South Florida vs Memphis Prediction, Picks & Odds | 25 Oct 2025

College Football Betting Preview: South Florida vs Memphis

South Florida clash with Memphis in this NCAAF Week 9 matchup at Simmons Bank Liberty Stadium, with kickoff scheduled for 12:00 on Saturday, October 25. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

We’re delighted to see Memphis have been given a headstart on the spread. Take the +5.5 at -100 when they go up against South Florida.

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South Florida made it four consecutive wins after a 48-13 home success over Florida Atlantic Owls at Raymond James Stadium.

Memphis Tigers have won their last three home games. Most recently, they lost 31-24 on the road at Protective Stadium against UAB Blazers.

Head-to-Head Statistics

The scoreline was 21-3 in favor of Memphis when they last played South Florida, with the matchup taking place at Raymond James Stadium. In the past 4 meetings between these teams, Memphis have won all of them.

South Florida vs Memphis Prediction & Picks

Step into South Florida vs Memphis with confidence as we bring you our main match prediction, projected scoreline and a custom-built bet builder. Dive into each section below for the latest insights.

Game Prediction

We’ll take a chance on the underdogs in this college football battle. Memphis have been given a generous +5.5 on the spread and we think -100 can be taken with confidence that they cover the line.

Tracking injury updates is a big part of our CFB analysis and team news plays a major role in shaping our picks. We combine this with recent form and the most important stats to get a complete picture.

Key South Florida vs Memphis stats:

• The +5.5 line has been covered by Memphis in 12 consecutive games at home.
• The +5.5 line has been covered by Memphis in 18 of their last 20 games at home.
• The -5.5 line hasn’t been covered by South Florida in 4 of their last 5 games on the road.
• The -5.5 line hasn’t been covered by South Florida in 14 of their last 20 games on the road.
• The +5.5 line has been covered by Memphis in 4 consecutive games against South Florida.

Memphis +5.5 Probability

According to the best betting apps, there’s a 50% chance that our pick is settled as a winner. However, our cappers have this figure closer to 60% based on their in-depth research. This is why we regard this as a value bet.

The sportsbooks give you the chance to buy or sell points, meaning that you can select from a variety of lines. Buying means shorter prices, with selling sending the odds upwards.

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Our Game Prediction

Memphis +5.5 @ -100 Bet Now

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Correct Score Prediction

South Florida 34 - 31 Memphis

the Bulls are available at massive odds to register a 34-31 victory and they might have the edge. This should be a close matchup and there won’t be much between the teams.

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South Florida vs Memphis Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

South Florida are -175 favorites and that means a 64% chance of winning this college game according to the Moneyline betting odds with the sportsbooks. The market suggests that Memphis are least likely to win at +148.

3.5 is the spread and 60.5 is the total points line. The Totals offers football bettors an alternative way of getting involved. If you want to bet Under 60.5, there are odds of -115.

Consider every angle when placing your college football wagers. The best betting sites have a huge selection of team props and game lines and it’s all about finding a bet which matches your prediction of the game.

Moneyline

USF

-175

Memphis

+148

Point Spread

USF -3.5

-115

Memphis +3.5

-105

Total Points

Under 60.5

-115

Over 60.5

-105

There is regularly value to be found from betting the quarterback and player props with the best online gambling sites. You can find lots of ways to back for or against a specific player lining up for one of the two teams.

It’s possible to use stats to your advantage when it comes to college football micro betting, especially if you’re predicting outcomes such as the Next Drive Result. Check out the live player, score and team props and see if you can find an angle.

Memphis Keep Piling Up Home Wins

Memphis have gone 10-0 across their last 10 home games, averaging 38.90 points on offense and surrendering 18.20 on defense.

South Florida own a 6-4 mark in their past 10 games away from home, scoring 34.00 points per contest and conceding 33.10.

Memphis beat South Florida 59-50 when they last met at Simmons Bank Liberty Stadium.

Last 10 Games		W-L	P	PF	PA	O59.5	U59.5
Memphis Home Stats		10-0	57.10	38.90	18.20	4	6
South Florida Away Stats		6-4	67.10	34.00	33.10	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O59.5 = Games Over 59.5 Points
• U59.5 = Games Under 59.5 Points

Latest regular season and playoff games stats.

South Florida Stats

Memphis Tigers Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 10 wins and 0 defeats in the last 10 home games

Point Spread

• -5.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -5.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• +5.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +5.5 Betting Line at Home: Have covered the spread in the last 10 home games

Total Points

• Game Totals: An average of 68.90 pts in the previous 10 games
• Game Totals on the Road: An average of 67.10 pts in the previous 10 games on the road
• Over 59.5: Covered in 8 of the previous 10 games
• Over 59.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 42.40 pts and allowed 26.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 34.00 pts and allowed 33.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 60.30 pts in the previous 10 games
• Game Totals at Home: An average of 57.10 pts in the previous 10 home games
• Over 59.5: Covered in 4 of the previous 10 games
• Over 59.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 39.60 pts and allowed 20.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 38.90 pts and allowed 18.20 pts in the last 10 home games

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