Arizona Cardinals
American Football NFL Lucas Oil Stadium Sun 12 Oct 13:00
Indianapolis Colts
  1. Prediction
  2. SGP Picks
  3. Odds
  4. Player Props
  5. Stats
  6. Team News
  7. Lineups
  8. Injuries
  9. Standings

NFL Betting Preview: Cardinals vs Colts

The Arizona Cardinals face the Indianapolis Colts in this NFL Week 6 matchup at Lucas Oil Stadium, with kickoff scheduled for 13:00 on Sunday 12 October. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Find Out Why Colts Can Cover the Line

There’s a great opportunity to cover the spread by backing the Colts at -7. We can get odds of -105 and our prediction is that they will have the edge over the Cardinals.

Feeling good about our ATS pick? Grab the best BetMGM promo code and check out our comprehensive site review before you jump in.

Colts Won 22-16 in Teams’ Last Meeting

Arizona Cardinals have lost in their previous three outings. In a recent home game at State Farm Stadium, they were turned over 22-21 by Tennessee Titans. The Cardinals moved the ball for 360 yards, with 192 through the air and 168 on the ground. They picked up 16 first downs and scored 3 touchdowns, all coming on the ground.

Indianapolis Colts won their last game 40-6, making it three home wins on the bounce. This was recorded at Lucas Oil Stadium against Las Vegas Raiders. The Colts totaled 317 yards, split between 221 passing and 96 rushing yards. The offense picked up 24 first downs and scored 6 touchdowns, with 2 through the air and one on the ground.

Head-to-Head Statistics

The Colts beat the Cardinals in their last head-to-head matchup. It was a 22-16 scoreline at State Farm Stadium.

Quarterbacks

Cardinals vs Colts Prediction & Picks

Tackle Cardinals vs Colts with all the betting insight you need, including our match prediction, scoreline forecast, key player prop selections and a hand-picked bet builder.

Game Prediction

We’re backing the Colts against the spread in this NFL battle. It could be shrewd to bet on the favorites to cover the appealing -7 line, with -105 on offer.

We put solid research behind every NFL prediction, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Cardinals vs Colts stats:

  • The -7 line has been covered by Colts in 2 of their last 3 games at home this season.
  • The -7 line has been covered by Colts in 3 of their last 5 games this season.

Colts -7 Probability

The top betting sites imply that our pick has a 51.3% prospect of winning. However, our analysts research has found that the actual probability is closer to 60%. That means we’re regarding it as a value bet.

Looking for Bigger Odds?

If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your point spread pick. It all comes down to how confident you feel.

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Best Bet

Colts -7 @ -105 Bet Now BetMGM logo
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Published 19:26, 10 October 2025

Player Prop Picks

Top Pick: Kyler Murray Under 224.5 Passing Yards -114 BetMGM logo

The odds for Kyler Murray (Cardinals) to finish with fewer than 224.5 passing yards are -114. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the QB Passing Yards line.

Latest Kyler Murray Player Prop Odds

Michael Pittman Jr. Anytime TD +165 BetMGM logo

Michael Pittman Jr. (Colts) is priced at +165 to score a TD. It’s worth a play that he is Anytime Touchdown Scorer as there’s lots of value for these betting odds.

Latest Michael Pittman Jr. Player Prop Odds

Same Game Parlay Picks

Spread Colts -7
Totals Under 47.5
Passing Yards Kyler Murray Under 224.5

Try out our same game parlay pick which starts with Colts -7. We’ve also gone for Under 47.5 points and Kyler Murray (Cardinals) to have Under 224.5 passing yards.

A same game parlay is a fantastic way of cheering on different picks within the same football game. You can predict a number of outcomes and get bigger odds than a single bet. The odds can combine to great effect.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Cardinals Cardinals logo 13 - 28 Colts logo Colts

There are many different ways to back the Colts on the correct score betting and something like 28-13 in their favor might be along the right lines at huge odds.

Cardinals vs Colts Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Giving Colts Plenty of Respect

With a 76% chance of securing victory, Indianapolis Colts are favorites for this game and the sportsbooks have them at betting odds of -313. Arizona Cardinals are trading at bigger odds than their opponents and they can be backed at +250.

The spread currently stands at 7 and the total points line is 47.5. NFL fans regularly enjoy the opportunity to bet on the Totals. There’s the chance to back Under 47.5 at -115.

You can find a wide range of game lines and team props for every matchup, with the best NFL sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your bets.

Jonathan Taylor Favorite to Be First TD Scorer

Favorite Jonathan Taylor is available at +280 to be the First TD Scorer. Similar odds apply if you’re interested in this player to score the final touchdown.

Touchdown

Jonathan Taylor (Colts)
First TD
+280
Anytime TD
-263
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Tyler Warren (Colts)
First TD
+950
Anytime TD
+160
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Michael Pittman Jr. (Colts)
First TD
+950
Anytime TD
+165
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Receiving Yards

Trey McBride (Cardinals)
Over 58.5
-114
Under 58.5
-114
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Marvin Harrison Jr. (Cardinals)
Over 53.5
-114
Under 53.5
-114
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Michael Pittman Jr. (Colts)
Over 49.5
-114
Under 49.5
-114
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Rushing Yards

Jonathan Taylor (Colts)
Over 84.5
-114
Under 84.5
-114
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Michael Carter (Cardinals)
Over 48.5
-114
Under 48.5
-114
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Kyler Murray (Cardinals)
Over 19.5
-114
Under 19.5
-114
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Passing Yards

Best Betting Offers
Lucas Oil Stadium
Lucas Oil Stadium

Will Colts Extend Their Home Winning Streak?

The Colts have won five straight at Lucas Oil Stadium. They have eight wins and two losses in the last 10 home games, posting 25.60 points per contest while yielding 19.90.

The Cardinals have a 3-7 record in their last 10 road games, putting up 19.50 points per contest and giving up 23.50.

The Colts beat the Cardinals 21-13 when they last met at Lucas Oil Stadium.

Last 10 Games W-L P PF PA O47.5 U47.5
Colts logo Colts Home Stats 8-2 45.50 25.60 19.90 5 5
Cardinals logo Cardinals Away Stats 3-7 43.00 19.50 23.50 3 7
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O47.5 = Games Over 47.5 Points
  • U47.5 = Games Under 47.5 Points
Team Stats

Latest regular season and playoff games stats.

Arizona Cardinals logo Arizona Cardinals Stats
Indianapolis Colts logo Indianapolis Colts Stats
Moneyline
  • 4 wins and 6 defeats in the last 10 games
  • 3 wins and 7 defeats in the last 10 games on the road
Moneyline
  • 7 wins and 3 defeats in the last 10 games
  • 8 wins and 2 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Team News

Arizona Cardinals Injuries

Type
Name
Info
Trey Benson
Knee - Meniscus
Joey Blount
Neck
L.J. Collier
Knee
Hayden Conner
Knee
James Conner
Foot
Blake Gillikin
Back
Christian Jones
Knee
Justin Jones
Knee
Zay Jones
Knee
Max Melton
Hamstring
Sean Murphy-Bunting
Knee
Kyler Murray
Foot
Walter Nolen
Calf
BJ Ojulari
Knee - ACL
Tip Reiman
Ankle
Darius Robinson
Pectoral
J.J. Russell
Concussion
Valentin Senn
Undisclosed
Cody Simon
Knee
Starling Thomas
Knee - ACL
Garrett Williams
Knee
Mack Wilson
Ankle

Indianapolis Colts Injuries

Type
Name
Info
Salvon Ahmed
Ankle
Joe Bachie
Undisclosed
Jaylon Carlies
Ankle
Blake Freeland
Leg
Tyler Goodson
Groin
Xavien Howard
Personal
Jaylon Jones
Hamstring
D.J. Montgomery
Undisclosed
Kenny Moore
Achilles
Jacob Phillips
Biceps
Daniel Scott
Knee
Spencer Shrader
Knee - ACL + MCL
Justin Walley
Knee - ACL
Jack Wilson
Undisclosed
Hunter Wohler
Foot

Previous Arizona Cardinals Lineups

05 Oct NFL
Titans 22-21 Cardinals
25 Sep NFL
Seahawks 23-20 Cardinals
21 Sep NFL
Cardinals 15-16 49ers
14 Sep NFL
Panthers 22-27 Cardinals
07 Sep NFL
Cardinals 20-13 Saints
05 Jan NFL
49ers 24-47 Cardinals
28 Dec NFL
Cardinals 9-13 Rams
22 Dec NFL
Cardinals 30-36 Panthers
15 Dec NFL
Patriots 17-30 Cardinals
08 Dec NFL
Seahawks 30-18 Cardinals

Previous Indianapolis Colts Lineups

05 Oct NFL
Raiders 6-40 Colts
28 Sep NFL
Colts 20-27 Rams
21 Sep NFL
Colts 41-20 Titans
14 Sep NFL
Broncos 28-29 Colts
07 Sep NFL
Dolphins 8-33 Colts
05 Jan NFL
Jaguars 23-26 Colts
29 Dec NFL
Colts 33-45 Giants
22 Dec NFL
Titans 30-38 Colts
15 Dec NFL
Colts 13-31 Broncos
01 Dec NFL
Colts 25-24 Patriots

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 4 1 0 0.800 153 113 40 3-1-0 1-0-0 2-1-0 3-1-0 4-1-0 1L
Patriots 3 2 0 0.600 125 101 24 1-2-0 2-0-0 2-0-0 2-2-0 3-2-0 2W
Dolphins 1 4 0 0.200 107 145 -38 1-1-0 0-3-0 1-2-0 1-3-0 1-4-0 1L
Jets 0 5 0 0.000 112 157 -45 0-3-0 0-2-0 0-2-0 0-3-0 0-5-0 5L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Steelers 3 1 0 0.750 96 98 -2 1-1-0 2-0-0 0-0-0 2-0-0 3-1-0 2W
Bengals 2 3 0 0.400 85 156 -71 1-1-0 1-2-0 1-0-0 2-1-0 2-3-0 3L
Ravens 1 4 0 0.200 141 177 -36 1-2-0 0-2-0 1-0-0 1-3-0 1-4-0 3L
Browns 1 4 0 0.200 73 123 -50 1-2-0 0-2-0 0-2-0 0-2-0 1-4-0 2L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 4 1 0 0.800 163 89 74 3-0-0 1-1-0 1-0-0 4-0-0 4-1-0 1W
Jaguars 4 1 0 0.800 127 100 27 3-0-0 1-1-0 1-0-0 2-1-0 4-1-0 3W
Texans 2 3 0 0.400 108 61 47 1-1-0 1-2-0 1-1-0 2-1-0 2-3-0 2W
Titans 1 4 0 0.200 73 141 -68 0-2-0 1-2-0 0-2-0 0-3-0 1-4-0 1W
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 3 2 0 0.600 98 98 0 2-1-0 1-1-0 3-0-0 3-0-0 3-2-0 2L
Broncos 3 2 0 0.600 117 84 33 2-0-0 1-2-0 0-1-0 2-2-0 3-2-0 2W
Chiefs 2 3 0 0.400 125 107 18 1-1-0 1-2-0 0-1-0 1-2-0 2-3-0 1L
Raiders 1 4 0 0.200 83 139 -56 0-2-0 1-2-0 0-1-0 1-2-0 1-4-0 4L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 4 2 0 0.667 142 143 -1 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 2L
Commanders 3 2 0 0.600 134 101 33 2-0-0 1-2-0 1-0-0 1-2-0 3-2-0 1W
Cowboys 2 2 1 0.400 151 154 -3 1-0-1 1-2-0 1-1-0 1-2-1 2-2-1 1W
Giants 2 4 0 0.333 121 144 -23 2-1-0 0-3-0 1-2-0 1-3-0 2-3-0 1W
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Lions 4 1 0 0.800 174 112 62 2-0-0 2-1-0 1-1-0 1-1-0 4-1-0 4W
Packers 2 1 1 0.500 104 84 20 2-0-0 0-1-1 1-0-0 2-0-1 2-1-1 1D
Vikings 3 2 0 0.600 123 97 26 1-1-0 2-1-0 1-0-0 1-1-0 3-2-0 1W
Bears 2 2 0 0.500 101 117 -16 1-1-0 1-1-0 0-2-0 1-2-0 2-2-0 2W
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 4 1 0 0.800 135 132 3 1-1-0 3-0-0 1-0-0 2-1-0 4-1-0 1W
Falcons 2 2 0 0.500 76 86 -10 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 1W
Panthers 2 3 0 0.400 102 119 -17 2-0-0 0-3-0 1-0-0 1-1-0 2-3-0 1W
Saints 1 4 0 0.200 92 135 -43 1-2-0 0-2-0 0-0-0 1-3-0 1-4-0 1W
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
49ers 4 1 0 0.800 106 98 8 1-1-0 3-0-0 3-0-0 4-0-0 4-1-0 1W
Seahawks 3 2 0 0.600 146 105 41 1-2-0 2-0-0 1-1-0 2-2-0 3-2-0 1L
Rams 3 2 0 0.600 123 107 16 2-1-0 1-1-0 0-1-0 0-2-0 3-2-0 1L
Cardinals 2 3 0 0.400 103 96 7 1-2-0 1-1-0 0-2-0 2-2-0 2-3-0 3L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 4 1 0 0.800 163 89 74 3-0-0 1-1-0 1-0-0 4-0-0 4-1-0 1W
Bills 4 1 0 0.800 153 113 40 3-1-0 1-0-0 2-1-0 3-1-0 4-1-0 1L
Steelers 3 1 0 0.750 96 98 -2 1-1-0 2-0-0 0-0-0 2-0-0 3-1-0 2W
Chargers 3 2 0 0.600 98 98 0 2-1-0 1-1-0 3-0-0 3-0-0 3-2-0 2L
Jaguars 4 1 0 0.800 127 100 27 3-0-0 1-1-0 1-0-0 2-1-0 4-1-0 3W
Broncos 3 2 0 0.600 117 84 33 2-0-0 1-2-0 0-1-0 2-2-0 3-2-0 2W
Patriots 3 2 0 0.600 125 101 24 1-2-0 2-0-0 2-0-0 2-2-0 3-2-0 2W
Bengals 2 3 0 0.400 85 156 -71 1-1-0 1-2-0 1-0-0 2-1-0 2-3-0 3L
Texans 2 3 0 0.400 108 61 47 1-1-0 1-2-0 1-1-0 2-1-0 2-3-0 2W
Chiefs 2 3 0 0.400 125 107 18 1-1-0 1-2-0 0-1-0 1-2-0 2-3-0 1L
Raiders 1 4 0 0.200 83 139 -56 0-2-0 1-2-0 0-1-0 1-2-0 1-4-0 4L
Ravens 1 4 0 0.200 141 177 -36 1-2-0 0-2-0 1-0-0 1-3-0 1-4-0 3L
Dolphins 1 4 0 0.200 107 145 -38 1-1-0 0-3-0 1-2-0 1-3-0 1-4-0 1L
Browns 1 4 0 0.200 73 123 -50 1-2-0 0-2-0 0-2-0 0-2-0 1-4-0 2L
Titans 1 4 0 0.200 73 141 -68 0-2-0 1-2-0 0-2-0 0-3-0 1-4-0 1W
Jets 0 5 0 0.000 112 157 -45 0-3-0 0-2-0 0-2-0 0-3-0 0-5-0 5L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 4 2 0 0.667 142 143 -1 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 2L
49ers 4 1 0 0.800 106 98 8 1-1-0 3-0-0 3-0-0 4-0-0 4-1-0 1W
Buccaneers 4 1 0 0.800 135 132 3 1-1-0 3-0-0 1-0-0 2-1-0 4-1-0 1W
Lions 4 1 0 0.800 174 112 62 2-0-0 2-1-0 1-1-0 1-1-0 4-1-0 4W
Packers 2 1 1 0.500 104 84 20 2-0-0 0-1-1 1-0-0 2-0-1 2-1-1 1D
Seahawks 3 2 0 0.600 146 105 41 1-2-0 2-0-0 1-1-0 2-2-0 3-2-0 1L
Vikings 3 2 0 0.600 123 97 26 1-1-0 2-1-0 1-0-0 1-1-0 3-2-0 1W
Commanders 3 2 0 0.600 134 101 33 2-0-0 1-2-0 1-0-0 1-2-0 3-2-0 1W
Rams 3 2 0 0.600 123 107 16 2-1-0 1-1-0 0-1-0 0-2-0 3-2-0 1L
Falcons 2 2 0 0.500 76 86 -10 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 1W
Bears 2 2 0 0.500 101 117 -16 1-1-0 1-1-0 0-2-0 1-2-0 2-2-0 2W
Cowboys 2 2 1 0.400 151 154 -3 1-0-1 1-2-0 1-1-0 1-2-1 2-2-1 1W
Cardinals 2 3 0 0.400 103 96 7 1-2-0 1-1-0 0-2-0 2-2-0 2-3-0 3L
Panthers 2 3 0 0.400 102 119 -17 2-0-0 0-3-0 1-0-0 1-1-0 2-3-0 1W
Saints 1 4 0 0.200 92 135 -43 1-2-0 0-2-0 0-0-0 1-3-0 1-4-0 1W
Giants 2 4 0 0.333 121 144 -23 2-1-0 0-3-0 1-2-0 1-3-0 2-3-0 1W
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 4 1 0 0.800 153 113 40 3-1-0 1-0-0 2-1-0 3-1-0 4-1-0 1L
Lions 4 1 0 0.800 174 112 62 2-0-0 2-1-0 1-1-0 1-1-0 4-1-0 4W
Colts 4 1 0 0.800 163 89 74 3-0-0 1-1-0 1-0-0 4-0-0 4-1-0 1W
Jaguars 4 1 0 0.800 127 100 27 3-0-0 1-1-0 1-0-0 2-1-0 4-1-0 3W
49ers 4 1 0 0.800 106 98 8 1-1-0 3-0-0 3-0-0 4-0-0 4-1-0 1W
Buccaneers 4 1 0 0.800 135 132 3 1-1-0 3-0-0 1-0-0 2-1-0 4-1-0 1W
Steelers 3 1 0 0.750 96 98 -2 1-1-0 2-0-0 0-0-0 2-0-0 3-1-0 2W
Eagles 4 2 0 0.667 142 143 -1 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 2L
Packers 2 1 1 0.500 104 84 20 2-0-0 0-1-1 1-0-0 2-0-1 2-1-1 1D
Broncos 3 2 0 0.600 117 84 33 2-0-0 1-2-0 0-1-0 2-2-0 3-2-0 2W
Chargers 3 2 0 0.600 98 98 0 2-1-0 1-1-0 3-0-0 3-0-0 3-2-0 2L
Rams 3 2 0 0.600 123 107 16 2-1-0 1-1-0 0-1-0 0-2-0 3-2-0 1L
Vikings 3 2 0 0.600 123 97 26 1-1-0 2-1-0 1-0-0 1-1-0 3-2-0 1W
Patriots 3 2 0 0.600 125 101 24 1-2-0 2-0-0 2-0-0 2-2-0 3-2-0 2W
Seahawks 3 2 0 0.600 146 105 41 1-2-0 2-0-0 1-1-0 2-2-0 3-2-0 1L
Commanders 3 2 0 0.600 134 101 33 2-0-0 1-2-0 1-0-0 1-2-0 3-2-0 1W
Falcons 2 2 0 0.500 76 86 -10 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 1W
Bears 2 2 0 0.500 101 117 -16 1-1-0 1-1-0 0-2-0 1-2-0 2-2-0 2W
Cowboys 2 2 1 0.400 151 154 -3 1-0-1 1-2-0 1-1-0 1-2-1 2-2-1 1W
Cardinals 2 3 0 0.400 103 96 7 1-2-0 1-1-0 0-2-0 2-2-0 2-3-0 3L
Panthers 2 3 0 0.400 102 119 -17 2-0-0 0-3-0 1-0-0 1-1-0 2-3-0 1W
Bengals 2 3 0 0.400 85 156 -71 1-1-0 1-2-0 1-0-0 2-1-0 2-3-0 3L
Texans 2 3 0 0.400 108 61 47 1-1-0 1-2-0 1-1-0 2-1-0 2-3-0 2W
Chiefs 2 3 0 0.400 125 107 18 1-1-0 1-2-0 0-1-0 1-2-0 2-3-0 1L
Giants 2 4 0 0.333 121 144 -23 2-1-0 0-3-0 1-2-0 1-3-0 2-3-0 1W
Ravens 1 4 0 0.200 141 177 -36 1-2-0 0-2-0 1-0-0 1-3-0 1-4-0 3L
Browns 1 4 0 0.200 73 123 -50 1-2-0 0-2-0 0-2-0 0-2-0 1-4-0 2L
Raiders 1 4 0 0.200 83 139 -56 0-2-0 1-2-0 0-1-0 1-2-0 1-4-0 4L
Dolphins 1 4 0 0.200 107 145 -38 1-1-0 0-3-0 1-2-0 1-3-0 1-4-0 1L
Saints 1 4 0 0.200 92 135 -43 1-2-0 0-2-0 0-0-0 1-3-0 1-4-0 1W
Titans 1 4 0 0.200 73 141 -68 0-2-0 1-2-0 0-2-0 0-3-0 1-4-0 1W
Jets 0 5 0 0.000 112 157 -45 0-3-0 0-2-0 0-2-0 0-3-0 0-5-0 5L