Wyoming vs Colorado Prediction, Picks & Odds | 20 Sep 2025

College Football Betting Preview: Wyoming vs Colorado

Wyoming meet Colorado in this NCAAF Week 4 matchup at Folsom Field, with kickoff scheduled for 22:15 on Saturday 20 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Colorado Look Far Too Strong

Our wager is Colorado against the spread. Back the favorites off -13.5 at odds of -110 and be confident they can cover the line against Wyoming.

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Two Teams Defeated in Last Game

Wyoming Cowboys were defeated in their previous game. They were beaten at home to Utah Utes by a 31-6 scoreline at Jonah Field at War Memorial Stadium.

Colorado Buffaloes lost on the road in their last game. Houston Cougars won 36-20 at TDECU Stadium.

Wyoming vs Colorado Prediction & Picks

We cover the essential Wyoming vs Colorado betting angles, featuring our main match prediction, correct score guidance and a carefully crafted bet builder.

Game Prediction

We strongly fancy the chances of Colorado beating the underdogs handsomely in this college football matchup. That is why we’re betting them at -13.5 on the spread at -110.

We only make our college football picks after confirming the latest team news. Studying recent form and digging into the most relevant stats also helps us build a complete picture.

Key Wyoming vs Colorado stats:

• The -13.5 line has been covered by Colorado in 3 of their last 5 games at home.

Colorado -13.5 Probability

If you go by the top betting apps, there’s a 52.4% chance that our pick is settled as a winner. In our opinion, there’s actually a probability of success between 55-60%. This is why we can recommend this college wager.

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Best Bet

Colorado -13.5 @ -110 Bet Now

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Correct Score Prediction

Wyoming 14 - 35 Colorado

There are a range of correct score lines to choose from and we’re taking a chance on Colorado to claim a 35-14 win. There’s a huge return if we get this right.

Wyoming vs Colorado Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Colorado Big Favorites to Win

Colorado are strong -588 favorites to win this college game according to the Moneyline betting odds. The sportsbooks give them a 85% chance of claiming victory. The market suggests that Wyoming are least likely to win at +420.

The spread is currently 13.5, with the total points line at 44.5. Football bettors regularly enjoy the opportunity to wager on the Totals. Those that want to back Under 44.5 can find odds of -110 available.

College football bettors are spoilt for choice thanks to the huge selection of team props and game lines which are available for every matchup on the coupon. Head to the top sportsbooks and find the best value wagers.

Moneyline

Wyoming

+420

Colorado

-588

Point Spread

Wyoming +13.5

-110

Colorado -13.5

-110

Total Points

Under 44.5

-110

Over 44.5

-110

Player Props & Micro Betting

You shouldn’t overlook the player props when it comes to betting on individual games. Many gambling sites will give you the chance to get with or bet against a specific player or quarterback when it comes to number of Touchdowns, Passing or Rushing Yards.

There are lots of exciting college football micro betting lines that are created and they are available in-game. Among them are whether a field goal will be scored and you simply bet whether the player will make it or miss.

Colorado Own Six Victories From Previous Ten at Home

Colorado own a 6-4 mark in their past 10 home games, averaging 33.30 points scored and 22.90 points allowed.

Wyoming own a 4-6 mark in their past 10 games away from home, averaging 18.50 points on offense and surrendering 27.10 on defense.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
Colorado Home Stats		6-4	56.20	33.30	22.90	9	1
Wyoming Away Stats		4-6	45.60	18.50	27.10	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Wyoming Cowboys Stats

Colorado Buffaloes Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +13.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +13.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -13.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -13.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 41.30 pts in the previous 10 games
• Game Totals on the Road: An average of 45.60 pts in the previous 10 games on the road
• Over 44.5: Covered in 3 of the previous 10 games
• Over 44.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 19.70 pts and allowed 21.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 18.50 pts and allowed 27.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 54.00 pts in the previous 10 games
• Game Totals at Home: An average of 56.70 pts in the previous 10 home games
• Over 44.5: Covered in 8 of the previous 10 games
• Over 44.5 at Home: Covered in 9 of the previous 10 home games
• Team Totals: Have scored an average of 31.60 pts and allowed 22.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 32.80 pts and allowed 23.90 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big 12	W	L	PF	PA	N. Pts	Home	Away	Strk
Arizona	3	0	111	26	85	3-0	0-0	3W
BYU	2	0	96	3	93	2-0	0-0	2W
Houston	3	0	98	29	69	2-0	1-0	3W
Iowa State	4	0	119	57	62	2-0	2-0	4W
TCU	2	0	90	35	55	1-0	1-0	2W
Texas Tech	3	0	174	35	139	3-0	0-0	3W
UCF	2	0	85	17	68	2-0	0-0	2W
Utah	3	0	137	25	112	1-0	2-0	3W
Baylor	2	1	114	90	24	1-1	1-0	2W
Cincinnati	2	1	121	40	81	2-1	0-0	2W
Kansas	2	1	108	56	52	2-0	0-1	1L
West Virginia	2	1	86	44	42	2-0	0-1	1W
Oklahoma State	1	1	30	76	-46	1-0	0-1	1L
Colorado	1	2	71	70	1	1-1	0-1	1L
Kansas State	1	3	97	106	-9	1-2	0-1	2L

Mountain West	W	L	PF	PA	N. Pts	Home	Away	Strk
UNLV	3	0	106	75	31	2-0	1-0	3W
Fresno State	3	1	141	79	62	2-0	1-1	3W
Hawaii	3	1	89	83	6	3-0	0-1	2W
New Mexico	2	1	84	66	18	1-0	1-1	2W
Utah State	2	1	99	90	9	2-0	0-1	1W
Wyoming	2	1	47	38	9	1-1	1-0	1L
Air Force	1	1	79	62	17	1-0	0-1	1L
Boise State	1	1	58	48	10	1-0	0-1	1W
Colorado State	1	1	42	55	-13	1-0	0-1	1W
San Diego State	1	1	55	36	19	1-0	0-1	1L
Nevada	1	2	44	77	-33	1-1	0-1	1L
San Jose State	0	2	21	54	-33	0-1	0-1	2L