South Carolina vs Missouri Prediction, Picks & Odds | 20 Sep 2025

College Football Betting Preview: South Carolina vs Missouri

South Carolina face Missouri in this NCAAF Week 4 matchup at Faurot Field, with kickoff scheduled for 19:00 on Saturday 20 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Mizzou Look the Value Bet

Missouri are available at odds of -110 when it comes to backing them against the spread. The -9.5 line could be covered with ease in their clash against against South Carolina and this looks like a value bet.

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Mizzou Have Won 5 of Previous 6 H2H Matchups

South Carolina Gamecocks were defeated in their previous game. They were beaten at home to Vanderbilt Commodores by a 31-7 scoreline at Williams-Brice Stadium.

Missouri Tigers won their last game 52-10, making it three victories on the bounce. This was a home win at Faurot Field against Louisiana Ragin Cajuns.

Head-to-Head Statistics

The last matchup between South Carolina and Missouri saw the former win. It was a 34-30 scoreline at Williams-Brice Stadium. Missouri have won five of the previous 6 H2H meetings.

Quarterbacks

LaNorris Sellers

206.5 Passing Yards

Over -114

Under -114

Beau Pribula

230.5 Passing Yards

Over -114

Under -114

South Carolina vs Missouri Prediction & Picks

Get the full betting picture for South Carolina vs Missouri, including our expert match prediction, likely scoreline, must-watch player props and a tailored bet builder ready to use.

Game Prediction

Missouri should secure a comfortable win and a bet on the spread could be the best way forward in this college football battle. Back this selection off -9.5 to cover the line at -110.

Tracking injury updates is a big part of our CFB analysis and team news plays a major role in shaping our picks. We combine this with recent form and the most important stats to get a complete picture.

Key South Carolina vs Missouri stats:

• The -9.5 line has been covered by Missouri in 3 consecutive games.

Mizzou -9.5 Probability

Looking at the latest betting odds, our pick has a 52.4% chance of winning. After careful examination, our cappers have this probability somewhere between 55-60%. This is why we regard this as a value bet.

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Best Bet

Missouri -9.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Beau Pribula Over 230.5 Passing Yards -114

You can back Beau Pribula (Missouri) at -114 to exceed 230.5 passing yards. We feel confident that he’ll cover the QB Passing Yards line, which looks generous.

Latest Beau Pribula Player Prop Odds

Passing Yards

Over 230.5

-114

Under 230.5

-114

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LaNorris Sellers Over 24.5 Rushing Yards -114

You can back LaNorris Sellers (South Carolina) at -114 to record more than 24.5 rushing yards. We're confident in him covering the Player Rushing Yards line and hitting our Over bet.

Latest LaNorris Sellers Player Prop Odds

Passing Yards

Over 206.5

-114

Under 206.5

-114

Rushing Yards

Over 30.5

-114

Under 30.5

-114

Correct Score Prediction

South Carolina 17 - 34 Missouri

There’s a massive payout on the cards should you correctly predict the correct score. We’re siding with the Tigers to enjoy a 34-17 victory which will hopefully go close.

South Carolina vs Missouri Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Have Mizzou as Heavy Favorites

Missouri have the shortest price to win this college game, with the sportsbooks giving them a 79% probability due to their -370 Moneyline betting odds. For those wanting to oppose the market leader, you can get +285 about South Carolina.

The spread currently stands at 9.5 and the total points line is 48.5. Football fans love the chance to get an alternative angle by going for a Total wager. There’s the chance to back Under 48.5 at -110.

There are a wide range of game lines and team props when it comes to most college football matchups and we recommend visiting the best betting apps to find the wager that matches your view on the game.

Moneyline

South Carolina

+285

Missouri

-370

Point Spread

South Carolina +9.5

-105

Missouri -9.5

-115

Total Points

Under 48.5

-110

Over 48.5

-110

Player Odds

Receiving Yards

Kevin Coleman Jr. (Missouri)

Over 72.5

-114

Under 72.5

-114

Nyck Harbor (South Carolina)

Over 60.5

-114

Under 60.5

-114

Marquis Johnson (Missouri)

Over 37.5

-114

Under 37.5

-114

Donovan Murph (South Carolina)

Over 33.5

-114

Under 33.5

-114

Brett Norfleet (Missouri)

Over 15.5

-114

Under 15.5

-114

Rushing Yards

Ahmad Hardy (Missouri)

Over 90.5

-114

Under 90.5

-114

Rahsul Faison (South Carolina)

Over 63.5

-114

Under 63.5

-114

Jamal Roberts (Missouri)

Over 49.5

-114

Under 49.5

-114

LaNorris Sellers (South Carolina)

Over 30.5

-114

Under 30.5

-114

Passing Yards

Beau Pribula (Missouri)

Over 230.5

-114

Under 230.5

-114

LaNorris Sellers (South Carolina)

Over 206.5

-114

Under 206.5

-114

Can Missouri Continue Strong Home Form?

Missouri have ten wins and zero loss in the last 10 home games, scoring 38.00 points per contest and conceding 15.60.

South Carolina have four wins and six losses in the last 10 games on the road, averaging 21.60 points scored and 21.30 points allowed.

Missouri beat South Carolina 34-12 when the teams last met at Faurot Field. Looking at the past 3 head-to-head meetings at Faurot Field, Missouri have taken every win.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Missouri Home Stats		10-0	53.60	38.00	15.60	7	3
South Carolina Away Stats		4-6	42.90	21.60	21.30	2	8

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

South Carolina Gamecocks Stats

Missouri Tigers Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 10 wins and 0 defeats in the last 10 home games

Point Spread

• +9.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +9.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -9.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -9.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 46.50 pts in the previous 10 games
• Game Totals on the Road: An average of 42.90 pts in the previous 10 games on the road
• Over 48.5: Covered in 3 of the previous 10 games
• Over 48.5 on the Road: Covered in 2 of the previous 10 games on the road
• Team Totals: Have scored an average of 30.00 pts and allowed 16.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.60 pts and allowed 21.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 55.00 pts in the previous 10 games
• Game Totals at Home: An average of 53.60 pts in the previous 10 home games
• Over 48.5: Covered in 8 of the previous 10 games
• Over 48.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 33.00 pts and allowed 22.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 35.60 pts and allowed 18.00 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Southeastern	W	L	PF	PA	N. Pts	Home	Away	Strk
Auburn	3	0	111	42	69	2-0	1-0	3W
Georgia	3	0	117	54	63	2-0	1-0	3W
LSU	3	0	60	27	33	2-0	1-0	3W
Mississippi State	3	0	121	37	84	2-0	1-0	3W
Missouri	3	0	155	47	108	3-0	0-0	3W
Oklahoma	3	0	101	19	82	2-0	1-0	3W
Ole Miss	3	0	134	65	69	2-0	1-0	3W
Texas A&M	3	0	127	86	41	2-0	1-0	3W
Vanderbilt	3	0	120	30	90	1-0	2-0	3W
Alabama	2	1	128	45	83	2-0	0-1	2W
Arkansas	2	1	143	62	81	2-0	0-1	1L
Kentucky	2	1	95	69	26	2-1	0-0	1W
South Carolina	2	1	69	52	17	2-1	0-0	1L
Tennessee	2	1	158	87	71	2-1	0-0	1L
Texas	2	1	72	31	41	2-0	0-1	2W
Florida	1	2	81	38	43	1-1	0-1	2L