and that leads us to taking this QB Passing Yards bet.
Bo Jackson (Ohio State) can be backed at -114 to record more than 70.5 rushing yards. The line for him on the Overs looks attractive and bettors can get plenty of juice from this Player Rushing Yards wager.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Ohio State -29.5 on the spread, combined with Under 48.5 and Julian Sayin (Ohio State) to have Over 293.5 passing yards.
We recommend a same game parlay as it’s a great way of betting on a single event. Many football bettors like to create a personalised wager which reflects their predictions for how a game is going to play out.
Correct Score Prediction
38
-
6
Purdue
We’re going for the Buckeyes to win by a 38-6 scoreline, something which is available at massive odds. This speculative bet can provide a big return for a small stake.
Ohio State vs Purdue Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
According to the Moneyline betting odds, Ohio State are red-hot -10000 favorites with the sportsbooks and that means a 99% chance of winning this college game. At +3000, Purdue are regarded as having a lower probability of winning.
The spread is currently 29.5, with the total points line at 50.5. There are many ways to wager on football including the Totals. There’s the chance to back Under 50.5 at -110.
If you're wagering on college football, it's a good idea to visit the top betting apps and browse the extensive selection of team props and game lines. You'll find great opportunities to place bets both pre-game and in-game.
Receiving Yards
Rushing Yards
Purdue Home Record Stands at Three Straight Losses
Purdue have endured three straight losses at Ross-Ade Stadium. They have two wins and eight losses in the last 10 home games, averaging 18.00 points on offense and surrendering 32.40 on defense.
Ohio State are riding eight straight road wins. They are 9-1 in their last 10 road games, averaging 31.50 points on offense and surrendering 13.90 on defense.
The previous meeting at Ross-Ade Stadium saw Ohio State defeat Purdue 41-7.
| Last 10 Games | W-L | P | PF | PA | O48.5 | U48.5 | |
|---|---|---|---|---|---|---|---|
 Purdue Home Stats |
2-8 | 50.40 | 18.00 | 32.40 | 6 | 4 | |
 Ohio State Away Stats |
9-1 | 45.40 | 31.50 | 13.90 | 4 | 6 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O48.5 = Games Over 48.5 Points
- U48.5 = Games Under 48.5 Points
Latest regular season and playoff games stats.
Ohio State Buckeyes Stats
Purdue Boilermakers Stats
- 10 wins and 0 defeats in the last 10 games
- 9 wins and 1 defeat in the last 10 games on the road
- -29.5 Betting Line: Have covered the spread in 3 of the last 10 games
- -29.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road
- +29.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +29.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 44.70 pts in the previous 10 games
- Game Totals on the Road: An average of 45.40 pts in the previous 10 games on the road
- Over 48.5: Covered in 4 of the previous 10 games
- Over 48.5 on the Road: Covered in 4 of the previous 10 games on the road
- Team Totals: Have scored an average of 35.50 pts and allowed 9.20 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 31.50 pts and allowed 13.90 pts in the last 10 games on the road
- Game Totals: An average of 50.80 pts in the previous 10 games
- Game Totals at Home: An average of 50.40 pts in the previous 10 home games
- Over 48.5: Covered in 6 of the previous 10 games
- Over 48.5 at Home: Covered in 6 of the previous 10 home games
- Team Totals: Have scored an average of 19.90 pts and allowed 30.90 pts in the last 10 games
- Team Totals at Home: Have scored an average of 18.00 pts and allowed 32.40 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
13 | 0 | 545 | 141 | 404 | 7-0 | 6-0 | 13W |
|
Ohio State
|
12 | 1 | 454 | 106 | 348 | 7-1 | 5-0 | 1L |
Oregon
|
11 | 1 | 458 | 178 | 280 | 6-1 | 5-0 | 6W |
Michigan
|
9 | 3 | 331 | 224 | 107 | 5-1 | 4-2 | 1L |
USC
|
9 | 3 | 438 | 269 | 169 | 7-0 | 2-3 | 1W |
Iowa
|
8 | 4 | 347 | 182 | 165 | 5-2 | 3-2 | 2W |
Illinois
|
8 | 4 | 352 | 279 | 73 | 6-1 | 2-3 | 1W |
Washington
|
8 | 4 | 405 | 233 | 172 | 5-2 | 3-2 | 1L |
Minnesota
|
7 | 5 | 279 | 281 | -2 | 7-0 | 0-5 | 1W |
Nebraska
|
7 | 5 | 351 | 276 | 75 | 4-3 | 3-2 | 2L |
Northwestern
|
6 | 6 | 270 | 251 | 19 | 5-2 | 1-4 | 1L |
Penn State
|
6 | 6 | 381 | 257 | 124 | 4-3 | 2-3 | 3W |
Rutgers
|
5 | 7 | 344 | 382 | -38 | 4-3 | 1-4 | 2L |
Wisconsin
|
4 | 8 | 154 | 259 | -105 | 4-3 | 0-5 | 1L |
Maryland
|
4 | 8 | 282 | 318 | -36 | 3-4 | 1-4 | 8L |
Michigan State
|
4 | 8 | 295 | 359 | -64 | 4-3 | 0-5 | 1W |
UCLA
|
3 | 9 | 218 | 401 | -183 | 2-4 | 1-5 | 5L |
|
Purdue
|
2 | 10 | 225 | 382 | -157 | 2-5 | 0-5 | 10L |
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