Virginia vs Missouri Prediction, Picks & Odds | 27 Dec 2025

College Football Betting Preview: Virginia vs Missouri

Virginia battle Missouri at EverBank Stadium, with kickoff scheduled for 19:30 on Saturday, December 27.

We’re delighted to see Virginia have been given a headstart on the spread. Take the +4.5 at -114 when they go up against Missouri.

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Virginia Cavaliers have triumphed in four straight road games. Their previous contest was a 27-20 (OT) home defeat against Duke Blue Devils at Bank of America Stadium.

Missouri Tigers won their last game 31-17. This was a road victory at Razorback Stadium against Arkansas Razorbacks.

Virginia vs Missouri Prediction & Picks

Get ahead of the game with our Virginia vs Missouri betting rundown, featuring our trusted match prediction, most likely correct score outcome and a fully loaded bet builder.

Game Prediction

We’re confident that Virginia can produce a strong performance in this college football matchup. Our pick is that the underdogs will cover the +4.5 line and you can currently get -114.

The CFB handicappers at Sportsgambler.com regularly track injury updates and pair that with current form. We also tap into a deep stats database to highlight the key numbers that help shape our picks.

Key Virginia vs Missouri stats:

• The +4.5 line has been covered by Virginia in 11 of their last 13 games this season.
• The +4.5 line has been covered by Virginia in 8 of their last 10 games.
• The -4.5 line hasn’t been covered by Missouri in 3 of their last 5 games.

UVA +4.5 Probability

The best betting apps imply that our pick has a 53.2% chance of winning. Our cappers think there’s a stronger chance of success and calculate the probability to be closer to 60%. It is the reason why we are recommending this college wager.

A Bet Builder provides you with the opportunity to combine Virginia on the spread with other picks. For every additional selection, the price is boosted.

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Our Game Prediction

Virginia +4.5 @ -114 Bet Now

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Correct Score Prediction

Virginia 21 - 20 Missouri

There are massive odds available when it comes to the Cavs claiming a 21-20 victory. A close battle is anticipated between two evenly-matched teams.

Virginia vs Missouri Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Sportsbooks’ favorites Missouri are regarded as likeliest victors for this college game and the -185 about them triumphing means a 65% chance based on their current Moneyline betting odds. For those wanting to oppose the market leader, you can get +154 about Virginia.

The spread is calculated to be 4.5, while total points comes in at 45.5. A Total wager is always available and can often provide value selections. If you’re going for Under 45.5, this outcome can be backed at -118.

You can find a wide range of team props and game lines for every college football matchup, with the best sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your wagers.

Moneyline

Virginia

+154

Missouri

-185

Point Spread

Virginia +4.5

-114

Missouri -4.5

-106

Total Points

Under 45.5

-118

Over 45.5

-104

The best gambling sites offer quarterback and player prop betting to their customers. These can be a great alternative if you want to focus on an individual’s performance within a game and it often involves wagering over or under a line.

Micro betting is an exciting way to wager on college football. There are a huge range of live lines and it’s a simple case of predicting what is going to happen next. Field Goal Outcome, Next Drive Result and Next Play Result are often among the options.

Latest regular season and playoff games stats.

Virginia Cavaliers Stats

Missouri Tigers Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +4.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +4.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -4.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -4.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 49.30 pts in the previous 10 games
• Game Totals on the Road: An average of 55.10 pts in the previous 10 games on the road
• Over 45.5: Covered in 6 of the previous 10 games
• Over 45.5 on the Road: Covered in 8 of the previous 10 games on the road
• Team Totals: Have scored an average of 28.40 pts and allowed 20.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 27.20 pts and allowed 27.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 47.90 pts in the previous 10 games
• Game Totals at Home: An average of 58.10 pts in the previous 10 home games
• Over 45.5: Covered in 7 of the previous 10 games
• Over 45.5 at Home: Covered in the previous 10 home games
• Team Totals: Have scored an average of 28.30 pts and allowed 19.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 37.10 pts and allowed 21.00 pts in the last 10 home games

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