Western Kentucky vs LSU Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: Western Kentucky vs LSU

Western Kentucky face LSU at Tiger Stadium, with kickoff scheduled for 19:45 on Saturday, November 22.

Let’s back Western Kentucky at +21.5 to outrun their odds on the spread. They are a good shout at -106 to stay relatively close to LSU and we really like this pick.

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Western Kentucky Hilltoppers claimed a home victory in their previous game. A 42-26 triumph against Middle Tennessee State Blue Raiders at Houchens Industries-L.T. Smith Stadium made it three straight wins.

LSU Tigers last game saw them claim a 23-22 home win over Arkansas Razorbacks at Tiger Stadium.

Western Kentucky vs LSU Prediction & Picks

Discover our expert Western Kentucky vs LSU betting tips, featuring a key match prediction, correct score suggestion, top player prop picks and bet builder advice. Scroll down for full analysis.

Game Prediction

It’s hard to resist backing the underdogs considering they’ve been given +21.5 on the spread. Western Kentucky are a good shout at -106 to keep things close in this college football battle.

Our CFB predictions are always well-researched, starting with a combination of the latest team news and current form. Once we’ve got a solid read on the matchup, we layer in the key data to back it up.

Key Western Kentucky vs LSU stats:

• The +21.5 line has been covered by Western Kentucky in 7 consecutive games.
• The +21.5 line has been covered by Western Kentucky in 9 of their last 10 games.
• The +21.5 line has been covered by Western Kentucky in 18 of their last 20 games.
• The -21.5 line hasn’t been covered by LSU in 6 consecutive games.
• The -21.5 line hasn’t been covered by LSU in 9 of their last 10 games.
• The -21.5 line hasn’t been covered by LSU in 17 of their last 20 games.

WKU +21.5 Probability

According to the top sportsbooks, there’s a 51.5% likelihood of our pick landing a return. Our analysts think there’s a stronger chance of success and calculate the probability to be closer to 60%. It is therefore regarded as a value bet.

If the initial odds don’t grab your fancy, there’s the alternative to shoot for more juice by moving the line when it comes to your pick. It all comes down to how confident you feel.

Don’t bet without checking our complete guide to the latest betting promo codes, free bets, and welcome bonuses.

Our Game Prediction

Western Kentucky +21.5 @ -106 Bet Now

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Player Prop Picks

Top Pick: Harlem Berry Anytime TD -145

Harlem Berry (LSU) is available at -145 to record a TD. Based on all the evidence, we're happy to back him to punch it in on the Anytime Touchdown Scorer market.

Latest Harlem Berry Player Prop Odds

Touchdown

Anytime

-141

First

+600

Correct Score Prediction

Western Kentucky 21 - 35 LSU

For those wanting a big return from a small stake, consider the correct score lines. For example, LSU can be backed to win 35-21 at enormous betting odds.

Western Kentucky vs LSU Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

With an estimated 98% chance of winning, the sportsbooks are taking no chances with their -5000 betting odds about LSU triumphing in this college game. If you’re looking for an alternative angle, Western Kentucky are trading at +1500.

24.5 is the spread and 51.5 is the total points line. There is no denying the popularity of wagering on the Totals. Those expecting a low total can back Under 51.5 at -105.

If you’re betting on college football, we recommend heading to the top betting apps and scanning through the many team props and game lines. There’s a chance to wager pre-game and in-game.

Moneyline

WKU

+1500

LSU

-5000

Point Spread

WKU +24.5

-110

LSU -24.5

-110

Total Points

Under 51.5

-105

Over 51.5

-115

Trey'Dez Green is the market leader to score a touchdown at anytime and you can get -169. There is the chance to back the favorite to grab the first TD at odds of +500.

Trey'Dez Green

First TD

+500

Anytime TD

-169

Harlem Berry

First TD

+600

Anytime TD

-141

Caden Durham

First TD

+650

Anytime TD

-125

Barion Brown

First TD

+700

Anytime TD

-100

Aaron Anderson

First TD

+800

Anytime TD

+110

Michael Van Buren Jr.

First TD

+1000

Anytime TD

+145

Zavion Thomas

First TD

+1300

Anytime TD

+200

Kyle Parker

First TD

+1500

Anytime TD

+220

Matthew Henry

First TD

+2000

Anytime TD

+280

La'Vell Wright

First TD

+2200

Anytime TD

+330

K.D. Hutchinson

First TD

+2500

Anytime TD

+300

Marvis Parrish

First TD

+2700

Anytime TD

+380

Rodney Tisdale Jr.

First TD

+3300

Anytime TD

+500

George Hart III

First TD

+3500

Anytime TD

+550

Moussa Barry

First TD

+3500

Anytime TD

+550

Noah Meyers

First TD

+4500

Anytime TD

+650

An increasing number of bettors are now enjoying micro betting on college football and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

LSU Have Collected Eight Wins in Past Ten Home Games

LSU have gone 8-2 across their last 10 home games, averaging 27.00 points scored and 21.00 points allowed.

Western Kentucky have stacked up three straight wins away from home. They have five wins and five losses in the last 10 road games, putting up 24.50 points per matchup and giving up 29.80.

Last 10 Games		W-L	P	PF	PA	O50.5	U50.5
LSU Home Stats		8-2	48.00	27.00	21.00	5	5
Western Kentucky Away Stats		5-5	54.30	24.50	29.80	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O50.5 = Games Over 50.5 Points
• U50.5 = Games Under 50.5 Points

Latest regular season and playoff games stats.

Western Kentucky Hilltoppers Stats

LSU Tigers Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +21.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +21.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -21.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -21.5 Betting Line at Home: Have covered the spread in 1 of the last 10 home games

Total Points

• Game Totals: An average of 54.40 pts in the previous 10 games
• Game Totals on the Road: An average of 54.30 pts in the previous 10 games on the road
• Over 50.5: Covered in 7 of the previous 10 games
• Over 50.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 31.30 pts and allowed 23.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 24.50 pts and allowed 29.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 42.90 pts in the previous 10 games
• Game Totals at Home: An average of 50.00 pts in the previous 10 home games
• Over 50.5: Covered in 3 of the previous 10 games
• Over 50.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 23.60 pts and allowed 19.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 28.50 pts and allowed 21.50 pts in the last 10 home games

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