Penn State vs Ohio State Prediction, Picks & Odds | 01 Nov 2025

College Football Betting Preview: Penn State vs Ohio State

Penn State lock horns with Ohio State in this NCAAF matchup at Ohio Stadium, with kickoff scheduled for 12:00 on Saturday 1 November. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Points to Flow Between Penn State and Ohio State

There are odds of -110 available for our Ohio State vs Penn State prediction. We think that the points will be racked up cumulatively and we’re going for Over 45.5 in total.

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Ohio State Have Enjoyed Upper Hand Over Penn State

Penn State Nittany Lions have suffered a defeat in their previous four games including a recent 25-24 loss. This occurred on the road at Kinnick Stadium against Iowa Hawkeyes.

Ohio State Buckeyes won last time out by a 34-0 scoreline. On the road against Wisconsin Badgers at Camp Randall Stadium, they made it seven wins on the spin.

Head-to-Head Statistics

Ohio State triumphed 20-13 when they last played Penn State. This head-to-head was played at Beaver Stadium. The past 6 clashes between these teams have resulted in a Ohio State win each time.

Quarterbacks

Ethan Grunkemeyer

131.5 Passing Yards

Over -114

Under -114

Julian Sayin

253.5 Passing Yards

Over -114

Under -114

Penn State vs Ohio State Prediction & Picks

From our main match prediction to correct score advice, must-watch player props and a custom bet builder — this Penn State vs Ohio State betting preview covers it all.

Game Prediction

We’re forecasting that the two teams will produce a significant combined points total in this college football showdown. Therefore, our pick is to take the -110 that there are Over 45.5 points.

We use the latest team news and injury updates to help shape the best possible CFB predictions. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.

Key Penn State vs Ohio State stats:

• The 45.5 line has been covered in 4 of the last 5 Penn State games.
• The 45.5 line has been covered in 15 of the last 20 Penn State games on the road.
• The 45.5 line has been covered in the last 2 Penn State games on the road.
• The 45.5 line has been covered in 3 of the last 5 Ohio State games at home.

Over 45.5 Probability

According to the best betting apps, our pick has a 52.4% chance of winning. However, our cappers have this number between 55-60% based on their in-depth research. It is therefore regarded as a value bet.

If you are wanting bigger odds for your Total bet, then it’s possible to move the line and get more juice. You can choose to wager Over when it comes to different levels.

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Best Bet

Over 45.5 Points @ -110 Bet Now

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Player Prop Picks

Top Pick: Ethan Grunkemeyer Over 131.5 Passing Yards -114

The odds for Ethan Grunkemeyer (Penn State) to go over 131.5 passing yards are -114. We can back him in the QB Passing Yards market and hope the Over hits.

Latest Ethan Grunkemeyer Player Prop Odds

Passing Yards

Over 131.5

-114

Under 131.5

-114

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Bo Jackson Over 59.5 Rushing Yards -114

You can place a bet on Bo Jackson (Penn State) at -114 to go over 59.5 rushing yards. We can place a Player Rushing Yards bet with confidence, as we expect him to cover the line.

Latest Bo Jackson Player Prop Odds

Rushing Yards

Over 59.5

-114

Under 59.5

-114

Correct Score Prediction

Penn State 14 - 38 Ohio State

For those looking to get more bang for their buck, consider a correct score wager on the Buckeyes. Backing them to win 38-14 means you can land a potential monster return.

Penn State vs Ohio State Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Ohio State Heavy Favorites in Eyes of the Books

At betting odds of -1429 with the sportsbooks, Ohio State are regarded as 93% likely to win this college game. At +870, Penn State are regarded as having a lower probability of winning.

The spread is 19.5 and the total points line is currently 44.5. A wager on the Totals allows football bettors to use the latest data to good effect. If you want to back Over 44.5, it’s -115.

Whether you are betting pre-game or in-game on college football, the best sportsbooks let you feast on a wide range of game lines and team props. The selections are practically endless, and it’s fantastic to have so many options.

Moneyline

Penn State

+870

Ohio State

-1429

Point Spread

Penn State +19.5

-106

Ohio State -19.5

-114

Total Points

Under 44.5

-105

Over 44.5

-115

Player Odds

Receiving Yards

Jeremiah Smith (Ohio State)

Over 82.5

-114

Under 82.5

-114

Carnell Tate (Ohio State)

Over 68.5

-114

Under 68.5

-114

Max Klare (Ohio State)

Over 32.5

-114

Under 32.5

-114

Trebor Pena (Penn State)

Over 25.5

-114

Under 25.5

-114

Kyron Hudson (Penn State)

Over 23.5

-114

Under 23.5

-114

Luke Reynolds (Penn State)

Over 18.5

-114

Under 18.5

-114

Rushing Yards

Bo Jackson (Ohio State)

Over 59.5

-114

Under 59.5

-114

Kaytron Allen (Penn State)

Over 49.5

-114

Under 49.5

-114

Passing Yards

Julian Sayin (Ohio State)

Over 253.5

-114

Under 253.5

-114

Ethan Grunkemeyer (Penn State)

Over 131.5

-114

Under 131.5

-114

Ohio State Racking Up the Home Wins

Ohio State have posted five consecutive wins at Ohio Stadium. They are 9-1 in their last 10 home games, posting 35.40 points per contest while yielding 8.80.

Penn State own a 7-3 mark in their past 10 road games, posting 34.10 points per contest while yielding 21.60.

The last Ohio Stadium meeting saw Ohio State beat Penn State 20-12. All of the last 3 head-to-head matchups at Ohio Stadium have ended with wins for Ohio State.

Last 10 Games		W-L	P	PF	PA	O45.5	U45.5
Ohio State Home Stats		9-1	44.20	35.40	8.80	4	6
Penn State Away Stats		7-3	55.70	34.10	21.60	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O45.5 = Games Over 45.5 Points
• U45.5 = Games Under 45.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Penn State Nittany Lions Stats

Ohio State Buckeyes Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 10 wins and 0 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +20.5 Betting Line: Have covered the spread in the last 10 games
• +20.5 Betting Line on the Road: Have covered the spread in the last 10 games on the road

Point Spread

• -20.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -20.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 51.80 pts in the previous 10 games
• Game Totals on the Road: An average of 55.70 pts in the previous 10 games on the road
• Over 45.5: Covered in 7 of the previous 10 games
• Over 45.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 33.10 pts and allowed 18.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 34.10 pts and allowed 21.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 45.70 pts in the previous 10 games
• Game Totals at Home: An average of 44.20 pts in the previous 10 home games
• Over 45.5: Covered in 5 of the previous 10 games
• Over 45.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 35.80 pts and allowed 9.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 35.40 pts and allowed 8.80 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	W	L	PF	PA	N. Pts	Home	Away	Strk
Indiana	8	0	363	87	276	6-0	2-0	8W
Ohio State	7	0	255	41	214	4-0	3-0	7W
Oregon	7	1	330	108	222	4-1	3-0	2W
Iowa	6	2	250	105	145	4-1	2-1	3W
Michigan	6	2	232	139	93	4-0	2-2	2W
Nebraska	6	2	280	157	123	4-1	2-1	1W
Washington	6	2	284	167	117	4-1	2-1	1W
USC	5	2	297	162	135	4-0	1-2	1L
Northwestern	5	3	180	134	46	4-1	1-2	1L
Minnesota	5	3	191	174	17	5-0	0-3	1L
Illinois	5	3	263	220	43	3-1	2-2	2L
Maryland	4	3	198	121	77	3-2	1-1	3L
Rutgers	4	4	251	245	6	3-2	1-2	1W
Penn State	3	4	238	136	102	3-2	0-2	4L
Michigan State	3	5	210	260	-50	3-2	0-3	5L
UCLA	3	5	163	248	-85	2-2	1-3	1L
Purdue	2	6	183	222	-39	2-3	0-3	6L
Wisconsin	2	6	100	191	-91	2-3	0-3	6L