Vanderbilt vs South Carolina Prediction, Picks & Odds | 13 Sep 2025

College Football Betting Preview: Vanderbilt vs South Carolina

Vanderbilt lock horns with South Carolina in this NCAAF matchup at Williams-Brice Stadium, with kickoff scheduled for 19:45 on Saturday 13 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

South Carolina Look the Value Bet

Bet on South Carolina against the spread, with an attractive line of -3.5 that they have the upper hand against Vanderbilt. There are odds of -106 that are currently on offer for this selection.

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South Carolina Bidding to Maintain Winning Run Over Vandy

Vanderbilt Commodores won their previous game 44-20. This road victory at Lane Stadium against Virginia Tech Hokies was their second on the spin.

South Carolina Gamecocks won their last game 38-10, making it successive victories. This was a home win at Williams-Brice Stadium against South Carolina State Bulldogs.

Head-to-Head Statistics

The last matchup between South Carolina and Vanderbilt saw the former win. It was a 28-7 scoreline at FirstBank Stadium. South Carolina have a 100% win record when it comes to the previous 6 H2H meetings.

Quarterbacks

Diego Pavia

189.5 Passing Yards

Over -114

Under -114

LaNorris Sellers

217.5 Passing Yards

Over -114

Under -114

Vanderbilt vs South Carolina Prediction & Picks

This Vanderbilt vs South Carolina betting guide features sharp analysis across major markets, including a match prediction, correct score bet, valuable player prop picks and a strategic bet builder.

Game Prediction

We are confident that South Carolina will cover the spread in this college football showdown. -3.5 seems a more than generous line and you can get -106 that the favorites will win by a bigger margin.

The CFB handicappers at Sportsgambler.com regularly track injury updates and pair that with current form. We also tap into a deep stats database to highlight the key numbers that help shape our picks.

Key Vanderbilt vs South Carolina stats:

• The -3.5 line has been covered by South Carolina in 5 consecutive games at home.
• The -3.5 line has been covered by South Carolina in 7 of their last 10 games.
• The -3.5 line has been covered by South Carolina in 12 of their last 20 games.
• The +3.5 line hasn’t been covered by Vanderbilt in 6 of their last 10 games on the road.
• The +3.5 line hasn’t been covered by Vanderbilt in 11 of their last 20 games on the road.
• The -3.5 line has been covered by South Carolina in 3 consecutive games against Vanderbilt.

South Carolina -3.5 Probability

Based on the odds from the top betting apps, our pick has a 51.5% chance of landing a return. However, our analysts think that the probability is close to 60% taking all factors into consideration. This college wager can therefore be backed with confidence.

The sportsbooks give you the chance to buy or sell points, meaning that you can select from a variety of lines. Buying means shorter prices, with selling sending the odds upwards.

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Best Bet

South Carolina -3.5 @ -106 Bet Now

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Player Prop Picks

Top Pick: Diego Pavia Under 189.5 Passing Yards -114

The odds for Diego Pavia (Vanderbilt) to end with fewer than 189.5 passing yards stand at -114. The line looks too high and we’re confident he’ll fall short of the QB Passing Yards total.

Latest Diego Pavia Player Prop Odds

Passing Yards

Over 189.5

-114

Under 189.5

-114

Rushing Yards

Over 57.5

-114

Under 57.5

-114

Correct Score Prediction

Vanderbilt 17 - 27 South Carolina

There’s a massive payout on the cards should you correctly predict the correct score. We’re siding with South Carolina to enjoy a 27-17 victory which will hopefully go close.

Vanderbilt vs South Carolina Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

South Carolina Made Favorites by the Books

For this college game, the sportsbooks’ Moneyline betting odds mean South Carolina are -154 favorites to win and that means a 61% chance of landing a victory. For those wanting to oppose the market leader, you can get +128 about Vanderbilt.

The current spread is 3.5 and the total points line is 48.5. A Total bet relates to the number of points that will be scored overall. If you want to bet Under 48.5, there are odds of -110.

If you’re wagering on college football, we recommend heading to the best betting sites and scanning through the huge selection of team props and game lines. There’s the opportunity to bet pre-game and in-game.

Moneyline

Vanderbilt

+128

South Carolina

-154

Point Spread

Vanderbilt +3.5

-114

South Carolina -3.5

-106

Total Points

Under 48.5

-110

Over 48.5

-110

Player Odds

Receiving Yards

Nyck Harbor (South Carolina)

Over 46.5

-114

Under 46.5

-114

Eli Stowers (Vanderbilt)

Over 46.5

-114

Under 46.5

-114

Rushing Yards

Diego Pavia (Vanderbilt)

Over 57.5

-114

Under 57.5

-114

Sedrick Alexander (Vanderbilt)

Over 50.5

-114

Under 50.5

-114

LaNorris Sellers (South Carolina)

Over 50.5

-114

Under 50.5

-114

Oscar Adaway III (South Carolina)

Over 47.5

-114

Under 47.5

-114

Passing Yards

LaNorris Sellers (South Carolina)

Over 217.5

-114

Under 217.5

-114

Diego Pavia (Vanderbilt)

Over 189.5

-114

Under 189.5

-114

South Carolina Looking to Keep Rolling at Home

South Carolina have put together four consecutive victories at Williams-Brice Stadium. They have seven wins and three losses in the last 10 home games, posting 30.50 points per contest while yielding 19.10.

Vanderbilt have three wins and seven losses in the last 10 road games, posting 20.80 points per matchup while yielding 29.60.

The last Williams-Brice Stadium meeting saw South Carolina beat Vanderbilt 47-6. South Carolina have taken all 3 of the recent head-to-head meetings at Williams-Brice Stadium.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
South Carolina Home Stats		7-3	49.60	30.50	19.10	5	5
Vanderbilt Away Stats		3-7	50.40	20.80	29.60	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Vanderbilt Commodores Stats

South Carolina Gamecocks Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 45.50 pts in the previous 10 games
• Game Totals on the Road: An average of 50.40 pts in the previous 10 games on the road
• Over 48.5: Covered in 4 of the previous 10 games
• Over 48.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.60 pts and allowed 19.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.80 pts and allowed 29.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 47.90 pts in the previous 10 games
• Game Totals at Home: An average of 50.00 pts in the previous 10 home games
• Over 48.5: Covered in 4 of the previous 10 games
• Over 48.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 31.80 pts and allowed 16.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.20 pts and allowed 18.80 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Southeastern	W	L	PF	PA	N. Pts	Home	Away	Strk
Arkansas	2	0	108	21	87	2-0	0-0	2W
Auburn	2	0	80	27	53	1-0	1-0	2W
Georgia	2	0	73	13	60	2-0	0-0	2W
LSU	2	0	40	17	23	1-0	1-0	2W
Mississippi State	2	0	58	37	21	1-0	1-0	2W
Missouri	2	0	103	37	66	2-0	0-0	2W
Oklahoma	2	0	59	16	43	2-0	0-0	2W
Ole Miss	2	0	93	30	63	1-0	1-0	2W
South Carolina	2	0	62	21	41	2-0	0-0	2W
Tennessee	2	0	117	43	74	2-0	0-0	2W
Texas A&M	2	0	86	46	40	2-0	0-0	2W
Vanderbilt	2	0	89	23	66	1-0	1-0	2W
Alabama	1	1	90	31	59	1-0	0-1	1W
Florida	1	1	71	18	53	1-1	0-0	1L
Kentucky	1	1	47	46	1	1-1	0-0	1L
Texas	1	1	45	21	24	1-0	0-1	1W