Penn State vs Ohio State Prediction, Picks & Odds | 01 Nov 2025
College Football Betting Preview: Penn State vs Ohio State
Penn State lock horns with Ohio State in this NCAAF matchup at Ohio Stadium, with kickoff scheduled for 11:00 on Saturday, November 1. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
There are odds of -110 available for our Ohio State vs Penn State prediction. We think that the points will be racked up cumulatively and we’re going for Over 45.5 in total.
Backing our Totals call? Get up to speed with our in-depth BetMGM review, then grab the promo code to make your bet go further.
Penn State Nittany Lions have suffered a defeat in their previous four games including a recent 25-24 loss. This occurred on the road at Kinnick Stadium against Iowa Hawkeyes.
Ohio State Buckeyes won last time out by a 34-0 scoreline. On the road against Wisconsin Badgers at Camp Randall Stadium, they made it seven wins on the spin.
Head-to-Head Statistics
Ohio State triumphed 20-13 when they last played Penn State. This head-to-head was played at Beaver Stadium. The past 6 clashes between these teams have resulted in a Ohio State win each time.
Quarterbacks
Ethan Grunkemeyer
Julian Sayin
Penn State vs Ohio State Prediction & Picks
From our main match prediction to correct score advice, must-watch player props and a custom bet builder — this Penn State vs Ohio State betting preview covers it all.
Game Prediction
We’re forecasting that the two teams will produce a significant combined points total in this college football showdown. Therefore, our pick is to take the -110 that there are Over 45.5 points.
We use the latest team news and injury updates to help shape the best possible CFB predictions. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.
Key Penn State vs Ohio State stats:
Over 45.5 Probability
According to the best betting apps, our pick has a 52.4% chance of winning. However, our cappers have this number between 55-60% based on their in-depth research. It is therefore regarded as a value bet.
If you are wanting bigger odds for your Total bet, then it’s possible to move the line and get more juice. You can choose to wager Over when it comes to different levels.
Check our complete list of betting promo codes, free bet deals and the latest welcome bonuses before wagering.
Player Prop Picks
The odds for Ethan Grunkemeyer (Penn State) to go over 131.5 passing yards are -114. We can back him in the QB Passing Yards market and hope the Over hits.
You can place a bet on Bo Jackson (Penn State) at -114 to go over 59.5 rushing yards. We can place a Player Rushing Yards bet with confidence, as we expect him to cover the line.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Our same game parlay pick is Over 45.5, Ohio State -20.5 on the spread and Ethan Grunkemeyer (Penn State) to go Over 131.5 passing yards.
A same game parlay allows bettors to place a multiple wager on the same football game. You can go through the available betting lines and cherry-pick the outcomes that you think will happen. The odds for each selection are then combined together.
Correct Score Prediction
14
-
38
Ohio State
For those looking to get more bang for their buck, consider a correct score wager on the Buckeyes. Backing them to win 38-14 means you can land a potential monster return.
Penn State vs Ohio State Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
At betting odds of -164 with the sportsbooks, Ohio State are regarded as 62% likely to win this college game. At +136, Penn State are regarded as having a lower probability of winning.
The spread is 3.5 and the total points line is currently 48.5. A wager on the Totals allows football bettors to use the latest data to good effect. If you want to back Over 48.5, it’s -105.
Whether you are betting pre-game or in-game on college football, the best sportsbooks let you feast on a wide range of game lines and team props. The selections are practically endless, and it’s fantastic to have so many options.
Receiving Yards
Rushing Yards
Passing Yards
Ohio State Racking Up the Home Wins
Ohio State have posted five consecutive wins at Ohio Stadium. They are 9-1 in their last 10 home games, posting 35.40 points per contest while yielding 8.80.
Penn State own a 7-3 mark in their past 10 road games, posting 34.10 points per contest while yielding 21.60.
The last Ohio Stadium meeting saw Ohio State beat Penn State 20-12. All of the last 3 head-to-head matchups at Ohio Stadium have ended with wins for Ohio State.
| Last 10 Games | W-L | P | PF | PA | O45.5 | U45.5 | |
|---|---|---|---|---|---|---|---|
 Ohio State Home Stats |
9-1 | 44.20 | 35.40 | 8.80 | 4 | 6 | |
 Penn State Away Stats |
7-3 | 55.70 | 34.10 | 21.60 | 7 | 3 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O45.5 = Games Over 45.5 Points
- U45.5 = Games Under 45.5 Points
Latest regular season and playoff games stats.
Penn State Nittany Lions Stats
Ohio State Buckeyes Stats
- 5 wins and 5 defeats in the last 10 games
- 7 wins and 3 defeats in the last 10 games on the road
- +20.5 Betting Line: Have covered the spread in the last 10 games
- +20.5 Betting Line on the Road: Have covered the spread in the last 10 games on the road
- -20.5 Betting Line: Have covered the spread in 4 of the last 10 games
- -20.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 51.80 pts in the previous 10 games
- Game Totals on the Road: An average of 55.70 pts in the previous 10 games on the road
- Over 45.5: Covered in 7 of the previous 10 games
- Over 45.5 on the Road: Covered in 7 of the previous 10 games on the road
- Team Totals: Have scored an average of 33.10 pts and allowed 18.70 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 34.10 pts and allowed 21.60 pts in the last 10 games on the road
- Game Totals: An average of 45.70 pts in the previous 10 games
- Game Totals at Home: An average of 44.20 pts in the previous 10 home games
- Over 45.5: Covered in 5 of the previous 10 games
- Over 45.5 at Home: Covered in 4 of the previous 10 home games
- Team Totals: Have scored an average of 35.80 pts and allowed 9.90 pts in the last 10 games
- Team Totals at Home: Have scored an average of 35.40 pts and allowed 8.80 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
13 | 0 | 545 | 141 | 404 | 7-0 | 6-0 | 13W |
|
Ohio State
|
12 | 1 | 454 | 106 | 348 | 7-1 | 5-0 | 1L |
Oregon
|
11 | 1 | 458 | 178 | 280 | 6-1 | 5-0 | 6W |
Michigan
|
9 | 3 | 331 | 224 | 107 | 5-1 | 4-2 | 1L |
USC
|
9 | 3 | 438 | 269 | 169 | 7-0 | 2-3 | 1W |
Iowa
|
8 | 4 | 347 | 182 | 165 | 5-2 | 3-2 | 2W |
Illinois
|
8 | 4 | 352 | 279 | 73 | 6-1 | 2-3 | 1W |
Washington
|
8 | 4 | 405 | 233 | 172 | 5-2 | 3-2 | 1L |
Minnesota
|
7 | 5 | 279 | 281 | -2 | 7-0 | 0-5 | 1W |
Nebraska
|
7 | 5 | 351 | 276 | 75 | 4-3 | 3-2 | 2L |
Northwestern
|
6 | 6 | 270 | 251 | 19 | 5-2 | 1-4 | 1L |
|
Penn State
|
6 | 6 | 381 | 257 | 124 | 4-3 | 2-3 | 3W |
Rutgers
|
5 | 7 | 344 | 382 | -38 | 4-3 | 1-4 | 2L |
Wisconsin
|
4 | 8 | 154 | 259 | -105 | 4-3 | 0-5 | 1L |
Maryland
|
4 | 8 | 282 | 318 | -36 | 3-4 | 1-4 | 8L |
Michigan State
|
4 | 8 | 295 | 359 | -64 | 4-3 | 0-5 | 1W |
UCLA
|
3 | 9 | 218 | 401 | -183 | 2-4 | 1-5 | 5L |
Purdue
|
2 | 10 | 225 | 382 | -157 | 2-5 | 0-5 | 10L |
Belmont
UIC
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