San Diego State vs Northern Illinois Prediction, Picks & Odds | 27 Sep 2025

College Football Betting Preview: San Diego State vs Northern Illinois

San Diego State meet Northern Illinois in this NCAAF Week 5 matchup at Huskie Stadium, with kickoff scheduled for 15:30 on Saturday 27 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Northern Illinois to Put Up a Fight

Our prediction is that Northern Illinois can outperform their odds against San Diego State. It leads us to a wager on the spread lines considering that an appealing +2.5 has been chalked up at -112.

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SDSU Landed Big Win in Last Game

San Diego State Aztecs previous game saw them claim a 34-0 home win over Cal at Snapdragon Stadium.

Northern Illinois Huskies have been defeated in back-to-back games. On the road, they recently suffered a 38-10 loss against Mississippi State Bulldogs at Davis Wade Stadium.

San Diego State vs Northern Illinois Prediction & Picks

Our San Diego State vs Northern Illinois betting guide delivers expert insight, including a main match pick, our correct score angle and bet builder recommendations. Dive into each section below for more.

Game Prediction

There’s a good opportunity to back Northern Illinois against the spread considering the underdogs should perform well in this college football matchup. Snap up the -112 when it comes to them covering the +2.5.

Team news and current form always play a key role in shaping our expert CFB predictions. We also dig into the latest stats and trends to help deliver the most accurate picks possible.

Key San Diego State vs Northern Illinois stats:

• The +2.5 line has been covered by Northern Illinois in 4 of their last 5 games at home.
• The +2.5 line has been covered by Northern Illinois in 7 of their last 10 games at home.
• The +2.5 line has been covered by Northern Illinois in 3 consecutive games at home.
• The -2.5 line hasn’t been covered by San Diego State in 4 consecutive games on the road.
• The -2.5 line hasn’t been covered by San Diego State in 8 of their last 10 games on the road.
• The -2.5 line hasn’t been covered by San Diego State in 14 of their last 20 games.

Northern Illinois +2.5 Probability

According to the best betting apps, there’s a 52.9% chance that our pick is settled as a winner. After careful examination, our team calculate this probability to be closer to 60%. It is the reason why we are recommending this college wager.

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Best Bet

Northern Illinois +2.5 @ -112 Bet Now

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Correct Score Prediction

San Diego State 23 - 24 Northern Illinois

We’re expecting this to be a close matchup and we’ll take Northern Illinois to win 24-23. This is available at massive odds for those that want to have a speculative wager.

San Diego State vs Northern Illinois Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Latest Odds Suggest a Close Contest

There are betting odds of +105 about Northern Illinois winning, with San Diego State currently available at -127. In the eyes of the leading sportsbooks, the home team are regarded as 49% likely to claim a victory.

The spread is calculated to be 2.5, while total points comes in at 43.5. A wager on the Totals allows football bettors to use the latest data to good effect. If you want to bet Under 43.5, there are odds of -110.

College football fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every clash on the coupon. Head to the top betting sites and find the best value picks.

Moneyline

SDSU

-127

NIU

+105

Point Spread

SDSU -2.5

-105

NIU +2.5

-115

Total Points

Under 43.5

-110

Over 43.5

-110

Player Props & Micro Betting

Prop betting is very popular, with bettors looking to wager on quarterback and player props such as First/Last Touchdown Scorer, Passing Yards, Player Passing Attempts, Interceptions and Kicking Points. The gambling sites will provide plenty of options.

An increasing number of bettors are now enjoying micro betting on college football and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Can Northern Illinois Stay Hot at Home?

Northern Illinois have reeled off three in a row at Huskie Stadium. They are 7-3 in their last 10 home games, posting 24.80 points per contest while yielding 15.90.

San Diego State have fallen in four consecutive away contests. They have two wins and eight losses in the last 10 games on the road, averaging 20.80 points scored and 33.10 points allowed.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Northern Illinois Home Stats		7-3	40.70	24.80	15.90	3	7
San Diego State Away Stats		2-8	53.90	20.80	33.10	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O43.5 = Games Over 43.5 Points
• U43.5 = Games Under 43.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

San Diego State Aztecs Stats

Northern Illinois Huskies Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 52.10 pts in the previous 10 games
• Game Totals on the Road: An average of 53.90 pts in the previous 10 games on the road
• Over 43.5: Covered in 7 of the previous 10 games
• Over 43.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 24.20 pts and allowed 27.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.80 pts and allowed 33.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 41.20 pts in the previous 10 games
• Game Totals at Home: An average of 40.70 pts in the previous 10 home games
• Over 43.5: Covered in 5 of the previous 10 games
• Over 43.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 19.90 pts and allowed 21.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 24.80 pts and allowed 15.90 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Mid-American	W	L	PF	PA	N. Pts	Home	Away	Strk
Bowling Green	2	2	86	94	-8	2-0	0-2	1L
Buffalo	2	2	103	78	25	1-1	1-1	1L
Central Michigan	2	2	85	132	-47	1-0	1-2	1W
Ohio	2	2	109	116	-7	2-0	0-2	1W
Toledo	2	2	134	59	75	2-0	0-2	1L
Northern Illinois	1	2	38	75	-37	1-0	0-2	2L
Akron	1	3	79	116	-37	1-1	0-2	1W
Ball State	1	3	62	133	-71	1-0	0-3	1L
Eastern Michigan	1	3	107	159	-52	1-1	0-2	1W
Kent State	1	3	73	176	-103	1-1	0-2	3L
Western Michigan	1	3	50	107	-57	1-1	0-2	1W
Massachusetts	0	3	43	116	-73	0-2	0-1	3L
Miami (OH)	0	3	55	103	-48	0-1	0-2	3L

Mountain West	W	L	PF	PA	N. Pts	Home	Away	Strk
UNLV	4	0	147	113	34	2-0	2-0	4W
Fresno State	4	1	164	100	64	2-0	2-1	4W
Utah State	3	1	147	97	50	3-0	0-1	2W
Boise State	2	1	107	85	22	1-0	1-1	2W
New Mexico	2	1	84	66	18	1-0	1-1	2W
San Diego State	2	1	89	36	53	2-0	0-1	1W
Hawaii	3	2	110	106	4	3-1	0-1	1L
Wyoming	2	2	67	75	-8	1-1	1-1	2L
Air Force	1	2	116	111	5	1-1	0-1	2L
Colorado State	1	2	58	72	-14	1-1	0-1	1L
San Jose State	1	2	52	82	-30	1-1	0-1	1W
Nevada	1	3	60	108	-48	1-1	0-2	2L