Cardinals vs Colts Prediction, Picks & Odds | 12 Oct 2025

NFL Betting Preview: Cardinals vs Colts

The Arizona Cardinals face the Indianapolis Colts in this NFL Week 6 matchup at Lucas Oil Stadium, with kickoff scheduled for 13:00 on Sunday, October 12. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

There’s a great opportunity to cover the spread by backing the Colts at -7. We can get odds of -105 and our prediction is that they will have the edge over the Cardinals.

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Arizona Cardinals have lost in their previous three outings. In a recent home game at State Farm Stadium, they were turned over 22-21 by Tennessee Titans. The Cardinals moved the ball for 360 yards, with 192 through the air and 168 on the ground. They picked up 16 first downs and scored 3 touchdowns, all coming on the ground.

Indianapolis Colts won their last game 40-6, making it three home wins on the bounce. This was recorded at Lucas Oil Stadium against Las Vegas Raiders. The Colts totaled 317 yards, split between 221 passing and 96 rushing yards. The offense picked up 24 first downs and scored 6 touchdowns, with 2 through the air and one on the ground.

Head-to-Head Statistics

The Colts beat the Cardinals in their last head-to-head matchup. It was a 22-16 scoreline at State Farm Stadium.

Quarterbacks

Kyler Murray

220.5 Passing Yards

Over -114

Under -114

Daniel Jones

233.5 Passing Yards

Over -112

Under -112

Cardinals vs Colts Prediction & Picks

Tackle Cardinals vs Colts with all the betting insight you need, including our match prediction, scoreline forecast, key player prop selections and a hand-picked bet builder.

Game Prediction

We’re backing the Colts against the spread in this NFL battle. It could be shrewd to bet on the favorites to cover the appealing -7 line, with -105 on offer.

We put solid research behind every NFL prediction, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Cardinals vs Colts stats:

• The -7 line has been covered by Colts in 2 of their last 3 games at home this season.
• The -7 line has been covered by Colts in 3 of their last 5 games this season.

Colts -7 Probability

The top betting sites imply that our pick has a 51.3% prospect of winning. However, our analysts research has found that the actual probability is closer to 60%. That means we’re regarding it as a value bet.

If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your point spread pick. It all comes down to how confident you feel.

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Our Game Prediction

Colts -7 @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:26, 10 October 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Kyler Murray Under 224.5 Passing Yards -114

The odds for Kyler Murray (Cardinals) to finish with fewer than 224.5 passing yards are -114. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the QB Passing Yards line.

Latest Kyler Murray Player Prop Odds

Touchdown

Anytime

+480

First

+2700

Passing Yards

Over 220.5

-114

Under 220.5

-114

Rushing Yards

Over 19.5

-114

Under 19.5

-114

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Michael Pittman Jr. Anytime TD +165

Michael Pittman Jr. (Colts) is priced at +165 to score a TD. It’s worth a play that he is Anytime Touchdown Scorer as there’s lots of value for these betting odds.

Latest Michael Pittman Jr. Player Prop Odds

Touchdown

Anytime

+170

First

+950

Receiving Yards

Over 49.5

-112

Under 49.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Cardinals 13 - 28 Colts

There are many different ways to back the Colts on the correct score betting and something like 28-13 in their favor might be along the right lines at huge odds.

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Cardinals vs Colts Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With a 50% chance of securing victory, Indianapolis Colts are favorites for this game and the sportsbooks have them at betting odds of +102. Arizona Cardinals are trading at bigger odds than their opponents and they can be backed at -122.

The spread currently stands at 1.5 and the total points line is 47.5. NFL fans regularly enjoy the opportunity to bet on the Totals. There’s the chance to back Under 47.5 at -112.

You can find a wide range of game lines and team props for every matchup, with the best NFL sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your bets.

Moneyline

Cardinals

-122

Colts

+102

Point Spread

Cardinals -1.5

-110

Colts +1.5

-110

Total Points

Under 47.5

-112

Over 47.5

-108

Favorite Jonathan Taylor is available at +260 to be the First TD Scorer. Similar odds apply if you’re interested in this player to score the final touchdown.

Touchdown

Jonathan Taylor (Colts)

First TD

+260

Anytime TD

-278

Tyler Warren (Colts)

First TD

+800

Anytime TD

+165

Michael Pittman Jr. (Colts)

First TD

+950

Anytime TD

+170

Daniel Jones (Colts)

First TD

+1000

Anytime TD

+195

Bam Knight (Cardinals)

First TD

+1200

Anytime TD

+210

Josh Downs (Colts)

First TD

+1300

Anytime TD

+290

Trey McBride (Cardinals)

First TD

+1600

Anytime TD

+250

Marvin Harrison Jr. (Cardinals)

First TD

+1600

Anytime TD

+230

Alec Pierce (Colts)

First TD

+1700

Anytime TD

+360

Michael Carter (Cardinals)

First TD

+2000

Anytime TD

+310

Kyler Murray (Cardinals)

First TD

+2700

Anytime TD

+480

Michael Wilson (Cardinals)

First TD

+3000

Anytime TD

+500

Adonai Mitchell (Colts)

First TD

+3300

Anytime TD

+650

Anthony Gould (Colts)

First TD

+3500

Anytime TD

+700

Ashton Dulin (Colts)

First TD

+3500

Anytime TD

+700

Emari Demercado (Cardinals)

First TD

+4000

Anytime TD

+600

Greg Dortch (Cardinals)

First TD

+4500

Anytime TD

+700

DJ Giddens (Colts)

First TD

+4500

Anytime TD

+950

Zay Jones (Cardinals)

First TD

+5500

Anytime TD

+850

Mo Alie-Cox (Colts)

First TD

+6000

Anytime TD

+1300

Elijah Higgins (Cardinals)

First TD

+6000

Anytime TD

+1000

Drew Ogletree (Colts)

First TD

+8000

Anytime TD

+2200

Will Mallory (Colts)

First TD

+8000

Anytime TD

+2200

Simi Fehoko (Cardinals)

First TD

+10000

Anytime TD

+2200

Xavier Weaver (Cardinals)

First TD

+10000

Anytime TD

+2200

Travis Vokolek (Cardinals)

First TD

+10000

Anytime TD

+3300

Receiving Yards

Trey McBride (Cardinals)

Over 55.5

-112

Under 55.5

-112

Tyler Warren (Colts)

Over 51.5

-112

Under 51.5

-112

Marvin Harrison Jr. (Cardinals)

Over 50.5

-112

Under 50.5

-112

Michael Pittman Jr. (Colts)

Over 49.5

-112

Under 49.5

-112

Josh Downs (Colts)

Over 36.5

-112

Under 36.5

-112

Alec Pierce (Colts)

Over 30.5

-112

Under 30.5

-112

Michael Wilson (Cardinals)

Over 20.5

-112

Under 20.5

-112

Jonathan Taylor (Colts)

Over 16.5

-112

Under 16.5

-112

Michael Carter (Cardinals)

Over 10.5

-112

Under 10.5

-112

Rushing Yards

Jonathan Taylor (Colts)

Over 86.5

-112

Under 86.5

-112

Bam Knight (Cardinals)

Over 37.5

-112

Under 37.5

-112

Michael Carter (Cardinals)

Over 25.5

-112

Under 25.5

-112

Kyler Murray (Cardinals)

Over 19.5

-114

Under 19.5

-114

Daniel Jones (Colts)

Over 16.5

-112

Under 16.5

-112

Passing Yards

Daniel Jones (Colts)

Over 233.5

-112

Under 233.5

-112

Kyler Murray (Cardinals)

Over 220.5

-114

Under 220.5

-114

There are lots of exciting NFL micro betting lines that are created and they are available in-game. Among them are whether a field goal will be scored and you simply bet whether the player will make it or miss.

Will Colts Extend Their Home Winning Streak?

The Colts have won five straight at Lucas Oil Stadium. They have eight wins and two losses in the last 10 home games, posting 25.60 points per contest while yielding 19.90.

The Cardinals have a 3-7 record in their last 10 road games, putting up 19.50 points per contest and giving up 23.50.

The Colts beat the Cardinals 21-13 when they last met at Lucas Oil Stadium.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
Colts Home Stats		8-2	45.50	25.60	19.90	5	5
Cardinals Away Stats		3-7	43.00	19.50	23.50	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Latest regular season and playoff games stats.

Arizona Cardinals Stats

Indianapolis Colts Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +7 Betting Line: Have covered the spread in 9 of the last 10 games
• +7 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -7 Betting Line: Have covered the spread in 4 of the last 10 games
• -7 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 45.30 pts in the previous 10 games
• Game Totals on the Road: An average of 43.00 pts in the previous 10 games on the road
• Over 47.5: Covered in 4 of the previous 10 games
• Over 47.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 23.70 pts and allowed 21.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 19.50 pts and allowed 23.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 54.00 pts in the previous 10 games
• Game Totals at Home: An average of 45.50 pts in the previous 10 home games
• Over 47.5: Covered in 6 of the previous 10 games
• Over 47.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 29.80 pts and allowed 24.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 25.60 pts and allowed 19.90 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 336.10 Yds. Allowed 348.60 Yds
• Rushing Yards: Gained 132.80 Yds. Allowed 114.70 Yds
• Passing Yards: Gained 203.30 Yds. Allowed 233.90 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 19.90. Allowed 19.90
• Total Turnovers: Committed 1.20. Committed by opponents 1.00
• Total Penalties: Committed 7.00. Committed by opponents 7.90
• Penalty Yards: Lost 49.70 Yds. Gained 65.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 380.20 Yds. Allowed 320.50 Yds
• Rushing Yards: Gained 157.20 Yds. Allowed 102.00 Yds
• Passing Yards: Gained 223.00 Yds. Allowed 218.50 Yds
• Total Touchdowns: Scored 3.30 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.70 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 22.20. Allowed 19.00
• Total Turnovers: Committed 1.40. Committed by opponents 1.60
• Total Penalties: Committed 6.10. Committed by opponents 6.00
• Penalty Yards: Lost 48.30 Yds. Gained 62.60 Yds

Last 10 Games on the Road

• Total Yards: Gained 333.50 Yds. Allowed 337.50 Yds
• Rushing Yards: Gained 122.10 Yds. Allowed 118.00 Yds
• Passing Yards: Gained 211.40 Yds. Allowed 219.50 Yds
• Total Touchdowns: Scored 1.70 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 19.60. Allowed 20.20
• Total Turnovers: Committed 1.20. Committed by opponents 0.80
• Total Penalties: Committed 7.00. Committed by opponents 6.20
• Penalty Yards: Lost 54.00 Yds. Gained 51.60 Yds

Last 10 Home Games

• Total Yards: Gained 367.20 Yds. Allowed 339.80 Yds
• Rushing Yards: Gained 158.60 Yds. Allowed 112.50 Yds
• Passing Yards: Gained 208.60 Yds. Allowed 227.30 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 1.40 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 20.30. Allowed 20.80
• Total Turnovers: Committed 0.80. Committed by opponents 1.90
• Total Penalties: Committed 6.50. Committed by opponents 5.40
• Penalty Yards: Lost 50.80 Yds. Gained 48.20 Yds

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