Toledo vs Louisville Prediction, Picks & Odds | 23 Dec 2025
College Football Betting Preview: Toledo vs Louisville
Toledo face Louisville at L&N Federal Credit Union Stadium, with kickoff scheduled for 14:00 on Tuesday, December 23.
We wouldn’t be surprised to see Toledo win and it makes sense to take +6.5 on the spread at -104 when they go up against Louisville.
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Toledo Rockets have triumphed in their previous four games. The latest was on the road where Central Michigan Chippewas were beaten 21-3 at Kelly/Shorts Stadium.
Louisville Cardinals won their last game which was at home. It was a 41-0 triumph at L&N Federal Credit Union Stadium against Kentucky Wildcats.
Quarterbacks
Kalieb Osborne
Miller Moss
Toledo vs Louisville Prediction & Picks
Our expert Toledo vs Louisville tips include betting advice on all fronts — from a main match prediction and player prop guidance to a correct score selection and a ready-made bet builder.
Game Prediction
Toledo should give a good account of themselves in this college football showdown and the pick is to bet the underdogs against the spread. The +6.5 looks attractive and -104 is available.
Team news plays a key role in our college football forecasts and we’re always tracking players with injury concerns. We also stay on top of the form guide, supported by detailed stats that help paint a clearer picture of what to expect
Key Toledo vs Louisville stats:
Toledo +6.5 Probability
The top betting apps are suggesting that our pick has a 51% chance of delivering a return. Our experts think there’s a stronger chance of success and calculate the probability to be 55-60%. It is the reason why we are recommending this college wager.
There are bigger prices available to bettors who are willing to move the line. If you’re prepared for additional risk, more juice can be landed from your betting selections.
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Player Prop Picks
You can place a bet on Chip Trayanum (Toledo) to score a TD at +105. We think this is the pick of the player props, with generous odds available when it comes to backing him to score a touchdown at any time.
You can back Junior Vandeross III (Toledo) at -114 to exceed 60.5 receiving yards. The line for him on the Overs looks attractive and bettors can get plenty of juice from this Player Receiving Yards wager.
Same Game Parlay Picks
We’ve got a same game parlay with three options: Toledo +6.5, Under 44.5 points and Chip Trayanum (Toledo) to record a touchdown.
The same game parlay option allows you to combine different outcomes within the same game. You need all your predictions to be correct although bettors love to place a tailored football bet on the event which interests them most.
Correct Score Prediction
21
-
20
Louisville
A close battle could be on the cards. We’ll bet on the Rockets to claim a 21-20 victory at huge odds and this correct score pick should hopefully be a fun one.
Toledo vs Louisville Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Louisville are regarded as having a 72% chance of winning this college game according to the latest betting odds. The sportsbooks have priced them up at -256. If you’re looking for an alternative angle, Toledo are trading at +210.
The spread currently stands at 6.5 and the total points line is 44.5. Football bettors regularly enjoy the opportunity to wager on the Totals. There’s the chance to back Under 44.5 at -105.
The good news is that you can access a wide range of team props and game lines for most college football clashes. The top betting sites offer a great selection of pre-game and in-game wagering options.
The First Touchdown Scorer favorite is Isaac Brown at +410. Similar odds can be found if you’re interested in this player to register the final TD.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Latest regular season and playoff games stats.
Toledo Rockets Stats
Louisville Cardinals Stats
- 7 wins and 3 defeats in the last 10 games
- 4 wins and 6 defeats in the last 10 games on the road
- +6.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +6.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road
- -6.5 Betting Line: Have covered the spread in 5 of the last 10 games
- -6.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games
- Game Totals: An average of 41.90 pts in the previous 10 games
- Game Totals on the Road: An average of 36.00 pts in the previous 10 games on the road
- Over 44.5: Covered in 6 of the previous 10 games
- Over 44.5 on the Road: Covered in 3 of the previous 10 games on the road
- Team Totals: Have scored an average of 31.80 pts and allowed 10.10 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 17.50 pts and allowed 18.50 pts in the last 10 games on the road
- Game Totals: An average of 50.50 pts in the previous 10 games
- Game Totals at Home: An average of 56.40 pts in the previous 10 home games
- Over 44.5: Covered in 6 of the previous 10 games
- Over 44.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 28.30 pts and allowed 22.20 pts in the last 10 games
- Team Totals at Home: Have scored an average of 35.20 pts and allowed 21.20 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Virginia
|
10 | 3 | 418 | 267 | 151 | 6-2 | 4-1 | 1L |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
|
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
Duke
|
8 | 5 | 442 | 373 | 69 | 3-3 | 5-2 | 3W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
| Mid-American | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Western Michigan
|
9 | 4 | 307 | 237 | 70 | 6-1 | 3-3 | 5W |
Ohio
|
8 | 4 | 344 | 275 | 69 | 6-0 | 2-4 | 2W |
|
Toledo
|
8 | 4 | 379 | 146 | 233 | 6-0 | 2-4 | 4W |
Central Michigan
|
7 | 5 | 286 | 272 | 14 | 4-1 | 3-4 | 1L |
Miami (OH)
|
7 | 6 | 326 | 286 | 40 | 4-2 | 3-4 | 1L |
Akron
|
5 | 7 | 267 | 329 | -62 | 3-3 | 2-4 | 1W |
Buffalo
|
5 | 7 | 288 | 282 | 6 | 2-5 | 3-2 | 3L |
Kent State
|
5 | 7 | 255 | 403 | -148 | 3-2 | 2-5 | 1W |
Ball State
|
4 | 8 | 190 | 358 | -168 | 4-1 | 0-7 | 3L |
Eastern Michigan
|
4 | 8 | 289 | 357 | -68 | 3-3 | 1-5 | 1L |
Bowling Green
|
4 | 8 | 246 | 291 | -45 | 3-3 | 1-5 | 1W |
Northern Illinois
|
3 | 9 | 205 | 292 | -87 | 2-4 | 1-5 | 2L |
UMass
|
0 | 12 | 133 | 463 | -330 | 0-6 | 0-6 | 12L |
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