Southern Miss vs Louisiana Tech Prediction, Picks & Odds | 20 Sep 2025

College Football Betting Preview: Southern Miss vs Louisiana Tech

Southern Miss go up against Louisiana Tech in this NCAAF Week 4 matchup at Joe Aillet Stadium, with kickoff scheduled for 19:30 on Saturday 20 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Louisiana Tech Look the Best Bet

Louisiana Tech should be able to cover the -3.5 betting line against Southern Miss. We’re confident of a strong showing and a wager on the spread is the best play at odds of -110.

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Southern Miss Beat Louisiana Tech in their Last Matchup

Southern Mississippi Golden Eagles made it back-to-back wins after a 38-22 home success over Appalachian State Mountaineers at M.M. Roberts Stadium.

Louisiana Tech Bulldogs last game was a 49-14 victory over New Mexico State Aggies at Joe Aillet Stadium. That means it’s now been two home wins on the spin.

Head-to-Head Statistics

Southern Miss won the last matchup between the pair. Enjoying a 35-19 triumph when facing Louisiana Tech at Joe Aillet Stadium. We’ve seen two Louisiana Tech wins in the past 3 meetings between the teams.

Southern Miss vs Louisiana Tech Prediction & Picks

Explore our best Southern Miss vs Louisiana Tech picks, including a main match prediction, correct score forecast and a bet builder ready to use. Scroll down for full analysis.

Game Prediction

Louisiana Tech are available at odds of -110 when it comes to backing them against the spread in this college football battle. The -3.5 line could be covered with ease by the favorites and this looks like a value bet.

Recent form is always part of the equation and we combine it with team news as soon as it’s available. To deliver expert predictions, our college football handicappers also analyze the latest stats to ensure we’re working with the best information possible.

Key Southern Miss vs Louisiana Tech stats:

• The -3.5 line has been covered by Louisiana Tech in 4 of their last 5 games at home.
• The -3.5 line has been covered by Louisiana Tech in 6 of their last 10 games at home.
• The -3.5 line has been covered by Louisiana Tech in 3 consecutive games at home.
• The +3.5 line hasn’t been covered by Southern Miss in 7 consecutive games on the road.
• The +3.5 line hasn’t been covered by Southern Miss in 9 of their last 10 games on the road.
• The +3.5 line hasn’t been covered by Southern Miss in 15 of their last 20 games.

Louisiana Tech -3.5 Probability

Based on the odds from the top betting apps, our pick has a 52.4% chance of landing a return. After careful examination, our experts have this probability somewhere between 55-60%. That means we’re regarding it as a value bet.

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Best Bet

Louisiana Tech -3.5 @ -110 Bet Now

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Correct Score Prediction

Southern Miss 23 - 34 Louisiana Tech

There’s the chance to back Louisiana Tech in lots of different ways and this includes predicting the correct winning score. We’ll go for a 34-23 triumph in their favor.

Southern Miss vs Louisiana Tech Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Louisiana Tech Betting Favorites on the Moneyline

Louisiana Tech are -172 favorites and that means a 63% chance of winning this college game according to the Moneyline betting odds with the sportsbooks. At +142, Southern Miss are regarded as having a lower probability of winning.

3.5 is the spread and 50.5 is the total points line. The Totals offers football bettors an alternative way of getting involved. Those expecting a low total can back Under 50.5 at -106.

The good news is that you can access a wide range of team props and game lines for most college football clashes. The top betting sites offer a great selection of pre-game and in-game wagering options.

Moneyline

Southern Miss

+142

Louisiana Tech

-172

Point Spread

Southern Miss +3.5

-110

Louisiana Tech -3.5

-110

Total Points

Under 50.5

-106

Over 50.5

-114

Player Props & Micro Betting

There is regularly value to be found from betting the quarterback and player props with the best online gambling sites. You can find lots of ways to back for or against a specific player lining up for one of the two teams.

For those looking to enjoy a thrilling in-game wager, then college football micro betting could be up your street. You are now able to wager on what will happen on the next snap by staking your money on the Next Play Result.

Louisiana Tech Riding a Home Hot Streak

Louisiana Tech have chalked up three straight victories at Joe Aillet Stadium. They are 6-4 in their last 10 home games, putting up 30.10 points per contest and giving up 19.80.

Southern Miss have been on the losing end in seven straight road games. They have one win and nine losses in the last 10 games away from home, averaging 16.10 points scored and 43.00 points allowed.

The last Joe Aillet Stadium meeting saw Southern Miss beat Louisiana Tech 35-19.

Last 10 Games		W-L	P	PF	PA	O50.5	U50.5
Louisiana Tech Home Stats		6-4	49.90	30.10	19.80	5	5
Southern Miss Away Stats		1-9	59.10	16.10	43.00	8	2

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O50.5 = Games Over 50.5 Points
• U50.5 = Games Under 50.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Southern Mississippi Golden Eagles Stats

Louisiana Tech Bulldogs Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 2 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 1 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 56.90 pts in the previous 10 games
• Game Totals on the Road: An average of 59.10 pts in the previous 10 games on the road
• Over 50.5: Covered in 7 of the previous 10 games
• Over 50.5 on the Road: Covered in 8 of the previous 10 games on the road
• Team Totals: Have scored an average of 19.70 pts and allowed 37.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 16.10 pts and allowed 43.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 36.80 pts in the previous 10 games
• Game Totals at Home: An average of 49.90 pts in the previous 10 home games
• Over 50.5: Covered in 2 of the previous 10 games
• Over 50.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 19.90 pts and allowed 16.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 30.10 pts and allowed 19.80 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Conference USA	W	L	PF	PA	N. Pts	Home	Away	Strk
Delaware Blue Hens	2	1	86	89	-3	2-0	0-1	1W
FIU	2	1	80	71	9	2-0	0-1	1W
Louisiana Tech	2	1	80	37	43	2-0	0-1	1W
New Mexico St	2	1	54	66	-12	2-0	0-1	1L
Western Kentucky	2	1	117	75	42	2-0	0-1	1L
Jacksonville State	1	2	78	82	-4	1-0	0-2	1L
Kennesaw State	1	2	45	79	-34	1-0	0-2	1W
Liberty	1	2	65	64	1	1-0	0-2	2L
M. Tennessee	1	2	38	89	-51	0-1	1-1	1W
Missouri State	1	2	44	121	-77	0-1	1-1	1L
UTEP	1	2	68	72	-4	1-0	0-2	1L
Sam Houston	0	3	65	116	-51	0-1	0-2	3L

Sun Belt	W	L	PF	PA	N. Pts	Home	Away	Strk
Appalachian State	2	1	76	62	14	1-0	1-1	1L
Old Dominion	2	1	113	59	54	1-0	1-1	2W
Southern Miss	2	1	93	76	17	2-1	0-0	2W
Texas State	2	1	110	97	13	1-0	1-1	1L
James Madison	1	1	59	38	21	1-0	0-1	1L
UL Monroe	1	1	29	73	-44	1-0	0-1	1L
Coastal Carolina	1	2	20	86	-66	1-1	0-1	1L
Georgia Southern	1	2	75	135	-60	1-0	0-2	1W
Georgia State	1	2	60	122	-62	1-1	0-1	1W
Marshall	1	2	65	73	-8	1-1	0-1	1W
Arkansas State	1	2	72	104	-32	1-1	0-1	2L
Louisiana	1	2	56	76	-20	1-1	0-1	1L
South Alabama	1	2	84	85	-1	1-1	0-1	2L
Troy State	1	2	61	75	-14	1-1	0-1	2L