Purdue vs Northwestern Prediction, Picks & Odds | 18 Oct 2025

College Football Betting Preview: Purdue vs Northwestern

Purdue face Northwestern in this NCAAF Week 8 clash at Northwestern Medicine Field at Martin Stadium, with kickoff scheduled for 15:00 on Saturday 18 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Northwestern Set to Deliver Victory

For a value bet, head to the Moneyline where you can back Northwestern to beat Purdue. Our game prediction is currently available at an attractive -143.

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Northwestern Won Last H2H in Overtime

Purdue Boilermakers have been defeated in their previous four games. On the road, they recently suffered a 27-20 loss against Minnesota Golden Gophers at Huntington Bank Stadium.

Northwestern Wildcats won last time out by a 22-21 scoreline. On the road against Penn State Nittany Lions at Beaver Stadium, they made it three wins on the spin.

Head-to-Head Statistics

Northwestern have beaten Purdue in the last two matchups. They won 23-15 at Ryan Field and triumphed 26-20 (OT) at Ross-Ade Stadium. Both teams have won three games when it comes to the previous 6 H2H meetings.

Purdue vs Northwestern Prediction & Picks

Step into Purdue vs Northwestern with confidence as we bring you our main match prediction, projected scoreline and a custom-built bet builder. Dive into each section below for the latest insights.

Game Prediction

We think that Northwestern should prove too strong in this college football battle. Therefore, we’re confidently wagering them to win and there’s juice in the -143 available.

We use the latest team news and injury updates to help shape the best possible CFB predictions. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.

Key Purdue vs Northwestern stats:

• Northwestern have won 4 of their last 5 games.
• Northwestern have won 4 of their last 6 games this season.
• Northwestern have won 3 consecutive games.
• Purdue have lost their last 12 games on the road.
• Purdue have lost 16 of their last 20 games.
• Northwestern have won the last 2 games between these teams.

Northwestern Moneyline Probability

According to the best betting apps, there’s a 58.8% chance that our pick is settled as a winner. Taking all factors into consideration, our experts think there’s a stronger chance of success and have a probability interval between 65-70%. This is why we regard this as a value wager.

If you can correctly predict that Northwestern will win along with the number of points, then you are able to combine the two options and getting larger odds on the Result & Total lines.

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Best Bet

Northwestern Moneyline @ -143 Bet Now

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Correct Score Prediction

Purdue 21 - 30 Northwestern

Should you wish to go for a speculative bet, try the Wildcats to triumph 30-21 on the correct score lines. This should be a fun wager which could potentially yield a huge return.

Purdue vs Northwestern Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Northwestern Moneyline Odds Suggest Victory

With a 61% chance of securing victory, Northwestern are favorites for this college game and the sportsbooks have them at betting odds of -154. Purdue are trading at bigger odds than their opponents and they can be backed at +130.

The spread currently stands at 3.5 and the total points line is 46.5. There are many ways to wager on football including the Totals. If you’re going for Under 46.5, this outcome can be backed at -110.

The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.

Moneyline

Purdue

+130

Northwestern

-154

Point Spread

Purdue +3.5

-122

Northwestern -3.5

-100

Total Points

Under 46.5

-110

Over 46.5

-110

Player Props & Micro Betting

Prop bets don’t involve betting on a team to win and instead might look at a player’s individual performance. For example, the number of Passing Yards a quarterback might have or the number of Touchdowns a player might score.

There are always opportunities to enjoy college football micro betting. It’s generally the case that you will find player and team props in-game and bettors can use their insight to wager on outcomes such as the Next Punt, Turnover or Score Play.

Northwestern Home Form Reads Six Defeats in Last Ten

Northwestern have four wins and six losses in the last 10 games at home, averaging 22.80 points on offense and surrendering 22.80 on defense.

Purdue have suffered ten consecutive road defeats. They have zero win and ten losses in the last 10 games away from home, averaging 17.10 points scored and 42.20 points allowed.

In their most recent matchup at Northwestern Medicine Field at Martin Stadium, Northwestern got the better of Purdue 23-15.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
Northwestern Home Stats		4-6	45.60	22.80	22.80	5	5
Purdue Away Stats		0-10	59.30	17.10	42.20	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O46.5 = Games Over 46.5 Points
• U46.5 = Games Under 46.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Purdue Boilermakers Stats

Northwestern Wildcats Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 0 wins and 10 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 2 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 1 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 54.60 pts in the previous 10 games
• Game Totals on the Road: An average of 59.30 pts in the previous 10 games on the road
• Over 46.5: Covered in 7 of the previous 10 games
• Over 46.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 18.60 pts and allowed 36.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 17.10 pts and allowed 42.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 45.20 pts in the previous 10 games
• Game Totals at Home: An average of 45.60 pts in the previous 10 home games
• Over 46.5: Covered in 5 of the previous 10 games
• Over 46.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 20.70 pts and allowed 24.50 pts in the last 10 games
• Team Totals at Home: Have scored an average of 22.80 pts and allowed 22.80 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	W	L	PF	PA	N. Pts	Home	Away	Strk
Indiana	7	0	307	81	226	5-0	2-0	7W
Ohio State	7	0	255	41	214	4-0	3-0	7W
Oregon	6	1	309	101	208	3-1	3-0	1W
Nebraska	5	2	252	136	116	3-1	2-1	1L
Washington	5	2	242	142	100	3-1	2-1	1L
Northwestern	5	2	159	106	53	4-1	1-1	4W
USC	5	2	297	162	135	4-0	1-2	1L
Minnesota	5	2	188	133	55	5-0	0-2	2W
Michigan	5	2	201	119	82	4-0	1-2	1W
Iowa	5	2	209	102	107	3-1	2-1	2W
Illinois	5	2	238	178	60	3-1	2-1	1L
Maryland	4	3	198	121	77	3-2	1-1	3L
Michigan State	3	4	190	229	-39	3-1	0-3	4L
Penn State	3	4	238	136	102	3-2	0-2	4L
Rutgers	3	4	224	221	3	3-2	0-2	4L
UCLA	3	4	157	192	-35	2-2	1-2	3W
Purdue	2	5	159	195	-36	2-2	0-3	5L
Wisconsin	2	5	93	170	-77	2-3	0-2	5L