USC vs Notre Dame Prediction, Picks & Odds | 18 Oct 2025
College Football Betting Preview: USC vs Notre Dame
USC lock horns with Notre Dame in this NCAAF Week 8 battle at Notre Dame Stadium, with kickoff scheduled for 19:30 on Saturday 18 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
Get With Notre Dame to Cover the Line
We’re bullish about Notre Dame on the spread at -9.5. They should be able to win by a comfortable margin in their clash against USC and you can get odds of -110.
Feeling our spread angle? Grab the exclusive BetMGM promo code and read our expert sportsbook review to get the best value.
Notre Dame Are 4 From 5 on the Head-to-Head
USC Trojans previous game saw them claim a 31-13 home win over Michigan Wolverines at LA Memorial Coliseum.
Notre Dame Fighting Irish last game was a 36-7 home win. This victory over North Carolina State Wolfpack at Notre Dame Stadium was their fourth successive victory.
Head-to-Head Statistics
Notre Dame have beaten USC in the last two matchups. A 48-20 victory at Notre Dame Stadium was followed by a 49-35 win at LA Memorial Coliseum. We’ve seen four Notre Dame wins in the past 5 meetings between the teams.
Quarterbacks
Jayden Maiava
CJ Carr
USC vs Notre Dame Prediction & Picks
We dive into the best USC vs Notre Dame betting angles, including an expert match prediction, correct score forecast, top player prop bets and a value-focused bet builder.
Game Prediction
It’s great to see Notre Dame given a -9.5 line on the spread at -110 as we’re expecting a bigger margin of victory in this college football matchup.
Our CFB handicappers start by reviewing the latest team news for each team, followed by a close look at recent form. That information is then applied to the most relevant stats to reach a well-informed verdict.
Key USC vs Notre Dame stats:
Notre Dame -9.5 Probability
If you go by the top betting apps, there’s a 52.4% chance that our pick is settled as a winner. Based on our in-depth research, our analysts calculate the actual probability to be 55-60%. That means we are regarding it as a value wager.
Want to back Notre Dame to cover the line at bigger odds? Get more juice by taking the Bet Builder route where different selections can be combined to good effect.
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Best Bet
Notre Dame -9.5 @ -110
Player Prop Picks
The odds for CJ Carr (Notre Dame) to surpass 285.5 passing yards are -114. We’re happy to take him to cover the QB Passing Yards line and bettors can place this wager with confidence.
The odds for Jordan Faison (Notre Dame) to exceed 61.5 receiving yards stand at -114. The line for him on the Overs is highly appealing, with Player Receiving Yards bettors able to get plenty of juice.
Same Game Parlay Picks
Get in the game with a same game parlay. Our picks are Notre Dame to cover the -9.5 spread, Under 61.5 on the total and CJ Carr (Notre Dame) to have Over 285.5 passing yards.
The same game parlay option is fantastic for football bettors wanting a personalised multi-leg wager on the same game. It’s especially good if you have a strong opinion on the likely outcomes and the odds for each selection are combined.
Correct Score Prediction
20
-
38
Notre Dame
We’re going for the Irish to claim a 38-20 victory and the good news is that there are huge odds for this outcome. A small stake can return a potentially large amount.
USC vs Notre Dame Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Notre Dame Heavy Favorites to Win
With a 78% chance of securing victory, Notre Dame are favorites for this college game and the sportsbooks have them at betting odds of -345. USC are trading at bigger odds than their opponents and they can be backed at +280.
There is a spread of 9.5 and total points has a line of 60.5. There is no denying the popularity of wagering on the Totals. Those who wager Under 60.5 can get -105.
The top sportsbooks offer a huge selection of team props and game lines when it comes to most college football games. Make sure you look through all the available options before deciding which bet to place.
Jeremiyah Love Favorite to Be First Touchdown Scorer
You will find Jeremiyah Love at +430 to be First Touchdown Scorer which makes him the favorite. There’s the opportunity to get -278 that he scores a TD at anytime.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Notre Dame Eye Another Home Win
Notre Dame have put together three in a row at Notre Dame Stadium. They have nine wins and one loss in the last 10 home games, putting up 40.30 points on average and giving up 16.40.
USC have a 4-6 record in their last 10 road games, putting up 27.80 points per contest and giving up 27.50.
The last time Notre Dame faced USC at Notre Dame Stadium, they won 48-20. Across 3 head-to-head meetings at Notre Dame Stadium, Notre Dame have come out on top each time.
| Last 10 Games | W-L | P | PF | PA | O61.5 | U61.5 | |
|---|---|---|---|---|---|---|---|
 Notre Dame Home Stats |
9-1 | 56.70 | 40.30 | 16.40 | 3 | 7 | |
 USC Away Stats |
4-6 | 55.30 | 27.80 | 27.50 | 3 | 7 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O61.5 = Games Over 61.5 Points
- U61.5 = Games Under 61.5 Points
Last 5 & H2H
Latest regular season and playoff games stats.
USC Stats
Notre Dame Fighting Irish Stats
- 8 wins and 2 defeats in the last 10 games
- 4 wins and 6 defeats in the last 10 games on the road
- +9.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +9.5 Betting Line on the Road: Have covered the spread in the last 10 games on the road
- -9.5 Betting Line: Have covered the spread in 6 of the last 10 games
- -9.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games
- Game Totals: An average of 63.10 pts in the previous 10 games
- Game Totals on the Road: An average of 55.30 pts in the previous 10 games on the road
- Over 61.5: Covered in 6 of the previous 10 games
- Over 61.5 on the Road: Covered in 3 of the previous 10 games on the road
- Team Totals: Have scored an average of 39.00 pts and allowed 24.10 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 27.80 pts and allowed 27.50 pts in the last 10 games on the road
- Game Totals: An average of 55.00 pts in the previous 10 games
- Game Totals at Home: An average of 56.90 pts in the previous 10 home games
- Over 61.5: Covered in 3 of the previous 10 games
- Over 61.5 at Home: Covered in 3 of the previous 10 home games
- Team Totals: Have scored an average of 34.00 pts and allowed 21.00 pts in the last 10 games
- Team Totals at Home: Have scored an average of 39.50 pts and allowed 17.40 pts in the last 10 home games
NCAAF Standings Select Season
| Independents I-A | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
UConn
|
4 | 2 | 222 | 136 | 86 | 3-0 | 1-2 | 3W |
|
Notre Dame
|
4 | 2 | 240 | 125 | 115 | 3-1 | 1-1 | 4W |
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
6 | 0 | 269 | 68 | 201 | 4-0 | 2-0 | 6W |
Ohio State
|
6 | 0 | 221 | 41 | 180 | 4-0 | 2-0 | 6W |
Oregon
|
5 | 1 | 253 | 91 | 162 | 3-1 | 2-0 | 1L |
|
USC
|
5 | 1 | 273 | 128 | 145 | 4-0 | 1-1 | 1W |
Washington
|
5 | 1 | 235 | 118 | 117 | 3-1 | 2-0 | 2W |
Illinois
|
5 | 2 | 238 | 178 | 60 | 3-1 | 2-1 | 1L |
Minnesota
|
5 | 2 | 188 | 133 | 55 | 5-0 | 0-2 | 2W |
Nebraska
|
5 | 2 | 252 | 136 | 116 | 3-1 | 2-1 | 1L |
Northwestern
|
4 | 2 | 140 | 106 | 34 | 3-1 | 1-1 | 3W |
Maryland
|
4 | 2 | 181 | 101 | 80 | 3-2 | 1-0 | 2L |
Michigan
|
4 | 2 | 177 | 112 | 65 | 3-0 | 1-2 | 1L |
Iowa
|
4 | 2 | 184 | 78 | 106 | 2-1 | 2-1 | 1W |
Michigan State
|
3 | 3 | 177 | 191 | -14 | 3-1 | 0-2 | 3L |
Penn State
|
3 | 3 | 214 | 111 | 103 | 3-2 | 0-1 | 3L |
Rutgers
|
3 | 3 | 214 | 165 | 49 | 3-1 | 0-2 | 3L |
Purdue
|
2 | 4 | 159 | 176 | -17 | 2-2 | 0-2 | 4L |
UCLA
|
2 | 4 | 137 | 175 | -38 | 1-2 | 1-2 | 2W |
Wisconsin
|
2 | 4 | 93 | 136 | -43 | 2-2 | 0-2 | 4L |
LSU
Vanderbilt
Betting Tips
12:00 - Sat 18 Oct
NCAAF
Washington
Michigan
Betting Tips
12:00 - Sat 18 Oct
NCAAF
Army
Tulane
Betting Tips
12:00 - Sat 18 Oct
NCAAF
Georgia Tech
Duke
Betting Tips
12:00 - Sat 18 Oct
NCAAF
UConn
Boston College
Betting Tips
12:00 - Sat 18 Oct
NCAAF
Arizona
Houston
Betting Tips
12:00 - Sat 18 Oct
NCAAF
Baylor
TCU
Betting Tips
12:00 - Sat 18 Oct
NCAAF
Central Michigan
Bowling Green
Betting Tips
12:00 - Sat 18 Oct
NCAAF
Eastern Michigan
Miami (OH)
Betting Tips
12:45 - Sat 18 Oct
NCAAF
Oklahoma
South Carolina
Betting Tips
13:00 - Sat 18 Oct
NCAAF
West Virginia
UCF
Betting Tips
14:00 - Sat 18 Oct
NCAAF
Kent State
Toledo
Betting Tips
14:30 - Sat 18 Oct
NCAAF
Buffalo
Massachusetts
Betting Tips
15:00 - Sat 18 Oct
NCAAF
Purdue
Northwestern
Betting Tips
15:00 - Sat 18 Oct
NCAAF
Troy State
UL Monroe
Betting Tips
15:30 - Sat 18 Oct
NCAAF
Texas A&M
Arkansas
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Yokohama
Nagoya Grampus
Betting Tips
01:00 - Sat 18 Oct
K League 1
Anyang
Gimcheon Sangmu
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01:00 - Sat 18 Oct
K League 1
Daegu
Gangwon
Betting Tips
01:00 - Sat 18 Oct
K League 1
Jeonbuk FC
Suwon
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01:00 - Sat 18 Oct
K League 1
Daejeon Citizen
Jeju SK
Betting Tips
01:00 - Sat 18 Oct
K League 1
FC Seoul
Pohang Steelers
Betting Tips