Ohio State vs Purdue Prediction, Picks & Odds | 08 Nov 2025

College Football Betting Preview: Ohio State vs Purdue

Ohio State battle Purdue at Ross-Ade Stadium, with kickoff scheduled for 13:00 on Saturday, November 8. Our betting preview features expert NCAAF predictions, picks, the latest betting odds and H2H stats.

Ohio State Set for Big Win

Go for the favorites on the spread in order to get the best value. Ohio State should be able to cover a line of -29.5 at odds of -115 when they take on Purdue.

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Teams’ Previous H2H Saw 45-0 Ohio State Victory

Ohio State Buckeyes beat Penn State Nittany Lions in their previous game, making it eight straight victories. It was a 38-14 home win at Ohio Stadium.

Purdue Boilermakers have suffered defeat in their last seven games. Most recently, a 21-16 scoreline occurred on the road at Michigan Stadium against Michigan Wolverines.

Head-to-Head Statistics

Ohio State won the last matchup between the pair. Enjoying a 45-0 triumph when facing Purdue at Ohio Stadium. It’s been a succession of Ohio State wins in the past 3 H2H meetings.

Ohio State vs Purdue Prediction & Picks

Be fully equipped for Ohio State vs Purdue with our betting guide, offering a key match prediction, a correct score recommendation, top player prop picks and a bet builder tailored for value.

Game Prediction

We’re predicting that this could be a one-sided college football affair. Our best bet is to take Ohio State at -115 to cover a -29.5 betting line on the spread.

Our CFB predictions are always well-researched, starting with a combination of the latest team news and current form. Once we’ve got a solid read on the matchup, we layer in the key data to back it up.

Key Ohio State vs Purdue stats:

• The +29.5 line hasn’t been covered by Purdue in 2 consecutive games against Ohio State.

Ohio State -29.5 Probability

According to the top sportsbooks, there’s a 53.5% likelihood of our pick landing a return. Taking all factors into consideration, our experts think there’s a stronger chance of success and estimate the probability to be closer to 60%. This is why we regard this as a value bet.

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Best Bet

Ohio State -29.5 @ -115 Bet Now

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Player Prop Picks

Top Pick: Julian Sayin Over 293.5 Passing Yards -114

You can back Julian Sayin (Ohio State) at -114 to go over 293.5 passing yards. He looks capable of covering the line and that leads us to taking this QB Passing Yards bet.

Latest Julian Sayin Player Prop Odds

Passing Yards

Over 293.5

-114

Under 293.5

-114

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Bo Jackson Over 70.5 Rushing Yards -114

Bo Jackson (Ohio State) can be backed at -114 to record more than 70.5 rushing yards. The line for him on the Overs looks attractive and bettors can get plenty of juice from this Player Rushing Yards wager.

Latest Bo Jackson Player Prop Odds

Rushing Yards

Over 70.5

-114

Under 70.5

-114

Correct Score Prediction

Ohio State 38 - 6 Purdue

We’re going for the Buckeyes to win by a 38-6 scoreline, something which is available at massive odds. This speculative bet can provide a big return for a small stake.

Ohio State vs Purdue Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Ohio State Heavy Favorites to Win

According to the Moneyline betting odds, Ohio State are red-hot -10000 favorites with the sportsbooks and that means a 99% chance of winning this college game. At +3000, Purdue are regarded as having a lower probability of winning.

The spread is currently 29.5, with the total points line at 48.5. There are many ways to wager on football including the Totals. There’s the chance to back Under 48.5 at -115.

If you're wagering on college football, it's a good idea to visit the top betting apps and browse the extensive selection of team props and game lines. You'll find great opportunities to place bets both pre-game and in-game.

Moneyline

Ohio State

-10000

Purdue

+3000

Point Spread

Ohio State -29.5

-115

Purdue +29.5

-105

Total Points

Under 48.5

-115

Over 48.5

-105

Player Odds

Receiving Yards

Jeremiah Smith (Ohio State)

Over 85.5

-114

Under 85.5

-114

Carnell Tate (Ohio State)

Over 79.5

-114

Under 79.5

-114

Max Klare (Ohio State)

Over 30.5

-114

Under 30.5

-114

Rushing Yards

Bo Jackson (Ohio State)

Over 70.5

-114

Under 70.5

-114

Purdue Home Record Stands at Three Straight Losses

Purdue have endured three straight losses at Ross-Ade Stadium. They have two wins and eight losses in the last 10 home games, averaging 18.00 points on offense and surrendering 32.40 on defense.

Ohio State are riding eight straight road wins. They are 9-1 in their last 10 road games, averaging 31.50 points on offense and surrendering 13.90 on defense.

The previous meeting at Ross-Ade Stadium saw Ohio State defeat Purdue 41-7.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Purdue Home Stats		2-8	50.40	18.00	32.40	6	4
Ohio State Away Stats		9-1	45.40	31.50	13.90	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Ohio State Buckeyes Stats

Purdue Boilermakers Stats

Moneyline

• 10 wins and 0 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 home games

Point Spread

• -29.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -29.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road

Point Spread

• +29.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +29.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 44.70 pts in the previous 10 games
• Game Totals on the Road: An average of 45.40 pts in the previous 10 games on the road
• Over 48.5: Covered in 4 of the previous 10 games
• Over 48.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 35.50 pts and allowed 9.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 31.50 pts and allowed 13.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 50.80 pts in the previous 10 games
• Game Totals at Home: An average of 50.40 pts in the previous 10 home games
• Over 48.5: Covered in 6 of the previous 10 games
• Over 48.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 19.90 pts and allowed 30.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 18.00 pts and allowed 32.40 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	W	L	PF	PA	N. Pts	Home	Away	Strk
Indiana	9	0	418	97	321	6-0	3-0	9W
Ohio State	8	0	293	55	238	5-0	3-0	8W
Oregon	7	1	330	108	222	4-1	3-0	2W
Michigan	7	2	253	155	98	5-0	2-2	3W
Iowa	6	2	250	105	145	4-1	2-1	3W
USC	6	2	318	179	139	4-0	2-2	1W
Washington	6	2	284	167	117	4-1	2-1	1W
Minnesota	6	3	214	194	20	6-0	0-3	1W
Nebraska	6	3	297	178	119	4-2	2-1	1L
Illinois	6	3	298	233	65	4-1	2-2	1W
Northwestern	5	3	180	134	46	4-1	1-2	1L
Maryland	4	4	208	176	32	3-3	1-1	4L
Rutgers	4	5	264	280	-16	3-2	1-3	1L
UCLA	3	5	163	248	-85	2-2	1-3	1L
Penn State	3	5	252	174	78	3-2	0-3	5L
Michigan State	3	6	230	283	-53	3-2	0-4	6L
Wisconsin	2	6	100	191	-91	2-3	0-3	6L
Purdue	2	7	199	243	-44	2-3	0-4	7L